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Entry version 118 (29 Sep 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Teneurin-4

Gene

tenm4

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May play a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation of oligodendrocytes and myelination of axons. May function as a cellular signal transducer (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teneurin-4
Short name:
Ten-4
Alternative name(s):
Protein Odd Oz/ten-m homolog 4
Tenascin-M4
Short name:
Ten-m4
Teneurin transmembrane protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tenm4
Synonyms:odz4, tnm4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-990714-20, tenm4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei417 – 437HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Morpholino knockdown of the gene in embryos resulted in a modest reduction of myelin in the brain and an increase in the number of small-diameter neuronal axons with aberrant branching along the notochord.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595101 – 2824Teneurin-4Add BLAST2824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi457N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi536N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi637 ↔ 647PROSITE-ProRule annotation
Disulfide bondi641 ↔ 652PROSITE-ProRule annotation
Disulfide bondi654 ↔ 663PROSITE-ProRule annotation
Disulfide bondi672 ↔ 683PROSITE-ProRule annotation
Disulfide bondi685 ↔ 694PROSITE-ProRule annotation
Disulfide bondi701 ↔ 712PROSITE-ProRule annotation
Disulfide bondi706 ↔ 717PROSITE-ProRule annotation
Disulfide bondi719 ↔ 728PROSITE-ProRule annotation
Disulfide bondi733 ↔ 744PROSITE-ProRule annotation
Disulfide bondi738 ↔ 749PROSITE-ProRule annotation
Disulfide bondi751 ↔ 760PROSITE-ProRule annotation
Disulfide bondi771 ↔ 784PROSITE-ProRule annotation
Disulfide bondi786 ↔ 795PROSITE-ProRule annotation
Glycosylationi789N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi800 ↔ 810PROSITE-ProRule annotation
Disulfide bondi804 ↔ 815PROSITE-ProRule annotation
Disulfide bondi817 ↔ 826PROSITE-ProRule annotation
Disulfide bondi831 ↔ 841PROSITE-ProRule annotation
Disulfide bondi835 ↔ 846PROSITE-ProRule annotation
Disulfide bondi848 ↔ 857PROSITE-ProRule annotation
Disulfide bondi862 ↔ 872PROSITE-ProRule annotation
Disulfide bondi866 ↔ 881PROSITE-ProRule annotation
Disulfide bondi883 ↔ 892PROSITE-ProRule annotation
Glycosylationi1002N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1173N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1647N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1664N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1760N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1796N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1854N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1939N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2040N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2243N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2383N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2701N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W7R3

PRoteomics IDEntifications database

More...
PRIDEi
Q9W7R3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Mainly expressed in the brain.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During gastrulation, expressed throughout the embryo very faintly. Expressed along the anterior margin of the neural plate. Later, this marginal expression extends caudally, and eventually restricted only to the caudal neural plate. At 14 hours post-fertilization, it is expressed in the brain. Expressed in the rhombomere 5 (r5) and more strongly in r6. Expressed in the rostral diencephalon with weak expression in the optic vesicles, and a region covering the mesencephalon and the midbrain/hindbrain boundary (MHB) in a gradient manner with stronger expression at its posterior end. At 17 hpf, expressed weakly in the dorsal edge of the most caudal part of the neural tube. Faint expression is detected in several neurons located at ventral and dorsal parts of the caudal spinal cord.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked (Probable). May also form heterodimer with either TENM1 or TENM2 or TENM3 (By similarity).

