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Entry version 130 (02 Jun 2021)
Sequence version 2 (25 Apr 2018)
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Protein

Teneurin-3

Gene

tenm3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in neural development by regulating the establishment of proper connectivity within the nervous system (PubMed:24183672, PubMed:27374343).

Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion (By similarity).

Required by retinal ganglion cells for acquisition of their correct morphological and functional connectivity, thereby playing a key role in the development of the visual pathway (PubMed:24183672, PubMed:27374343).

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion, Differentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teneurin-3
Short name:
Ten-3
Alternative name(s):
Protein Odd Oz/ten-m homolog 3
Tenascin-M3
Short name:
Ten-m3
Teneurin transmembrane protein 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tenm3
Synonyms:odz3, tnm3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-990714-19, tenm3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 312CytoplasmicSequence analysisAdd BLAST312
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei313 – 333HelicalSequence analysisAdd BLAST21
Topological domaini334 – 2694ExtracellularSequence analysisAdd BLAST2361

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Morpholino knockdown of the protein causes retinal ganglion cell dendrite stratification defects within the inner plexiform layer, as well as mistargeting of dendritic processes into outer portions of the retina.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595071 – 2694Teneurin-3Add BLAST2694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi413N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi512 ↔ 522PROSITE-ProRule annotation
Disulfide bondi516 ↔ 527PROSITE-ProRule annotation
Disulfide bondi529 ↔ 538PROSITE-ProRule annotation
Disulfide bondi547 ↔ 558PROSITE-ProRule annotation
Disulfide bondi560 ↔ 569PROSITE-ProRule annotation
Disulfide bondi576 ↔ 587PROSITE-ProRule annotation
Disulfide bondi581 ↔ 592PROSITE-ProRule annotation
Disulfide bondi594 ↔ 603PROSITE-ProRule annotation
Disulfide bondi608 ↔ 619PROSITE-ProRule annotation
Disulfide bondi613 ↔ 624PROSITE-ProRule annotation
Disulfide bondi626 ↔ 635PROSITE-ProRule annotation
Disulfide bondi646 ↔ 659PROSITE-ProRule annotation
Disulfide bondi661 ↔ 670PROSITE-ProRule annotation
Glycosylationi664N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi675 ↔ 685PROSITE-ProRule annotation
Disulfide bondi679 ↔ 690PROSITE-ProRule annotation
Disulfide bondi692 ↔ 701PROSITE-ProRule annotation
Disulfide bondi706 ↔ 716PROSITE-ProRule annotation
Disulfide bondi710 ↔ 721PROSITE-ProRule annotation
Disulfide bondi723 ↔ 732PROSITE-ProRule annotation
Disulfide bondi737 ↔ 747PROSITE-ProRule annotation
Disulfide bondi741 ↔ 756PROSITE-ProRule annotation
Disulfide bondi758 ↔ 767PROSITE-ProRule annotation
Glycosylationi854N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi877N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1048N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1196N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1521N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1538N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1634N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1671N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1729N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1814N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1915N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2258N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2571N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W7R4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by retinal ganglion cells and their presynaptic amacrine and postsynaptic tectal cell targets.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at the notochord and the somite around tailbud stage. At 14 hours post-fertilization (hpf), expressed in the somites, notochord, and the brain. Found in the rhombomere 3 (r3) and r5. Expressed in the optic vesicles and a region covering the caudal diencephalon and the mesencephalon with the strongest expression at its most anterior part. Mesodermal expression is observed in both forming and formed somites. In forming and newly formed somites, transcripts are distributed evenly. In contrast, distribution in somites located on more anterior trunk seems to be uneven, strongest in the ventral, intermediate in the dorsal, and weakest in the medial parts. At 23 hpf, there is no expression in the medial parts of somites. Expression in somites fades away by 36 hpf. At 20 hpf, additional expression is detected in the pharyngeal arches.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000005479, Expressed in retina and 52 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9W7R4, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked; to mediate homophilic cell adhesion.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000109423

