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Entry version 142 (29 Sep 2021)
Sequence version 3 (05 Jul 2004)
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Protein

DENN domain-containing protein Crag

Gene

Crag

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calmodulin-binding protein that acts as a guanine exchange factor for Rab10 and Rab11 (PubMed:9813038, PubMed:23369713, PubMed:23226104).

Essential for maintenance of adult photoreceptor cells (PubMed:23226104).

Upon light stimulation, required for trafficking of newly synthesized ninaE (Rh1) from the trans-Golgi network to rhabdomere membranes via Rab11-dependent vesicular transport (PubMed:23226104).

During egg development, essential for establishing and maintaining epithelial cell polarity by regulating the correct polarized deposition of basal membrane (BM) proteins in follicular epithelial (FE) cells (PubMed:18331716, PubMed:23369713, PubMed:24828534).

Functions by targeting Rab10 to the basal cytoplasm, where it restricts the secretion of BM proteins such as trol/Pcan and vkg/Coll IV to the basal surface (PubMed:18331716, PubMed:23369713, PubMed:24828534).

Appears to be involved in regulating the levels and distribution of the guanine nucleotide exchange factor strat, however the two proteins appear to have independent roles in regulating polarized BM protein secretion in the FE (PubMed:28228250).

6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding, Guanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-8876198, RAB GEFs exchange GTP for GDP on RABs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DENN domain-containing protein Crag1 Publication
Alternative name(s):
Calmodulin-binding protein related to a Rab3 GDP/GTP exchange proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Crag1 PublicationImported
ORF Names:CG12737Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0025864, Crag

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
VectorBase:FBgn0025864

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Endosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi161 – 1671Missing in GG43; larvae lethal. 1 PublicationAdd BLAST1511
Mutagenesisi367 – 1671Missing in CJ101; larvae lethal. In egg chambers, follicle cells (FC) display abnormal localization of various apical, junctional and basolateral proteins, and loss of epithelial integrity. In follicle epithelium (FE) cells, the basal membrane proteins, trol, Lam and vkg display abnormal localization; accumulating on the apical side of the cell in addition to the normal basal accumulation. Expression of strat in the FE is reduced. In egg chambers, trol also shows abnormal apical localization at the posterior pole. Many FCs appear irregularly shaped at the poles, form multiple layers and are often found in the germline cluster. FCs on the lateral side however, appear normal. 3 PublicationsAdd BLAST1305
Mutagenesisi659 – 1671Missing in CZ085; larvae lethal. 1 PublicationAdd BLAST1013
Mutagenesisi798 – 1671Missing : Larvae lethal at the L2 stage. In photoreceptor cells, light-induced accumulation of newly synthesized ninaE (Rh1) post-Golgi vesicles leads to a reduction in membrane stack volume, and eventually, photoreceptor cell degeneration. Disruption of photoreceptor cell function is light- and age-dependent. 1 PublicationAdd BLAST874
Mutagenesisi1372C → S: Larvae lethal at the L2 stage. Adult flies display subtle defects in ommatidial organization. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004450771 – 1671DENN domain-containing protein CragAdd BLAST1671

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W3D3

PRoteomics IDEntifications database

More...
PRIDEi
Q9W3D3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the adult head and body.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in the follicle epithelial cells throughout their development (PubMed:18331716). Not detected until the adult stage (PubMed:9813038).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
FBgn0025864, Expressed in cleaving embryo and 40 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9W3D3, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Cam (PubMed:18331716, PubMed:9813038).

Interacts with Rab10 (PubMed:23369713).

Interacts (via the DENN domains) with Rab11 (PubMed:23226104).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-59994N

Protein interaction database and analysis system

More...
IntActi
Q9W3D3, 2 interactors

STRING: functional protein association networks

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STRINGi
7227.FBpp0071165

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W3D3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini39 – 195MABPPROSITE-ProRule annotationAdd BLAST157
Domaini187 – 364uDENNPROSITE-ProRule annotationAdd BLAST178
Domaini385 – 521cDENNPROSITE-ProRule annotationAdd BLAST137
Domaini523 – 632dDENNPROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni997 – 1160DisorderedSequence analysisAdd BLAST164
Regioni1245 – 1311DisorderedSequence analysisAdd BLAST67
Regioni1415 – 1435DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1046 – 1061Acidic residuesSequence analysisAdd BLAST16
Compositional biasi1070 – 1125Polar residuesSequence analysisAdd BLAST56
Compositional biasi1137 – 1160Polar residuesSequence analysisAdd BLAST24
Compositional biasi1256 – 1276Basic residuesSequence analysisAdd BLAST21
Compositional biasi1277 – 1309Basic and acidic residuesSequence analysisAdd BLAST33