By similarityCurated

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000016395

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W7R3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 412Teneurin N-terminalPROSITE-ProRule annotationAdd BLAST412
Domaini633 – 664EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini665 – 695EGF-like 2PROSITE-ProRule annotationAdd BLAST31
Domaini697 – 729EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini730 – 761EGF-like 4PROSITE-ProRule annotationAdd BLAST32
Domaini763 – 796EGF-like 5PROSITE-ProRule annotationAdd BLAST34
Domaini797 – 828EGF-like 6PROSITE-ProRule annotationAdd BLAST32
Domaini829 – 858EGF-like 7PROSITE-ProRule annotationAdd BLAST30
Domaini859 – 893EGF-like 8PROSITE-ProRule annotationAdd BLAST35
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1278 – 1321NHL 1Add BLAST44
Repeati1326 – 1363NHL 2Add BLAST38
Repeati1389 – 1433NHL 3Add BLAST45
Repeati1448 – 1499NHL 4Add BLAST52
Repeati1522 – 1552NHL 5Add BLAST31
Repeati1578 – 1621NHL 6Add BLAST44
Repeati1631 – 1650YD 1Add BLAST20
Repeati1667 – 1687YD 2Add BLAST21
Repeati1730 – 1749YD 3Add BLAST20
Repeati1750 – 1772YD 4Add BLAST23
Repeati1942 – 1961YD 5Add BLAST20
Repeati1983 – 2001YD 6Add BLAST19
Repeati2002 – 2022YD 7Add BLAST21
Repeati2029 – 2046YD 8Add BLAST18
Repeati2047 – 2068YD 9Add BLAST22
Repeati2069 – 2086YD 10Add BLAST18
Repeati2089 – 2109YD 11Add BLAST21
Repeati2112 – 2132YD 12Add BLAST21
Repeati2140 – 2159YD 13Add BLAST20
Repeati2165 – 2182YD 14Add BLAST18
Repeati2183 – 2209YD 15Add BLAST27
Repeati2211 – 2224YD 16Add BLAST14
Repeati2225 – 2248YD 17Add BLAST24
Repeati2251 – 2271YD 18Add BLAST21
Repeati2272 – 2292YD 19Add BLAST21
Repeati2294 – 2314YD 20Add BLAST21
Repeati2326 – 2346YD 21Add BLAST21
Repeati2348 – 2368YD 22Add BLAST21
Repeati2394 – 2435YD 23Add BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni157 – 220DisorderedSequence analysisAdd BLAST64
Regioni232 – 308DisorderedSequence analysisAdd BLAST77

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 27Basic and acidic residuesSequence analysisAdd BLAST27
Compositional biasi28 – 44Polar residuesSequence analysisAdd BLAST17
Compositional biasi157 – 178Polar residuesSequence analysisAdd BLAST22
Compositional biasi186 – 206Polar residuesSequence analysisAdd BLAST21
Compositional biasi232 – 248Polar residuesSequence analysisAdd BLAST17
Compositional biasi256 – 308Polar residuesSequence analysisAdd BLAST53

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4659, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W7R3

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W7R3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR000742, EGF-like_dom
IPR011041, Quinoprot_gluc/sorb_DH
IPR022385, Rhs_assc_core
IPR031325, RHS_repeat
IPR027691, Ten-3/4
IPR009471, Ten_N
IPR028916, Tox-GHH_dom
IPR006530, YD

The PANTHER Classification System

More...
PANTHERi
PTHR11219:SF65, PTHR11219:SF65, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05593, RHS_repeat, 1 hit
PF06484, Ten_N, 1 hit
PF15636, Tox-GHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464, SSF49464, 1 hit
SSF50952, SSF50952, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03696, Rhs_assc_core, 1 hit
TIGR01643, YD_repeat_2x, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits
PS51361, TENEURIN_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q9W7R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVKERRPYR SLTSRRDTER RYTSSSADSE DGKINPKSYS SSETLKAFDQ
60 70 80 90 100
DSRLAYGSRV KDLVHHEADE FSRQGPDFSL RDMAFGDPVP PHMGAYRTEM
110 120 130 140 150
GLPHRDYSVS VASDADTETD GIMSPEHAVR LWGRSNTKSG RSSCLFSRAN
160 170 180 190 200
SNLTLTDTEH ENTENGPPLH CSSASSSPVD SPYPPPSHAA NQSQGRLLGN
210 220 230 240 250
SGAQAGRDSE SEDEFGPNSF LVKTGSGNVC TPAAATANEG SFQNHSRLRT
260 270 280 290 300
PPLPLFHSHS PSQHHTASIG SLSRSNYTQR SNPSPAPTDS SAPNEGPTSA
310 320 330 340 350
QDSSSAQDNW LLNSNVPLET RNIAKQTFLE TLQDNFIEMD ILATARRDGA
360 370 380 390 400
YTDGHFLFKP GGTSPLYCTT SPGYPLTSST VYSPPPRPLP RNTFSRPAFS
410 420 430 440 450
LKKPYKHCNW KCAALSAILI SVTLVFLLAY FIAMHLFGLN WHLQPVQRQI
460 470 480 490 500
YQLTEDNTSG LHLPTDLGLP PLGNTGLEFP DRGSRDDGKL DGFFPEDSFI
510 520 530 540 550
DMGEIDVGRK VAQLIPPGIF WRSQVFIDHP MYLKFNVSLS KDALVGIYGR
560 570 580 590 600
RGLPPSHTQF DFVELLDGRR LLSQGLPGLD GPPFPAQQRS LVPITSHDTG
610 620 630 640 650
CIQYMDSGIW HLAVYNDGKE TEQVSFLTTA IDSIDDCPSN CFGNGDCVSG
660 670 680 690 700
NCHCFPGFRG PDCSRASCPV LCSGNGQYLK GRCMCHSGWK GSECDVPTNQ
710 720 730 740 750
CIDITCSGHG TCIVGTCICN PSYKGENCEE VDCLDPTCSG RGVCVRGECH
760 770 780 790 800
CFVGWGGPGC ESPRASCMEQ CSGHGSFLAD TNTCNCDHNW TGHDCSTELC
810 820 830 840 850
AADCGGHGIC VAGSCRCDEG WMGTGCEQRA CHPRCSEHGT CKDGKCECSP
860 870 880 890 900
GWNGEHCTIE GCPGLCNGNG RCTLGNNGWY CVCQLGWRGA GCDTSMETAC
910 920 930 940 950
SDGKDNDGDG LTDCMDPDCC LQASCHTTSL CVGSPDPLDI IQETQISSSL
960 970 980 990 1000
STLQSFYQRI HFLVGRDSTH VIPDVNPFDG IHACVIRGQV VTSDGTPLVG
1010 1020 1030 1040 1050
VNISFINKPA YGYTITRQDG SFDLVSNGGV AIGLRFERAP FITQEHTLWL
1060 1070 1080 1090 1100
PWGRFFVMDT IVMRHEVNDI PSCDLSSFTR PMPIVLPAPL TAFAGTCPER
1110 1120 1130 1140 1150
GIVVPEIQTL QEEVRIPGTD MRLGYLSSRT SGYKSLLRIT LTHSTIPFSL
1160 1170 1180 1190 1200
MKVHLMVAVE GRLFRKWFSA APNLSYDFVW DKTDVYSQKV YGLSEAFVSV
1210 1220 1230 1240 1250
GFEYESCPDL ILWEKRTAVL QGYETTASNL GGWSVDKHHA LNIQSGILHK
1260 1270 1280 1290 1300
GNGENIFISQ QPPVIGSIMG NGRRRSISCP SCNGLADGNK LLAPVALACG
1310 1320 1330 1340 1350
SDGSLYVGDF NYVRRIFTTG NVTSVLELSN SPAHKYYLAT SPVSGWLYLS
1360 1370 1380 1390 1400
DTSSRKVFKV KSLYAVKDVA KNLELVAGTG DQCLPYDETR CGDGGKAVEA
1410 1420 1430 1440 1450
TLTNPRGITV DKYGVIFFVD GTMIRRIDQN GIISTLLGFN DLTSARPLSC
1460 1470 1480 1490 1500
DSVMDISQVR LEWPTDLAVS PMDNSLYVLD NNVVLQISEN HQVRIVAGRP
1510 1520 1530 1540 1550
MHCQVPGLDH FLVSKIAIHA TLESANALAV SHNGLLYIAE SDEKKINRVR
1560 1570 1580 1590 1600
QVSTNGEISL LAGAPSGCDC KNDANCDCYS GDDGYAKDAK LNAPSSLAVS
1610 1620 1630 1640 1650
PDGELFIADL GNIRIRYVRR NKAFLNPLNM YEISSPIDDE LYLFDVNASH
1660 1670 1680 1690 1700
VFTQSLTTGD YLYNFTYSGE GDLSSITDKN KNRVSIRRDS TGLPLWLMGP
1710 1720 1730 1740 1750
DGQTFWFTMG TNNALKSVAA QGQEIAVMTY HGSSGLLATK SNEDGWSTFY
1760 1770 1780 1790 1800
EYDNYGRLTN VTYPTGRVSS YRTDSDSTVR VQTEGSNKED ITVTTNLSAS
1810 1820 1830 1840 1850
GTFYTLMQDQ VKNSYYIGLD GSLRLVLANG MEVSLHTEPH LLSGTVNPTI
1860 1870 1880 1890 1900
SKRNVTLPID NGLNLVEWRQ RKEQARGQVT VYGRRLRVHN RNLLSMDFDR
1910 1920 1930 1940 1950
VTRTEKVYDD HRKFTLRIHY DHAGRPTLWA PSSRLNGVNV TYSPGGHIAG
1960 1970 1980 1990 2000
IQRGTMSVRM EYDQNGRITS KIFADGKSWS YTYLEKSMVL LLYSQRQYIF
2010 2020 2030 2040 2050
EFDKNDRLSS VTMPNVARQT LETTRSIGYY RNTYRPPEGN ATVLQDYSED
2060 2070 2080 2090 2100
GLLLQTIHQG TGRRVIYKYG KLSRLLEILY DTTRIAFSYD ESAGMLKTVG
2110 2120 2130 2140 2150
LQSEGFACTI RYRQIGPLID RQIFRFSEEG MVNARFDYNY DNSFRVTSMQ
2160 2170 2180 2190 2200
AVINETPLPI DLYRYDDVSG KTEQFGKFGV IYYDINQIIT TAVMTHTKHF
2210 2220 2230 2240 2250
DAYGRVKEVQ YEIFRSLMYW MMVQFDNMGR VVAKELKVGP YANTTRYAYE
2260 2270 2280 2290 2300
YDADGQLQVV SINDKPLWRY SYDLNGNLHL LSPGNSARLT PLRYDIRDRI
2310 2320 2330 2340 2350
TRLGDVQYRL DEDGFLRQRG NDFFEYNSAG LLVKTYNKVN GWTIKYRYDG
2360 2370 2380 2390 2400
LGRRVSSRST QGHHLQFFYA DLSSPTRVTH MYNHSSSEIT SLYYDLQGHL
2410 2420 2430 2440 2450
FAMELSSGDE FYVACDNIGT PLAVFSGAGL MIKQILHTAF GEVYLDSNPS
2460 2470 2480 2490 2500
FQLVIGYQGG LYEPLTKLVH MGRRDYDVLA GRWTTPDHDI RKRLNSDNIV
2510 2520 2530 2540 2550
PFNLYMFKNN NPLSNSQETK CYMTDVNSWL VTFGFQLYNV IPGYRKPVTD
2560 2570 2580 2590 2600
AMEPSYELVH TQIKTQEWDS TKSVLGVQCE VQRQLKSFVR LERFGQIYSA
2610 2620 2630 2640 2650
SDSGCPPTPL HTLFATGTSL FGKGVKVAIR EGRVEADIIS LANEDGRRIA
2660 2670 2680 2690 2700
AVLDKASYLQ DLHFTIAGLD THYFVKSGLV EGDLSLLGMT VGQRTLETGV
2710 2720 2730 2740 2750
NVTVSQVNMV LGGRSRRITD IQMQYGTLSL NVRYGSSVDE EKVRVLELAR
2760 2770 2780 2790 2800
QRAVATAWAH ERHRLRQGEE GSRAWTDGER QQLLSSGRVQ GYEGFYIVSV
2810 2820
DQFPELTDNI NNVHFWRQTE MGRR
Length:2,824
Mass (Da):313,506
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i27007746DD34E356
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4IN22A0A0R4IN22_DANRE
Teneurin-4
tenm4
2,824Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4ICV6A0A0R4ICV6_DANRE
Teneurin-4
tenm4
2,831Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8QIZ5A0A2R8QIZ5_DANRE
Teneurin-4
tenm4
2,840Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8RZ80A0A2R8RZ80_DANRE
Teneurin-4
tenm4
2,798Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IGJ8A0A0R4IGJ8_DANRE
Teneurin-4
tenm4
2,772Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Q661A0A2R8Q661_DANRE
Teneurin-4
tenm4
2,792Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A286Y9C5A0A286Y9C5_DANRE
Teneurin-4
tenm4
2,865Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4IZR2A0A0R4IZR2_DANRE
Teneurin-4
tenm4
83Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB026980 mRNA Translation: BAA81893.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB026980 mRNA Translation: BAA81893.1

