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Entry version 146 (11 Dec 2019)
Sequence version 4 (05 May 2009)
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Protein

Microtubule-associated protein futsch

Gene

futsch

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

During embryogenesis, necessary for dendritic and axonal organization and growth at the neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton (PubMed:10839355, PubMed:10839356, PubMed:11733059). Microtubule hairpin loops are found within a small subset of synaptic boutons at the neuromuscular synapse, these loops are stabilized by Futsch (PubMed:10839355, PubMed:10839356, PubMed:11733059). Loop morphology and dynamics suggest that rearrangement of these microtubule-based loops is a critical component of the process of bouton division and for subsequent nerve-terminal growth and branching (PubMed:10839355, PubMed:10839356, PubMed:11733059). Translation is repressed by Fmr1 (PubMed:10839355, PubMed:10839356, PubMed:11733059). Together with Ringer, required for neuromuscular junction (NMJ) bouton growth by regulating synaptic microtubules (PubMed:31156389).4 Publications

Miscellaneous

'Futsch' means 'gone' in German.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Microtubule-associated protein futsch
Alternative name(s):
MAP1B homolog
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:futsch
ORF Names:CG34387
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0259108 futsch

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Flies lacking both Ringer and Futsch display a significant reduction in microtubule loops at the neuromuscular junctions (NMJ) and reduced acetylated-tubulin levels.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000873881 – 5495Microtubule-associated protein futschAdd BLAST5495
ChainiPRO_00004183741 – 5328Futsch heavy chainAdd BLAST5328
ChainiPRO_00004183755329 – 5495Futsch light chain LC(f)Add BLAST167

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2800Phosphoserine; by GSK3-beta1 Publication1
Modified residuei3067Phosphoserine1 Publication1
Modified residuei3071Phosphoserine1 Publication1
Modified residuei3075Phosphoserine1 Publication1
Modified residuei4950Phosphoserine; by GSK3-beta1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Several minor light chains can be created with markedly different pIs.1 Publication
Phosphorylated by SGG/GSK3. Phosphorylated by LRRK2 at the presynapse of neuromuscular junctions, which negatively regulates the activity controlling synaptic differentiation.3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W596

PRoteomics IDEntifications database

More...
PRIDEi
Q9W596

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9W596

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Neuronal cells within the PNS and CNS.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

All stages.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0259108 Expressed in 11 organ(s), highest expression level in second segment of antenna (Drosophila)

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9W596 differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9W596 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer of a heavy and a light chain (PubMed:18419581).

Interacts with Fmr1 (PubMed:11733059).

Found in a complex with tubulin and Futsch (PubMed:31156389).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
625175, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q9W596, 10 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0300236

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1469 – 15021Add BLAST34
Repeati1513 – 15392Add BLAST27
Repeati1622 – 16493Add BLAST28
Repeati1660 – 16864Add BLAST27
Repeati1690 – 17185Add BLAST29
Repeati1755 – 17826Add BLAST28
Repeati1790 – 18187Add BLAST29
Repeati1837 – 18658Add BLAST29
Repeati1874 – 19029Add BLAST29
Repeati1911 – 193910Add BLAST29
Repeati1948 – 197611Add BLAST29
Repeati1985 – 201312Add BLAST29
Repeati2022 – 205013Add BLAST29
Repeati2059 – 208714Add BLAST29
Repeati2096 – 212415Add BLAST29
Repeati2133 – 216116Add BLAST29
Repeati2170 – 219817Add BLAST29
Repeati2215 – 224318Add BLAST29
Repeati2262 – 229219Add BLAST31
Repeati2355 – 239120Add BLAST37
Repeati2703 – 272621Add BLAST24
Repeati2761 – 278722Add BLAST27
Repeati2820 – 284623Add BLAST27
Repeati2864 – 289224Add BLAST29
Repeati2907 – 293325Add BLAST27
Repeati2956 – 298726Add BLAST32
Repeati3006 – 303427Add BLAST29
Repeati3049 – 307528Add BLAST27
Repeati3089 – 311729Add BLAST29
Repeati3131 – 315830Add BLAST28
Repeati3200 – 322431Add BLAST25
Repeati3228 – 325632Add BLAST29
Repeati3265 – 329333Add BLAST29
Repeati3302 – 333034Add BLAST29
Repeati3339 – 336735Add BLAST29
Repeati3376 – 340436Add BLAST29
Repeati3413 – 344137Add BLAST29
Repeati3450 – 347838Add BLAST29
Repeati3487 – 351539Add BLAST29
Repeati3524 – 355240Add BLAST29
Repeati3561 – 358941Add BLAST29
Repeati3598 – 362642Add BLAST29
Repeati3635 – 366343Add BLAST29
Repeati3672 – 370044Add BLAST29
Repeati3709 – 373745Add BLAST29
Repeati3746 – 377446Add BLAST29
Repeati3783 – 381147Add BLAST29
Repeati3820 – 384848Add BLAST29
Repeati3867 – 389449Add BLAST28
Repeati3895 – 392150Add BLAST27
Repeati3931 – 395851Add BLAST28
Repeati3968 – 399552Add BLAST28
Repeati4005 – 403253Add BLAST28

