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Entry version 83 (18 Sep 2019)
Sequence version 1 (01 Nov 1999)
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Protein

RNA1 polyprotein

Gene
N/A
Organism
Satsuma dwarf virus (isolate Satsuma mandarin/Japan/S-58/1977) (SDV)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Picornain 3C-like protease is a thiol protease that probably cleaves the polyprotein.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1210For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei1255For picornain 3C-like protease activityPROSITE-ProRule annotation1
Active sitei1348For picornain 3C-like protease activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi741 – 748ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processDNA replication, Viral RNA replication
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA1 polyprotein
Alternative name(s):
P1
Cleaved into the following 3 chains:
Putative helicase (EC:3.6.4.-)
Alternative name(s):
Putative NTP-binding protein
Probable picornain 3C-like protease (EC:3.4.22.-)
Short name:
3C-like protease
Probable RNA-directed RNA polymerase (EC:2.7.7.48)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSatsuma dwarf virus (isolate Satsuma mandarin/Japan/S-58/1977) (SDV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri650481 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaPicornaviralesSecoviridaeSadwavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCitrus sinensis (Sweet orange) (Citrus aurantium var. sinensis) [TaxID: 2711]
Citrus unshiu (Satsuma mandarin) (Citrus nobilis var. unshiu) [TaxID: 55188]
Viburnum odoratissimum [TaxID: 237951]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000675 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei481 – 501HelicalSequence analysisAdd BLAST21
Transmembranei515 – 535HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004027721 – 2081RNA1 polyproteinAdd BLAST2081
ChainiPRO_0000402773?1 – ?1174Putative helicaseSequence analysisAdd BLAST1174
ChainiPRO_0000402774?1175 – ?1400Probable picornain 3C-like proteaseBy similarityAdd BLAST226
ChainiPRO_0000402775?1401 – 2081Probable RNA-directed RNA polymeraseBy similarityAdd BLAST681

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9WAL8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini714 – 881SF3 helicasePROSITE-ProRule annotationAdd BLAST168
Domaini1166 – 1388Peptidase C3PROSITE-ProRule annotationAdd BLAST223
Domaini1679 – 1810RdRp catalyticPROSITE-ProRule annotationAdd BLAST132

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi259 – 262Poly-Thr4
Compositional biasi482 – 485Poly-Leu4
Compositional biasi859 – 862Poly-Arg4

