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Entry version 139 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein

RNA-binding protein 4F

Gene

Rnp4F

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in gene regulation during development. Binds RNA.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • mRNA binding Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, RNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-binding protein 4F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rnp4FImported
Synonyms:4f-rnpImported
ORF Names:CG3312
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0014024, Rnp4F

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000818111 – 941RNA-binding protein 4FAdd BLAST941

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei43Phosphoserine1 Publication1
Modified residuei153Phosphoserine1 Publication1
Modified residuei713Phosphoserine1 Publication1
Modified residuei717Phosphotyrosine1 Publication1
Modified residuei718Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W4D2

PeptideAtlas

More...
PeptideAtlasi
Q9W4D2

PRoteomics IDEntifications database

More...
PRIDEi
Q9W4D2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9W4D2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed moderately during embryonic stages (0-18 hours) but then declines in late stage embryos (15-21 hours).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0014024, Expressed in female gonad and 64 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9W4D2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W4D2, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
57958, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q9W4D2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0089396

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini724 – 801RRMPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi637 – 680Gln-richAdd BLAST44

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0128, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00900000141107

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_361804_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W4D2

Identification of Orthologs from Complete Genome Data

More...
OMAi
LWAQVEY

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W4D2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.10, 1 hit
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003107, HAT
IPR008669, LSM_interact
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR011990, TPR-like_helical_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05391, Lsm_interact, 1 hit
PF00076, RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00386, HAT, 3 hits
SM00360, RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48452, SSF48452, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102, RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform A1 Publication (identifier: Q9W4D2-1) [UniParc]FASTAAdd to basket
Also known as: H6.1, E33.2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDADKQLERQ LEKELDEMPA EDLDDDAYDE YDLIVIPDQG KGSPQQGHSE
60 70 80 90 100
SPQQEEEHKS EELRQRSRPT WPPSSAGGDM TTIELISSDD EPSVEETEGG
110 120 130 140 150
NAAGRGRARN DSSSSSDDVG VIEGSELESN SEVSSDSDSD SDNAGGGNQL
160 170 180 190 200
ERSYQELNAL PSKKFAQMVS LIGIAFKLND LEKIESSVLE LQNLATVPAH
210 220 230 240 250
VWLKYLKARL VVTQTDEERK AFEEQCAKAL GYYYSIPLSE YVVNYLVDQG
260 270 280 290 300
NVQNHVLWAK LLADYDVERP DFGDKLRSLI STITDENEAA AFVEMLQKHC
310 320 330 340 350
VTWTCNVEQR QMIKSVVDKF KQHLDETTRG WDWSEQHKAH VYDVETLSLD
360 370 380 390 400
DDLKNAVIRF IFERSVAKFP IVDVLWLSYI EFIQFEGVTV PENEDENEVT
410 420 430 440 450
AEMVAKRAKR LGKGFLRNTE LDLANRGVRS HPSVQLNHRF LDLMERSDFE
460 470 480 490 500
LAEVDEEIRL ILQRIVTDMD MTVELHLDYL AYRIRNTNAS DEQQVASLRA
510 520 530 540 550
AFNHAWEELT VLYGDQADTR YEVLQLWAQV EYTQLGSPDN GREIWRQIMG
560 570 580 590 600
YPGSSIRGLL WLNFAQMESE YNGGHGTRDV LRKALSQPVL ENGLMVQEFF
610 620 630 640 650
RRYERCYGTY ESIAACQALD LPVEYVKPRS RIKPNSQSAY PRQQKLKPRQ
660 670 680 690 700
QQQQTNREPL NREQRRRQAH EQQQQQQQQQ KHGIKKSRTE PSGGATSPPS
710 720 730 740 750
KVKGPANAEA KESNFKYSPN MEINKIFVRN LHPACSKEEL HELFSPFGTI
760 770 780 790 800
KDVRLVHKLN KQFKGIAYVE FEKPGEAQRA VAGRDGCLFK GMNISVAISN
810 820 830 840 850
PPPRGTSAVK PSVAPKRRVP TSLIPTTLVR QEVAAKKLRL LLPEPGDISS
860 870 880 890 900
TSASVDVAIK REANGEEQKG DVQERDEQKG EEQKGEEQKG EEPKGEEQKG
910 920 930 940
DDQIGEEQSG VEQKGDEKKE EEMPAAVPKS NDDFRKLFLK D
Note: Intron retention event in non-edited RNA.
Length:941
Mass (Da):106,740
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEAF2775B499FECFD
GO
Isoform B1 Publication (identifier: Q9W4D2-2) [UniParc]FASTAAdd to basket
Also known as: Pupal

