UniProtKB - Q9W7I5 (RBBP4_CHICK)
Protein
Histone-binding protein RBBP4
Gene
RBBP4
Organism
Gallus gallus (Chicken)
Status
Functioni
Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA.By similarity
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- chromatin assembly Source: UniProtKB
- chromatin remodeling Source: HGNC-UCL
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | Chromatin regulator, Repressor |
Biological process | Cell cycle, DNA replication, Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Histone-binding protein RBBP4Alternative name(s): Chromatin assembly factor 1 subunit C Short name: CAF-1 subunit C Chromatin assembly factor I p48 subunit Short name: CAF-I 48 kDa subunit Short name: CAF-I p48 Short name: chCAF-1 p48 Retinoblastoma-binding protein 4 Short name: RBBP-4 Retinoblastoma-binding protein p48 |
Gene namesi | Name:RBBP4 Synonyms:RBAP48 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- ESC/E(Z) complex Source: UniProtKB
- nucleus Source: HGNC-UCL
Other locations
- CAF-1 complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000051189 | 2 – 425 | Histone-binding protein RBBP4Add BLAST | 424 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 |
Keywords - PTMi
AcetylationProteomic databases
PaxDbi | Q9W7I5 |
Interactioni
Subunit structurei
Component of the DREAM complex (By similarity). Binds directly to histone H4, probably via helix 1 of the histone fold, a region that is not accessible when histone H4 is in chromatin (PubMed:11112423).
Interacts with CHAF1A, HDAC1, HDAC2, HDAC3 and HIRA (PubMed:10347232, PubMed:15527972, PubMed:17065558). May also interact with HAT1 (PubMed:11112423, PubMed:11160883).
By similarity5 PublicationsProtein-protein interaction databases
BioGRIDi | 675936, 1 interactor |
STRINGi | 9031.ENSGALP00000005565 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 122 – 155 | WD 1Add BLAST | 34 | |
Repeati | 175 – 206 | WD 2Add BLAST | 32 | |
Repeati | 225 – 256 | WD 3Add BLAST | 32 | |
Repeati | 271 – 302 | WD 4Add BLAST | 32 | |
Repeati | 315 – 346 | WD 5Add BLAST | 32 | |
Repeati | 372 – 403 | WD 6Add BLAST | 32 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 361 – 406 | Interaction with HAT1Add BLAST | 46 |
Sequence similaritiesi
Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.Curated
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0264, Eukaryota |
InParanoidi | Q9W7I5 |
OrthoDBi | 831322at2759 |
PhylomeDBi | Q9W7I5 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR022052, Histone-bd_RBBP4_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12265, CAF1C_H4-bd, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9W7I5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADKEAAFDD AVEERVINEE YKIWKKNTPF LYDLVMTHAL EWPSLTAQWL
60 70 80 90 100
PDVTRPEGKD FSIHRLVLGT HTSDEQNHLV IASVQLPNDD AQFDASHYDS
110 120 130 140 150
EKGEFGGFGS VSGKIEIEIK INHEGEVNRA RYMPQNPCII ATKTPSSDVL
160 170 180 190 200
VFDYTKHPSK PDPSGECNPD LRLRGHQKEG YGLSWNPNLS GHLLSASDDH
210 220 230 240 250
TICLWDISAV PKEGKVVDAK TIFTGHTAVV EDVSWHLLHE SLFGSVADDQ
260 270 280 290 300
KLMIWDTRSN NTSKPSHSVD AHTAEVNCLS FNPYSEFILA TGSADKTVAL
310 320 330 340 350
WDLRNLKLKL HSFESHKDEI FQVQWSPHNE TILASSGTDR RLNVWDLSKI
360 370 380 390 400
GEEQSPEDAE DGPPELLFIH GGHTAKISDF SWNPNEPWVI CSVSEDNIMQ
410 420
VWQMAENINN DEDPEGSVDP EGQGS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF097750 mRNA Translation: AAD40568.1 |
RefSeqi | NP_990183.1, NM_204852.1 |
Genome annotation databases
GeneIDi | 395658 |
KEGGi | gga:395658 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF097750 mRNA Translation: AAD40568.1 |
RefSeqi | NP_990183.1, NM_204852.1 |
3D structure databases
SMRi | Q9W7I5 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 675936, 1 interactor |
STRINGi | 9031.ENSGALP00000005565 |
Proteomic databases
PaxDbi | Q9W7I5 |
Genome annotation databases
GeneIDi | 395658 |
KEGGi | gga:395658 |
Organism-specific databases
CTDi | 5928 |
Phylogenomic databases
eggNOGi | KOG0264, Eukaryota |
InParanoidi | Q9W7I5 |
OrthoDBi | 831322at2759 |
PhylomeDBi | Q9W7I5 |
Miscellaneous databases
PROi | PR:Q9W7I5 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR020472, G-protein_beta_WD-40_rep IPR022052, Histone-bd_RBBP4_N IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12265, CAF1C_H4-bd, 1 hit PF00400, WD40, 5 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM00320, WD40, 6 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS00678, WD_REPEATS_1, 3 hits PS50082, WD_REPEATS_2, 5 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RBBP4_CHICK | |
Accessioni | Q9W7I5Primary (citable) accession number: Q9W7I5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 7, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 116 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families