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Protein

Transcription factor SOX-21

Gene

SOX21

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a negative regulator of transcription.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi8 – 76HMG boxPROSITE-ProRule annotationAdd BLAST69

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor SOX-21
Gene namesi
Name:SOX21
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000487721 – 280Transcription factor SOX-21Add BLAST280

Expressioni

Tissue specificityi

Expressed predominantly in CNS.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ9W7R5
SMRiQ9W7R5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi137 – 146Poly-Ala10
Compositional biasi154 – 166Poly-AlaAdd BLAST13
Compositional biasi183 – 187Poly-Ser5
Compositional biasi212 – 223Poly-AlaAdd BLAST12

Phylogenomic databases

GeneTreeiENSGT00760000118988
HOVERGENiHBG105618
InParanoidiQ9W7R5
KOiK09267
PhylomeDBiQ9W7R5

Family and domain databases

Gene3Di1.10.30.10, 1 hit
InterProiView protein in InterPro
IPR009071 HMG_box_dom
IPR036910 HMG_box_dom_sf
IPR022097 SOX_fam
PfamiView protein in Pfam
PF00505 HMG_box, 1 hit
PF12336 SOXp, 1 hit
SMARTiView protein in SMART
SM00398 HMG, 1 hit
SUPFAMiSSF47095 SSF47095, 1 hit
PROSITEiView protein in PROSITE
PS50118 HMG_BOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9W7R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLS
60 70 80 90 100
EAEKRPFIDE AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL
110 120 130 140 150
GAVAEHEPPH GLKAAALHGG AAGGLGPDSL LGNPEKAAAA AAAAAARVFF
160 170 180 190 200
PQSAAAAAAA AAAAAAGGPY SLLDLGSKMA EISSSSSAGS ALPYASSLGY
210 220 230 240 250
PGAGGAGAFH GAAAAAAAAA AAAGGHTHSH PSPGNPGYMI PCNCSAWPGP
260 270 280
GLQPPLAYIL LPGMGKPQLD PYPAAYAAAL
Length:280
Mass (Da):28,796
Last modified:November 1, 1999 - v1
Checksum:iDA858428B29F1F47
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026623 Genomic DNA Translation: BAA77266.1
RefSeqiXP_015130211.1, XM_015274725.1

Genome annotation databases

EnsembliENSGALT00000053144; ENSGALP00000049013; ENSGALG00000035157
GeneIDi107051027
KEGGigga:107051027

Similar proteinsi

Entry informationi

Entry nameiSOX21_CHICK
AccessioniPrimary (citable) accession number: Q9W7R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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