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Entry version 177 (07 Oct 2020)
Sequence version 2 (26 Jun 2013)
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Protein
Submitted name:

Raptor, isoform B

Gene

raptor

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1632852, Macroautophagy
R-DME-165159, MTOR signalling
R-DME-166208, mTORC1-mediated signalling
R-DME-3371571, HSF1-dependent transactivation
R-DME-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-DME-5628897, TP53 Regulates Metabolic Genes
R-DME-8943724, Regulation of PTEN gene transcription
R-DME-9639288, Amino acids regulate mTORC1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Raptor, isoform BImported
Submitted name:
Raptor, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:raptorImported
Synonyms:4320Imported, Dmel\CG4320Imported, dRapImported, dRAPTORImported, dRaptorImported, RaptorImported
ORF Names:CG4320Imported, Dmel_CG4320Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0029840, raptor

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0029840, Expressed in embryo and 29 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305180

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini213 – 366Raptor_NInterPro annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni901 – 944DisorderedSequence analysisAdd BLAST44
Regioni1083 – 1131DisorderedSequence analysisAdd BLAST49
Regioni1279 – 1301DisorderedSequence analysisAdd BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi901 – 935PolarSequence analysisAdd BLAST35
Compositional biasi1114 – 1131PolarSequence analysisAdd BLAST18
Compositional biasi1279 – 1295PolarSequence analysisAdd BLAST17

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the WD repeat RAPTOR family.ARBA annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1517, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00640000091541

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001136_3_1_1

KEGG Orthology (KO)

More...
KOi
K07204

Identification of Orthologs from Complete Genome Data

More...
OMAi
GCRFIRI

Database of Orthologous Groups

More...
OrthoDBi
97083at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR004083, Raptor
IPR029347, Raptor_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12848, PTHR12848, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14538, Raptor_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01302, Raptor_N, 1 hit
SM00320, WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W437-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSAVRAKSA AAAVGVAVDE SSGSSNGSVA DQEVASSKEA VLSVLIRKRY
60 70 80 90 100
EKYVFAPWDD PIILIMEQLE HIEHCRSAAL GNQVAIGRDP SQDDSLNDLG
110 120 130 140 150
KVISNMRQDQ SLVPIVKHIE QISDIQASNG QELASLGSLR ELIRTIRKEW
160 170 180 190 200
PRDDSIKLRL KEIQILGMPP ARSLCFGERI RDDRCPLSLQ TKRHKERIQA
210 220 230 240 250
MMYERQPWRI RERMKTASVA LVLCLNIGVD PPDVVKIQPC SRLECWIDPS
260 270 280 290 300
SVSPPKAMEL IGSNLQMQYE RWQPRARYKK CNDPTVDDVK KLCTSLRRNA
310 320 330 340 350
KGERILFHYN GHGVPKPTAN GEIWVFNKTF TQYIPLSIFE LITWMSAPSI
360 370 380 390 400
YVYDCSNAGI IINSFQPYAK QHEEELGKAL AAAQQRGGVQ QLVGGSGGAA
410 420 430 440 450
NVAANQVQLT NQMVSYKNCI HLAACAANEI LPMNAQLPAD LFTSCLTTPI
460 470 480 490 500
NIALKWYAMQ EKLGMVPRIQ SELIDKIPGK VNDRRTMMGE LNWIFTAITD
510 520 530 540 550
TIAWNTLPRE LFQRLFRQDL LVASLFRNFL LAERILRSHD CTPVSLPALP
560 570 580 590 600
PCYRHPMWKA WDLVVDLALQ QLPEILDHNA PYRQLPFFEH QLTAFQVWLD
610 620 630 640 650
SESESRTPPE QLPIVLQVLL SQVHRLRALE LLARFLDLGP WAVNLALGVG
660 670 680 690 700
IFPYVLKLLQ SSTRELRPVL VFIWAKILAV DPSCQVDLVK EYKYFLSVLQ
710 720 730 740 750
DTSVSKEHRT LSAFVLSSIV HNFLLGQTSA LQGPLLSICL EQLNDGSWLL
760 770 780 790 800
RQWLAICLGM LWQNFEKARW SGARDLAHEK LYVLLRDSIP EVRAAAVFAL
810 820 830 840 850
GTFISSVTDR SEEQANNIDR IIAITMLETV GEDMSPLVRM ELAAALQWMV
860 870 880 890 900
VLFESQFVAV YLTEHMRGHV SAASFVMCPD PRDLTSSTHS LERHVTIRRG
910 920 930 940 950
ASSSSISNMG GASISSGTGS SSNPLGRSKS GSGSSGGRGA AGAAGGTNSI
960 970 980 990 1000
PFQSIFTKLW LGICNLAQDP FPRVAAIAQE IVEHVRDTAL CPIMAAKEAT
1010 1020 1030 1040 1050
MANASEKCSS LSVSLPPSPN TRVNYLGGGG APGGAGATAE SPPVGAAASG
1060 1070 1080 1090 1100
ASHWAQKLRL SGSGACMGAG DPQTILQRKL RTSSINDETD SGPGYSRGVA
1110 1120 1130 1140 1150
GAGTGLGLPS GPRESTHSAR SSGSESNHYL EPGHSLTPIV LTEFIPWAIS
1160 1170 1180 1190 1200
YFTRPGKERY SSAEGSAEEG RQRFPVDRNS AELRRRRLRF LRNDFVRRHA
1210 1220 1230 1240 1250
GRKHQELIDP YGFDVCVWNR KTQFTPSIVK LLPYEPQIAV AYREKVLVYD
1260 1270 1280 1290 1300
FQYNSVRTYG AESLGGNFTG YSSGYGSGSG SSSSLNGSTP RKSGAHTSGG
1310 1320 1330 1340 1350
GGGGFSAAPF ARVSSIEFIN AQDMALNLVA HEDGVVRVWQ SSPPASSATS
1360 1370 1380 1390 1400
EDTPSKARLV TAWTALGQVN QHNHRQRSVA SGGSIGKGAD ASGLSSAAIG
1410 1420 1430 1440 1450
SGGIVTAWQQ CSQHLVIGGG GCRFIRIWDV ERELKLADIP LGRSETCARV
1460 1470 1480 1490 1500
LSPYLPNMRS DVILAGCDDG SVRLFDKRCA PQDAGISVYR RHSAPILHAS
1510 1520 1530 1540 1550
LRANGLVLVS GCTEGRISVA DMRGSQSSIN PFDVVYEWDA GGDVTAITSH
1560 1570 1580 1590 1600
QLEDTVACGN ASKIVIYSLD GRQQKVLRTN EGFIGPKIGH PTYLYFHPYK
1610 1620
AQLAVGFVDN TVAIYSPTPV L
Length:1,621
Mass (Da):177,182
Last modified:June 26, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2AD280739C91DF3F
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46122.2
AE014298 Genomic DNA Translation: AHN59395.1

