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Protein

60S ribosomal protein L5

Gene

RpL5

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.By similarity

GO - Molecular functioni

GO - Biological processi

  • cytoplasmic translation Source: FlyBase
  • ribosomal large subunit assembly Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-DME-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-DME-1799339 SRP-dependent cotranslational protein targeting to membrane
R-DME-72689 Formation of a pool of free 40S subunits
R-DME-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-DME-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-DME-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L5
Gene namesi
Name:RpL5
Synonyms:yip6
ORF Names:CG17489
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0064225 RpL5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002915591 – 29960S ribosomal protein L5Add BLAST299

Proteomic databases

PaxDbiQ9W5R8
PRIDEiQ9W5R8

Expressioni

Gene expression databases

BgeeiFBgn0064225
ExpressionAtlasiQ9W5R8 baseline and differential
GenevisibleiQ9W5R8 DM

Interactioni

Subunit structurei

Component of the large ribosomal subunit (LSU).By similarity

Protein-protein interaction databases

BioGridi78249, 38 interactors
DIPiDIP-17125N
IntActiQ9W5R8, 8 interactors
STRINGi7227.FBpp0304879

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CD1-299[»]
ProteinModelPortaliQ9W5R8
SMRiQ9W5R8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0875 Eukaryota
COG0256 LUCA
InParanoidiQ9W5R8
KOiK02932
OMAiVAEYMES
OrthoDBiEOG091G0GZO
PhylomeDBiQ9W5R8

Family and domain databases

HAMAPiMF_01337_A Ribosomal_L18_A, 1 hit
InterProiView protein in InterPro
IPR005485 Rbsml_L5_euk/L18_arc
IPR025607 Rbsml_L5e/L18P_C
PANTHERiPTHR23410 PTHR23410, 1 hit
PfamiView protein in Pfam
PF14204 Ribosomal_L18_c, 1 hit
PF17144 Ribosomal_L5e, 1 hit
PRINTSiPR00058 RIBOSOMALL5

Sequencei

Sequence statusi: Complete.

Q9W5R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFVKVVKNK QYFKRYQVKF RRRREGKTDY YARKRLTFQD KNKYNTPKYR
60 70 80 90 100
LIVRLSNKDI TVQIAYARIE GDRVVCAAYS HELPKYGIQV GLTNYAAAYC
110 120 130 140 150
TGLLVARRVL NKLGLDSLYA GCTEVTGEEF NVEPVDDGPG AFRCFLDVGL
160 170 180 190 200
ARTTTGARVF GAMKGAVDGG LNIPHSVKRF PGYSAETKSF NADVHRAHIF
210 220 230 240 250
GQHVADYMRS LEEEDEESFK RQFSRYIKLG IRADDLEDIY KKAHQAIRND
260 270 280 290
PTHKVTAKKS SAVTKKRWNA KKLTNEQRKT KIAAHKAAYV AKLQSETEA
Length:299
Mass (Da):34,037
Last modified:March 1, 2001 - v2
Checksum:i523F50ED67E7841A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA Translation: EAA46016.1
AE014134 Genomic DNA Translation: EAA46019.1
AY071305 mRNA Translation: AAL48927.1
RefSeqiNP_001036387.1, NM_001042922.3
NP_001036388.1, NM_001042923.3
NP_001036390.2, NM_001042925.3
NP_001036391.2, NM_001042926.2
UniGeneiDm.7121

Genome annotation databases

EnsemblMetazoaiFBtr0111129; FBpp0110421; FBgn0064225
FBtr0111132; FBpp0110424; FBgn0064225
FBtr0332633; FBpp0304879; FBgn0064225
FBtr0344793; FBpp0311121; FBgn0064225
GeneIDi3355124
KEGGidme:Dmel_CG17489

Similar proteinsi

Entry informationi

Entry nameiRL5_DROME
AccessioniPrimary (citable) accession number: Q9W5R8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: March 1, 2001
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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