Sodium-dependent nutrient amino acid transporter 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• amino acid:cation symporter activity Source: FlyBaseInferred from sequence modelⁱ
  • "Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster."
    Thimgan M.S., Berg J.S., Stuart A.E.
    J Exp Biol 209:3383-3404(2006) [PubMed] [Europe PMC] [Abstract]
• amino acid:sodium symporter activity Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.1

    "The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions."
    Miller M.M., Popova L.B., Meleshkevitch E.A., Tran P.V., Boudko D.Y.
    Insect Biochem. Mol. Biol. 38:923-931(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• D-amino acid transmembrane transporter activity Source: FlyBase <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions."
    Miller M.M., Popova L.B., Meleshkevitch E.A., Tran P.V., Boudko D.Y.
    Insect Biochem. Mol. Biol. 38:923-931(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• L-amino acid transmembrane transporter activity Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions."
    Miller M.M., Popova L.B., Meleshkevitch E.A., Tran P.V., Boudko D.Y.
    Insect Biochem. Mol. Biol. 38:923-931(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• neurotransmitter transmembrane transporter activity Source: FlyBase <p>Inferred from Sequence or Structural Similarity<br />Used for any analysis based on sequence alignment, structure comparison, or evaluation of sequence features such as composition.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iss">GO evidence code guide</a></p> Inferred from sequence or structural similarityⁱ
  • "A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes."
    Romero-Calderon R., Shome R.M., Simon A.F., Daniels R.W., DiAntonio A., Krantz D.E.
    Dev Neurobiol 67:550-569(2007) [PubMed] [Europe PMC] [Abstract]
• neutral amino acid transmembrane transporter activity Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions."
    Miller M.M., Popova L.B., Meleshkevitch E.A., Tran P.V., Boudko D.Y.
    Insect Biochem. Mol. Biol. 38:923-931(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

GO - Biological processⁱ

• amino acid transmembrane transport Source: FlyBaseInferred from sequence modelⁱ
  • "Comparative sequence analysis and tissue localization of members of the SLC6 family of transporters in adult Drosophila melanogaster."
    Thimgan M.S., Berg J.S., Stuart A.E.
    J Exp Biol 209:3383-3404(2006) [PubMed] [Europe PMC] [Abstract]
• D-amino acid transport Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions."
    Miller M.M., Popova L.B., Meleshkevitch E.A., Tran P.V., Boudko D.Y.
    Insect Biochem. Mol. Biol. 38:923-931(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• L-amino acid transport Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions."
    Miller M.M., Popova L.B., Meleshkevitch E.A., Tran P.V., Boudko D.Y.
    Insect Biochem. Mol. Biol. 38:923-931(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• neurotransmitter transport Source: FlyBaseInferred from sequence or structural similarityⁱ
  • "A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes."
    Romero-Calderon R., Shome R.M., Simon A.F., Daniels R.W., DiAntonio A., Krantz D.E.
    Dev Neurobiol 67:550-569(2007) [PubMed] [Europe PMC] [Abstract]
• neutral amino acid transport Source: FlyBaseInferred from direct assayⁱ
  • Ref.1

    "The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions."
    Miller M.M., Popova L.B., Meleshkevitch E.A., Tran P.V., Boudko D.Y.
    Insect Biochem. Mol. Biol. 38:923-931(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
• sodium ion transmembrane transport Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sodium ion transport Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.1

    "The invertebrate B(0) system transporter, D. melanogaster NAT1, has unique d-amino acid affinity and mediates gut and brain functions."
    Miller M.M., Popova L.B., Meleshkevitch E.A., Tran P.V., Boudko D.Y.
    Insect Biochem. Mol. Biol. 38:923-931(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MELKGVQPSN GSSNGSGNGA TNAASTEKTD AEKPTAERTN WGNGLEFLMS 
        60         70         80         90        100
CISVSVGLGN VWRFPFTAYE NGGGAFLIPY IIVLFLIGKP MYYLEMIMGQ 
       110        120        130        140        150
FTSQGTVKIW SVVPGFVGVG YGQAFGTICI ISYYSSLLAL TLYYLFVSFQ 
       160        170        180        190        200
SELPWSYCRD EWTNCVNSRP QEYVDNLLTG VSLANESARN LSGIVANDET 
       210        220        230        240        250
EKLQSSSELY FLNVVIKEKL DISDGVGDPD WKLTLALFVA WVVIFLVIMR 
       260        270        280        290        300
GVKSSGKAAY FLALFPYVVL FVLLIRAVTL EGARDGILFF LEPQWGELLN 
       310        320        330        340        350
PTVWKEAVVQ CFFSLAVGSG PIIMFASYNR FDHGIYRDAM IVTTLDTLTS 
       360        370        380        390        400
LLGGITIFAI LGNLAHNLQI ENIRDVVRSG TGLAFISYPD AISKFQAVPQ 
       410        420        430        440        450
LFSVLFFFML FVLGIGSIVA LQSTIVTIIC DQFKGWKYWK VALTTSVCGF 
       460        470        480        490        500
LMGLVYVTPG GQWILTLVDF YGGTYVVFIL AIFELAGIVW VYGLQNFCDD 
       510        520        530        540        550
IEFMCNRRVS LYWRVCWSFF TPVMMIIIFI YSMVTIEPIK YSELYFPEAA 
       560        570        580        590        600
NIAGWLLFAI GAAQFPLWGL WYISRHPQGT YWKSLKASLK PSDRWGPANP 
       610        620        630        640 
EIRREWVIFK NQKAAQRATQ KDTSKLGFFW RKVANFCGSN K          

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Drosophila
   Drosophila: entries, gene names and cross-references to FlyBase
2. SIMILARITY comments
   Index of protein domains and families