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Entry version 182 (10 Feb 2021)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

Uncharacterized protein, isoform A

Gene

SPH198

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized protein, isoform AImported
Submitted name:
Uncharacterized protein, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPH198Imported
Synonyms:Dmel\CG1632Imported
ORF Names:CG1632Imported, Dmel_CG1632Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0030027, CG1632

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei197 – 223HelicalSequence analysisAdd BLAST27

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi385 ↔ 446PROSITE-ProRule annotation
Disulfide bondi393 ↔ 439PROSITE-ProRule annotation
Disulfide bondi518 ↔ 533PROSITE-ProRule annotation
Disulfide bondi556 ↔ 571PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0030027, Expressed in pupa and 15 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W3H0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071118

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini229 – 352SEAInterPro annotationAdd BLAST124
Domaini380 – 507FZInterPro annotationAdd BLAST128
Domaini695 – 1054Peptidase S1InterPro annotationAdd BLAST360

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni8 – 176DisorderedSequence analysisAdd BLAST169
Regioni358 – 381DisorderedSequence analysisAdd BLAST24
Regioni854 – 880DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi21 – 89PolarSequence analysisAdd BLAST69
Compositional biasi128 – 163PolyampholyteSequence analysisAdd BLAST36

Keywords - Domaini

SignalARBA annotation, Signal-anchorARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3577, Eukaryota
KOG3627, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000169306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006842_19_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQPKAEW

Database of Orthologous Groups

More...
OrthoDBi
170711at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112, LDLa, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.2000.10, 1 hit
2.40.10.10, 3 hits
3.30.70.960, 1 hit
4.10.400.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
IPR001254, Trypsin_dom
IPR017343, UCP037987

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01392, Fz, 1 hit
PF00057, Ldl_recept_a, 1 hit
PF01390, SEA, 1 hit
PF00089, Trypsin, 2 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037987, UCP037987, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00063, FRI, 1 hit
SM00192, LDLa, 2 hits
SM00020, Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50494, SSF50494, 1 hit
SSF57424, SSF57424, 1 hit
SSF63501, SSF63501, 1 hit
SSF82671, SSF82671, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038, FZ, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 2 hits
PS50024, SEA, 1 hit
PS50240, TRYPSIN_DOM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W3H0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDIYYCSNS QMKKSRDADK SSATLSATNT NANAVNLSAA DKKNNNNNCS
60 70 80 90 100
NRNKEKSMQA NGKNWKGIVQ SNPNPSGGVG TTAQPPKVFH NTRCTRHHKP
110 120 130 140 150
HHSHGNGSAA SAVGGAAGLA NGPPMEATQQ RERERERDRD RERERERDRE
160 170 180 190 200
RDREREREHQ LHMHQHNHGL RRKSESVLST DSDIRFTRRK LGDGQKCGCA
210 220 230 240 250
VIAGFLIALL VAGIFVYVGY TYFRPEPLPD RVFRGRFMVL NDKWSMELAN
260 270 280 290 300
QNSMRFQHKA RDYRERINLT LRRSDLREAY EGSEILALDG SEDNNNIVVH
310 320 330 340 350
FNMIFDPYAG LVSSGDLLAL FHEEMTQPPQ QRRHFANMTV DVASLSIKET
360 370 380 390 400
TGLIEEPIMS SSPLGGHDET TEPVVTTTPA PPRRCSPLEL SYCRQVGYNI
410 420 430 440 450
TTYPNLLGHA SYEQLAEDVI VFRELVDGEC HREAYDFVCR LLQPPCDTHG
460 470 480 490 500
SDLQPTPGQI CREYCESFMA GCGGRLPQRF RQFFDCERFP ESTGTQSCHQ
510 520 530 540 550
KPHCVSDMQS NVQSPRLCDG YADCPDLSDE RSCAFCSPNA LYCGRGRACV
560 570 580 590 600
PRKARCDGKA DCPDGADEKD CLSIAPLAAD LLQPEPLVPY LSRFHSAGYA
610 620 630 640 650
VFSEKGVVGK LCAEGLEGDA KLVVRQTVSE SLCKSLGYES VEIFDVQNDT
660 670 680 690 700
ERLNDYVRVL DPHAPEISFI RTHCPRRQVL YVGCGELRCG VQSALFNAKQ
710 720 730 740 750
HLSLPKMSAP GDWPWLVALF REDIHVCDGT LITQDWVLTT EGCFQGQPRA
760 770 780 790 800
TWMAIVGAVR LSAKAPWTQR RRIIGMIKSP VEGSTAALVR LETPVSYSDH
810 820 830 840 850
VRPICLPDAL QRRLLQQPPA QRRSHVPVAE RLEGQLVSQQ RSRLSQENQQ
860 870 880 890 900
FFLIPSQEQQ DSSTENQGDE DQDEQEDHFG GESAASYMPK AEALHQELDG
910 920 930 940 950
YPLPDHAPQV NYYSSSSTVT SSSTAARIAT KAPILAAVPA AQEQIWTNCN
960 970 980 990 1000
TLGWSRQRDH LQRVQLKMGD MAPCENVSIA TVNSMCMEAT YQKYDCTQEE
1010 1020 1030 1040 1050
YSGAPVQCLI PGTNQWALIG VSSWRIACGP TGVERPRMYD KIASNAAWIR

