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Protein
Submitted name:

Regulatory particle triple-A ATPase 4

Gene

Rpt4

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • ovarian follicle cell development Source: FlyBase
  • positive regulation of RNA polymerase II transcriptional preinitiation complex assembly Source: GO_Central
  • positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: FlyBase
  • proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
  • ubiquitin-dependent ERAD pathway Source: GO_Central

Keywordsi

Molecular functionHydrolaseImported
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-1169091 Activation of NF-kappaB in B cells
R-DME-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-DME-1236978 Cross-presentation of soluble exogenous antigens (endosomes)
R-DME-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-DME-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-195253 Degradation of beta-catenin by the destruction complex
R-DME-202424 Downstream TCR signaling
R-DME-2871837 FCERI mediated NF-kB activation
R-DME-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-DME-4608870 Asymmetric localization of PCP proteins
R-DME-4641257 Degradation of AXIN
R-DME-4641258 Degradation of DVL
R-DME-5358346 Hedgehog ligand biogenesis
R-DME-5607761 Dectin-1 mediated noncanonical NF-kB signaling
R-DME-5607764 CLEC7A (Dectin-1) signaling
R-DME-5610785 GLI3 is processed to GLI3R by the proteasome
R-DME-5632684 Hedgehog 'on' state
R-DME-5658442 Regulation of RAS by GAPs
R-DME-5676590 NIK-->noncanonical NF-kB signaling
R-DME-5689603 UCH proteinases
R-DME-5689880 Ub-specific processing proteases
R-DME-68949 Orc1 removal from chromatin
R-DME-69017 CDK-mediated phosphorylation and removal of Cdc6
R-DME-69229 Ubiquitin-dependent degradation of Cyclin D1
R-DME-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
R-DME-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
R-DME-8939902 Regulation of RUNX2 expression and activity
R-DME-8941858 Regulation of RUNX3 expression and activity
R-DME-8948751 Regulation of PTEN stability and activity
R-DME-9020702 Interleukin-1 signaling
R-DME-983168 Antigen processing: Ubiquitination & Proteasome degradation

Names & Taxonomyi

Protein namesi
Submitted name:
Regulatory particle triple-A ATPase 4Imported (EC:3.-.-.-Imported, EC:3.6.1.3Imported)
Gene namesi
Name:Rpt4Imported
Synonyms:Dm_Rpt4aImported, Dm_Rpt4bImported, Dmel\CG3455Imported, Dmp42DImported, l(1)G0114Imported, l(1)G0227Imported, l(1)G0345Imported, p42DImported, S10bImported
ORF Names:CG3455Imported, Dmel_CG3455Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome X

Organism-specific databases

FlyBaseiFBgn0028685 Rpt4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PaxDbiQ9W414
PeptideAtlasiQ9W414
PRIDEiQ9W414

Expressioni

Gene expression databases

BgeeiFBgn0028685
ExpressionAtlasiQ9W414 baseline and differential
GenevisibleiQ9W414 DM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9W414, 12 interactors
STRINGi7227.FBpp0293948

Structurei

3D structure databases

ProteinModelPortaliQ9W414
SMRiQ9W414
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini174 – 313AAAInterPro annotationAdd BLAST140

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili20 – 61Sequence analysisAdd BLAST42

Sequence similaritiesi

Belongs to the AAA ATPase family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0651 Eukaryota
COG1222 LUCA
GeneTreeiENSGT00550000074826
InParanoidiQ9W414
KOiK03064
OMAiHIELPNE
OrthoDBiEOG091G096W
PhylomeDBiQ9W414

Family and domain databases

InterProiView protein in InterPro
IPR005937 26S_Psome_P45-like
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
IPR035263 PSMC6
PANTHERiPTHR23073:SF59 PTHR23073:SF59, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR01242 26Sp45, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9W414-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTVTATPMPD NLRVKALSEY RKKLLEHKEI EGRLKEKREE IKDLTKLYDK
60 70 80 90 100
SENDLKALQS VGQIVGEVLK QLTEDKFIVK ATNGPRYVVG CRRQLDKAKL
110 120 130 140 150
KSGTRVALDM TTLTIMRYLP REVDPLVYNM SHEDPGDVTY SAIGGLTDQI
160 170 180 190 200
RELREVIELP LLNPELFLRV GITPPKGCLL YGPPGTGKTL LARAVASQLD
210 220 230 240 250
ANFLKVVSSA IVDKYIGESA RLIREMFNYA RDHQPCIIFM DEIDAIGGRR
260 270 280 290 300
FSEGTSADRE IQRTLMELLN QMDGFDSLGQ VKMIMATNRP DTLDPALLRP
310 320 330 340 350
GRLDRKIEIP LPNEQARLEI LKIHALKIAK HGEIDYEAIV KLSDNFNGAD
360 370 380 390
LRNVCTEAGL FAIRAEREYV IQEDFMKAVR KVSDNKKLES KLDYKPV
Length:397
Mass (Da):44,911
Last modified:June 26, 2013 - v3
Checksum:i14B04A81DC717AA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46146.3
RefSeqiNP_572308.3, NM_132080.4

Genome annotation databases

EnsemblMetazoaiFBtr0305495; FBpp0293948; FBgn0028685
GeneIDi31567
KEGGidme:Dmel_CG3455
UCSCiCG3455-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9W414_DROME
AccessioniPrimary (citable) accession number: Q9W414
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: June 26, 2013
Last modified: July 18, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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