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Entry version 169 (02 Jun 2021)
Sequence version 1 (01 May 2000)
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Protein

Ubiquitinyl hydrolase 1

Gene

Usp16-45

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).ARBA annotation EC:3.4.19.12

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri96 – 161UBP-typePROSITE-ProRule annotationAdd BLAST66

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, ProteaseImported
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitinyl hydrolase 1ARBA annotation (EC:3.4.19.12ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Usp16-45Imported
Synonyms:Dmel\CG4165Imported, Q9W4C3Imported, Usp16Imported, USP45Imported, Usp45Imported
ORF Names:CG4165Imported, Dmel_CG4165Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0029763, Usp16-45

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0029763, Expressed in cleaving embryo and 34 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070738

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini96 – 161UBP-typeInterPro annotationAdd BLAST66
Domaini306 – 1125USPInterPro annotationAdd BLAST820

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 44DisorderedSequence analysisAdd BLAST44
Regioni215 – 264DisorderedSequence analysisAdd BLAST50
Regioni513 – 547DisorderedSequence analysisAdd BLAST35
Regioni570 – 762DisorderedSequence analysisAdd BLAST193
Regioni795 – 833DisorderedSequence analysisAdd BLAST39
Regioni1037 – 1089DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 29Basic and acidic residuesSequence analysisAdd BLAST29
Compositional biasi522 – 547Polar residuesSequence analysisAdd BLAST26
Compositional biasi583 – 597Basic residuesSequence analysisAdd BLAST15
Compositional biasi598 – 617Polar residuesSequence analysisAdd BLAST20
Compositional biasi636 – 658Polar residuesSequence analysisAdd BLAST23
Compositional biasi671 – 700Polar residuesSequence analysisAdd BLAST30
Compositional biasi729 – 759Polar residuesSequence analysisAdd BLAST31
Compositional biasi816 – 833Polar residuesSequence analysisAdd BLAST18
Compositional biasi1044 – 1085Polar residuesSequence analysisAdd BLAST42

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri96 – 161UBP-typePROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Zinc-fingerARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1873, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000176220

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007938_0_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GSKSWFY

Database of Orthologous Groups

More...
OrthoDBi
278083at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
IPR013083, Znf_RING/FYVE/PHD
IPR001607, Znf_UBP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00443, UCH, 1 hit
PF02148, zf-UBP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54001, SSF54001, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit
PS50271, ZF_UBP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W4C3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVKKRQADSR DHDCSTDSGN EDLHHRKGLG SPGQSDGATP TTASCQHIKK
60 70 80 90 100
AVDAARLRRL LKSTGLLYEC SQCQKLGKTA GSAAGAGASE GAVGPGGNPV
110 120 130 140 150
TFEFDNTLWL CLKCGSQLCG RARHKHALEH YQTPHSDSHA LAMNTRSFDI
160 170 180 190 200
WCYECDMKIC SNLRKNLLEC VELVKKLAQK PPTSTVTPST PTISYIEEKL
210 220 230 240 250
KAALEHLTPI VPMTGGSFDD SSSRGSLAAA GGGGGVGSSR NRQVAIPMPP
260 270 280 290 300
PEPSSGLSTS DSLTSVPGMA KRIDQYSATT NGNTGNKRLL TLETPRIENE
310 320 330 340 350
RLPRVRGLTN LGNTCFFNAV MQCLAQTPFL LSVLKELSEP GEEFILPGGT
360 370 380 390 400
FTIKDKGDIE LPMIKGTLSS WGGLTAALAN ALEELQAGGS VFTPRKLFDR
410 420 430 440 450
LCVKCPQFTG GDQHDAHELL RQLLESVRNE DLKRYQRVIL QNLGYKDQDV
460 470 480 490 500
NSVSEEMRQK CKIYGNQAGD RILRPEQVFR GFLVSTLTCQ DCHNVSSRHE
510 520 530 540 550
YFLDMSLPVA VEKPQPPQRR KPSPELSLTS SSSSVTPSTG QPTINTKFTD
560 570 580 590 600
GSVNFTASSP SFFLHAHEAA SLGPSKSQVK KEKERQRKAK RAAKKRQKSS
610 620 630 640 650
LNLNGNDSGN GNELAESVDQ DDASLASLGA GDGQANDGLE QTNGQTEDST
660 670 680 690 700
TSSVTTSEHS DADVEDNLVE DTAAPSTNNV PSSTASLTAP SKTYMDSNGN
710 720 730 740 750
AQPPGEKRDD TPEHMDKDSL EEDENDSGIA TSPAPTATNS STSTSATGNN
760 770 780 790 800
NSVAGSGLSG SSGALEDPLA PASLVTAGLS EKGASVIRQV SVGAEQGASN
810 820 830 840 850
GTEDADGEAK AIEQPEKTPS QAQAMAQAQA RTKRVRTQSY SDWSTTIAPR
860 870 880 890 900
YQCEDGECSV QSCLNNFTAV ELMTGQNKVG CDSCTQRING SDPKAKSVNT
910 920 930 940 950
NATKQLLVSS PPAVLILHLK RFQLGPRCIF RKLTRPVSYP NLLDIAAFCG
960 970 980 990 1000
SKVKNLPNID RKQKKLLYAL YGVVEHSGGM YGGHYTAYVK VRPKVAPGDK
1010 1020 1030 1040 1050
RWKFLPHGSK AELDQDDDQL KKLEELLAKE KAREQHLKVL DDSDDFSNSS
1060 1070 1080 1090 1100
SNSSTSDESQ TPATPLEEQQ TQQAQQPQQP QQLEEAANVR APPGKWYYVS
1110 1120
DSRVQEVSED TALKAQAYLL FYERIY
Length:1,126
Mass (Da):121,487
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE57A10AF0A5E5849
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46033.1
AY051846 mRNA Translation: AAK93270.1
AE014298 Genomic DNA Translation: AAN09140.1
AE014298 Genomic DNA Translation: AAN09141.1
AE014298 Genomic DNA Translation: AAN09142.1
AE014298 Genomic DNA Translation: AHN59361.1

