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Entry version 163 (25 May 2022)
Sequence version 2 (01 Oct 2002)
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Protein

Actin-histidine N-methyltransferase

Gene

Setd3

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-74'.

1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei114S-adenosyl-L-methionineBy similarity1
Binding sitei299S-adenosyl-L-methionineBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Methyltransferase, Transferase
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Actin-histidine N-methyltransferaseCurated (EC:2.1.1.85By similarity)
Alternative name(s):
Protein-L-histidine N-tele-methyltransferaseCurated
SET domain-containing protein 3 homolog1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Setd31 PublicationImported
ORF Names:CG32732Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0052732, Setd3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0052732

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype (PubMed:30067821). Cells show complete loss of actin histidine methylation (PubMed:30526847).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004463841 – 537Actin-histidine N-methyltransferaseAdd BLAST537

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W3U1

PRoteomics IDEntifications database

More...
PRIDEi
Q9W3U1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0052732, Expressed in cleaving embryo and 36 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W3U1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0070998

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q9W3U1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W3U1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini133 – 364SETPROSITE-ProRule annotationAdd BLAST232

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 50DisorderedSequence analysisAdd BLAST50
Regioni143 – 145S-adenosyl-L-methionine bindingBy similarity3
Regioni325 – 329S-adenosyl-L-methionine bindingBy similarity5
Regioni375 – 377S-adenosyl-L-methionine bindingBy similarity3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi11 – 50Polar residuesSequence analysisAdd BLAST40

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1337, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153577

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_028272_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W3U1

Identification of Orthologs from Complete Genome Data

More...
OMAi
DFWMKIP

Database of Orthologous Groups

More...
OrthoDBi
489371at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W3U1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd19176, SET_SETD3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.90.1420.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015353, Rubisco_LSMT_subst-bd
IPR036464, Rubisco_LSMT_subst-bd_sf
IPR001214, SET_dom
IPR046341, SET_dom_sf
IPR025785, SETD3
IPR044428, SETD3_SET

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09273, Rubis-subs-bind, 1 hit
PF00856, SET, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF81822, SSF81822, 1 hit
SSF82199, SSF82199, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51565, SAM_MT85_SETD3, 1 hit
PS50280, SET, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W3U1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKNTKRNKK TKQQQQQPQQ NGVTASASGT AVEDFEDQQA ASSLPSLNGK
60 70 80 90 100
KRSQLNKLVE ELLDLVEKQP ANPNEEWKQY GQLQELLKQI MILEEPLSQA
110 120 130 140 150
VCPQISDSPD DQTRLAKVEA FSAWAKDGGV HSEGLEIAIF PGYQLGLRAT
160 170 180 190 200
RPLAKDELVL SVPRKLILSE ENNSDCRLFG KMTQATHLNL AYDLVIEKIR
210 220 230 240 250
GEFSEWRPYI DVLPAKYNTV LYFTTKQMEL LRGTAAAALA MRQCRVIAKQ
260 270 280 290 300
YAFLYKYAHT MTEPSTGNRS HPGERGLFFT QHGLCYKLYR WAVSTVMTRQ
310 320 330 340 350
NLVPSEKQES EDGPKLISAL IPYWDMANHR PGKITSFYAT VSRQLECTAQ
360 370 380 390 400
EAVNTGEQFF IYYGDRSNTD LLVHNGFVDP NNTKDYVNIR VGLSLTDALA
410 420 430 440 450
AKRASILDKL NIRHTAELRV LPAPDFISKE LLAFVRVFKM SAEQLDHWCS
460 470 480 490 500
DLDRAGDLLH IDCALETDHE TRTWQFLEDR LKLLLAVFNK EMHEADEVKE
510 520 530
LELKDGQEIE LMLFLYRRLE RSILAGALQY AQEHRKV
Length:537
Mass (Da):61,158
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF12FBFAAEAF8304B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46222.2
BT003482 mRNA Translation: AAO39485.1

NCBI Reference Sequences

More...
RefSeqi
NP_727144.1, NM_167100.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071039; FBpp0070998; FBgn0052732

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31638

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32732

UCSC genome browser

More...
UCSCi
CG32732-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46222.2
BT003482 mRNA Translation: AAO39485.1
RefSeqiNP_727144.1, NM_167100.3

3D structure databases

AlphaFoldDBiQ9W3U1
SMRiQ9W3U1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9W3U1, 1 interactor
STRINGi7227.FBpp0070998

Proteomic databases

PaxDbiQ9W3U1
PRIDEiQ9W3U1

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
31638

Genome annotation databases

EnsemblMetazoaiFBtr0071039; FBpp0070998; FBgn0052732
GeneIDi31638
KEGGidme:Dmel_CG32732
UCSCiCG32732-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84193
FlyBaseiFBgn0052732, Setd3
VEuPathDBiVectorBase:FBgn0052732

Phylogenomic databases

eggNOGiKOG1337, Eukaryota
GeneTreeiENSGT00940000153577
HOGENOMiCLU_028272_1_0_1
InParanoidiQ9W3U1
OMAiDFWMKIP
OrthoDBi489371at2759
PhylomeDBiQ9W3U1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31638, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31638

Protein Ontology

More...
PROi
PR:Q9W3U1

Gene expression databases

BgeeiFBgn0052732, Expressed in cleaving embryo and 36 other tissues

Family and domain databases

CDDicd19176, SET_SETD3, 1 hit
Gene3Di3.90.1420.10, 1 hit
InterProiView protein in InterPro
IPR015353, Rubisco_LSMT_subst-bd
IPR036464, Rubisco_LSMT_subst-bd_sf
IPR001214, SET_dom
IPR046341, SET_dom_sf
IPR025785, SETD3
IPR044428, SETD3_SET
PfamiView protein in Pfam
PF09273, Rubis-subs-bind, 1 hit
PF00856, SET, 1 hit
SUPFAMiSSF81822, SSF81822, 1 hit
SSF82199, SSF82199, 1 hit
PROSITEiView protein in PROSITE
PS51565, SAM_MT85_SETD3, 1 hit
PS50280, SET, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSETD3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W3U1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 13, 2019
Last sequence update: October 1, 2002
Last modified: May 25, 2022
This is version 163 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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