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Entry version 167 (17 Jun 2020)
Sequence version 1 (01 May 2000)
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Protein

AP-3 complex subunit beta

Gene

rb

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportUniRule annotationSAAS annotation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-432722 Golgi Associated Vesicle Biogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-3 complex subunit betaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rbImported
Synonyms:AP-3betaImported, apl6Imported, beta3Imported, cg11427Imported, Dmel\CG11427Imported, RbImported
ORF Names:CG11427Imported, Dmel_CG11427Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0003210 rb

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

MembraneUniRule annotationSAAS annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0003210 Expressed in embryonic/larval hemocyte (Drosophila) and 29 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9W4K1 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W4K1, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0290745

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini868 – 1019AP3B1_CInterPro annotationAdd BLAST152

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni263 – 325DisorderedSequence analysisAdd BLAST63
Regioni693 – 867DisorderedSequence analysisAdd BLAST175

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi280 – 305PolyampholyteSequence analysisAdd BLAST26
Compositional biasi306 – 325PolarSequence analysisAdd BLAST20
Compositional biasi700 – 730PolyampholyteSequence analysisAdd BLAST31
Compositional biasi731 – 755PolarSequence analysisAdd BLAST25
Compositional biasi789 – 833PolarSequence analysisAdd BLAST45
Compositional biasi834 – 866PolyampholyteSequence analysisAdd BLAST33

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the adaptor complexes large subunit family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1060 Eukaryota
COG5096 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169094

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006320_3_1_1

KEGG Orthology (KO)

More...
KOi
K12397

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYRLDPN

Database of Orthologous Groups

More...
OrthoDBi
323029at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026740 AP3_beta
IPR029390 AP3B_C
IPR026739 AP_beta
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N

The PANTHER Classification System

More...
PANTHERi
PTHR11134 PTHR11134, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01602 Adaptin_N, 1 hit
PF14796 AP3B1_C, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037096 AP3_complex_beta, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01355 AP3B1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W4K1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQQNSASNPF AMSTYVERPQ MGLDVEFGAD PASGAAFFQS DGRKHDDLKQ
60 70 80 90 100
MLDSNKDGLK LEAMKRIIGM IARGRDASDL FPAVVKNVVS KNIEVKKLVY
110 120 130 140 150
VYLVRYAEEQ QDLALLSIST FQRALKDPNQ LIRASALRVL SSIRVSMIVP
160 170 180 190 200
IVMLAIRDSA ADLSPYVRKT AAHAIPKLYS LDADQKDELV MVIEKLLSDR
210 220 230 240 250
TTLVVGSAVM AFDEVCPERV DLIHKNYRKL CNFLLDVDEW GQVIIINMLT
260 270 280 290 300
RYARTQFVDP NADDEDLVND GLGETPVSER FYDESSHSSS HSDDGSSDDE
310 320 330 340 350
KNKSSTNNKN NGGGNGSRTP SSPSNSYHID VDHRLLLRQT KPLLQSRNAS
360 370 380 390 400
VVMAVAQLYH HVAPKNEVQL IAKALIRLLR SHKEVQSVVL NCIASMSTKR
410 420 430 440 450
KAIFEPHLKS FFVRTSDPTH IKLLKLDILT NLASAGSISL ILREFQTYIS
460 470 480 490 500
SSDRSFVAAT IQAIGRCASS IKEVTETCLS GLVHLLSNHD EHVVAESVVV
510 520 530 540 550
IKRLLQTKAA EHFEIITQMA KLIDYINVPA ARAAIIWLIG EYNEKVPLIA
560 570 580 590 600
PDVLRKMAKS FVDEQDVVKL QVLNLGVKLY LTNPEQTSLL CQYVFTLARY
610 620 630 640 650
DPNYDVRDRA RFLRQIIFPA SGTSSVLSQH ARQVFLASKP APVPESKYRD
660 670 680 690 700
GNNFQLGSLS HYLNMPAAGY KELPAFPVIP PDSSVRNIAG FMQDKLPGED
710 720 730 740 750
SPSGHSKDKS GREGGKEKGA GGEKGFLSES DDKSSAYSES GSSSGSGTSD
760 770 780 790 800
SESDSDGSGS SDEEEEEVQK QQPTKVSSVK ERLIDAGSNE LAATSSPVKA
810 820 830 840 850
TINNNNNARG SSGTSDSEDS SAYSGSSSDD SASGSDNEVK KNETKTDTGT
860 870 880 890 900
KPEKLKEKHE KQPEQTAVKS NLDLLLDLDD IPPIGPVMTP SLGGFLTPGT
910 920 930 940 950
PMMAGQAAPL QPQHARNRVE LVGPSHIEFK HKELLNKVSG HGLHLAYRFT
960 970 980 990 1000
RSPHLYSSSM CSIELQFQNR GEKEITAIRL GQTTLPAGMQ LNEFAPITVL
1010 1020 1030 1040 1050
QPQQTASGVL GVDFNDSTHA VDLELLSSAG SSRLQLKPPV GELVRSVQIG
1060 1070 1080 1090 1100
ESCHREERAK LRGMNEHQCE LRGLRQDLID VVALRQKVFE SINVAHTHSS
1110 1120 1130 1140 1150
SSGQLHCFAG QTLSSKSLVL LTLDWKTEDA LTLLVNCEKM VIGSMVLNEL
1160
RNALQLSFAM
Length:1,160
Mass (Da):127,137
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i660CD0CB74E2F0E4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45950.1
AE014298 Genomic DNA Translation: ACZ95201.2
AE014298 Genomic DNA Translation: AGB95085.1