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W7R4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 306Teneurin N-terminalPROSITE-ProRule annotationAdd BLAST306
Domaini508 – 539EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini540 – 570EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini572 – 604EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini605 – 636EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Domaini638 – 671EGF-like 5PROSITE-ProRule annotationAdd BLAST34
Domaini672 – 703EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Domaini704 – 733EGF-like 7PROSITE-ProRule annotationAdd BLAST30
Domaini734 – 768EGF-like 8PROSITE-ProRule annotationAdd BLAST35
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1166 – 1192NHL 1Add BLAST27
Repeati1194 – 1238NHL 2Add BLAST45
Repeati1264 – 1308NHL 3Add BLAST45
Repeati1325 – 1365NHL 4Add BLAST41
Repeati1452 – 1495NHL 5Add BLAST44
Repeati1505 – 1524YD 1Add BLAST20
Repeati1541 – 1561YD 2Add BLAST21
Repeati1604 – 1623YD 3Add BLAST20
Repeati1624 – 1646YD 4Add BLAST23
Repeati1817 – 1836YD 5Add BLAST20
Repeati1858 – 1876YD 6Add BLAST19
Repeati1877 – 1897YD 7Add BLAST21
Repeati1904 – 1921YD 8Add BLAST18
Repeati1922 – 1943YD 9Add BLAST22
Repeati1944 – 1961YD 10Add BLAST18
Repeati1964 – 1984YD 11Add BLAST21
Repeati1987 – 2007YD 12Add BLAST21
Repeati2015 – 2034YD 13Add BLAST20
Repeati2040 – 2057YD 14Add BLAST18
Repeati2058 – 2084YD 15Add BLAST27
Repeati2086 – 2099YD 16Add BLAST14
Repeati2100 – 2123YD 17Add BLAST24
Repeati2126 – 2146YD 18Add BLAST21
Repeati2147 – 2167YD 19Add BLAST21
Repeati2169 – 2189YD 20Add BLAST21
Repeati2201 – 2221YD 21Add BLAST21
Repeati2223 – 2243YD 22Add BLAST21
Repeati2269 – 2310YD 23Add BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45DisorderedSequence analysisAdd BLAST45
Regioni106 – 132DisorderedSequence analysisAdd BLAST27
Regioni161 – 198DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 28Basic and acidic residuesSequence analysisAdd BLAST28
Compositional biasi30 – 45Polar residuesSequence analysisAdd BLAST16
Compositional biasi163 – 182Polar residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4659, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234566

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W7R4

Database of Orthologous Groups

More...
OrthoDBi
7516at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W7R4

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR000742, EGF-like_dom
IPR022385, Rhs_assc_core
IPR027691, Ten-3/4
IPR009471, Ten_N
IPR028916, Tox-GHH_dom
IPR006530, YD