3D structure databases

SMRiQ9W7R3
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000016395

Proteomic databases

PaxDbiQ9W7R3
PRIDEiQ9W7R3

Organism-specific databases

ZFINiZDB-GENE-990714-20, tenm4

Phylogenomic databases

eggNOGiKOG4659, Eukaryota
InParanoidiQ9W7R3
PhylomeDBiQ9W7R3

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9W7R3

Family and domain databases

Gene3Di2.120.10.30, 2 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR000742, EGF-like_dom
IPR011041, Quinoprot_gluc/sorb_DH
IPR022385, Rhs_assc_core
IPR031325, RHS_repeat
IPR027691, Ten-3/4
IPR009471, Ten_N
IPR028916, Tox-GHH_dom
IPR006530, YD
PANTHERiPTHR11219:SF65, PTHR11219:SF65, 1 hit
PfamiView protein in Pfam
PF05593, RHS_repeat, 1 hit
PF06484, Ten_N, 1 hit
PF15636, Tox-GHH, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SUPFAMiSSF49464, SSF49464, 1 hit
SSF50952, SSF50952, 1 hit
TIGRFAMsiTIGR03696, Rhs_assc_core, 1 hit
TIGR01643, YD_repeat_2x, 3 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 6 hits
PS50026, EGF_3, 4 hits
PS51361, TENEURIN_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEN4_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W7R3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: September 29, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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