ETISAI
Length:1,056
Mass (Da):117,927
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80577215F561A47A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46357.2
AE014298 Genomic DNA Translation: AFH07291.1

NCBI Reference Sequences

More...
RefSeqi
NP_001245577.1, NM_001258648.2
NP_572467.1, NM_132239.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071170; FBpp0071118; FBgn0030027
FBtr0307282; FBpp0298283; FBgn0030027

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31763

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG1632

UCSC genome browser

More...
UCSCi
CG1632-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46357.2
AE014298 Genomic DNA Translation: AFH07291.1
RefSeqiNP_001245577.1, NM_001258648.2
NP_572467.1, NM_132239.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9W3H0, 2 interactors
STRINGi7227.FBpp0071118

Genome annotation databases

EnsemblMetazoaiFBtr0071170; FBpp0071118; FBgn0030027
FBtr0307282; FBpp0298283; FBgn0030027
GeneIDi31763
KEGGidme:Dmel_CG1632
UCSCiCG1632-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0030027, CG1632

Phylogenomic databases

eggNOGiKOG3577, Eukaryota
KOG3627, Eukaryota
GeneTreeiENSGT00940000169306
HOGENOMiCLU_006842_19_1_1
OMAiGQPKAEW
OrthoDBi170711at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
31763, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CG1632, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31763

Gene expression databases

BgeeiFBgn0030027, Expressed in pupa and 15 other tissues

Family and domain databases

CDDicd00112, LDLa, 2 hits
Gene3Di1.10.2000.10, 1 hit
2.40.10.10, 3 hits
3.30.70.960, 1 hit
4.10.400.10, 1 hit
InterProiView protein in InterPro
IPR020067, Frizzled_dom
IPR036790, Frizzled_dom_sf
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR002172, LDrepeatLR_classA_rpt
IPR009003, Peptidase_S1_PA
IPR043504, Peptidase_S1_PA_chymotrypsin
IPR000082, SEA_dom
IPR036364, SEA_dom_sf
IPR001254, Trypsin_dom
IPR017343, UCP037987
PfamiView protein in Pfam
PF01392, Fz, 1 hit
PF00057, Ldl_recept_a, 1 hit
PF01390, SEA, 1 hit
PF00089, Trypsin, 2 hits
PIRSFiPIRSF037987, UCP037987, 1 hit
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00063, FRI, 1 hit
SM00192, LDLa, 2 hits
SM00020, Tryp_SPc, 1 hit
SUPFAMiSSF50494, SSF50494, 1 hit
SSF57424, SSF57424, 1 hit
SSF63501, SSF63501, 1 hit
SSF82671, SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50038, FZ, 1 hit
PS01209, LDLRA_1, 1 hit
PS50068, LDLRA_2, 2 hits
PS50024, SEA, 1 hit
PS50240, TRYPSIN_DOM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W3H0_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W3H0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: February 10, 2021
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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