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Entry version 159 (16 Oct 2019)
Sequence version 2 (01 Mar 2001)
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Protein

General vesicular transport factor p115

Gene

p115

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Essential for maintaining the architecture of the Golgi stacks and for normal organization of the transitional endoplasmic reticulum (tER). Required for both the formation of the Golgi stacks and the maintenance of the individual cisternae.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-204005 COPII-mediated vesicle transport
R-DME-6807878 COPI-mediated anterograde transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
General vesicular transport factor p115Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:p115Imported
ORF Names:CG1422Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0040087 p115

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

RNAi-mediated knockdown results in a loss of Golgi stacks and affects the organization of the transitional ER (tER) sites. Golgi stacks break down and form clusters of vesicles and tubules. The Golgi stacks that are present have an adherent morphology, including a decrease in stack diameter and total cisternae (stacked and single). The tER sites lose their organization and become dispersed throughout the cytoplasm. However, the efficiency of anterograde intracellular transport is not affected.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004394891 – 836General vesicular transport factor p115CuratedAdd BLAST836

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W3N6

PRoteomics IDEntifications database

More...
PRIDEi
Q9W3N6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected in embryos and larvae (at protein level) (PubMed:12876273). Expressed in larval imaginal disks (at protein level) (PubMed:11514618).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0040087 Expressed in 47 organ(s), highest expression level in arthropod fat body

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9W3N6, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071045

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W3N6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati24 – 64ARM 1By similarityAdd BLAST41
Repeati65 – 124ARM 2By similarityAdd BLAST60
Repeati126 – 166ARM 3By similarityAdd BLAST41
Repeati169 – 210ARM 4By similarityAdd BLAST42
Repeati211 – 256ARM 5By similarityAdd BLAST46
Repeati316 – 359ARM 7By similarityAdd BLAST44
Repeati368 – 413ARM 8By similarityAdd BLAST46
Repeati424 – 463ARM 9By similarityAdd BLAST40
Repeati477 – 518ARM 10By similarityAdd BLAST42
Repeati523 – 577ARM 11By similarityAdd BLAST55
Repeati579 – 636ARM 12By similarityAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili663 – 707Sequence analysisAdd BLAST45
Coiled coili744 – 806Sequence analysisAdd BLAST63

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VDP/USO1/EDE1 family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0946 Eukaryota
ENOG410XRCG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017018

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W3N6

Identification of Orthologs from Complete Genome Data

More...
OMAi
CAFLMGL

Database of Orthologous Groups

More...
OrthoDBi
1273987at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W3N6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR041209 P115_Arm_rpt
IPR006955 Uso1_p115_C
IPR006953 Vesicle_Uso1_P115_head

