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Entry version 121 (29 Sep 2021)
Sequence version 1 (01 Nov 1999)
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Protein

Teneurin-1

Gene

TENM1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity).

By similarity

Plays a role in the regulation of neuroplasticity in the limbic system. Mediates a rapid reorganization of actin- and tubulin-based cytoskeleton elements with an increase in dendritic arborization and spine density formation of neurons in the hippocampus and amygdala. Induces BDNF transcription inhibition in neurons. Activates the mitogen-activated protein (MAP) kinase 2 (MEK2) and extracellular signal-regulated kinase (ERK) cascade (By similarity).

By similarity

Induces gene transcription activation.

1 Publication

Miscellaneous

Binds to the plasma membrane and may be internalized by a receptor- and caveolae-mediated endocytosis manner to reach cytosolic compartments in a dynamin-dependent manner.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNeuropeptide, Repressor
Biological processStress response, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Teneurin-1
Short name:
Ten-1
Alternative name(s):
Protein Odd Oz/ten-m homolog 1
Tenascin-M1
Short name:
Ten-m1
Teneurin transmembrane protein 1
Cleaved into the following 2 chains:
Ten-1 intracellular domain
Short name:
IDten-1
Short name:
Ten-1 ICD
Alternative name(s):
Ten-1 extracellular domain
Short name:
Ten-1 ECD
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TENM1
Synonyms:ODZ1, TNM1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 305CytoplasmicSequence analysisAdd BLAST305
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei306 – 326HelicalSequence analysisAdd BLAST21
Topological domaini327 – 2705ExtracellularSequence analysisAdd BLAST2379

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi62 – 65RKRK → AAAA: Inhibits translocation to the nucleus (Ten-1 ICD form). 1 Publication4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002595001 – 2705Teneurin-1Add BLAST2705
ChainiPRO_00004210091 – ?Ten-1 intracellular domain
ChainiPRO_00004210102576 – 2705Teneurin C-terminal-associated peptideBy similarityAdd BLAST130

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi414N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi513 ↔ 523PROSITE-ProRule annotation
Disulfide bondi517 ↔ 528PROSITE-ProRule annotation
Disulfide bondi530 ↔ 539PROSITE-ProRule annotation
Disulfide bondi548 ↔ 559PROSITE-ProRule annotation
Disulfide bondi561 ↔ 570PROSITE-ProRule annotation
Disulfide bondi577 ↔ 588PROSITE-ProRule annotation
Disulfide bondi582 ↔ 593PROSITE-ProRule annotation
Disulfide bondi595 ↔ 604PROSITE-ProRule annotation
Disulfide bondi609 ↔ 620PROSITE-ProRule annotation
Disulfide bondi614 ↔ 625PROSITE-ProRule annotation
Disulfide bondi627 ↔ 636PROSITE-ProRule annotation
Disulfide bondi647 ↔ 660PROSITE-ProRule annotation
Disulfide bondi662 ↔ 671PROSITE-ProRule annotation
Disulfide bondi676 ↔ 686PROSITE-ProRule annotation
Disulfide bondi680 ↔ 691PROSITE-ProRule annotation
Disulfide bondi693 ↔ 702PROSITE-ProRule annotation
Disulfide bondi707 ↔ 717PROSITE-ProRule annotation
Disulfide bondi711 ↔ 722PROSITE-ProRule annotation
Disulfide bondi724 ↔ 733PROSITE-ProRule annotation
Disulfide bondi738 ↔ 748PROSITE-ProRule annotation
Disulfide bondi742 ↔ 757PROSITE-ProRule annotation
Disulfide bondi759 ↔ 768PROSITE-ProRule annotation
Glycosylationi878N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1057N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1530N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1547N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1643N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1679N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1737N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1761N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1822N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2125N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2265N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2582N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Derives from the plasma membrane form by proteolytic processing. Further proteolytic cleavage may be generated (By similarity).By similarity
Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei2575 – 2576CleavageCurated2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W6V6

PRoteomics IDEntifications database

More...
PRIDEi
Q9W6V6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the neurons of the developing visual system and in fetal brain.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in mitral cell, glomerular layer of the olfactory bulb, hippocampus, posteromedial cortex piriformis, nucleus rotundu, laminae 2 and 5 within the inner plexiform layer of the retina, stratum griseum, nucleus laminaris and magnocellularis in the hindbrain and Purkinje cells at embryonic day (E) 17 (at protein level). At E14, it is concentrated in the retina, the optic tectum and in specific nuclei in the dorsal diencephalon, it is concentrated in the stratum griseum centrale. Expression is seen in diencephalon, concentrated in the rotund nucleus and in the neighboring ovoid nucleus. Similar expression patterns are seen at E17.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer; disulfide-linked. Heterodimer with other teneurins (By similarity). Ten-1 ICD interacts with SORBS1 (via third SH3 domain).