The sequence of this isoform differs from the canonical sequence as follows:
     625-639: YVKPRSRIKPNSQSA → SLSRASSSNKRIVSH
     640-941: Missing.

Note: Intron excised in non-edited RNA.Curated
Show »
Length:639
Mass (Da):72,728
Checksum:iBDC4D863B7BCEBCA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A8JUY0A8JUY0_DROME
RNA-binding protein 4F, isoform D
Rnp4F 4F-rnp, 4f-rnp, Dmel\CG3312, RNP-4F, Rnp-4F
941Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti104G → D in CAA75533 (PubMed:9434193).Curated1
Sequence conflicti104G → D in CAA75535 (PubMed:9434193).Curated1
Sequence conflicti104G → D in Y15250 (PubMed:9434193).Curated1
Sequence conflicti499R → G in CAA75533 (PubMed:9434193).Curated1
Sequence conflicti499R → G in CAA75535 (PubMed:9434193).Curated1
Sequence conflicti499R → G in Y15250 (PubMed:9434193).Curated1
Sequence conflicti672Q → QQQ in CAA75533 (PubMed:9434193).Curated1
Sequence conflicti672Q → QQQ in CAA75535 (PubMed:9434193).Curated1
Sequence conflicti672Q → QQQ in Y15250 (PubMed:9434193).Curated1

<p>This subsection of the 'Sequence' section provides information relevant to all types of RNA editing events (conversion, insertion, deletion of nucleotides) that lead to one or more amino acid changes compared to the translation of the non-edited RNA version.<p><a href='/help/rna_editing' target='_top'>More...</a></p>RNA editingi

