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Protein

60S ribosomal protein L5

Gene

RpL5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • ribosomal large subunit assembly Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L5
Gene namesi
Name:RpL5
Synonyms:yip6
ORF Names:CG17489
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0064225 RpL5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002915591 – 29960S ribosomal protein L5Add BLAST299

Proteomic databases

PaxDbiQ9W5R8
PRIDEiQ9W5R8

Expressioni

Gene expression databases

BgeeiFBgn0064225 Expressed in 27 organ(s), highest expression level in eye disc (Drosophila)
ExpressionAtlasiQ9W5R8 baseline and differential
GenevisibleiQ9W5R8 DM

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU) (By similarity). Interacts with Fmr1 to form the RNA-induced silencing complex (RISC), a ribonucleoprotein (RNP) complex involved in translation regulation, other components of the complex are Rm62, RpL11, AGO2 and Dcr-1 (PubMed:12368261).By similarity1 Publication

Protein-protein interaction databases

BioGridi78249, 38 interactors
DIPiDIP-17125N
IntActiQ9W5R8, 8 interactors
STRINGi7227.FBpp0304879

Structurei

3D structure databases

ProteinModelPortaliQ9W5R8
SMRiQ9W5R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0875 Eukaryota
COG0256 LUCA
InParanoidiQ9W5R8
KOiK02932
OMAiVAEYMES
OrthoDBiEOG091G0GZO
PhylomeDBiQ9W5R8

Family and domain databases

HAMAPiMF_01337_A Ribosomal_L18_A, 1 hit
InterProiView protein in InterPro
IPR005485 Rbsml_L5_euk/L18_arc
IPR025607 Rbsml_L5e/L18P_C
PANTHERiPTHR23410 PTHR23410, 1 hit
PfamiView protein in Pfam
PF14204 Ribosomal_L18_c, 1 hit
PF17144 Ribosomal_L5e, 1 hit
PRINTSiPR00058 RIBOSOMALL5

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9W5R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFVKVVKNK QYFKRYQVKF RRRREGKTDY YARKRLTFQD KNKYNTPKYR
60 70 80 90 100
LIVRLSNKDI TVQIAYARIE GDRVVCAAYS HELPKYGIQV GLTNYAAAYC
110 120 130 140 150
TGLLVARRVL NKLGLDSLYA GCTEVTGEEF NVEPVDDGPG AFRCFLDVGL
160 170 180 190 200
ARTTTGARVF GAMKGAVDGG LNIPHSVKRF PGYSAETKSF NADVHRAHIF
210 220 230 240 250
GQHVADYMRS LEEEDEESFK RQFSRYIKLG IRADDLEDIY KKAHQAIRND
260 270 280 290
PTHKVTAKKS SAVTKKRWNA KKLTNEQRKT KIAAHKAAYV AKLQSETEA
Length:299
Mass (Da):34,037
Last modified:March 1, 2001 - v2
Checksum:i523F50ED67E7841A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
R9Q794R9Q794_DROME
Ribosomal protein L5, isoform G
RpL5 Dmel\CG17489, dRPL5, E-2d, L5, M(2)40B RpL5 Dmel\CG17489, dRPL5, E-2d, L5, M(2)40B, Rp L5, Rpl5, yip6, CG17489, Dmel_CG17489
299Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: EAA46016.1
AE014134 Genomic DNA Translation: EAA46019.1
AY071305 mRNA Translation: AAL48927.1
RefSeqiNP_001036387.1, NM_001042922.3
NP_001036388.1, NM_001042923.3
NP_001036390.2, NM_001042925.3
NP_001036391.2, NM_001042926.2
UniGeneiDm.7121

Genome annotation databases

EnsemblMetazoaiFBtr0111129; FBpp0110421; FBgn0064225
FBtr0111132; FBpp0110424; FBgn0064225
FBtr0332633; FBpp0304879; FBgn0064225
FBtr0344793; FBpp0311121; FBgn0064225
GeneIDi3355124
KEGGidme:Dmel_CG17489

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: EAA46016.1
AE014134 Genomic DNA Translation: EAA46019.1
AY071305 mRNA Translation: AAL48927.1
RefSeqiNP_001036387.1, NM_001042922.3
NP_001036388.1, NM_001042923.3
NP_001036390.2, NM_001042925.3
NP_001036391.2, NM_001042926.2
UniGeneiDm.7121

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CD1-299[»]
ProteinModelPortaliQ9W5R8
SMRiQ9W5R8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi78249, 38 interactors
DIPiDIP-17125N
IntActiQ9W5R8, 8 interactors
STRINGi7227.FBpp0304879

Proteomic databases

PaxDbiQ9W5R8
PRIDEiQ9W5R8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0111129; FBpp0110421; FBgn0064225
FBtr0111132; FBpp0110424; FBgn0064225
FBtr0332633; FBpp0304879; FBgn0064225
FBtr0344793; FBpp0311121; FBgn0064225
GeneIDi3355124
KEGGidme:Dmel_CG17489

Organism-specific databases

CTDi6125
FlyBaseiFBgn0064225 RpL5

Phylogenomic databases

eggNOGiKOG0875 Eukaryota
COG0256 LUCA
InParanoidiQ9W5R8
KOiK02932
OMAiVAEYMES
OrthoDBiEOG091G0GZO
PhylomeDBiQ9W5R8

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRSiRpL5 fly
GenomeRNAii3355124
PROiPR:Q9W5R8

Gene expression databases

BgeeiFBgn0064225 Expressed in 27 organ(s), highest expression level in eye disc (Drosophila)
ExpressionAtlasiQ9W5R8 baseline and differential
GenevisibleiQ9W5R8 DM

Family and domain databases

HAMAPiMF_01337_A Ribosomal_L18_A, 1 hit
InterProiView protein in InterPro
IPR005485 Rbsml_L5_euk/L18_arc
IPR025607 Rbsml_L5e/L18P_C
PANTHERiPTHR23410 PTHR23410, 1 hit
PfamiView protein in Pfam
PF14204 Ribosomal_L18_c, 1 hit
PF17144 Ribosomal_L5e, 1 hit
PRINTSiPR00058 RIBOSOMALL5
ProtoNetiSearch...

Entry informationi

Entry nameiRL5_DROME
AccessioniPrimary (citable) accession number: Q9W5R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 135 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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