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Protein

Mothers against decapentaplegic homolog 6

Gene

SMAD6

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling, preventing NF-kappa-B activation, and BMP-SMAD1 signaling pathway. Binds to regulatory elements in target promoter regions (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi139ZincBy similarity1
Metal bindingi182ZincBy similarity1
Metal bindingi194ZincBy similarity1
Metal bindingi199ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mothers against decapentaplegic homolog 6
Short name:
MAD homolog 6
Short name:
Mothers against DPP homolog 6
Alternative name(s):
SMAD family member 6
Short name:
SMAD 6
Short name:
Smad6
Gene namesi
Name:SMAD6
Synonyms:MADH6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000908711 – 431Mothers against decapentaplegic homolog 6Add BLAST431

Expressioni

Tissue specificityi

Developing heart, eyes and limbs.

Gene expression databases

BgeeiENSGALG00000025898 Expressed in 10 organ(s), highest expression level in lung

Structurei

3D structure databases

ProteinModelPortaliQ9W734
SMRiQ9W734
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini85 – 209MH1PROSITE-ProRule annotationAdd BLAST125
Domaini265 – 431MH2PROSITE-ProRule annotationAdd BLAST167

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi74 – 82Poly-Pro9
Compositional biasi209 – 212Poly-Pro4

Sequence similaritiesi

Belongs to the dwarfin/SMAD family.Curated

Phylogenomic databases

HOVERGENiHBG053021
InParanoidiQ9W734
OrthoDBiEOG091G0XBN
PhylomeDBiQ9W734

Family and domain databases

Gene3Di2.60.200.10, 1 hit
3.90.520.10, 1 hit
InterProiView protein in InterPro
IPR013790 Dwarfin
IPR003619 MAD_homology1_Dwarfin-type
IPR013019 MAD_homology_MH1
IPR017855 SMAD-like_dom_sf
IPR001132 SMAD_dom_Dwarfin-type
IPR008984 SMAD_FHA_dom_sf
IPR036578 SMAD_MH1_sf
PANTHERiPTHR13703 PTHR13703, 2 hits
PfamiView protein in Pfam
PF03165 MH1, 1 hit
PF03166 MH2, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
SM00524 DWB, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF56366 SSF56366, 1 hit
PROSITEiView protein in PROSITE
PS51075 MH1, 1 hit
PS51076 MH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.iShow all

Q9W734-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFRSKRSGLV RRLWRSRVIP ERDGGDGNGQ SSERNATAVT AEGQRMAQPR
60 70 80 90 100
RAQEGEGRPV RCCLFAERPG PELPPPPPPP PPGGASPPGP GGGEARSRLV
110 120 130 140 150
LLERELKAVT YALLKRLKER SLHSLLQAVE SRGGTPGGCV LVARGELRLG
160 170 180 190 200
AARRPPPHLL LGKLFRWPDL QHPAELKALC ECQSFGAADG PTVCCNPYHF
210 220 230 240 250
SRLCGPESPP PPYSRLSPND EQKPLDLSDS TLSYTETEAT NSPNVTPGEF
260 270 280 290 300
SDASTSPDAV KRSHWCNVAY WEHRTRVGRL YTVYEQSVSI FYDLPQGNGF
310 320 330 340 350
CLGQLNLENR SETVRRTRSK IGYGILLSKE PDGVWAYNRS EHPIFVNSPT
360 370 380 390 400
LDIPNCRTLI VRKVMPGYSI KVFDYEKSCL LQHTAELDYA DGPYDPNSVR
410 420 430
ISFAKGWGPC YSRQFITSCP CWLEILLSNN R
Length:431
Mass (Da):47,824
Last modified:November 1, 1999 - v1
Checksum:i393185BB00ADA04E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R4GHC9R4GHC9_CHICK
Mothers against decapentaplegic hom...
SMAD6
225Annotation score:
A0A1D5PB14A0A1D5PB14_CHICK
Mothers against decapentaplegic hom...
SMAD6
429Annotation score:
A0A1D5PJL5A0A1D5PJL5_CHICK
Mothers against decapentaplegic hom...
SMAD6
290Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF165889 mRNA Translation: AAD45160.1
UniGeneiGga.3878

Similar proteinsi

Entry informationi

Entry nameiSMAD6_CHICK
AccessioniPrimary (citable) accession number: Q9W734
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1999
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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