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18770 Arm_vescicular, 1 hit
PF04871 Uso1_p115_C, 1 hit
PF04869 Uso1_p115_head, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W3N6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEFLKSGIKT VLGSTEPGQQ PSAAETVEKL VDRVYSSTLL EDRRDACRAL
60 70 80 90 100
KALSRKYRIE VGAQGMPPLV QVLQNDGQDA EIISYALDTL CNVVTSEEFD
110 120 130 140 150
EEADNPTVSV NVGEQFTEMF IKTPEHVTLV MGYLDEYDFR VRRAAIQLIT
160 170 180 190 200
SLISNKTREL QDLILVSPMG VSKLMDLLTD SREVIRNDVL LLLIELTKGN
210 220 230 240 250
SNIQKIVAFE NAFDRLFEIV REEGCSDGGI VVEDCLILLL NLLKNNSSNQ
260 270 280 290 300
QFFKEGSYIQ RLSPMFELSQ DAEEVGWSPQ KVSNFHCLLQ VVRALVTPSN
310 320 330 340 350
QQQVVAACQR VMQKSRLLHA LCEILMSSGV PADILTETIN AVAEVVRGDR
360 370 380 390 400
DNQDELGRVM APSSPPRPAI VVLLMSMINE KQLLALRCAV LYCFECFLYR
410 420 430 440 450
NADGQRAVVQ TLLPSSASDV SALSTGQLLC TGLFSTDALA NWFSAVALMH
460 470 480 490 500
SLVENVALKE ELLRVLLATP GGQKPITLLE QCTNLMQQER YRLQSKVGLL
510 520 530 540 550
MLLSLWLAHC PGAVKALLET QGTMAYLTAQ LCSNEHDERE FLVQGMCAFL
560 570 580 590 600
MGLCIQFNDN SLPGQKREDI SQLIIKRIGQ ESFCSKLAEV SRHEAYSRAC
610 620 630 640 650
KQAQIRAKSA GELLLDFEYC KLYKGLEALI AKLVSGFDVD GIELTELTLS
660 670 680 690 700
SEASALVSQY KGIIRGMDAQ IQALQQSSKE LEQENAELKE KLGEEQSLKA
710 720 730 740 750
QLLDQNTLLK AQLGASTGQV QSAQGAEATP PNEEELNAAR YQANMYFAEN
760 770 780 790 800
IRLTKELETL RQQLSAEKQS ADAAQDSLAA MQKDQEDLLE LLADQEAKLT
810 820 830
RYEEAGSTNT LPTSNVAPSV PAAGGGSPIP SGTASR
Length:836
Mass (Da):92,069
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE802308CB3219334
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB72935 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti455N → D in CAB72935 (PubMed:11514618).Curated1
Sequence conflicti508A → P in CAB72935 (PubMed:11514618).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ272048 mRNA Translation: CAB72935.1 Frameshift.
AE014298 Genomic DNA Translation: AAF46286.2
AE014298 Genomic DNA Translation: AHN59463.1
AY058751 mRNA Translation: AAL13980.1

NCBI Reference Sequences

More...
RefSeqi
NP_001284992.1, NM_001298063.1
NP_572417.1, NM_132189.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071089; FBpp0071045; FBgn0040087
FBtr0340162; FBpp0309148; FBgn0040087

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31698

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1422

UCSC genome browser

More...
UCSCi
CG1422-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272048 mRNA Translation: CAB72935.1 Frameshift.
AE014298 Genomic DNA Translation: AAF46286.2
AE014298 Genomic DNA Translation: AHN59463.1
AY058751 mRNA Translation: AAL13980.1
RefSeqiNP_001284992.1, NM_001298063.1
NP_572417.1, NM_132189.3

3D structure databases

SMRiQ9W3N6
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9W3N6, 5 interactors
STRINGi7227.FBpp0071045

Proteomic databases

PaxDbiQ9W3N6
PRIDEiQ9W3N6

Genome annotation databases

EnsemblMetazoaiFBtr0071089; FBpp0071045; FBgn0040087
FBtr0340162; FBpp0309148; FBgn0040087
GeneIDi31698
KEGGidme:Dmel_CG1422
UCSCiCG1422-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31698
FlyBaseiFBgn0040087 p115

Phylogenomic databases

eggNOGiKOG0946 Eukaryota
ENOG410XRCG LUCA
GeneTreeiENSGT00390000017018
InParanoidiQ9W3N6
OMAiCAFLMGL
OrthoDBi1273987at2759
PhylomeDBiQ9W3N6

Enzyme and pathway databases

ReactomeiR-DME-204005 COPII-mediated vesicle transport
R-DME-6807878 COPI-mediated anterograde transport

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31698

Protein Ontology

More...
PROi
PR:Q9W3N6

Gene expression databases

BgeeiFBgn0040087 Expressed in 47 organ(s), highest expression level in arthropod fat body

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR041209 P115_Arm_rpt
IPR006955 Uso1_p115_C
IPR006953 Vesicle_Uso1_P115_head
PfamiView protein in Pfam
PF18770 Arm_vescicular, 1 hit
PF04871 Uso1_p115_C, 1 hit
PF04869 Uso1_p115_head, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 2 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUSO1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W3N6
Secondary accession number(s): Q9NFR8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2017
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 159 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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