NCBI Reference Sequences

More...
RefSeqi
NP_001284890.1, NM_001297961.1
NP_572220.1, NM_131992.3
NP_726993.1, NM_167035.2
NP_726994.1, NM_167036.2
NP_726995.1, NM_167037.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070772; FBpp0070738; FBgn0029763
FBtr0070773; FBpp0070739; FBgn0029763
FBtr0070775; FBpp0070741; FBgn0029763
FBtr0340461; FBpp0309403; FBgn0029763
FBtr0340462; FBpp0309404; FBgn0029763

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31458

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4165

UCSC genome browser

More...
UCSCi
CG4165-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46033.1
AY051846 mRNA Translation: AAK93270.1
AE014298 Genomic DNA Translation: AAN09140.1
AE014298 Genomic DNA Translation: AAN09141.1
AE014298 Genomic DNA Translation: AAN09142.1
AE014298 Genomic DNA Translation: AHN59361.1
RefSeqiNP_001284890.1, NM_001297961.1
NP_572220.1, NM_131992.3
NP_726993.1, NM_167035.2
NP_726994.1, NM_167036.2
NP_726995.1, NM_167037.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0070738

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
31458

Genome annotation databases

EnsemblMetazoaiFBtr0070772; FBpp0070738; FBgn0029763
FBtr0070773; FBpp0070739; FBgn0029763
FBtr0070775; FBpp0070741; FBgn0029763
FBtr0340461; FBpp0309403; FBgn0029763
FBtr0340462; FBpp0309404; FBgn0029763
GeneIDi31458
KEGGidme:Dmel_CG4165
UCSCiCG4165-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31458
FlyBaseiFBgn0029763, Usp16-45

Phylogenomic databases

eggNOGiKOG1873, Eukaryota
GeneTreeiENSGT00940000176220
HOGENOMiCLU_007938_0_0_1
OMAiGSKSWFY
OrthoDBi278083at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31458, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31458

Gene expression databases

BgeeiFBgn0029763, Expressed in cleaving embryo and 34 other tissues

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR038765, Papain-like_cys_pep_sf
IPR001394, Peptidase_C19_UCH
IPR018200, USP_CS
IPR028889, USP_dom
IPR013083, Znf_RING/FYVE/PHD
IPR001607, Znf_UBP
PfamiView protein in Pfam
PF00443, UCH, 1 hit
PF02148, zf-UBP, 1 hit
SUPFAMiSSF54001, SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00972, USP_1, 1 hit
PS00973, USP_2, 1 hit
PS50235, USP_3, 1 hit
PS50271, ZF_UBP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W4C3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W4C3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: June 2, 2021
This is version 169 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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