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Protein
Submitted name:

Biotinidase

Gene

Btnd

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei72Proton acceptorUniRule annotation1
Active sitei165Proton donorUniRule annotation1
Active sitei200NucleophileUniRule annotation1

GO - Molecular functioni

GO - Biological processi

  • histone biotinylation Source: FlyBase
  • peptidyl-lysine biotinylation Source: FlyBase
  • response to heat Source: FlyBase

Keywordsi

Molecular functionHydrolaseImported

Enzyme and pathway databases

ReactomeiR-DME-196780 Biotin transport and metabolism
R-DME-199220 Vitamin B5 (pantothenate) metabolism
R-DME-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Submitted name:
BiotinidaseImported (EC:3.5.-.-Imported, EC:3.5.1.-Imported)
Submitted name:
RT06651p1Imported
Submitted name:
RT12656p1Imported
Gene namesi
Name:BtndImported
Synonyms:BTDImported, BtdImported, Btd-RAImported, CT12113Imported, Dmel\CG3599Imported
ORF Names:CG3599Imported, Dmel_CG3599Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0029848 Btnd

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501510092221 – 553Sequence analysisAdd BLAST533

Expressioni

Gene expression databases

BgeeiFBgn0029848 Expressed in 7 organ(s), highest expression level in Malpighian tubule

Interactioni

Protein-protein interaction databases

STRINGi7227.FBpp0070843

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 295CN hydrolaseInterPro annotationAdd BLAST267

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0806 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000013823
OMAiHLWRHEY
OrthoDBiEOG091G05JW

Family and domain databases

CDDicd07567 biotinidase_like, 1 hit
Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR012101 Biotinidase-like_euk
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
PIRSFiPIRSF011861 Biotinidase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q9W430-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKSIQLSFLL LSVLFSSSHQ LSKPEDPTYT AAVVEHSQPV GDSPRARTTS
60 70 80 90 100
ASESFQKIIR EVGDVDIIVF PEHILNSQAT ATFVPHESQN ITPCYQTDYE
110 120 130 140 150
LFLIELSCSA RANHLYVVIN VVEKELCAHG AGSDTYNPCP SSGVRYFNTN
160 170 180 190 200
VVFDRRGRIV SRYRKTHLWR HEYVSTSVLR SPDISIFRTD FGVTFGHFIC
210 220 230 240 250
FDMLFYDPAM KLVKEHKITD IVYPTYWFSE LPFLGAVQLQ EGWAFGNDVN
260 270 280 290 300
VLAADASNPD GRTSGSGIYA GRGGRLVAEI FEQPTTKLLI AEVPKREHGQ
310 320 330 340 350
LAPTFTPIFE PQRKTQRLTG LATYRDNNVD IFESELLDDD FLSFERQLCH
360 370 380 390 400
GSFCCTFSIE RKVTSAAENE LPSSGAKSYR YRIGVYWGNE TTVIGVDRTE
410 420 430 440 450
QATCALFACT DVRLASCGYI YPENEEVINT HHFTKLSISG NFPAAPRGRR
460 470 480 490 500
LIMPSSLNAL FLPVSVSDYE WIESPEAANN LDKTILVDLK LAKAQNDLLT
510 520 530 540 550
FAIWANYYTD IPSTHNLDHM QPNGTQSNPS TSASSTVSAF WILCVLNCFI

SVL
Length:553
Mass (Da):61,904
Last modified:May 1, 2000 - v1
Checksum:iF0D692D07C7A85DF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46130.1
BT122052 mRNA Translation: ADD31632.1
BT133497 mRNA Translation: AFI71927.1
RefSeqiNP_572298.1, NM_132070.3
UniGeneiDm.26470

Genome annotation databases

EnsemblMetazoaiFBtr0070878; FBpp0070843; FBgn0029848
GeneIDi31552
KEGGidme:Dmel_CG3599
UCSCiCG3599-RA d. melanogaster

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46130.1
BT122052 mRNA Translation: ADD31632.1
BT133497 mRNA Translation: AFI71927.1
RefSeqiNP_572298.1, NM_132070.3
UniGeneiDm.26470

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0070843

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0070878; FBpp0070843; FBgn0029848
GeneIDi31552
KEGGidme:Dmel_CG3599
UCSCiCG3599-RA d. melanogaster

Organism-specific databases

CTDi31552
FlyBaseiFBgn0029848 Btnd

Phylogenomic databases

eggNOGiKOG0806 Eukaryota
COG0388 LUCA
GeneTreeiENSGT00390000013823
OMAiHLWRHEY
OrthoDBiEOG091G05JW

Enzyme and pathway databases

ReactomeiR-DME-196780 Biotin transport and metabolism
R-DME-199220 Vitamin B5 (pantothenate) metabolism
R-DME-6798695 Neutrophil degranulation

Miscellaneous databases

GenomeRNAii31552

Gene expression databases

BgeeiFBgn0029848 Expressed in 7 organ(s), highest expression level in Malpighian tubule

Family and domain databases

CDDicd07567 biotinidase_like, 1 hit
Gene3Di3.60.110.10, 1 hit
InterProiView protein in InterPro
IPR012101 Biotinidase-like_euk
IPR003010 C-N_Hydrolase
IPR036526 C-N_Hydrolase_sf
PfamiView protein in Pfam
PF00795 CN_hydrolase, 1 hit
PIRSFiPIRSF011861 Biotinidase, 1 hit
SUPFAMiSSF56317 SSF56317, 1 hit
PROSITEiView protein in PROSITE
PS50263 CN_HYDROLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ9W430_DROME
AccessioniPrimary (citable) accession number: Q9W430
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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