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00680 RdRP_1, 1 hit
PF00910 RNA_helicase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51874 PCV_3C_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9WAL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEIYGFSPLS FQDTESWKNS AFAACRGCKT YPIEEVGTDG SVRIRELPVG
60 70 80 90 100
LVLKGVMAQY RSILWTQFVA DPATTTVDRK SFDFWLFCRR AEAAQERAFR
110 120 130 140 150
ARQSKRAAKA AALDAEGLID RSYKGRTYKV STRGLSWKSV RAAQKAARNA
160 170 180 190 200
AKNFGFAISA NPFSALSALP SEGKGLSAGE TPATVAEVAP QCFWAALRSL
210 220 230 240 250
KREFSETPVE DLPFLGLVLP ALPQRNGELA RTLRAQLRAH QAARVVASGV
260 270 280 290 300
SLREIPRRTT TTVKVVVPRV TIPVVTFNGA VLHHPKHPVI VALLKRVTIR
310 320 330 340 350
AKPICERRTY VRLVDGPGLF PSPRTPTLDL GFMEKVSELA TMPGDSIEKC
360 370 380 390 400
IAIKCILSND YNFKEDADMG DVLLSLQSKY TGGGDTAEHR GFISGALYGA
410 420 430 440 450
GVCVVTSAWK FLDATLHASQ IGTQISQILD YIQSGLAWLS SSYASIANFF
460 470 480 490 500
TKGKVYIMEC LELVKAKLPS YLFSAEVGRY ILLLLGVFLC LGLVNSLIYS
510 520 530 540 550
VAPQYSLSFG TVCKISLGAL ALVGLGDLVA YLFNSPGAKL RAFVNIVCNM
560 570 580 590 600
CGCKNFFAPS SDGEERSGFS VLSMMGAICA LQSLLPANVS RFSWDCGKWA
610 620 630 640 650
QTFKTGFDCH EKFATVCESL SVWLLSKVGL FKSSESQAMQ TILLSSGINT
660 670 680 690 700
CGWLEKVAAF HSDVHSSQIC IPDLLLRARQ LIETGDTISD LLSNSTVSLS
710 720 730 740 750
FLLRERIKLA LRELKEDHTQ LQLAVDVSVS SECPFVLFFA GDSGVGKSTA
760 770 780 790 800
MKKFREEVLD KLGYPKTARF YPRNPGEKFW SGYLRHTAVI YDDFAQIPQG
810 820 830 840 850
DMTYDEAELI RIVTNAVVTV PMAIAEEKGR TFRSKFVFAC TNRYCESEDA
860 870 880 890 900
PLADEMAFRR RRHLYIHVAR KPGVEPGPRG VDNLEFSEMD NRDSNGEPAY
910 920 930 940 950
QLNDQGKRVL INQKLTYDQL LQLYFERYQA FKVLEGQLEG SVARAPSSSN
960 970 980 990 1000
YEGCDNWWTL VGSEAKFEAV YFNGEPVSED DQLTQLGNYK TRYDILRARV
1010 1020 1030 1040 1050
ILESIDYADC DFIIKNFSAM GEGIYHADPE VNATGQRHFS AMSPVTRRLI
1060 1070 1080 1090 1100
CSCLKTRRED EIKSHSLLSK FKSLLTVPVD AWKAAPAWFK CISLLLVAGG
1110 1120 1130 1140 1150
VGYALCRAIS GIIGIFRKGP AAASLALFSG GIGAVLRGDS PDDPREERDN
1160 1170 1180 1190 1200
PDVIVTKGRG KAIWAGAEIP EALEALRKSQ VVLMGTGRKG EPVMCSALPI
1210 1220 1230 1240 1250
TSHSVLCTTH EIEAFDPNQN MSLIVNNSIY SFVLIPGAIM YKRYDQPNLV
1260 1270 1280 1290 1300
DKVHELVRVD LPKNKGFSLN ARAQFSEDFY DNGTAMKCWV VPNKNPAVAD
1310 1320 1330 1340 1350
IMRKVDCEKS SQIIDIFASE LSRSSGCEPV RQTQRFIYAD GPALNGHCGR
1360 1370 1380 1390 1400
LLCANLAGHW RVIGMCAGEG KNRAGVTKAL YADIPHEFLR ADNLNAVQRG
1410 1420 1430 1440 1450
AELDAAILDR FSIPISECRK ELTPMTTRLG YVVGQYPRAL RKTSIVPSII
1460 1470 1480 1490 1500
HDNLWRKPET EPTILGKIDD RSPFPYDPYA TIGEKFVQEV GPIDLSVGSD
1510 1520 1530 1540 1550
ASLVVANIGS SWKAVGKPQC PTVLTWEVAI NGDAAIPYCE RLPLSTSEGY
1560 1570 1580 1590 1600
PDSIQRNFGE KGKKRFFDLK GENVRVPTPA LMEELEVLER ELQKEEVCLT
1610 1620 1630 1640 1650
CINTACAKDE KTAPKKVRVQ PKTRIFEILP FQINIIIRRY LMFWMQLLMV
1660 1670 1680 1690 1700
AHDELPSKVG INVYSESWDR LLGRHTRLAN HFTGDYSGFD TSTPRVLVYA
1710 1720 1730 1740 1750
IIDKINELAD DGEVNQRTRR NIIRFVLNRY LISDGVLYEI HGGTPSGFAP
1760 1770 1780 1790 1800
TVMINSVVNE FYLKWSWIGL LKEAGYANQA TLYAFHEATE ISLYGDDNFV
1810 1820 1830 1840 1850
SVATPVASVY NLTTISNFLG RIGVKLGDGA KTGTIKPFIP LEEVDFLKRQ
1860 1870 1880 1890 1900
FVADSGSTAI LCPLKKISIE ERLFYVRGGQ DEIAALELNI ATALCEAFFH
1910 1920 1930 1940 1950
GKEYFSFLEG KIIEAMRKSG VALSRPLPTM ESVRAWYMSQ RGNTKIRSPS
1960 1970 1980 1990 2000
FEGLGTMSGI LNIGLAEARS VGGVACFSGI EFRGRSDDHL MVIPTYIPGG
2010 2020 2030 2040 2050
WRTKQQQTYI SFVRDSEKMA QVIKRVAHFS TVVATDKSMA YLVAICIAYS
2060 2070 2080
RGSISRMEVR CHVQNLKVAE MLLCNQICNF L
Length:2,081
Mass (Da):230,447
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD1B0955C25FAF0A3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB009958 Genomic RNA Translation: BAA76746.1

NCBI Reference Sequences

More...
RefSeqi
NP_620566.1, NC_003785.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
993327

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:993327

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB009958 Genomic RNA Translation: BAA76746.1
RefSeqiNP_620566.1, NC_003785.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Proteomic databases

PRIDEiQ9WAL8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi993327
KEGGivg:993327

Family and domain databases

InterProiView protein in InterPro
IPR000605 Helicase_SF3_ssDNA/RNA_vir
IPR014759 Helicase_SF3_ssRNA_vir
IPR001205 RNA-dir_pol_C
IPR007094 RNA-dir_pol_PSvirus
PfamiView protein in Pfam
PF00680 RdRP_1, 1 hit
PF00910 RNA_helicase, 1 hit
PROSITEiView protein in PROSITE
PS51874 PCV_3C_PRO, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit
PS51218 SF3_HELICASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPOL1_SDVS5
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9WAL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: November 1, 1999
Last modified: September 18, 2019
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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