NCBI Reference Sequences

More...
RefSeqi
NP_001162664.2, NM_001169193.2
NP_001259239.1, NM_001272310.1
NP_525071.2, NM_080332.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070702; FBpp0070670; FBgn0003210
FBtr0332290; FBpp0304569; FBgn0003210
FBtr0343568; FBpp0310168; FBgn0003210

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31381

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG11427

UCSC genome browser

More...
UCSCi
CG11427-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF45950.1
AE014298 Genomic DNA Translation: ACZ95201.2
AE014298 Genomic DNA Translation: AGB95085.1
RefSeqiNP_001162664.2, NM_001169193.2
NP_001259239.1, NM_001272310.1
NP_525071.2, NM_080332.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9W4K1, 2 interactors
STRINGi7227.FBpp0290745

Genome annotation databases

EnsemblMetazoaiFBtr0070702; FBpp0070670; FBgn0003210
FBtr0332290; FBpp0304569; FBgn0003210
FBtr0343568; FBpp0310168; FBgn0003210
GeneIDi31381
KEGGidme:Dmel_CG11427
UCSCiCG11427-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31381
FlyBaseiFBgn0003210 rb

Phylogenomic databases

eggNOGiKOG1060 Eukaryota
COG5096 LUCA
GeneTreeiENSGT00940000169094
HOGENOMiCLU_006320_3_1_1
KOiK12397
OMAiCYRLDPN
OrthoDBi323029at2759

Enzyme and pathway databases

ReactomeiR-DME-432722 Golgi Associated Vesicle Biogenesis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31381 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
rb fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31381

Gene expression databases

BgeeiFBgn0003210 Expressed in embryonic/larval hemocyte (Drosophila) and 29 other tissues
ExpressionAtlasiQ9W4K1 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR026740 AP3_beta
IPR029390 AP3B_C
IPR026739 AP_beta
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR002553 Clathrin/coatomer_adapt-like_N
PANTHERiPTHR11134 PTHR11134, 2 hits
PfamiView protein in Pfam
PF01602 Adaptin_N, 1 hit
PF14796 AP3B1_C, 1 hit
PIRSFiPIRSF037096 AP3_complex_beta, 1 hit
SMARTiView protein in SMART
SM01355 AP3B1_C, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W4K1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W4K1
Secondary accession number(s): E1JJE0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 17, 2020
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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