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UniProtKB - Q9W414 (Q9W414_DROME)
Protein
Submitted name:
Regulatory particle triple-A ATPase 4
Gene
Rpt4
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: InterPro
- proteasome-activating activity Source: FlyBase
- RNA polymerase I transcription regulatory region sequence-specific DNA binding Source: FlyBase
GO - Biological processi
- ovarian follicle cell development Source: FlyBase
- positive regulation of RNA polymerase II transcription preinitiation complex assembly Source: GO_Central
- positive regulation of transcription of nucleolar large rRNA by RNA polymerase I Source: FlyBase
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: FlyBase
- ubiquitin-dependent ERAD pathway Source: GO_Central
Keywordsi
Molecular function | HydrolaseImported |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-DME-1169091, Activation of NF-kappaB in B cells R-DME-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-DME-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174154, APC/C:Cdc20 mediated degradation of Securin R-DME-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-187577, SCF(Skp2)-mediated degradation of p27/p21 R-DME-195253, Degradation of beta-catenin by the destruction complex R-DME-202424, Downstream TCR signaling R-DME-2467813, Separation of Sister Chromatids R-DME-2871837, FCERI mediated NF-kB activation R-DME-350562, Regulation of ornithine decarboxylase (ODC) R-DME-382556, ABC-family proteins mediated transport R-DME-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-4608870, Asymmetric localization of PCP proteins R-DME-4641257, Degradation of AXIN R-DME-4641258, Degradation of DVL R-DME-5358346, Hedgehog ligand biogenesis R-DME-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607764, CLEC7A (Dectin-1) signaling R-DME-5610780, Degradation of GLI1 by the proteasome R-DME-5610785, GLI3 is processed to GLI3R by the proteasome R-DME-5632684, Hedgehog 'on' state R-DME-5676590, NIK-->noncanonical NF-kB signaling R-DME-5689603, UCH proteinases R-DME-5689880, Ub-specific processing proteases R-DME-68827, CDT1 association with the CDC6:ORC:origin complex R-DME-68949, Orc1 removal from chromatin R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6 R-DME-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-75815, Ubiquitin-dependent degradation of Cyclin D R-DME-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8932339, ROS sensing by NFE2L2 R-DME-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939902, Regulation of RUNX2 expression and activity R-DME-8941858, Regulation of RUNX3 expression and activity R-DME-8948751, Regulation of PTEN stability and activity R-DME-8951664, Neddylation R-DME-9020702, Interleukin-1 signaling R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Rpt4Imported Synonyms:Dm_Rpt4aImported, Dm_Rpt4bImported, Dmel\CG3455Imported, Dmp42DImported, l(1)G0114Imported, l(1)G0227Imported, l(1)G0345Imported, p42DImported, S10bImported ORF Names:CG3455Imported, Dmel_CG3455Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0028685, Rpt4 |
VEuPathDBi | VectorBase:FBgn0028685 |
Subcellular locationi
Cytosol
- cytosolic proteasome complex Source: GO_Central
Nucleus
- nucleus Source: FlyBase
Other locations
- proteasome regulatory particle Source: FlyBase
- proteasome regulatory particle, base subcomplex Source: FlyBase
Keywords - Cellular componenti
ProteasomeARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0028685, Expressed in Malpighian tubule and 39 other tissues |
ExpressionAtlasi | Q9W414, baseline and differential |
Genevisiblei | Q9W414, DM |
Interactioni
Protein-protein interaction databases
IntActi | Q9W414, 10 interactors |
STRINGi | 7227.FBpp0293948 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 174 – 313 | AAAInterPro annotationAdd BLAST | 140 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 20 – 61 | Sequence analysisAdd BLAST | 42 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
eggNOGi | KOG0651, Eukaryota |
GeneTreei | ENSGT01020000230346 |
HOGENOMi | CLU_000688_2_2_1 |
InParanoidi | Q9W414 |
OMAi | DHEPCVI |
OrthoDBi | 571919at2759 |
PhylomeDBi | Q9W414 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR032501, Prot_ATP_ID_OB IPR035263, PSMC6 |
PANTHERi | PTHR23073:SF76, PTHR23073:SF76, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF16450, Prot_ATP_ID_OB, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9W414-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTVTATPMPD NLRVKALSEY RKKLLEHKEI EGRLKEKREE IKDLTKLYDK
60 70 80 90 100
SENDLKALQS VGQIVGEVLK QLTEDKFIVK ATNGPRYVVG CRRQLDKAKL
110 120 130 140 150
KSGTRVALDM TTLTIMRYLP REVDPLVYNM SHEDPGDVTY SAIGGLTDQI
160 170 180 190 200
RELREVIELP LLNPELFLRV GITPPKGCLL YGPPGTGKTL LARAVASQLD
210 220 230 240 250
ANFLKVVSSA IVDKYIGESA RLIREMFNYA RDHQPCIIFM DEIDAIGGRR
