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UniProtKB - Q9W429 (S35B4_DROME)
Protein
UDP-xylose and UDP-N-acetylglucosamine transporter
Gene
Efr
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Sugar transporter that specifically mediates the transport of UDP-N-acetylglucosamine (UDP-GlcNAc), GDP-fucose and UDP-xylose. Functions redundantly with nac in the O-fucosylation of Notch, positively regulating Notch signaling. Involved in the biosynthesis of heparan sulfate-glycosaminoglycan (HS-GAG) and in Dpp signaling in the wing imaginal disk.
1 PublicationGO - Molecular functioni
- GDP-fucose transmembrane transporter activity Source: FlyBase
- transmembrane transporter activity Source: GO_Central
- UDP-N-acetylglucosamine transmembrane transporter activity Source: FlyBase
- UDP-xylose transmembrane transporter activity Source: FlyBase
GO - Biological processi
- carbohydrate transport Source: UniProtKB-KW
- GDP-fucose import into endoplasmic reticulum lumen Source: FlyBase
- GDP-fucose transmembrane transport Source: FlyBase
- heparan sulfate proteoglycan biosynthetic process Source: FlyBase
- protein O-linked fucosylation Source: FlyBase
- UDP-N-acetylglucosamine transmembrane transport Source: FlyBase
- UDP-xylose transmembrane transport Source: FlyBase
Keywordsi
Biological process | Sugar transport, Transport |
Enzyme and pathway databases
Reactomei | R-DME-727802, Transport of nucleotide sugars |
Names & Taxonomyi
Protein namesi | Recommended name: UDP-xylose and UDP-N-acetylglucosamine transporterAlternative name(s): ER GDP-fucose transporter Solute carrier family 35 member B4 homolog |
Gene namesi | Name:Efr ORF Names:CG3774 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0029849, Efr |
VEuPathDBi | VectorBase:FBgn0029849 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication
Endoplasmic reticulum
- endoplasmic reticulum Source: FlyBase
- integral component of endoplasmic reticulum membrane Source: GO_Central
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- integral component of Golgi membrane Source: GO_Central
Other locations
- integral component of membrane Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 9 – 29 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 70 – 90 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 96 – 116 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 126 – 146 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 163 – 183 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 201 – 221 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 249 – 271 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 276 – 298 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 305 – 325 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Disruption phenotypei
Homozygous lethal. In a weak loss-of-function phenotype, a gap in the fifth longitudinal vein of the adult wing is observed.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000213390 | 1 – 352 | UDP-xylose and UDP-N-acetylglucosamine transporterAdd BLAST | 352 |
Proteomic databases
PaxDbi | Q9W429 |
Expressioni
Developmental stagei
Expressed maternally and zygotically.1 Publication
Gene expression databases
Bgeei | FBgn0029849, Expressed in Malpighian tubule and 37 other tissues |
ExpressionAtlasi | Q9W429, baseline and differential |
Genevisiblei | Q9W429, DM |
Interactioni
Protein-protein interaction databases
IntActi | Q9W429, 1 interactor |
STRINGi | 7227.FBpp0070839 |
Structurei
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 350 – 352 | Prevents secretion from ER | 3 |
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1583, Eukaryota |
GeneTreei | ENSGT00390000002915 |
HOGENOMi | CLU_033007_1_0_1 |
InParanoidi | Q9W429 |
OMAi | NNYAFDF |
OrthoDBi | 1209974at2759 |
PhylomeDBi | Q9W429 |
Family and domain databases
InterProi | View protein in InterPro IPR013657, UAA |
PANTHERi | PTHR10778, PTHR10778, 1 hit |
Pfami | View protein in Pfam PF08449, UAA, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9W429-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALNLKALLG MLFVFIGCCS NVVFLELIIQ IDPGAGNLIT FAQFLFIALE
60 70 80 90 100
GLVFTSKFFT VRPKIALKDY VILVALFFGA NVCNNYAFNF NIPMPLHMIF
110 120 130 140 150
RSGSLMANMI MGIVLLKKRY NLRQYSSVAM ITAGIILCTL VSSGDVKDNT
160 170 180 190 200
HHSLKVDTSY SDFFWWTVGI GLLTIALLVT AYMGIYQEVI YKKYGKHPSE
210 220 230 240 250
ALFFTHMLPL PGFLIMAGNI VQHFGIAWSS EPVAVPLLGA IGLEWKFPLM
260 270 280 290 300
LFYLLCNVVT QYVCISAVYV LTTECASLTV TLVVTLRKFV SLLFSIIYFR
310 320 330 340 350
NPFTLNHWVG TILVFFGTIL FANVINQVRD AYRARSSRKT HFDTAPLAKK
VE
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA4V408 | A4V408_DROME | ER GDP-fucose transporter, isoform ... | Efr Dmel\CG3774, efr, CG3774, Dmel_CG3774 | 352 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 178 | L → Q in AAX33365 (Ref. 3) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF46131.1 BT021217 mRNA Translation: AAX33365.1 |
RefSeqi | NP_572299.1, NM_132071.3 NP_727071.1, NM_167062.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0070874; FBpp0070839; FBgn0029849 FBtr0070875; FBpp0070840; FBgn0029849 |
GeneIDi | 31553 |
KEGGi | dme:Dmel_CG3774 |
UCSCi | CG3774-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF46131.1 BT021217 mRNA Translation: AAX33365.1 |
RefSeqi | NP_572299.1, NM_132071.3 NP_727071.1, NM_167062.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q9W429, 1 interactor |
STRINGi | 7227.FBpp0070839 |
Proteomic databases
PaxDbi | Q9W429 |
Genome annotation databases
EnsemblMetazoai | FBtr0070874; FBpp0070839; FBgn0029849 FBtr0070875; FBpp0070840; FBgn0029849 |
GeneIDi | 31553 |
KEGGi | dme:Dmel_CG3774 |
UCSCi | CG3774-RA, d. melanogaster |
Organism-specific databases
CTDi | 31553 |
FlyBasei | FBgn0029849, Efr |
VEuPathDBi | VectorBase:FBgn0029849 |
Phylogenomic databases
eggNOGi | KOG1583, Eukaryota |
GeneTreei | ENSGT00390000002915 |
HOGENOMi | CLU_033007_1_0_1 |
InParanoidi | Q9W429 |
OMAi | NNYAFDF |
OrthoDBi | 1209974at2759 |
PhylomeDBi | Q9W429 |
Enzyme and pathway databases
Reactomei | R-DME-727802, Transport of nucleotide sugars |
Miscellaneous databases
BioGRID-ORCSi | 31553, 0 hits in 1 CRISPR screen |
GenomeRNAii | 31553 |
PROi | PR:Q9W429 |
Gene expression databases
Bgeei | FBgn0029849, Expressed in Malpighian tubule and 37 other tissues |
ExpressionAtlasi | Q9W429, baseline and differential |
Genevisiblei | Q9W429, DM |
Family and domain databases
InterProi | View protein in InterPro IPR013657, UAA |
PANTHERi | PTHR10778, PTHR10778, 1 hit |
Pfami | View protein in Pfam PF08449, UAA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | S35B4_DROME | |
Accessioni | Q9W429Primary (citable) accession number: Q9W429 Secondary accession number(s): Q5BIK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | May 1, 2000 | |
Last modified: | February 23, 2022 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families