Edited at positions 9, 13, 17, 21, 31, 41, 46, 50, 54, 57, 59, 70, 80, 84, 86, 91, 96, 101, 107, 113, 116, 130, 132, 135, 138, 139, 141, 163, 164, 183, 190, 193, 196, 200, 205, 207, 213, 218, 220, 225, 265, 275, 298, 299, 302, 311, 314, 319, 321, 322, 328, 354, 355, 368, 381, 383, 389, 393, 396, 398, 400, 406, 409, 430, 431, 433, 437, 444, 453, 456, 482, 490, 492, 493, 497, 510, 513, 516, 520, 521, 525, 540, 551, 552, 553, 554 and 555.2 Publications
Partially edited. RNA editing takes place in adult and creates an intron retention event that leads to a premature stop codon. The RNA edited version is called H8.3. A discistronic transcript of Sas10 and Rnp4F becomes an RNA duplex, which is a target for RNA-editing via Adar editase.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti9R → G in RNA edited version. 1
Natural varianti13K → R in RNA edited version. 1
Natural varianti17E → G in RNA edited version. 1
Natural varianti21E → G in RNA edited version. 1
Natural varianti31Y → C in RNA edited version. 1
Natural varianti41K → G in RNA edited version. 1
Natural varianti46Q → R in RNA edited version. 1
Natural varianti50E → G in RNA edited version. 1
Natural varianti54Q → R in RNA edited version. 1
Natural varianti57E → G in RNA edited version. 1
Natural varianti59K → R in RNA edited version. 1
Natural varianti70T → A in RNA edited version. 1
Natural varianti80M → V in RNA edited version. 1
Natural varianti84E → G in RNA edited version. 1
Natural varianti86I → V in RNA edited version. 1
Natural varianti91E → G in RNA edited version. 1
Natural varianti96E → G in RNA edited version. 1
Natural varianti101N → G in RNA edited version. 1
Natural varianti107R → G in RNA edited version. 1
Natural varianti113S → G in RNA edited version. 1
Natural varianti116S → G in RNA edited version. 1
Natural varianti130N → S in RNA edited version. 1
Natural varianti132E → G in RNA edited version. 1
Natural varianti135S → G in RNA edited version. 1
Natural varianti138D → G in RNA edited version. 1
Natural varianti139S → G in RNA edited version. 1
Natural varianti141S → G in RNA edited version. 1
Natural varianti163K → R in RNA edited version. 1
Natural varianti164K → G in RNA edited version. 1
Natural varianti183K → G in RNA edited version. 1
Natural varianti190E → G in RNA edited version. 1
Natural varianti193N → G in RNA edited version. 1
Natural varianti196T → A in RNA edited version. 1
Natural varianti200H → R in RNA edited version. 1
Natural varianti205Y → C in RNA edited version. 1
Natural varianti207K → G in RNA edited version. 1
Natural varianti213T → A in RNA edited version. 1
Natural varianti218E → G in RNA edited version. 1
Natural varianti220K → G in RNA edited version. 1
Natural varianti225Q → R in RNA edited version. 1
Natural varianti265Y → C in RNA edited version. 1
Natural varianti275K → R in RNA edited version. 1
Natural varianti298K → G in RNA edited version. 1
Natural varianti299H → R in RNA edited version. 1
Natural varianti302T → A in RNA edited version. 1
Natural varianti311Q → R in RNA edited version. 1
Natural varianti314K → G in RNA edited version. 1
Natural varianti319K → R in RNA edited version. 1
Natural varianti321K → E in RNA edited version. 1
Natural varianti322Q → R in RNA edited version. 1
Natural varianti328T → A in RNA edited version. 1
Natural varianti354K → R in RNA edited version. 1
Natural varianti355N → S in RNA edited version. 1
Natural varianti368K → G in RNA edited version. 1
Natural varianti381E → G in RNA edited version. 1
Natural varianti383I → V in RNA edited version. 1
Natural varianti389T → A in RNA edited version. 1
Natural varianti393N → S in RNA edited version. 1
Natural varianti396E → G in RNA edited version. 1
Natural varianti398E → G in RNA edited version. 1
Natural varianti400T → A in RNA edited version. 1
Natural varianti406K → R in RNA edited version. 1
Natural varianti409K → E in RNA edited version. 1
Natural varianti430S → G in RNA edited version. 1
Natural varianti431H → R in RNA edited version. 1
Natural varianti433S → G in RNA edited version. 1
Natural varianti437N → S in RNA edited version. 1
Natural varianti444M → V in RNA edited version. 1
Natural varianti453E → G in RNA edited version. 1
Natural varianti456E → G in RNA edited version. 1
Natural varianti482Y → C in RNA edited version. 1
Natural varianti490S → G in RNA edited version. 1
Natural varianti492E → G in RNA edited version. 1
Natural varianti493Q → R in RNA edited version. 1
Natural varianti497S → G in RNA edited version. 1
Natural varianti510T → A in RNA edited version. 1
Natural varianti513Y → C in RNA edited version. 1
Natural varianti516Q → R in RNA edited version. 1
Natural varianti520R → G in RNA edited version. 1
Natural varianti521Y → C in RNA edited version. 1
Natural varianti525Q → R in RNA edited version. 1
Natural varianti540N → G in RNA edited version. 1
Natural varianti551Y → E in RNA edited version. 1
Natural varianti552P → R in RNA edited version. 1
Natural varianti553G → F in RNA edited version. 1
Natural varianti554S → E in RNA edited version. 1
Natural varianti555S → I in RNA edited version. 1
Natural varianti556 – 941Missing in RNA edited version. Add BLAST386

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_051659625 – 639YVKPR…NSQSA → SLSRASSSNKRIVSH in isoform B. 2 PublicationsAdd BLAST15
Alternative sequenceiVSP_051660640 – 941Missing in isoform B. 2 PublicationsAdd BLAST302

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y15249 mRNA Translation: CAA75533.1
Y15250 Genomic DNA No translation available.
Y15251 mRNA Translation: CAA75535.1
AE014298 Genomic DNA Translation: AAF46022.1
AE014298 Genomic DNA Translation: AAS65263.1
AY061395 mRNA Translation: AAL28943.1
DQ269487 mRNA Translation: ABB89902.1
DQ269488 mRNA Translation: ABB89903.1
DQ269489 mRNA Translation: ABB89904.1
DQ269490 mRNA Translation: ABB89905.1
DQ269491 mRNA Translation: ABB89906.1
DQ272384 mRNA Translation: ABB82038.1