The PANTHER Classification System

More...
PANTHERi
PTHR11219:SF65, PTHR11219:SF65, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06484, Ten_N, 2 hits
PF15636, Tox-GHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464, SSF49464, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03696, Rhs_assc_core, 1 hit
TIGR01643, YD_repeat_2x, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 4 hits
PS51361, TENEURIN_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9W7R4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVKERRPYC SLTKSRREKE RRYTGSSGDS EDCRVPTQKS YSSSETLKAF
60 70 80 90 100
DHDSSRLLYG GHVKEMVHRE ADEYSRQGQN FNLRQLGICE PATRRGLAFC
110 120 130 140 150
AEMGMPSSLS SPSVTEHSHS QPPSPNLHDN QSSILSNATT QAVQDSDSEE
160 170 180 190 200
EYTAVLYRPV TQPAPSHSCN EQPSNQHQQG QSTLPPVPPP HKQQPSVTAL
210 220 230 240 250
NHNSLSSRRN VSPAPPAALP AELQTTPESV PLQDSWVLGS NVPLESRHFL
260 270 280 290 300
FKTGTGTTPL FSTATPGYTM ATGAVYSPPT RPLPRNTLSR SAFKFKKSSK
310 320 330 340 350
YCSWRCTALS AMAVSILLSV LLCYCIAMHL FGLNWQLQET EGYAFENGQV
360 370 380 390 400
KSDSTATNAV TALSTENKVY FQENNTIDTG EVDVGRRAVQ DVPPGTFWRT
410 420 430 440 450
QLFIDQPQSL KFNISVQRGA LVGVYGRKGL PPTHTQYDFV ELLDGSRLIA
460 470 480 490 500
KEKRGLVEVE GAARKARSVN VHEAEFIRFL DSGTWHLAFY NDGKNAEQVS
510 520 530 540 550
YNTIIIDTLT ECPHNCHGNG DCRTGTCHCF PGFLGPDCSR AACPVLCSGN
560 570 580 590 600
GQYSRGRCLC YSGWKGTECD VPSNQCIDIH CSGHGICIMG TCACNTGYKG
610 620 630 640 650
DNCEEVDCLD PSCSSHGVCI HGECHCNPGW GGNNCEILKT MCPDQCSGHG
660 670 680 690 700
TYQTESGTCT CDTNWTGPDC SIEVCAVDCG SHGVCIGGSC RCEEGWTGSV
710 720 730 740 750
CDLKACHPRC TEHGTCKDGK CECHQGWTGE HCTVEGCPGL CNSNGRCTLD
760 770 780 790 800
QNGWHCVCQP GWRGAGCDVA METLCADGKD NEGDGLVDCM DPDCCLQSSC
810 820 830 840 850
QTQPFCRGSP DPIDIISQNQ PASPQQAAQS FYQQISFLTG PESTHVINGE
860 870 880 890 900
NPFNRSLVSI IRGQVLTADG TPLIGVNVSF VHYPDHGYTI TRQDGMFDIL
910 920 930 940 950
ANGGASLTLS FERAPFLTQF RTVWIPWNVF YVMDTLVMKK EENDIPSCDL
960 970 980 990 1000
SGFIRPSPLI VATPLSTFFR SSPENGPIIP ETQVLQEETA IPGSDLNLMY
1010 1020 1030 1040 1050
LSSRAAGYRP VLKVTMTQAT IPFNLMKVHL MVAVVGRLFQ KWFPAEPNLS
1060 1070 1080 1090 1100
YTFIWDKTDA YNQRVYGLSE AVVSVGFEYE SCLDLILWEK RTAILQGYEL
1110 1120 1130 1140 1150
DASNMGGWTL DKHHVLDVQN GILYKGNGEN VFVSQQPPVI STIMGNGRRR
1160 1170 1180 1190 1200
SISCPSCNGQ ADGNKLLAPV ALACGSDGSL FVGDFNYIRR IFPSGNVTSV
1210 1220 1230 1240 1250
MELSNNPAHR YYLATDPMTG QLYVSDTNSR RIFRPKALTG TKELLQNAEV
1260 1270 1280 1290 1300
VAGTGEQCLP FDEARCGDGG KATEALLLGP KGIAVDKNGF IYFVDGTMIR
1310 1320 1330 1340 1350
KVDRNGIIST LLGSNDLTSA RPLTCDNSMH IGQVRLEWPT DLAINPMDNS
1360 1370 1380 1390 1400
IYVLDNNVVL QITENRQVRI VAGRPMHCQV PGIEYTMGKR AIQTTLEGAT
1410 1420 1430 1440 1450
AISLSYSGVL YIAETDEKKI NRIRQVSTDG EISHLAGAPS DCDCKNDANC
1460 1470 1480 1490 1500
DCYQTGDGYA KDARLNAPSS LVVSPDGTLY VADLGNIRIR AIRHNRPPQG
1510 1520 1530 1540 1550
SSGLFEVASP ASQELYVFDS NGTHQYTMSL VTGDYKYNFS YSNEDDVTAV
1560 1570 1580 1590 1600
TDSSGNTLRV RRDPNRMPVR IVAPDNQVIW LTIGTNGGLK TLTAQGQELV
1610 1620 1630 1640 1650
LFTYHGNSGL LATKSIQIGW TTFYDYDSEG RLTNVTFPTG VITSLIGEMD
1660 1670 1680 1690 1700
RALTVDIETS GRDDDVSITT NLSSIDSFYT LVQDQLRNSY QVGYDNSMRV
1710 1720 1730 1740 1750
IYANGMDSHF QTEPHILAGA SNPTVARRNM TLPGENGQNL VEWRFRKEQN
1760 1770 1780 1790 1800
RGKVVVFGRK LRVNGRNLLS VDYDRSLRTE KIYDDHRKFL LKIVYDASGH
1810 1820 1830 1840 1850
PTLWVPSSKL MSVNLTYSST GQVTSLQRGP TTERVEYDSQ GRIVSRTFAD
1860 1870 1880 1890 1900
AKIWSYTYLD KSMVLLLHSQ RQYIFDYDLQ DRLSAITMPS VARHTMQTIR
1910 1920 1930 1940 1950
SVGYYRNIYN PPESNASVTV DYSEDGQLLR VAHLGTGRRV LYKYRRQNKL
1960 1970 1980 1990 2000
SEILYDSTRV SFTYDETAGV LKTVNLQSEG FICSIRYRQI GPLVDRQIFR
2010 2020 2030 2040 2050
FSEDGMVNAR FDYTYDNSFR VTSMQGVINE TPLPIDLYQF DDISGKVEQF
2060 2070 2080 2090 2100
GKFGVIYYDI NQIISTAVMT YTKHFDVHGR IKEIQYEIFR SLMYWITIQY
2110 2120 2130 2140 2150
DNMGRVTKRE IKIGPFANTT KYGYEYDVDG QLQTVYLNEK MMWRYNYDLN
2160 2170 2180 2190 2200
GNLHLLNPGN SARLTPLRYD LRDRITRLGD VQYRMDEDGF LRQRGAEIFE
2210 2220 2230 2240 2250
YNSKGLLVRV HSKASGWTIQ YRYDGLGRRL ASRNSLGQHL QFFYADLNYP
2260 2270 2280 2290 2300
TRITHVYNHS SSEITSLYYD LQGHLFAMEI SSGEEFYIAC DNTGTPLAVF
2310 2320 2330 2340 2350
SSNGLLLKQV QYTAYGEIYF DSNPDFQLVI GFHGGLYDPL TRLLHFGERD
2360 2370 2380 2390 2400
YDIQAGRWTT PDISTWTRVG KDPAPFNLYM FRNNNPISKI HEVKEYVTDV
2410 2420 2430 2440 2450
NIWLVTFGFH LHNVIPGFPI PKFDLTQPSL EMRKSQLWDD LPSISGVQQE
2460 2470 2480 2490 2500
VMRQAKAFLS FERMPEIQLS RRRSSREKPW LWFATVKSLI GKGVMLAITS
2510 2520 2530 2540 2550
KGQVATNALN IANEDCIKVA TVLNNAFYLE DLHFTVEGRD THYFIKTSLP
2560 2570 2580 2590 2600
ESDLGALRLT SGRKSLENGV NVTVSQSTTV VNGRTRRFAD VELQYGALAL
2610 2620 2630 2640 2650
HVRYGMTLDE EKARVLEQAR QRALSSAWAR EQQRVRDGEE GVRLWTEGEK
2660 2670 2680 2690
RQLLSSGKVL GYDGYYVLSV EQYPELADSA NNVQFLRQSE IGKR
Length:2,694
Mass (Da):300,669
Last modified:April 25, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i65C41528CC4B4A10
GO
Isoform 2 (identifier: Q9W7R4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-104: Missing.