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1469 – 403253 X approximate repeatAdd BLAST2564

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3592 Eukaryota
ENOG410XRYM LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W596

Identification of Orthologs from Complete Genome Data

More...
OMAi
PCAPEDF

Database of Orthologous Groups

More...
OrthoDBi
22057at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W596

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026074 MAP1
IPR009603 MAP_Futsch

The PANTHER Classification System

More...
PANTHERi
PTHR13843 PTHR13843, 10 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06740 DUF1213, 51 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9W596-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDQPKATTT ATGGAAGPVP EGDAVMATTN QDALAKGAGD GPAQDAAQEP
60 70 80 90 100
GQAEHGEPGD GGDGGDDGAT DAGASSLPPS EIGGRAPLDT ACSDADGGAP
110 120 130 140 150
SSLAGGIVGP PSPLTGCYLL IVLGEPHSEE HKDNILQHLL KGFLSWDVSD
160 170 180 190 200
CHVDLEEELN TITQHAPEGE EARHGERLIQ YASENLVTEV LIHPQYNTLI
210 220 230 240 250
QCMRNLLSSF TRHRHIIHAG YTFSGNGSWI LQDGTFSVAD FSEAFQEHDV
260 270 280 290 300
QRVIRAYADT ITMNIHCADA GLWHTLPEKA FARQCRIRIN PVDVLDTSSE
310 320 330 340 350
CINGFIDYLA PMVMPTSLRE LLETSDVVGN IRFTHPTLYV FPGGQGDAAL
360 370 380 390 400
FGINGFNMLV DGGFNRKACF WDFARHLDRL DAVLMTRLNN SNVQGLGAVV
410 420 430 440 450
SRKRDAHVYP QIGHFFGNVP DRKGLPSPDG DKDRDPLLID LFERGHGIVS
460 470 480 490 500
DLKALDLKPQ CCYRNQEPVN LYHKVGHGTL DMYVISPARD SKEVKEFLQK
510 520 530 540 550
WHAGDQRLFA ARDSRDFNFP LQNLVSICAL LVWQPANPDD TITRILFPGS
560 570 580 590 600
TPDFKIQEGL EKLKHLEFMK HSTCTAKSIA PAIQTVTSTR KSLKSAIEAT
610 620 630 640 650
PAPPSASYKT TKFSPVASAA LAVQHPQQQD NKAKEAAAAA AAAAAAAASA
660 670 680 690 700
ATIARAKADS MDTDAEPEHE ADPEPADTGD EAAPTEQEPE AETEPEPEHE
710 720 730 740 750
PEAEQDKDVG EEKKVEVLIM KPQQATPAVI AASGKDGVDA ASADATPTGK
760 770 780 790 800
LSKASAKGKA DKPRAEVKPV VRSRIDTKPP KSMDRKLAKR DEKKSSPTTT
810 820 830 840 850
PAARAPVAQN AKPKVLSRPA TKSSPSSTPA KSAKEANNRK VLESKQQAAR
860 870 880 890 900
VQATSTVSRR VTSTASERRV QQQAEAKTAA TGATQATQRK PISRRPRGVS
910 920 930 940 950
PSKRAPAPGS PVKQAKPKAA DLKKTRLDKG GTTDSSLVST PSADEATAAK
960 970 980 990 1000
KLQDLTASQE LDAEKQRELD DLKEEQEVVR EIEAVFSRDE MKRQQHQQIK
1010 1020 1030 1040 1050
AELREMPAEG TGDGENEPDE EEEYLIIEKE EVEQYTEDSI VEQESSMTKE
1060 1070 1080 1090 1100
EEIQKHQRDS QESEKKRKKS AEEEIEAAIA KVEAAERKAR LEGASARQDE
1110 1120 1130 1140 1150
SELDVEPEQS KIKAEVQDII ATAKDIAKSR TEEQLAKPAE EELSSPTPEE
1160 1170 1180 1190 1200
KLSKKTSDTK DDQIGAPVDV LPVNLQESLP EEKFSATIES GATTAPTLPE
1210 1220 1230 1240 1250
DERIPLDQIK EDLVIEEKYV KEETKEAEAI VVATVQTLPE AAPLAIDTIL
1260 1270 1280 1290 1300
ASATKDAPKD ANAEALGELP DSGERVLPMK MTFEAQQNLL RDVIKTPDEV