260 270 280 290 300
FSEGTSADRE IQRTLMELLN QMDGFDSLGQ VKMIMATNRP DTLDPALLRP
310 320 330 340 350
GRLDRKIEIP LPNEQARLEI LKIHALKIAK HGEIDYEAIV KLSDNFNGAD
360 370 380 390
LRNVCTEAGL FAIRAEREYV IQEDFMKAVR KVSDNKKLES KLDYKPV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF46146.3 |
RefSeqi | NP_572308.3, NM_132080.4 |
Genome annotation databases
EnsemblMetazoai | FBtr0305495; FBpp0293948; FBgn0028685 |
GeneIDi | 31567 |
KEGGi | dme:Dmel_CG3455 |
UCSCi | CG3455-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE014298 Genomic DNA Translation: AAF46146.3 |
RefSeqi | NP_572308.3, NM_132080.4 |
3D structure databases
SMRi | Q9W414 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9W414, 10 interactors |
STRINGi | 7227.FBpp0293948 |
Proteomic databases
PaxDbi | Q9W414 |
PeptideAtlasi | Q9W414 |
PRIDEi | Q9W414 |
Protocols and materials databases
DNASUi | 31567 |
Genome annotation databases
EnsemblMetazoai | FBtr0305495; FBpp0293948; FBgn0028685 |
GeneIDi | 31567 |
KEGGi | dme:Dmel_CG3455 |
UCSCi | CG3455-RA, d. melanogaster |
Organism-specific databases
CTDi | 31567 |
FlyBasei | FBgn0028685, Rpt4 |
VEuPathDBi | VectorBase:FBgn0028685 |
Phylogenomic databases
eggNOGi | KOG0651, Eukaryota |
GeneTreei | ENSGT01020000230346 |
HOGENOMi | CLU_000688_2_2_1 |
InParanoidi | Q9W414 |
OMAi | DHEPCVI |
OrthoDBi | 571919at2759 |
PhylomeDBi | Q9W414 |
Enzyme and pathway databases
Reactomei | R-DME-1169091, Activation of NF-kappaB in B cells R-DME-1234176, Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-DME-1236978, Cross-presentation of soluble exogenous antigens (endosomes) R-DME-174084, Autodegradation of Cdh1 by Cdh1:APC/C R-DME-174154, APC/C:Cdc20 mediated degradation of Securin R-DME-174178, APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 R-DME-174184, Cdc20:Phospho-APC/C mediated degradation of Cyclin A R-DME-187577, SCF(Skp2)-mediated degradation of p27/p21 R-DME-195253, Degradation of beta-catenin by the destruction complex R-DME-202424, Downstream TCR signaling R-DME-2467813, Separation of Sister Chromatids R-DME-2871837, FCERI mediated NF-kB activation R-DME-350562, Regulation of ornithine decarboxylase (ODC) R-DME-382556, ABC-family proteins mediated transport R-DME-450408, AUF1 (hnRNP D0) binds and destabilizes mRNA R-DME-4608870, Asymmetric localization of PCP proteins R-DME-4641257, Degradation of AXIN R-DME-4641258, Degradation of DVL R-DME-5358346, Hedgehog ligand biogenesis R-DME-5607761, Dectin-1 mediated noncanonical NF-kB signaling R-DME-5607764, CLEC7A (Dectin-1) signaling R-DME-5610780, Degradation of GLI1 by the proteasome R-DME-5610785, GLI3 is processed to GLI3R by the proteasome R-DME-5632684, Hedgehog 'on' state R-DME-5676590, NIK-->noncanonical NF-kB signaling R-DME-5689603, UCH proteinases R-DME-5689880, Ub-specific processing proteases R-DME-68827, CDT1 association with the CDC6:ORC:origin complex R-DME-68949, Orc1 removal from chromatin R-DME-69017, CDK-mediated phosphorylation and removal of Cdc6 R-DME-69601, Ubiquitin Mediated Degradation of Phosphorylated Cdc25A R-DME-75815, Ubiquitin-dependent degradation of Cyclin D R-DME-8854050, FBXL7 down-regulates AURKA during mitotic entry and in early mitosis R-DME-8932339, ROS sensing by NFE2L2 R-DME-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs R-DME-8939902, Regulation of RUNX2 expression and activity R-DME-8941858, Regulation of RUNX3 expression and activity R-DME-8948751, Regulation of PTEN stability and activity R-DME-8951664, Neddylation R-DME-9020702, Interleukin-1 signaling R-DME-983168, Antigen processing: Ubiquitination & Proteasome degradation |
Miscellaneous databases
BioGRID-ORCSi | 31567, 0 hits in 1 CRISPR screen |
ChiTaRSi | Rpt4, fly |
GenomeRNAii | 31567 |
Gene expression databases
Bgeei | FBgn0028685, Expressed in Malpighian tubule and 39 other tissues |
ExpressionAtlasi | Q9W414, baseline and differential |
Genevisiblei | Q9W414, DM |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR005937, 26S_Psome_P45-like IPR003593, AAA+_ATPase IPR041569, AAA_lid_3 IPR003959, ATPase_AAA_core IPR003960, ATPase_AAA_CS IPR027417, P-loop_NTPase IPR032501, Prot_ATP_ID_OB IPR035263, PSMC6 |
PANTHERi | PTHR23073:SF76, PTHR23073:SF76, 1 hit |
Pfami | View protein in Pfam PF00004, AAA, 1 hit PF17862, AAA_lid_3, 1 hit PF16450, Prot_ATP_ID_OB, 1 hit |
SMARTi | View protein in SMART SM00382, AAA, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR01242, 26Sp45, 1 hit |
PROSITEi | View protein in PROSITE PS00674, AAA, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9W414_DROME | |
Accessioni | Q9W414Primary (citable) accession number: Q9W414 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | June 26, 2013 | |
Last modified: | January 19, 2022 | |
This is version 181 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |