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Protein

Probable chitinase 10

Gene

Cht10

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta-linkages in chitin and chitodextrins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1087Proton donorPROSITE-ProRule annotation1
Active sitei1531Proton donorPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandChitin-binding

Protein family/group databases

CAZyiCBM14 Carbohydrate-Binding Module Family 14
GH18 Glycoside Hydrolase Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Probable chitinase 10Imported (EC:3.2.1.14)
Alternative name(s):
Probable chitinase 1
Probable chitinase 3Imported
Gene namesi
Name:Cht10Imported
Synonyms:Cht1Imported, Cht3Imported
ORF Names:CG18140Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0250907 Cht10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000007705121 – 2286Probable chitinase 10Add BLAST2266

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi721 ↔ 734PROSITE-ProRule annotation
Disulfide bondi827 ↔ 840PROSITE-ProRule annotation
Disulfide bondi897 ↔ 910PROSITE-ProRule annotation
Disulfide bondi1857 ↔ 1868PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9W5U2
PRIDEiQ9W5U2

Expressioni

Gene expression databases

BgeeiFBgn0250907
ExpressionAtlasiQ9W5U2 baseline and differential
GenevisibleiQ9W5U2 DM

Interactioni

Protein-protein interaction databases

BioGridi78241, 2 interactors
DIPiDIP-19404N
IntActiQ9W5U2, 2 interactors
STRINGi7227.FBpp0110419

Structurei

3D structure databases

ProteinModelPortaliQ9W5U2
SMRiQ9W5U2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini689 – 744Chitin-binding type-2 1PROSITE-ProRule annotationAdd BLAST56
Domaini797 – 850Chitin-binding type-2 2PROSITE-ProRule annotationAdd BLAST54
Domaini866 – 920Chitin-binding type-2 3PROSITE-ProRule annotationAdd BLAST55
Domaini1826 – 1878Chitin-binding type-2 4PROSITE-ProRule annotationAdd BLAST53

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG2806 Eukaryota
COG3325 LUCA
GeneTreeiENSGT00550000074323
InParanoidiQ9W5U2
KOiK01183
OMAiDFKNRCG
OrthoDBiEOG091G014W
PhylomeDBiQ9W5U2