Interacts with MBD1 isoform 2.

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000038367

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W6V6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 299Teneurin N-terminalPROSITE-ProRule annotationAdd BLAST299
Domaini509 – 540EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini541 – 572EGF-like 2PROSITE-ProRule annotationAdd BLAST32
Domaini573 – 605EGF-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini606 – 638EGF-like 4PROSITE-ProRule annotationAdd BLAST33
Domaini639 – 672EGF-like 5PROSITE-ProRule annotationAdd BLAST34
Domaini673 – 702EGF-like 6PROSITE-ProRule annotationAdd BLAST30
Domaini703 – 734EGF-like 7PROSITE-ProRule annotationAdd BLAST32
Domaini735 – 769EGF-like 8PROSITE-ProRule annotationAdd BLAST35
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1167 – 1192NHL 1Add BLAST26
Repeati1202 – 1246NHL 2Add BLAST45
Repeati1272 – 1316NHL 3Add BLAST45
Repeati1331 – 1382NHL 4Add BLAST52
Repeati1461 – 1504NHL 5Add BLAST44
Repeati1514 – 1533YD 1Add BLAST20
Repeati1550 – 1570YD 2Add BLAST21
Repeati1588 – 1612YD 3Add BLAST25
Repeati1613 – 1634YD 4Add BLAST22
Repeati1635 – 1655YD 5Add BLAST21
Repeati1825 – 1844YD 6Add BLAST20
Repeati1845 – 1865YD 7Add BLAST21
Repeati1866 – 1884YD 8Add BLAST19
Repeati1885 – 1905YD 9Add BLAST21
Repeati1913 – 1929YD 10Add BLAST17
Repeati1930 – 1949YD 11Add BLAST20
Repeati1950 – 1969YD 12Add BLAST20
Repeati1972 – 1992YD 13Add BLAST21
Repeati1995 – 2015YD 14Add BLAST21
Repeati2065 – 2085YD 15Add BLAST21
Repeati2093 – 2113YD 16Add BLAST21
Repeati2133 – 2153YD 17Add BLAST21
Repeati2154 – 2174YD 18Add BLAST21
Repeati2176 – 2196YD 19Add BLAST21
Repeati2208 – 2228YD 20Add BLAST21
Repeati2230 – 2250YD 21Add BLAST21
Repeati2276 – 2293YD 22Add BLAST18
Repeati2294 – 2317YD 23Add BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 73DisorderedSequence analysisAdd BLAST73
Regioni135 – 222DisorderedSequence analysisAdd BLAST88

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi62 – 65Nuclear localization signal (NLS)4
Motifi271 – 278Required for interaction with SORBS1 (Ten-1 ICD form)8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 42Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi43 – 57Polar residuesSequence analysisAdd BLAST15
Compositional biasi146 – 160Basic and acidic residuesSequence analysisAdd BLAST15
Compositional biasi169 – 187Pro residuesSequence analysisAdd BLAST19

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds.
Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tenascin family. Teneurin subfamily.Curated