NCBI Reference Sequences

More...
RefSeqi
NP_001284924.1, NM_001297995.1
NP_572294.2, NM_132066.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0332964; FBpp0305180; FBgn0029840
FBtr0345895; FBpp0311819; FBgn0029840

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31543

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4320

UCSC genome browser

More...
UCSCi
CG4320-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46122.2
AE014298 Genomic DNA Translation: AHN59395.1
RefSeqiNP_001284924.1, NM_001297995.1
NP_572294.2, NM_132066.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0305180

Genome annotation databases

EnsemblMetazoaiFBtr0332964; FBpp0305180; FBgn0029840
FBtr0345895; FBpp0311819; FBgn0029840
GeneIDi31543
KEGGidme:Dmel_CG4320
UCSCiCG4320-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31543
FlyBaseiFBgn0029840, raptor

Phylogenomic databases

eggNOGiKOG1517, Eukaryota
GeneTreeiENSGT00640000091541
HOGENOMiCLU_001136_3_1_1
KOiK07204
OMAiGCRFIRI
OrthoDBi97083at2759

Enzyme and pathway databases

ReactomeiR-DME-1632852, Macroautophagy
R-DME-165159, MTOR signalling
R-DME-166208, mTORC1-mediated signalling
R-DME-3371571, HSF1-dependent transactivation
R-DME-380972, Energy dependent regulation of mTOR by LKB1-AMPK
R-DME-5628897, TP53 Regulates Metabolic Genes
R-DME-8943724, Regulation of PTEN gene transcription
R-DME-9639288, Amino acids regulate mTORC1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31543, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Rap1, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31543

Gene expression databases

BgeeiFBgn0029840, Expressed in embryo and 29 other tissues

Family and domain databases

Gene3Di1.25.10.10, 1 hit
2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR011989, ARM-like
IPR016024, ARM-type_fold
IPR004083, Raptor
IPR029347, Raptor_N
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR036322, WD40_repeat_dom_sf
PANTHERiPTHR12848, PTHR12848, 1 hit
PfamiView protein in Pfam
PF14538, Raptor_N, 1 hit
SMARTiView protein in SMART
SM01302, Raptor_N, 1 hit
SM00320, WD40, 5 hits
SUPFAMiSSF48371, SSF48371, 1 hit
SSF50978, SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W437_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W437
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 26, 2013
Last modified: October 7, 2020
This is version 177 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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