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Entry version 137 (07 Apr 2021)
Sequence version 2 (01 Dec 2000)
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Protein

Centromere/kinetochore protein zw10

Gene

Zw10

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis (PubMed:15886105, PubMed:17576797). Required for the assembly of the dynein-dynactin, Mad2 complexes and spindly/CG15415 onto kinetochores (PubMed:15886105, PubMed:17576797). During cytokinesis in male meiotic cells it is required for completion of cleavage furrow ingression, possibly in conjunction with Rint1 (PubMed:22685323). Required for maintenance of Golgi stack number and morphology, and acroblast assembly (PubMed:22685323). Its function related to the spindle assembly machinery is proposed to depend on its association in the RZZ complex (PubMed:22685323). Failure to assemble the complex due to the absence of any one of its components, results in the incorrect redistribution of the remaining components to diverse membrane compartments (PubMed:22685323).3 Publications

Caution

It is uncertain whether Met-1, Met-44, Met-81 or Met-100 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Meiosis, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Centromere/kinetochore protein zw10
Alternative name(s):
Mitotic 15 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zw10
Synonyms:mit(1)15
ORF Names:CG9900
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0004643, Zw10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Centromere, Chromosome, Cytoplasm, Cytoskeleton, Golgi apparatus, Kinetochore, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

In the spermatocytes the number of Golgi structures are reduced and they appear smaller or have collapsed Golgi stacks. In third instar larvae spermatocytes, cytokinesis is abnormal producing multinucleated spermatids with a single large Nebenkern. Acroblasts do not form and instead appear as an aggregate of multiple unfused vesicles. During anaphase and early-telophase the central spindle appears regular and acto-myosin contractile rings form normally but during mid-telophase the rings fail to constrict. By late-telophase the rings become fragmented, and the central spindle appears less dense, is irregularly shaped and eventually disassembles. Spermatocytes are unable to complete furrow ingression due to reduced plasma membrane formation during cytokinesis.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001849601 – 721Centromere/kinetochore protein zw10Add BLAST721

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W4X9

PRoteomics IDEntifications database

More...
PRIDEi
Q9W4X9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highest levels are found in embryo and adult. Levels decrease during the first and second larval instar and then decrease in third instar larvae and early pupae.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0004643, Expressed in female gonad and 32 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9W4X9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W4X9, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RZZ complex composed of rod, Zw10 and Zwilch.

1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
71022, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q9W4X9, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070425

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W4X9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZW10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2163, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012948_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W4X9

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W4X9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009361, RZZ-complex_Zw10

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06248, Zw10, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W4X9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEEAPRFNV LEEAFNGNGN GCANVEATQS AILKVLTRVN RFQMRVRKHI
60 70 80 90 100
EDNYTEFLPN NTSPDIFLEE SGSLNREIHD MLENLGSEGL DALDEANVKM
110 120 130 140 150
AGNGRQLREI LLGLGVSEHV LRIDELFQCV EEAKATKDYL VLLDLVGRLR
160 170 180 190 200
AFIYGDDSVD GDAQVATPEV RRIFKALECY ETIKVKYHVQ AYMLQQSLQE
210 220 230 240 250
RFDRLVQLQC KSFPTSRCVT LQVSRDQTQL QDIVQALFQE PYNPARLCEF
260 270 280 290 300
LLDNCIEPVI MRPVMADYSE EADGGTYVRL SLSYATKEPS SAHVRPNYKQ
310 320 330 340 350
VLENLRLLLH TLAGINCSVS RDQHVFGIIG DHVKDKMLKL LVDECLIPAV
360 370 380 390 400
PESTEEYQTS TLCEDVAQLE QLLVDSFIIN PEQDRALGQF VEKYETYYRN
410 420 430 440 450
RMYRRVLETA REIIQRDLQD MVLVAPNNHS AEVANDPFLF PRCMISKSAQ
460 470 480 490 500
DFVKLMDRIL RQPTDKLGDQ EADPIAGVIS IMLHTYINEV PKVHRKLLES
510 520 530 540 550
IPQQAVLFHN NCMFFTHWVA QHANKGIESL AALAKTLQAT GQQHFRVQVD
560 570 580 590 600
YQSSILMGIM QEFEFESTHT LGSGPLKLVR QCLRQLELLK NVWANVLPET
610 620 630 640 650
VYNATFCELI NTFVAELIRR VFTLRDISAQ MACELSDLID VVLQRAPTLF
660 670 680 690 700
REPNEVVQVL SWLKLQQLKA MLNASLMEIT ELWGDGVGPL TASYKSDEIK
710 720
HLIRALFQDT DWRAKAITQI V
Length:721
Mass (Da):82,263
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1341BC2BF752188D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti58L → M in CAB76122 (PubMed:1339459).Curated1
Sequence conflicti203D → A in CAB76122 (PubMed:1339459).Curated1
Sequence conflicti248C → A in CAB72295 (PubMed:10731137).Curated1
Sequence conflicti293 – 294HV → QL in AAF45794 (PubMed:10731132).Curated2
Sequence conflicti366V → A in CAB76122 (PubMed:1339459).Curated1
Sequence conflicti626D → H in CAB72295 (PubMed:10731137).Curated1
Sequence conflicti626D → H in CAB65854 (PubMed:10731137).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X64390 mRNA Translation: CAB76122.1
AE014298 Genomic DNA Translation: AAF45794.1
AL138972, AL121804 Genomic DNA Translation: CAB72295.1
AL121804 Genomic DNA Translation: CAB65854.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A43275

NCBI Reference Sequences

More...
RefSeqi
NP_524901.2, NM_080162.4

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
47874

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9900

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X64390 mRNA Translation: CAB76122.1
AE014298 Genomic DNA Translation: AAF45794.1
AL138972, AL121804 Genomic DNA Translation: CAB72295.1
AL121804 Genomic DNA Translation: CAB65854.1
PIRiA43275
RefSeqiNP_524901.2, NM_080162.4

3D structure databases

SMRiQ9W4X9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi71022, 19 interactors
IntActiQ9W4X9, 1 interactor
STRINGi7227.FBpp0070425

Proteomic databases

PaxDbiQ9W4X9
PRIDEiQ9W4X9

Genome annotation databases

GeneIDi47874
KEGGidme:Dmel_CG9900

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9183
FlyBaseiFBgn0004643, Zw10

Phylogenomic databases

eggNOGiKOG2163, Eukaryota
HOGENOMiCLU_012948_0_0_1
InParanoidiQ9W4X9
PhylomeDBiQ9W4X9

Enzyme and pathway databases

ReactomeiR-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
47874, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
47874

Protein Ontology

More...
PROi
PR:Q9W4X9

Gene expression databases

BgeeiFBgn0004643, Expressed in female gonad and 32 other tissues
ExpressionAtlasiQ9W4X9, baseline and differential
GenevisibleiQ9W4X9, DM

Family and domain databases

InterProiView protein in InterPro
IPR009361, RZZ-complex_Zw10
PfamiView protein in Pfam
PF06248, Zw10, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZW10_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W4X9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: April 7, 2021
This is version 137 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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