Show »
Length:2,590
Mass (Da):288,717
Checksum:iBC34E264F36891CF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W4C5F8W4C5_DANRE
Teneurin-3
tenm3 odz3
2,694Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q0D280Q0D280_DANRE
Teneurin-3
tenm3 odz3, zgc:153720
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti781N → S in BAA81892 (PubMed:10495292).Curated1
Sequence conflicti813I → F in BAA81892 (PubMed:10495292).Curated1
Sequence conflicti892R → Q in BAA81892 (PubMed:10495292).Curated1
Sequence conflicti1210R → G in BAA81892 (PubMed:10495292).Curated1
Sequence conflicti1880 – 1884QDRLS → HGKQI in BAA81892 (PubMed:10495292).Curated5
Sequence conflicti2520A → V in BAA81892 (PubMed:10495292).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0595631 – 104Missing in isoform 2. Add BLAST104

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB026979 mRNA Translation: BAA81892.1
BX005481 Genomic DNA No translation available.
BX322797 Genomic DNA No translation available.
BX324137 Genomic DNA No translation available.
BX324208 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_571043.1, NM_130968.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000122700; ENSDARP00000109423; ENSDARG00000005479 [Q9W7R4-2]
ENSDART00000137676; ENSDARP00000113440; ENSDARG00000005479 [Q9W7R4-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
30155

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026979 mRNA Translation: BAA81892.1
BX005481 Genomic DNA No translation available.
BX322797 Genomic DNA No translation available.
BX324137 Genomic DNA No translation available.
BX324208 Genomic DNA No translation available.
RefSeqiNP_571043.1, NM_130968.1

3D structure databases

SMRiQ9W7R4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000109423

Proteomic databases

PaxDbiQ9W7R4

Genome annotation databases

EnsembliENSDART00000122700; ENSDARP00000109423; ENSDARG00000005479 [Q9W7R4-2]
ENSDART00000137676; ENSDARP00000113440; ENSDARG00000005479 [Q9W7R4-2]
GeneIDi30155

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55714
ZFINiZDB-GENE-990714-19, tenm3

Phylogenomic databases

eggNOGiKOG4659, Eukaryota
GeneTreeiENSGT01030000234566
InParanoidiQ9W7R4
OrthoDBi7516at2759
PhylomeDBiQ9W7R4

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9W7R4

Gene expression databases

BgeeiENSDARG00000005479, Expressed in retina and 52 other tissues
ExpressionAtlasiQ9W7R4, baseline and differential

Family and domain databases

Gene3Di2.120.10.30, 2 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR000742, EGF-like_dom
IPR022385, Rhs_assc_core
IPR027691, Ten-3/4
IPR009471, Ten_N
IPR028916, Tox-GHH_dom
IPR006530, YD
PANTHERiPTHR11219:SF65, PTHR11219:SF65, 1 hit
PfamiView protein in Pfam
PF06484, Ten_N, 2 hits
PF15636, Tox-GHH, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SUPFAMiSSF49464, SSF49464, 1 hit
TIGRFAMsiTIGR03696, Rhs_assc_core, 1 hit
TIGR01643, YD_repeat_2x, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 4 hits
PS51361, TENEURIN_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEN3_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W7R4
Secondary accession number(s): E7EYS1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 25, 2018
Last modified: June 2, 2021
This is version 130 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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