1310 1320 1330 1340 1350
ADLPVHEEAD LGLYEKDSQD AGAKSISHKE ESAKEEKETD DEKENKVGEI
1360 1370 1380 1390 1400
ELGDEPNKVD ISHVLLKESV QEVAEKVVVI ETTVEKKQEE IVEATTVITQ
1410 1420 1430 1440 1450
ENQEDLMEQV KDKEEHEQKI ESGIITEKEA KKSASTPEEK ETSDITSDDE
1460 1470 1480 1490 1500
LPAQLADPTT VPPKSAKDRE DTGSIESPPT IEEAIEVEVQ AKQEAQKPVP
1510 1520 1530 1540 1550
APEEAIKTEK SPLASKETSR PESATGSVKE DTEQTKSKKS PVPSRPESEA
1560 1570 1580 1590 1600
KDKKSPFASG EASRPESVAE SVKDEAGKAE SRRESIAKTH KDESSLDKAK
1610 1620 1630 1640 1650
EQESRRESLA ESIKPESGID EKSALASKEA SRPESVTDKS KEPSRRESIA
1660 1670 1680 1690 1700
ESLKAESTKD EKSAPPSKEA SRPGSVVESV KDETEKSKEP SRRESIAESA
1710 1720 1730 1740 1750
KPPIEFREVS RPESVIDGIK DESAKPESRR DSPLASKEAS RPESVLESVK
1760 1770 1780 1790 1800
DEPIKSTEKS RRESVAESFK ADSTKDEKSP LTSKDISRPE SAVENVMDAV
1810 1820 1830 1840 1850
GSAERSQPES VTASRDVSRP ESVAESEKDD TDKPESVVES VIPASDVVEI
1860 1870 1880 1890 1900
EKGAADKEKG VFVSLEIGKP DSPSEVISRP GPVVESVKPE SRRESSTEIV
1910 1920 1930 1940 1950
LPCHAEDSKE PSRPESKVEC LKDESEVLKG STRRESVAES DKSSQPFKET
1960 1970 1980 1990 2000
SRPESAVGSM KDESMSKEPS RRESVKDGAA QSRETSRPAS VAESAKDGAD
2010 2020 2030 2040 2050
DLKELSRPES TTQSKEAGSI KDEKSPLASE EASRPASVAE SVKDEAEKSK
2060 2070 2080 2090 2100
EESRRESVAE KSPLPSKEAS RPASVAESIK DEAEKSKEES RRESVAEKSP
2110 2120 2130 2140 2150
LPSKEASRPA SVAESIKDEA EKSKEESRRE SVAEKSPLPS KEASRPASVA
2160 2170 2180 2190 2200
ESIKDEAEKS KEESRRESVA EKSPLPSKEA SRPASVAESI KDEAEKSKEE
2210 2220 2230 2240 2250
SRRESVAEKS PLPSKEASRP ASVAESIKDE AEKSKEESRR ESVAEKSPLP
2260 2270 2280 2290 2300
SKEASRPASV AESIKDEAEK SKEESRRESV AEKSPLPSKE ASRPASVAES
2310 2320 2330 2340 2350
IKDEAEKSKE ETRRESVAEK SPLPSKEASR PASVAESIKD EAEKSKEESR
2360 2370 2380 2390 2400
RESAAEKSPL PSKEASRPAS VAESVKDEAD KSKEESRRES MAESGKAQSI
2410 2420 2430 2440 2450
KGDQSPLKEV SRPESVAESV KDDPVKSKEP SRRESVAGSV TADSARDDQS
2460 2470 2480 2490 2500
PLESKGASRP ESVVDSVKDE AEKQESRRES KTESVIPPKA KDDKSPKEVL
2510 2520 2530 2540 2550
QPVSMTETIR EDADQPMKPS QAESRRESIA ESIKASSPRD EKSPLASKEA
2560 2570 2580 2590 2600
SRPGSVAESI KYDLDKPQII KDDKSTEHSR RESLEDKSAV TSEKSVSRPL
2610 2620 2630 2640 2650
SVASDHEAAV AIEDDAKSSI SPKDKSRPGF VAETVSSPIE EATMEFSKIE
2660 2670 2680 2690 2700
VVEKSSLALS LQGGSGGKLQ TDSSPVDVAE GDFSHAVASV STVTPTLTKP
2710 2720 2730 2740 2750
AELAQIGAAK TVSSPLDEAL RTPSAPEHIS RADSPAECAS EEIASQDKSP
2760 2770 2780 2790 2800
QVLKESSRPA WVAESKDDAA QLKSSVEDLR SPVASTEISR PASAGETASS
2810 2820 2830 2840 2850
PIEEAPKDFA EFEQAEKAVL PLTIELKGNL PTLSSPVDVA HGDFPQTSTP
2860 2870 2880 2890 2900
TSSPTVASVQ PAELSKVDIE KTASSPIDEA PKSLIGCPAE ERPESPAESA
2910 2920 2930 2940 2950
KDAAESVEKS KDASRPPSVV ESTKADSTKG DISPSPESVL EGPKDDVEKS
2960 2970 2980 2990 3000
