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Entry version 138 (23 Feb 2022)
Sequence version 1 (01 May 2000)
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Protein

tRNA (cytosine(34)-C(5))-methyltransferase

Gene

Nsun2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA methyltransferase that methylates tRNAs. Methylates cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Required for short-term memory.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei216S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei243S-adenosyl-L-methioninePROSITE-ProRule annotation1
Binding sitei270S-adenosyl-L-methioninePROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei323NucleophilePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, RNA-binding, Transferase, tRNA-binding
Biological processtRNA processing
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.203, 1994

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
tRNA (cytosine(34)-C(5))-methyltransferase (EC:2.1.1.2031 Publication)
Alternative name(s):
NOP2/Sun domain family member 2 ortholog1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nsun21 PublicationImported
ORF Names:CG6133Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0026079, Nsun2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0026079

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002892281 – 746tRNA (cytosine(34)-C(5))-methyltransferaseAdd BLAST746

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W4M9

PRoteomics IDEntifications database

More...
PRIDEi
Q9W4M9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed during embryonic development. Some enrichment is observed in the proventriculus area of the foregut and in the hindgut.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed maternally and zygotically. Expressed during embryonic development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0026079, Expressed in embryo and 36 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W4M9, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
69457, 22 interactors

Protein interaction database and analysis system

More...
IntActi
Q9W4M9, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070637

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W4M9

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30
Regioni184 – 190S-adenosyl-L-methionine bindingPROSITE-ProRule annotation7
Regioni454 – 475DisorderedSequence analysisAdd BLAST22
Regioni701 – 746DisorderedSequence analysisAdd BLAST46

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi12 – 30Basic and acidic residuesSequence analysisAdd BLAST19
Compositional biasi711 – 746Polar residuesSequence analysisAdd BLAST36

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. TRM4 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2198, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153665

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005316_4_3_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W4M9

Identification of Orthologs from Complete Genome Data

More...
OMAi
QLFTEYV

Database of Orthologous Groups

More...
OrthoDBi
911098at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W4M9

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018314, Fmu/NOL1/Nop2p_CS
IPR001678, MeTrfase_RsmB/NOP2
IPR023267, RCMT
IPR023270, RCMT_NCL1
IPR029063, SAM-dependent_MTases

The PANTHER Classification System

More...
PANTHERi
PTHR22808, PTHR22808, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01189, Methyltr_RsmB-F, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02008, RCMTFAMILY
PR02011, RCMTNCL1

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01153, NOL1_NOP2_SUN, 1 hit
PS51686, SAM_MT_RSMB_NOP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W4M9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGRNQKQNFF AARKRQKREN GPKRTDRQAQ PYEEIKRDNA FFIKYYQLQK
60 70 80 90 100
ICATDEEWTQ FLASIRDNLP TTFRVTGFKD EAKALLSIIE TQLFTEYVRA
110 120 130 140 150
VAELHQKAPE DVERPLCLPW YPNGLAYQLH LTRKDIRRSE PLYRLHNFLI
160 170 180 190 200
VETTAGGISR QEAVSMIPPI VLDVRPTDKV LDMCAAPGSK TAQLIEALHA
210 220 230 240 250
APEEHKIPPG FVLANDVDNN RCYMLVHQAK RLNSPCLLVT NHDSSVFPNL
260 270 280 290 300
VTTKPDGSKA ILKFDKILCD VPCSGDGTLR KNPDIWLKWN LAQAYNLHGI
310 320 330 340 350
QYRIVRRGAE MLEVGGRLVY STCSLNPIEN EAVLQRIIKD ADGALELVDA
360 370 380 390 400
GHLVPGLKYK PGMTDWKLAT KEVDQIFTRF EEVPESLHTI IRPGMFPLPA
410 420 430 440 450
DEMAKIGLEK CLRVLPHLQD SGGFFVAVLE KRRQLSFEKN DVVELVKLNE
460 470 480 490 500
TAKQPAAEPQ VDADGKPIEE KSVPWGPQRK KRRLHGYKED PYVFFGENDP
510 520 530 540 550
DYQAIKEFYQ LDESLSQRCL LTRCVTEKKK NIYYCSEPIR DLVLNNENNI
560 570 580 590 600
KIINTGVKTF VRCENRHTVH PFRLAQEGLQ TSNAFMGASR RIQVEREDLV
610 620 630 640 650
MMLNCTDPTQ PPSTHELKKE TQERCKELGV GSCILKYVDQ RFTLYTVGWR
660 670 680 690 700
GTSSLRAYVQ KDETIHILRL LGADLSKFET NKYEDARVAA AAAADAEVGK
710 720 730 740
SAEAEADSSG DGDATESTFS GSGAIDVTVA AETTGTPMDT EVVATS
Length:746
Mass (Da):84,162
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5178D0D26097C5F0
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA21831 differs from that shown. Reason: Frameshift.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45921.1
AL033125 Genomic DNA Translation: CAA21831.1 Frameshift.
AY061496 mRNA Translation: AAL29044.1

NCBI Reference Sequences

More...
RefSeqi
NP_652007.1, NM_143750.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070669; FBpp0070637; FBgn0026079

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
45064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG6133

UCSC genome browser

More...
UCSCi
CG6133-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45921.1
AL033125 Genomic DNA Translation: CAA21831.1 Frameshift.
AY061496 mRNA Translation: AAL29044.1
RefSeqiNP_652007.1, NM_143750.3

3D structure databases

SMRiQ9W4M9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi69457, 22 interactors
IntActiQ9W4M9, 2 interactors
STRINGi7227.FBpp0070637

Proteomic databases

PaxDbiQ9W4M9
PRIDEiQ9W4M9

Genome annotation databases

EnsemblMetazoaiFBtr0070669; FBpp0070637; FBgn0026079
GeneIDi45064
KEGGidme:Dmel_CG6133
UCSCiCG6133-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54888
FlyBaseiFBgn0026079, Nsun2
VEuPathDBiVectorBase:FBgn0026079

Phylogenomic databases

eggNOGiKOG2198, Eukaryota
GeneTreeiENSGT00940000153665
HOGENOMiCLU_005316_4_3_1
InParanoidiQ9W4M9
OMAiQLFTEYV
OrthoDBi911098at2759
PhylomeDBiQ9W4M9

Enzyme and pathway databases

BRENDAi2.1.1.203, 1994

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
45064, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
45064

Protein Ontology

More...
PROi
PR:Q9W4M9

Gene expression databases

BgeeiFBgn0026079, Expressed in embryo and 36 other tissues
GenevisibleiQ9W4M9, DM

Family and domain databases

InterProiView protein in InterPro
IPR018314, Fmu/NOL1/Nop2p_CS
IPR001678, MeTrfase_RsmB/NOP2
IPR023267, RCMT
IPR023270, RCMT_NCL1
IPR029063, SAM-dependent_MTases
PANTHERiPTHR22808, PTHR22808, 1 hit
PfamiView protein in Pfam
PF01189, Methyltr_RsmB-F, 1 hit
PRINTSiPR02008, RCMTFAMILY
PR02011, RCMTNCL1
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS01153, NOL1_NOP2_SUN, 1 hit
PS51686, SAM_MT_RSMB_NOP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNSUN2_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W4M9
Secondary accession number(s): O97427
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 1, 2000
Last modified: February 23, 2022
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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