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Entry version 105 (07 Oct 2020)
Sequence version 1 (01 Nov 1999)
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Protein

Spondin-1

Gene

SPON1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS (By similarity). Somite-derived spondin 1 is an inhibitory signal involved in patterning the segmental migration of neural crest cells and their topographical segregation within the rostral somites in vitro. May be required to prevent the lateral drifting of the commissural axons after having crossed the floor plate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi320CalciumBy similarity1
Metal bindingi349CalciumBy similarity1
Metal bindingi353Calcium; via carbonyl oxygenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: GO_Central

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion
LigandMetal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Spondin-1
Alternative name(s):
F-spondin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPON1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23By similarityAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003586824 – 802Spondin-1Add BLAST779

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi39 ↔ 123PROSITE-ProRule annotation
Disulfide bondi151 ↔ 177PROSITE-ProRule annotation
Disulfide bondi194 ↔ 331By similarity
Disulfide bondi195 ↔ 335By similarity
Disulfide bondi197 ↔ 410By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi209N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi438 ↔ 475PROSITE-ProRule annotation
Disulfide bondi449 ↔ 484PROSITE-ProRule annotation
Disulfide bondi454 ↔ 489PROSITE-ProRule annotation
Disulfide bondi497 ↔ 533PROSITE-ProRule annotation
Disulfide bondi508 ↔ 512PROSITE-ProRule annotation
Disulfide bondi543 ↔ 549PROSITE-ProRule annotation
Disulfide bondi554 ↔ 590PROSITE-ProRule annotation
Disulfide bondi565 ↔ 569PROSITE-ProRule annotation
Disulfide bondi600 ↔ 605PROSITE-ProRule annotation
Disulfide bondi610 ↔ 645PROSITE-ProRule annotation
Disulfide bondi621 ↔ 625PROSITE-ProRule annotation
Disulfide bondi655 ↔ 660PROSITE-ProRule annotation
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W770

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000039229

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W770

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 189ReelinPROSITE-ProRule annotationAdd BLAST166
Domaini190 – 383SpondinPROSITE-ProRule annotationAdd BLAST194
Domaini437 – 490TSP type-1 1PROSITE-ProRule annotationAdd BLAST54
Domaini496 – 550TSP type-1 2PROSITE-ProRule annotationAdd BLAST55
Domaini553 – 606TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini609 – 661TSP type-1 4PROSITE-ProRule annotationAdd BLAST53
Domaini663 – 716TSP type-1 5PROSITE-ProRule annotationAdd BLAST54
Domaini749 – 801TSP type-1 6PROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3539, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W770

Database of Orthologous Groups

More...
OrthoDBi
517669at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W770

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08544, Reeler, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.20.100.10, 6 hits
2.60.40.2130, 2 hits
2.60.40.4060, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002861, Reeler_dom
IPR042307, Reeler_sf
IPR009465, Spondin_N
IPR038678, Spondin_N_sf
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02014, Reeler, 1 hit
PF06468, Spond_N, 1 hit
PF00090, TSP_1, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00209, TSP1, 6 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82895, SSF82895, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51019, REELIN, 1 hit
PS51020, SPONDIN, 1 hit
PS50092, TSP1, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W770-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAARLRPLAL RLLARTFPLV ARGFSDETLE KAAKSEGYCS RILRAQGTRR
60 70 80 90 100
EGYNEFSLRV EGDPEFYKPG NSYRVTLSAA TPAYFRGFTL IALKEGKEGD
110 120 130 140 150
KEEDHAGTFQ IIDEEETQFM SNCPVAVTES TPRRRTRIQV FWTAPPTGTG
160 170 180 190 200
CVILKASIVQ KRIIYFQDEG SLTKRICEQD SASEGVTDKP TLDCCACGTA
210 220 230 240 250
KYRLTFYGNW SEKTHPKDFP RRTNHWSAII GSSHSKNYIL WEYGGYASEG
260 270 280 290 300
VKQVAELGSP VKMEEEIRQQ SDEVLTVIKA KAQWPAWQPL NVRAAPSAEF
310 320 330 340 350
SVDRHRHLMS FLTMLGPSPD WNVGLSAEDL CTKDCGWVQK VVQDLIPWDA
360 370 380 390 400
GTDSGVTYES PNKPTVPQEK IRPLTSLDHP QSPFYDPEGG SIKLVARVVL
410 420 430 440 450
ERIARKGEQC NFVPDNIDDI VADLAPEEKE EDDTPETCIY SNWSPWSACS
460 470 480 490 500
SSTCEKGKRM RQRMLKAQLD LSVPCPDTQD FQPCMGPGCS DEDGSTCMMS
510 520 530 540 550
DWITWSPCSV SCGMGTRSRE RYVKQFPEDG SMCKVPTEET EKCIVNEECS
560 570 580 590 600
PSSCLVTEWG EWDECSASCG TGMKRRHRMI KMTPADGSMC KAETTEAEKC
610 620 630 640 650
MMPECHTIPC LLSPWSEWSD CSVTCGKGMR TRQRMLKSAA ELGDCNEELE
660 670 680 690 700
QAEKCMLPEC PIDCELTEWS QWSECNTSCG KGHMIRTRMI KIEPQFGGTA
710 720 730 740 750
CPETVQRTKC RVRKCLRGPG MEKRRWKEAR EKRRSEQAKK NIDNEQYPVC
760 770 780 790 800
RLKPWTAWTE CSTLCGGGIQ ERYMMVKKRS KSTQFTSCKD KKELRACNVH

PC
Length:802
Mass (Da):90,510
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0644D2BDD0A0FE12
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF149302 mRNA Translation: AAD41495.1

NCBI Reference Sequences

More...
RefSeqi
NP_990182.1, NM_204851.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
395657

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:395657

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF149302 mRNA Translation: AAD41495.1
RefSeqiNP_990182.1, NM_204851.1

3D structure databases

SMRiQ9W770
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039229

Proteomic databases

PaxDbiQ9W770

Genome annotation databases

GeneIDi395657
KEGGigga:395657

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10418

Phylogenomic databases

eggNOGiKOG3539, Eukaryota
InParanoidiQ9W770
OrthoDBi517669at2759
PhylomeDBiQ9W770

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9W770

Family and domain databases

CDDicd08544, Reeler, 1 hit
Gene3Di2.20.100.10, 6 hits
2.60.40.2130, 2 hits
2.60.40.4060, 1 hit
InterProiView protein in InterPro
IPR002861, Reeler_dom
IPR042307, Reeler_sf
IPR009465, Spondin_N
IPR038678, Spondin_N_sf
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF02014, Reeler, 1 hit
PF06468, Spond_N, 1 hit
PF00090, TSP_1, 5 hits
SMARTiView protein in SMART
SM00209, TSP1, 6 hits
SUPFAMiSSF82895, SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS51019, REELIN, 1 hit
PS51020, SPONDIN, 1 hit
PS50092, TSP1, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPON1_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W770
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: November 1, 1999
Last modified: October 7, 2020
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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