KESSRPPSVS ASITGDSTKD VSRPASVVES VKDEHDKAES RRESIAKVES
3010 3020 3030 3040 3050
VIDEAGKSDS KSSSQDSQKD EKSTLASKEA SRRESVVESS KDDAEKSESR
3060 3070 3080 3090 3100
PESVIASGEP VPRESKSPLD SKDTSRPGSM VESVTAEDEK SEQQSRRESV
3110 3120 3130 3140 3150
AESVKADTKK DGKSQEASRP SSVDELLKDD DEKQESRRQS ITGSHKAMST
3160 3170 3180 3190 3200
MGDESPMDKA DKSKEPSRPE SVAESIKHEN TKDEESPLGS RRDSVAESIK
3210 3220 3230 3240 3250
SDITKGEKSP LPSKEVSRPE SVVGSIKDEK AESRRESVAE SVKPESSKDA
3260 3270 3280 3290 3300
TSAPPSKEHS RPESVLGSLK DEGDKTTSRR VSVADSIKDE KSLLVSQEAS
3310 3320 3330 3340 3350
RPESEAESLK DAAAPSQETS RPESVTESVK DGKSPVASKE ASRPASVAEN
3360 3370 3380 3390 3400
AKDSADESKE QRPESLPQSK AGSIKDEKSP LASKDEAEKS KEESRRESVA
3410 3420 3430 3440 3450
EQFPLVSKEV SRPASVAESV KDEAEKSKEE SPLMSKEASR PASVAGSVKD
3460 3470 3480 3490 3500
EAEKSKEESR RESVAEKSPL PSKEASRPAS VAESVKDEAD KSKEESRRES
3510 3520 3530 3540 3550
GAEKSPLASK EASRPASVAE SIKDEAEKSK EESRRESVAE KSPLPSKEAS
3560 3570 3580 3590 3600
RPTSVAESVK DEAEKSKEES RRDSVAEKSP LASKEASRPA SVAESVQDEA
3610 3620 3630 3640 3650
EKSKEESRRE SVAEKSPLAS KEASRPASVA ESIKDEAEKS KEESRRESVA
3660 3670 3680 3690 3700
EKSPLASKEA SRPTSVAESV KDEAEKSKEE SSRDSVAEKS PLASKEASRP
3710 3720 3730 3740 3750
ASVAESVQDE AEKSKEESRR ESVAEKSPLA SKEASRPASV AESVKDDAEK
3760 3770 3780 3790 3800
SKEESRRESV AEKSPLASKE ASRPASVAES VKDEAEKSKE ESRRESVAEK
3810 3820 3830 3840 3850
SPLPSKEASR PTSVAESVKD EAEKSKEESR RESVAEKSSL ASKKASRPAS
3860 3870 3880 3890 3900
VAESVKDEAE KSKEESRRES VAEKSPLASK EASRPASVAE SVKDEAEKSK
3910 3920 3930 3940 3950
EESRRESVAE KSPLPSKEAS RPTSVAESVK DEADKSKEES RRESGAEKSP
3960 3970 3980 3990 4000
LASMEASRPT SVAESVKDET EKSKEESRRE SVTEKSPLPS KEASRPTSVA
4010 4020 4030 4040 4050
ESVKDEAEKS KEESRRESVA EKSPLASKES SRPASVAESI KDEAEGTKQE
4060 4070 4080 4090 4100
SRRESMPESG KAESIKGDQS SLASKETSRP DSVVESVKDE TEKPEGSAID
4110 4120 4130 4140 4150
KSQVASRPES VAVSAKDEKS PLHSRPESVA DKSPDASKEA SRSLSVAETA
4160 4170 4180 4190 4200
SSPIEEGPRS IADLSLPLNL TGEAKGKLPT LSSPIDVAEG DFLEVKAESS
4210 4220 4230 4240 4250
PRPAVLSKPA EFSQPDTGHT ASTPVDEASP VLEEIEVVEQ HTTSGVGATG
4260 4270 4280 4290 4300
ATAETDLLDL TETKSETVTK QSETTLFETL TSKVESKVEV LESSVKQVEE
4310 4320 4330 4340 4350
KVQTSVKQAE TTVTDSLEQL TKKSSEQLTE IKSVLDTNFE EVAKIVADVA
4360 4370 4380 4390 4400
KVLKSDKDIT DIIPDFDERQ LEEKLKSTAD TEEESDKSTR DEKSLEISVK
4410 4420 4430 4440 4450
VEIESEKSSP DQKSGPISIE EKDKIEQSEK AQLRQGILTS SRPESVASQP
4460 4470 4480 4490 4500
ESVPSPSQSA ASHEHKEVEL SESHKAEKSS RPESVASQVS EKDMKTSRPA
4510 4520 4530 4540 4550
SSTSQFSTKE GDEETTESLL HSLTTTETVE TKQMEEKSSF ESVSTSVTKS
4560 4570 4580 4590 4600
TVLSSQSTVQ LREESTSESL SSSLKVEDSS RRESLSSLLA EKGGIATNTS
4610 4620 4630 4640 4650
LKEDTSASAS QLEELLVQSE ECSSESIVSE IQTSIAQKSN KEIKDARETK
4660 4670 4680 4690 4700