NCBI Reference Sequences

More...
RefSeqi
NP_001096883.3, NM_001103413.3 [Q9W4D2-1]
NP_001096884.1, NM_001103414.3 [Q9W4D2-1]
NP_511047.2, NM_078492.4 [Q9W4D2-1]
NP_996353.1, NM_206630.3 [Q9W4D2-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070752; FBpp0070720; FBgn0014024 [Q9W4D2-1]
FBtr0070753; FBpp0089396; FBgn0014024 [Q9W4D2-1]
FBtr0112876; FBpp0111789; FBgn0014024 [Q9W4D2-1]
FBtr0340477; FBpp0309418; FBgn0014024 [Q9W4D2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31448

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG3312

Keywords - Coding sequence diversityi

Alternative splicing, RNA editing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y15249 mRNA Translation: CAA75533.1
Y15250 Genomic DNA No translation available.
Y15251 mRNA Translation: CAA75535.1
AE014298 Genomic DNA Translation: AAF46022.1
AE014298 Genomic DNA Translation: AAS65263.1
AY061395 mRNA Translation: AAL28943.1
DQ269487 mRNA Translation: ABB89902.1
DQ269488 mRNA Translation: ABB89903.1
DQ269489 mRNA Translation: ABB89904.1
DQ269490 mRNA Translation: ABB89905.1
DQ269491 mRNA Translation: ABB89906.1
DQ272384 mRNA Translation: ABB82038.1
RefSeqiNP_001096883.3, NM_001103413.3 [Q9W4D2-1]
NP_001096884.1, NM_001103414.3 [Q9W4D2-1]
NP_511047.2, NM_078492.4 [Q9W4D2-1]
NP_996353.1, NM_206630.3 [Q9W4D2-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
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Protein-protein interaction databases

BioGRIDi57958, 3 interactors
IntActiQ9W4D2, 1 interactor
STRINGi7227.FBpp0089396

PTM databases

iPTMnetiQ9W4D2

Proteomic databases

PaxDbiQ9W4D2
PeptideAtlasiQ9W4D2
PRIDEiQ9W4D2

Genome annotation databases

EnsemblMetazoaiFBtr0070752; FBpp0070720; FBgn0014024 [Q9W4D2-1]
FBtr0070753; FBpp0089396; FBgn0014024 [Q9W4D2-1]
FBtr0112876; FBpp0111789; FBgn0014024 [Q9W4D2-1]
FBtr0340477; FBpp0309418; FBgn0014024 [Q9W4D2-1]
GeneIDi31448
KEGGidme:Dmel_CG3312

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
31448
FlyBaseiFBgn0014024, Rnp4F

Phylogenomic databases

eggNOGiKOG0128, Eukaryota
GeneTreeiENSGT00900000141107
HOGENOMiCLU_361804_0_0_1
InParanoidiQ9W4D2
OMAiLWAQVEY
PhylomeDBiQ9W4D2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
31448, 1 hit in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31448

Protein Ontology

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PROi
PR:Q9W4D2

Gene expression databases

BgeeiFBgn0014024, Expressed in female gonad and 64 other tissues
ExpressionAtlasiQ9W4D2, baseline and differential
GenevisibleiQ9W4D2, DM

Family and domain databases

Gene3Di1.25.40.10, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR003107, HAT
IPR008669, LSM_interact
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR035979, RBD_domain_sf
IPR000504, RRM_dom
IPR011990, TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF05391, Lsm_interact, 1 hit
PF00076, RRM_1, 1 hit
SMARTiView protein in SMART
SM00386, HAT, 3 hits
SM00360, RRM, 1 hit
SUPFAMiSSF48452, SSF48452, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102, RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNP4F_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W4D2
Secondary accession number(s): A4V3Z4
, O18351, O18352, Q2VC69, Q2VC70, Q2VC71, Q2VC72, Q2VC73, Q2XP46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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