Family and domain databases

Gene3Di3.10.50.10, 4 hits
InterProiView protein in InterPro
IPR002557 Chitin-bd_dom
IPR036508 Chitin-bd_dom_sf
IPR011583 Chitinase_II
IPR029070 Chitinase_insertion_sf
IPR001223 Glyco_hydro18_cat
IPR001579 Glyco_hydro_18_chit_AS
IPR017853 Glycoside_hydrolase_SF
PfamiView protein in Pfam
PF01607 CBM_14, 4 hits
PF00704 Glyco_hydro_18, 4 hits
SMARTiView protein in SMART
SM00494 ChtBD2, 4 hits
SM00636 Glyco_18, 4 hits
SUPFAMiSSF51445 SSF51445, 8 hits
SSF54556 SSF54556, 4 hits
SSF57625 SSF57625, 4 hits
PROSITEiView protein in PROSITE
PS50940 CHIT_BIND_II, 4 hits
PS01095 CHITINASE_18, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W5U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPYVPSVLV VVVLAISVKA HIRVDKLQIH SESNYKPAFI RSAVESIPLD
60 70 80 90 100
IDAILLLRNS TKPEFGDAFL PLRSAVESIP KLYQSNTSRF RKNPDVRSFV
110 120 130 140 150
RDSVESLPND EDGLEHIEIF TKYYNSVSDV AGVDLKSKKL THVNLDPGTI
160 170 180 190 200
SDKYAAFIAR GNSEDYYPKS YRAGSPHQEL LKMMNIEHTD KLDRYSDLQH
210 220 230 240 250
QQSYGALGLA NRNDLKMTKK VLCYMSNWAF YRSGEAHFVP EQIDPNLCSA
260 270 280 290 300
IIYSFASLDP DHLTIREFDS WVDLDNQYYR RVTSLGVPVL IALGGWTDSS
310 320 330 340 350
GSKYSRLVSD NLKRRVFISS VSSFLLRHGF SGLHLDWNYP KCWQSDCSRG
360 370 380 390 400
PVTDRPNLTK LLRELRTEFQ SVDPKFQLGV AISGYKEIIK EAYDFPALSD
410 420 430 440 450
IVDYMTVMTY DYHGAWEQKT GHVSPLYGLS SDTYPQYNTN YTMQLLLKMG
460 470 480 490 500
ARREKLVLSI PFYGQSFTLA TAHQILAGPG VAASGPGDAG ELTKQPGMLA
510 520 530 540 550
YYEICQRLTK FNWISDRNLN VIFGPFAMLN DQWVGYEDPT SAQAKARYAA
560 570 580 590 600
NNNFAGVAAW TIDLDDFRNL CCNESYPLLR AINRALGRLD SEPPTQPNCK
610 620 630 640 650
RPTLLATPVP PQMTTISSDG SGGLGQNHDH TTSLPSGQIS SSPVSTTITS
660 670 680 690 700
TFPWWSSTTK RPREPTKTTA QPTHTTILIP AGINPVVQPS NCKSGEFFAD
710 720 730 740 750
SNNCNAYYHC FFAGELQQQF CPSGLHWNNE AKGCDWPSSA QCSLKLDQHL
760 770 780 790 800
STSYPNPIQT SKKPETTLKP NKKPSEISTH HQVNSTSSRP QYMRPTILEC
810 820 830 840 850
TEGDYYPHRN CRKYYICVNK ALVPSECGGD LHWDGIKKLC DWPENVQCVT
860 870 880 890 900
SKKYLKIIKS SSANEEDPCK GEKRVPYPGN CSKYLFCLWN RLQASDCPPG
910 920 930 940 950
LHYNERIGNC DWPAAAKCNP KGSESSEEAE LNAMPKPPTP QTPSSHLRPT
960 970 980 990 1000
YPTEKPVPKP RDSHYKVICY FTNWAWYRKG IGRFTPDDIN TELCTHVIYG
1010 1020 1030 1040 1050
FAVLDYSELV LRTHDSWADV ENNFYTRVTS LKSKGIKVSL ALGGWNDSQG
1060 1070 1080 1090 1100
DKYSRLVRSP MARSRFVRHA LEFIEKYGFE GLDLDWEYPV CWQTECNKGS
1110 1120 1130 1140 1150
TEEKDGFTAW VQELSEAFRP RGLMLSTAVS PSRKIIDAGY DIPQLSRYFD
1160 1170 1180 1190 1200
WIAVMTYDFH GHWDKKTGHV APLYHHPDDD FEYFNVNYSI NYWMEKGAPS
1210 1220 1230 1240 1250
QKLVMGIPLY GQSFTLENTN SSGLNAKAPA PGEAGEFTRA AGFLAYYEIC
1260 1270 1280 1290 1300
ERVNRQGWQV VHDEFGRMGP YAYKGTQWVS YDSPDMVRKK SLLVRSLKLG
1310 1320 1330 1340 1350
GGMVWALDLD DFKNRCGNGV HPLLTEIHNV LKDPPSLMEI PGPIETTPTE
1360 1370 1380 1390 1400
YPGMEEEIHE SNGEGPEVQP IEAVMQTCEN EGEEHEGILD PNHVLEEENI
1410 1420 1430 1440 1450
EATEMATEFK IICYFTNWAW YRQGGGKFLP EDIDSDLCTH IIYGFAVLSR
1460 1470 1480 1490 1500
DNLTIQPHDS WADLDNKFYE RIVAYRKKGA KVTVAIGGWN DSAGDKYSRL
1510 1520 1530 1540 1550
VRNPEARSRF IRNVLDFIEE YNFDGLDLDW EYPVCWQVDC KKGTAEEKIG
1560 1570 1580 1590 1600
FSALVRELFY AFQPRGLILS AAVSPNKKVI DAGYEVAELS HYFSWISVMA
1610 1620 1630 1640 1650
YDYHGQWDKK TGHVAPMYSH PEGTANFNAN FSMNYWISMG ADRRKLVMGI
1660 1670 1680 1690 1700
PLYGQSFSLA ETTKHQLNAP TYGGGEAGEA TRARGFLAYY EICLKIRHHR
1710 1720 1730 1740 1750
WNVVRDTKGR IGPFAYHGDQ WVSFDDVPMI RHKSEYIKAM GLGGAMIWAL
1760 1770 1780 1790 1800
DLDDFKNVCE CESYPLLKAI NRVLRGFGGP QPKCLLENPK STMKPNIKPP
1810 1820 1830 1840 1850
FRPTINAPSG PNLDSPTQNV SLNVLSIKCH SKNYLAHEWD CTKYYICEHG
1860 1870 1880 1890 1900
TYVERSCPLG LQWNKTYCDW PTNVQSSLGS NQRTQEPAVH RPNPTSVITE
1910 1920 1930 1940 1950
PPIINNSYKV VCYFTSWAWY RSSQGKFVPE DIDANLCTHL IYGFAVLDSK
1960 1970 1980 1990 2000
SLTIKTHDSW TDIDNRFYER VVEYKQRGLR VMLAIGGWND SLGSKYARLV
2010 2020 2030 2040 2050
LNSQSRRRFV ASVISFLEQH GFEGLDLAWE FPVCWQVNCN RGNPTEKDGF
2060 2070 2080 2090 2100
VALVKELSEA FKENGLILSA AVSPSKMVID AGYNVFELSP YFDWVAVMTY
2110 2120 2130 2140 2150
DFHGHWDMRT GQIAPLFHRG GDENLYLNGN FSIHYWLERG IPNDKLVMGM
2160 2170 2180 2190 2200
PMYGQTFTLA DQNRRSLNDK TVGPGKAGTF TRADGFLAYY EICEKVVNDD
2210 2220 2230 2240 2250
WKVVRDEEGI FGSYAYSGNQ WISYDDVTTI RRKSQFIKSL QLGGGMIWAL
2260 2270 2280
DLDDFRGLCG CGKHPLLRTL SQELLGIPGQ KAKDCI
Length:2,286
Mass (Da):258,777
Last modified:November 25, 2008 - v2
Checksum:iB4FC42CE4719F12A
GO

Sequence cautioni

The sequence AAM50881 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: EAA46011.1
BT021372 mRNA Translation: AAX33520.1
AF026500 Genomic DNA Translation: AAB81858.1
AF026502 Genomic DNA Translation: AAB81860.1
AY119021 mRNA Translation: AAM50881.1 Different initiation.
RefSeqiNP_001036422.1, NM_001042957.2
NP_001260697.1, NM_001273768.1
NP_001260698.1, NM_001273769.1
UniGeneiDm.14448

Genome annotation databases

EnsemblMetazoaiFBtr0111127; FBpp0110419; FBgn0250907
FBtr0331165; FBpp0303592; FBgn0250907
FBtr0331166; FBpp0303593; FBgn0250907
GeneIDi3355116
KEGGidme:Dmel_CG18140
UCSCiCG18140-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiCHI10_DROME
AccessioniPrimary (citable) accession number: Q9W5U2
Secondary accession number(s): O17420
, O17422, Q7PL80, Q8MS85, Q9W5U3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: November 25, 2008
Last modified: July 18, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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