VTSQFTTTTS SATKDDSLKE TVAEFLATEK IVSAKEAFST EATKSADDCL
4710 4720 4730 4740 4750
KKTTASAVSS TSASQRALFV GTDESRRESL LSQASESRLT HSDPEDEEPA
4760 4770 4780 4790 4800
DDVDERSSVK ESRSKSIATI MMTSIYKPSE DMEPISKLVE EEHEHVEELA
4810 4820 4830 4840 4850
QEVTSTSKTT TLLQSSEQSS TTTSSTSKTG ASRVESITLT QMDQQTSQSQ
4860 4870 4880 4890 4900
GDPADRKTPP TAPVSPGVKA MSSTGSAGSV IGAGAGAVAA GGKCESSAAS
4910 4920 4930 4940 4950
IVSSSGPMSP KDISGKSSPG ALTSESQSIP TPLGRESHTD TPESSPKPTS
4960 4970 4980 4990 5000
PFPRVSKDEL KSLEMQHHSQ EQMLAGAAAA AGAECEGDIP ELHELRGLEC
5010 5020 5030 5040 5050
TTALSGSTDK IITTTITTVT KVISADGKEI VTEQKTVTTT DSSEPDSEKV
5060 5070 5080 5090 5100
VVTTTRTTSE SERDQLLPKE VALLRGLYRA STPGSEDDED LLLGSPRSAT
5110 5120 5130 5140 5150
SYELQHSSSG VSKRSDLDAD GDESQDDIPP QYGSEEHSTA RSILLPRTAD
5160 5170 5180 5190 5200
PMATSFYGAL PDSFDVVMKP STEPIPIQGA PSGDSQSSES VESSSQTWAG
5210 5220 5230 5240 5250
HKFLDQADKD FQRALEEHVQ ARGAEVMSSV TAKYSYSPSK AEEMEQIVSG
5260 5270 5280 5290 5300
TAERQRFPLS DVQRARVAES GFATVGSVAS QQQQQEKGGE VEQAVPTTTA
5310 5320 5330 5340 5350
VTASTTATAS STGALPKDRL EEWGKPLGLP SPAPLPVEGG ADIRTTPKKE
5360 5370 5380 5390 5400
RRLVATKTRL NNEKNLRRRS ESPNKAGKKP APVYVDLTYV PHNGNSYYAH
5410 5420 5430 5440 5450
VDFFKRVRAR YYVFSGTEPS RQVYDALLEA KQTWEDKELE VTIIPTYDTD
5460 5470 5480 5490
VLGYWVAENE ELLAKHRIDL SPSASRCTIN LQDHETSCSA YRLEF
Length:5,495
Mass (Da):592,078
Last modified:May 5, 2009 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4CBCB11D44981FB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9NGG5M9NGG5_DROME
Futsch, isoform F
futsch 22C10, 22c10, 22C20, CG14772, CG3064
5,495Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA20006 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti647 – 648Missing in CAA20006 (PubMed:10731137).Curated2
Sequence conflicti732A → T in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti799T → A in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti1322G → N in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti2312T → S in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti2887C → S in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti3080M → V in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti3557E → K in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti3571R → S in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti3620S → Y in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti3844K → E in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti3902E → V in CAA20006 (PubMed:10731137).Curated1
Sequence conflicti4439T → A in CAA20006 (PubMed:10731137).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ABW09325.1
AL031128 Genomic DNA Translation: CAA20006.1 Sequence problems.
EU523737 mRNA Translation: ACD38216.1

Protein sequence database of the Protein Information Resource

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PIRi
T13564

NCBI Reference Sequences

More...
RefSeqi
NP_001096864.1, NM_001103394.3
NP_001162632.2, NM_001169161.3
NP_001245461.1, NM_001258532.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0112628; FBpp0111540; FBgn0259108
FBtr0307597; FBpp0300235; FBgn0259108
FBtr0307598; FBpp0300236; FBgn0259108

Database of genes from NCBI RefSeq genomes

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GeneIDi
5740544

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG34387

UCSC genome browser

More...
UCSCi
CG34387-RC d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: ABW09325.1
AL031128 Genomic DNA Translation: CAA20006.1 Sequence problems.
EU523737 mRNA Translation: ACD38216.1
PIRiT13564
RefSeqiNP_001096864.1, NM_001103394.3
NP_001162632.2, NM_001169161.3
NP_001245461.1, NM_001258532.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi625175, 19 interactors
IntActiQ9W596, 10 interactors
STRINGi7227.FBpp0300236

PTM databases

iPTMnetiQ9W596

Proteomic databases

PaxDbiQ9W596
PRIDEiQ9W596

Genome annotation databases

EnsemblMetazoaiFBtr0112628; FBpp0111540; FBgn0259108
FBtr0307597; FBpp0300235; FBgn0259108
FBtr0307598; FBpp0300236; FBgn0259108
GeneIDi5740544
KEGGidme:Dmel_CG34387
UCSCiCG34387-RC d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5740544
FlyBaseiFBgn0259108 futsch

Phylogenomic databases

eggNOGiKOG3592 Eukaryota
ENOG410XRYM LUCA
InParanoidiQ9W596
OMAiPCAPEDF
OrthoDBi22057at2759
PhylomeDBiQ9W596

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
futsch fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5740544

Protein Ontology

More...
PROi
PR:Q9W596

Gene expression databases

BgeeiFBgn0259108 Expressed in 11 organ(s), highest expression level in second segment of antenna (Drosophila)
ExpressionAtlasiQ9W596 differential
GenevisibleiQ9W596 DM

Family and domain databases

InterProiView protein in InterPro
IPR026074 MAP1
IPR009603 MAP_Futsch
PANTHERiPTHR13843 PTHR13843, 10 hits
PfamiView protein in Pfam
PF06740 DUF1213, 51 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFUTSC_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W596
Secondary accession number(s): A8JTS2, B2YGG3, O76891
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 5, 2009
Last modified: December 11, 2019
This is version 146 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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