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Entry version 154 (12 Aug 2020)
Sequence version 2 (01 Oct 2002)
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Protein

GAS2-like protein pickled eggs

Gene

pigs

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for development and viability. Required for ovary development and oogenesis, and is essential for the development of the indirect flight muscles. May act as a negative regulator of the Notch signaling pathway in certain tissues, such as the muscle precursors and ovaries. May function as a linker protein between the actin and microtubule cytoskeletons.1 Publication

Miscellaneous

Named 'Picked eggs' based upon the mutant ovary phenotype.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
GAS2-like protein pickled eggsCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pigsImported
ORF Names:CG3973Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0029881, pigs

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004369181 – 977GAS2-like protein pickled eggsCuratedAdd BLAST977

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W3Y4

PRoteomics IDEntifications database

More...
PRIDEi
Q9W3Y4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the ovary and the ring canals of the germline cells. In larvae, expressed in the notal region of the wing disk.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0029881, Expressed in brain and 35 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W3Y4, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070909

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W3Y4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 159Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST140
Domaini252 – 324GARPROSITE-ProRule annotationAdd BLAST73

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GAS2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154849

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013204_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W3Y4

Identification of Orthologs from Complete Genome Data

More...
OMAi
EKCTCPS

Database of Orthologous Groups

More...
OrthoDBi
1343422at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W3Y4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR003108, GAR_dom
IPR036534, GAR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 1 hit
PF02187, GAS2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 1 hit
SM00243, GAS2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50021, CH, 1 hit
PS51460, GAR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W3Y4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAMLEARPYR PFKSSEEYLE AMREDLAEWL STLYPELSIN ADNFMDRLDT
60 70 80 90 100
GVALCKHANY VRQAAVDYLA RRQARNKSMT RSMTSGLAGP ILAMGNVHYL
110 120 130 140 150
PAAKSGTFFA RDNVSNFITW CRKSLKIIEC LLFETDDLIM RKNEKHVILC
160 170 180 190 200
LLEVARRGAK FGMLAPMLVQ MERQIDREIA ADIKANGAGC SENGTQTDAL
210 220 230 240 250
ETGNSSAATM TTITTTTVET DLYDDSDDSE TEDDGDQNPV LMYGPQPQII
260 270 280 290 300
TNDLKSLDEM VRDLVEKCTC PSQFPMVRVS EGKYRIGDTK VLIFVRILRS
310 320 330 340 350
HVMVRVGGGW DTLSHYLDKH DPCRCRAQHR SSVAARLIPR QSPNHNPSNG
360 370 380 390 400
IELHKAQVIF ERSPPAARRV FNSPNCNGGP GTGSSCGTGV VGVAVPPTLQ
410 420 430 440 450
NGHSLSPNSG KYRSRSPTPQ RKFLNQQANG GGIASATGSS QTVTTDTSSG
460 470 480 490 500
QLLGSPSLAR RSMSPSPRRL IDMRKKQSSL DSYSSGPKSL PGYSCSMEEA
510 520 530 540 550
NGGSGVGSAA GGVSSGSAGS GVAGEQGGAN KFENISDNGS EISDEGYRSL
560 570 580 590 600
GVIQSGAQKR ESLHSQASIE DAESNARLDQ TSSDSQISPS DEPAEKATTD
610 620 630 640 650
ILEEEDLNGQ DREEDQEDYS VCDGPQSLPA ILSGAHKLSD KFEQSGVFIT
660 670 680 690 700
DDEITVDIAK TEDQSVANTM GNPTPNLSKI PRSPLAQRRR RSIDNSTCGG
710 720 730 740 750
AGGSLQDLSS RSGLPAPAFS RKQPVYRSVR TRNSTGATTT PVAPPRSRQA
760 770 780 790 800
TQLPMVRDVT NTWSGRTTGA PKRRPPCTAD TFVAPTNGTG PAGSFERNGK
810 820 830 840 850
GRSSQILYDS NGRRVRSGAP GCTSSLTTSP VKNHASSPLA QQLLEAASSA
860 870 880 890 900
KNDAQILEKM KSLLSRYAAG NQTKAGVGAT ATAANKINSN GKKTPVYEDF
910 920 930 940 950
TTAWVHSNGN LERSESCSPP AKARSKRSSA ASSCESNNSN AGAGSGAAAG
960 970
SASVVSPRRE RGMSKIPAPV RHHTELY
Length:977
Mass (Da):104,466
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA0EDBEB4EDE851DA
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL13365 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti873T → I in AAL13365 (PubMed:12537569).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46177.2
AE014298 Genomic DNA Translation: AFH07264.1
AE014298 Genomic DNA Translation: AHN59420.1
AY059459 mRNA Translation: AAL13365.1 Different initiation.
BT003477 mRNA Translation: AAO39480.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245550.1, NM_001258621.2
NP_001284949.1, NM_001298020.1
NP_572331.2, NM_132103.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0070948; FBpp0070909; FBgn0029881
FBtr0308653; FBpp0300876; FBgn0029881
FBtr0343375; FBpp0310031; FBgn0029881

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31596

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3973

UCSC genome browser

More...
UCSCi
CG3973-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46177.2
AE014298 Genomic DNA Translation: AFH07264.1
AE014298 Genomic DNA Translation: AHN59420.1
AY059459 mRNA Translation: AAL13365.1 Different initiation.
BT003477 mRNA Translation: AAO39480.1
RefSeqiNP_001245550.1, NM_001258621.2
NP_001284949.1, NM_001298020.1
NP_572331.2, NM_132103.3

3D structure databases

SMRiQ9W3Y4
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9W3Y4, 5 interactors
STRINGi7227.FBpp0070909

Proteomic databases

PaxDbiQ9W3Y4
PRIDEiQ9W3Y4

Genome annotation databases

EnsemblMetazoaiFBtr0070948; FBpp0070909; FBgn0029881
FBtr0308653; FBpp0300876; FBgn0029881
FBtr0343375; FBpp0310031; FBgn0029881
GeneIDi31596
KEGGidme:Dmel_CG3973
UCSCiCG3973-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94005
FlyBaseiFBgn0029881, pigs

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000154849
HOGENOMiCLU_013204_0_0_1
InParanoidiQ9W3Y4
OMAiEKCTCPS
OrthoDBi1343422at2759
PhylomeDBiQ9W3Y4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31596, 0 hits in 5 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
pigs, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31596

Protein Ontology

More...
PROi
PR:Q9W3Y4

Gene expression databases

BgeeiFBgn0029881, Expressed in brain and 35 other tissues

Family and domain databases

CDDicd00014, CH, 1 hit
Gene3Di3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
PfamiView protein in Pfam
PF00307, CH, 1 hit
PF02187, GAS2, 1 hit
SMARTiView protein in SMART
SM00033, CH, 1 hit
SM00243, GAS2, 1 hit
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS50021, CH, 1 hit
PS51460, GAR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGA2PE_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W3Y4
Secondary accession number(s): Q95TD5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 7, 2016
Last sequence update: October 1, 2002
Last modified: August 12, 2020
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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