Keywords - Domaini

EGF-like domain, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4659, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W6V6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W6V6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR000742, EGF-like_dom
IPR009471, Ten_N
IPR028916, Tox-GHH_dom
IPR006530, YD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06484, Ten_N, 2 hits
PF15636, Tox-GHH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49464, SSF49464, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01643, YD_repeat_2x, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 4 hits
PS51361, TENEURIN_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W6V6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEQMDCKPYQ PLSKVKHEVD LTYTSSSDES EDGRKQRQSY DSRETLNEYS
60 70 80 90 100
QELRLNYNSQ SRKRKNTDQS TQDMEFCETP HILCSGYQTD LHGVSEHSYP
110 120 130 140 150
LEVGSDVDTE TEGGASPDHA LRMWMRGMKS EHSSCLSSRA NSALSLTDTD
160 170 180 190 200
HERKSDGEND MPGSPHNQFT FRPLPPPPPP PHACTCTRKP PPAADSLQRR
210 220 230 240 250
SMTTRSQPSP AAPTPPTSTQ DSVHLHNSWV LNSNIPLETR HFLFKHGSGS
260 270 280 290 300
SAIFSAASQN YPLTSNTVYS PPPRPLPRNT FSRPAFTFSK PYRCCNWKCT
310 320 330 340 350
ALSATAITVT LALLLAYVIA VHLFGLTWQL QPVEGQLYEN GVSKGNKGAE
360 370 380 390 400
STDTTYSPIG GKVSDKTEKK VFQKGRAIDT GEVEIGAQVM QTIPPGLFWR
410 420 430 440 450
FQITIHHPVY LKFNISLAKD SLLGIYGRRN IPPTHTQFDF VKLMDGKQLI
460 470 480 490 500
KQEPKNSEEP QQAPRNLILT SLQETGFIEY MDQGAWHMAF YNDGKKVEQV
510 520 530 540 550
FVLTTAIEVL DDCSTNCNGN GECISGHCHC FPGFLGPDCA KDSCPVLCSG
560 570 580 590 600
NGEYEKGHCV CRNGWKGPEC DVPEEQCIDP TCFGHGTCIM GVCICVPGYK
610 620 630 640 650
GEICEEEDCL DPMCSGHGVC VQGECHCSAG WGGVNCETSL PICQEHCSGH
660 670 680 690 700
GTFLLDVGLC SCEPQWTGSD CSTELCTLDC GSHGVCSRGI CQCEEGWVGP
710 720 730 740 750
TCEERTCHSH CAEHGQCKDG KCECSPGWEG DHCTIDGCPG LCYGNGRCTL
760 770 780 790 800
DQNGWHCVCQ VGWSGSGCNV VMEMACGDNL DNDGDGLTDC VDPDCCQQNN
810 820 830 840 850
CYASPLCQGS PDPLDLIQHS QPPFSQHPPR LFYDRIRFLI GKESTHVIPG
860 870 880 890 900
DISFESRRAS VIRGQVVAID GTPLVGVNVS FLHHDEYGYT ISRQDGSFDL
910 920 930 940 950
VAVGGISVTL VFDRSPFISE KRTLWLSWNR FVIVDKVVMQ RAESDIPSCD
960 970 980 990 1000
VSSFISPNPI VLPSPLTAFG GSCPERGTVI PELQVVQEEI PIPSSFVKLS
1010 1020 1030 1040 1050
YLSSRTPGYK TLLRVILTHT TIPSGMTKVH LIIAVEGRLL QKWFPAAANL
1060 1070 1080 1090 1100
VYTFAWNKTD IYGQKVSGLA EAMVSVGYEY ETCPDFILWE KRTVILQGFE
1110 1120 1130 1140 1150
MDASNLGGWS INKHHVLNPQ SGIVHKGNGE NMFISQQPPV ISTMMGNGHQ
1160 1170 1180 1190 1200
RSVSCSNCNG LALNSKLFAP VALTSGPDGS VYIGDFNFVR RIFPSGNSIG
1210 1220 1230 1240 1250
ILELRNRDTR HSTSPAHKYY LAVDPVSESL YLSDTNTRRV YKAKSLIETK
1260 1270 1280 1290 1300
DLAKNVDVVA GTGDQCLPFD QSHCGDGGKA SEASLNSPRG ITIDKHGFIY
1310 1320 1330 1340 1350
FVDGTMIRKI DENGMITTII GSNGLTSTQP LSCDSGMDIT QVRLEWPTDL
1360 1370 1380 1390 1400
TVNPLDNSLY VLDNNIVLQI SESRRVRIIA GRPIHCQVPG IDHFIVSKVA
1410 1420 1430 1440 1450
IHSTLESARA IAVSHSGIPY IRETDERKIN RIQQVTTNGE ISIIAGAPSD
1460 1470 1480 1490 1500
CDCKIDPNCD CFSGDGGYAK DAKLKAPSSL AVSPDDTLYV ADLGNIRIRA
1510 1520 1530 1540 1550
VSRNKAHLSD TNMYEIASPA DQELYQFTIN GTHLHTLNLI TRDYIYNFTY
1560 1570 1580 1590 1600
SGEGDVATIT SSNGNSVHIR RDTSGLPLWV VVPGGQVYWL TISSNGVLKR
1610 1620 1630 1640 1650
VYAQGYNLAL MTYPGNTGLL ATKSDENGWT TVYEYDSDGH LTNATFPTGE
1660 1670 1680 1690 1700
VSSFHSDVEK LTRVELDTSN RENMVTATNF SATSTIYTLK QDNTQNIYRV
1710 1720 1730 1740 1750
SPDGSLRVTF ASGMEITLNT EPHILAGVVS PTLGKCNISL PGEHNSNLIE
1760 1770 1780 1790 1800
WRQRREQTKG NISTFERRLR AHNRNLLSID FDHVTRTGKI YDDHRKFTLR
1810 1820 1830 1840 1850
IMYDQTGRPV LWSPISKYNE VNITYSHSGL VTYIQRGTWT EKMEYDPSGN
1860 1870 1880 1890 1900
IISRTWADGK IWSYTYLEKS VMLLLHSQRR YIFEYDQSDY LLSVTMPSMV
1910 1920 1930 1940 1950
RHALQTMLSV GYYRNIYTPP DSGAAFIQDV TRDGRLLQTL YPGTGRRVLY
1960 1970 1980 1990 2000
KYSKQSRLSE ILYDTTQVTF TYEESSGVIK TIHLMHDGFI CTIRYRQTGP
2010 2020 2030 2040 2050
LIGRQIFRFS EEGLVNARFD YSYNNFRVTS MQAMINETPL PIDLYRYVDV
2060 2070 2080 2090 2100
SGRTEQFGKF SVINYDLNQV ITTTVMKHTK IFSANGQVIE VQYEILKSIA
2110 2120 2130 2140 2150
YWMTIQYDNM GRMVICDIRV GVDANITRYF YEYDRDGQLQ TVSVNDKTQW
2160 2170 2180 2190 2200
RYSYDLNGNI NLLSHGNSAR LTPLRYDLRD RITRLGEIQY KMDEDGFLRQ
2210 2220 2230 2240 2250
RGNEIFEYNS NGLLNKAYNK VSGWTVQYCY DGLGRRVASK SSLGQHLQFF
2260 2270 2280 2290 2300
YADLSNPIRV THLYNHSSSE ITSLYYDLQG HLIAMELSSG EEYYVACDNT
2310 2320 2330 2340 2350
GTPLAVFSSR GQVIKEILYT PYGEIYQDTN PDFQVVIGFH GGLYDSLTKL
2360 2370 2380 2390 2400
VHLGQRDYDV IAGRWTTPNH HIWKHLNAVP QPFNLYSFEN NYPVGRIQDV
2410 2420 2430 2440 2450
AKYTTDIGSW LELFGFQLHN VLPGFPKPEI EALETTYELL QLQTKTQEWD
2460 2470 2480 2490 2500
PGKTILGIQC ELQKQLRNFI SLDQLPMTPR YSDGKCYEGV KQPRFAAIPS
2510 2520 2530 2540 2550
VFGKGIKFAI KDGIVTADII GVANEDSRRI AAILNNAHYL ENLHFTIEGR
2560 2570 2580 2590 2600
DTHYFIKLGS LEEDLSLIGN TGGRRILENG VNVTVSQMTS VINGRTRRFA
2610 2620 2630 2640 2650
DIQLQHGALC FNVRYGTTVE EEKNHVLEVA RQRAVAQAWT KEQRRLQEGE
2660 2670 2680 2690 2700
EGIRAWTDGE KQQLLNTGRV QGYDGYFVLS VEQYLELSDS ANNIHFMRQS

EIGRR
Length:2,705
Mass (Da):302,388
Last modified:November 1, 1999 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i230F03D1999037D2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ238613 mRNA Translation: CAB43098.1

NCBI Reference Sequences

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RefSeqi
NP_990193.1, NM_204862.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
395668

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
gga:395668

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ238613 mRNA Translation: CAB43098.1
RefSeqiNP_990193.1, NM_204862.1

3D structure databases

SMRiQ9W6V6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000038367

Proteomic databases

PaxDbiQ9W6V6
PRIDEiQ9W6V6

Genome annotation databases

GeneIDi395668
KEGGigga:395668

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10178

Phylogenomic databases

eggNOGiKOG4659, Eukaryota
InParanoidiQ9W6V6
PhylomeDBiQ9W6V6

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q9W6V6

Family and domain databases

Gene3Di2.120.10.30, 2 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR008969, CarboxyPept-like_regulatory
IPR000742, EGF-like_dom
IPR009471, Ten_N
IPR028916, Tox-GHH_dom
IPR006530, YD
PfamiView protein in Pfam
PF06484, Ten_N, 2 hits
PF15636, Tox-GHH, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SUPFAMiSSF49464, SSF49464, 1 hit
TIGRFAMsiTIGR01643, YD_repeat_2x, 2 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 8 hits
PS01186, EGF_2, 7 hits
PS50026, EGF_3, 4 hits
PS51361, TENEURIN_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTEN1_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W6V6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 1, 1999
Last modified: September 29, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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