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG2127, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000168597

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_003074_0_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9W3D3

Database of Orthologous Groups

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OrthoDBi
75304at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9W3D3

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11500, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR023341, MABP
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50211, DENN, 1 hit
PS51498, MABP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A1 PublicationImported (identifier: Q9W3D3-1) [UniParc]FASTAAdd to basket
Also known as: DImported

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEKRIADYF VVAGMPENPQ LLQENSFNDS GRLRAATTIE PITDIGVYFP
60 70 80 90 100
LLGEEVPEGY EILSHTPTGL QANLNHGSVR TTDCYIYFRR GKDRPPLVDI
110 120 130 140 150
GVLYDGHERI MSDAEIVAET PGGRVANVNN SSAKTFLTYR RARADMPCNE
160 170 180 190 200
LVVTELCVIV QSKGERAPHA FCLIYKTLNK GYVGSDVYLC YKKSMYRPKH
210 220 230 240 250
ISYKPEILLR YPTFDHTDFP LNLCPSVPLF CLPMGASLEA WPHVNGTEKR
260 270 280 290 300
KPISPVFSTF VLTVSDGTYK VYGSALTFYE DYDESKLSAE QKELLGWDEE
310 320 330 340 350
FGAQHSLHMI KAICLLSHHP FGDTFDKWLK YLHRMVLYDV NIPIPVERYI
360 370 380 390 400
TQLLDEVPFP APSIHLQLSS ESNDRILLTQ PEDSPLPRSG AGFHILLQNL
410 420 430 440 450
GTDNCLHVLL LALTEQKILI HSLRPATLTA VAEAIVSLLF PFKWQCPYIP
460 470 480 490 500
LCPLGLAEVL HAPLPYLIGV DSRFFDLYEP PTDVTCIDLD TNNISLCESQ
510 520 530 540 550
RHLSPKLLPK RAARLLRQTL TELENAKPIS YDSTNSLDRD IRKRKRELVL
560 570 580 590 600
EQRIQEAFLL FMASILRGYR DFLVPISKAP SVGATDPSAL FQLKAFLRSR
610 620 630 640 650
DKSHQKFFEL MMKTQMFIRF IEERSFVSDG DHGLSFFDEC AEKVGNYDET
660 670 680 690 700
PAQLHLVDWD TGQNSERTKY IFPPDSVTPA GSQPGGGGGG LAYNYENFTL
710 720 730 740 750
QPELLQSTKK TALSKFLQLQ LNASLSPGSP IARRTKHEIK LSQKMASRCQ
760 770 780 790 800
QHPEAWSKYL LATCYSLYFL ILPSMVLDPR HAGKEPEILR AAYDVLVRAS
810 820 830 840 850
RLKITCDEFC YRIMMQLCGI HNLPVLAVRL HYLMKRSGVQ ANALTYGFYN
860 870 880 890 900
RCVLESQWPQ DSTTISQIRW NRIKNVVLGA AQFRKAGKQR AASKVNKSLS
910 920 930 940 950
ASQDQNLSTL ETVDGQSRTS LASSSGDGGG HGLLDFAAFD RLRNKLGSIV
960 970 980 990 1000
RQTVTGGNNE TMGDAVNNTG LLIPGELSAP NTPTYGGDTE ILAKALQQQQ
1010 1020 1030 1040 1050
PRKQIMSIGG GDDDDEDEDE DEYTAGSPST PQKQLEAGAD DLEYAGGGDY
1060 1070 1080 1090 1100
EADEEDEDEV DEHVAAQRAR QRVQSPTKIS PRTPVTQNDP LGALNEEESA
1110 1120 1130 1140 1150
ASATPTQETQ QEQQHSQSQI DSSIYSDKPI LFRGQRSATF DESTQIGKSM
1160 1170 1180 1190 1200
HRSETMPVAS SGVTNSLANI GSSLKFTFGR YSPARLSLKK DLKLPANIIE
1210 1220 1230 1240 1250
NISSISPSLT GKKSNELIQG SLSSIKSAAN SLTKKFDEIK GVISANSTPT
1260 1270 1280 1290 1300
KTNNGHHPHG LHHGHHHPHH HHHHHSQHGN AEQEEHDAAV HEEGKLRRVS
1310 1320 1330 1340 1350
SDLDPWGRLS ESRKSSYNNL VPLGENSSTG ALHMHAFPAV PDNLYSLTSE
1360 1370 1380 1390 1400
NAADRDCDVL IQLTTCSQCH NCSVLVYDEE IMSGWTAEDS NLNTTCHACN
1410 1420 1430 1440 1450
KLTVPFLSVQ IERQVEESEQ SDPLQDGKEQ IANGNSHKTS LTVPYLNPLV
1460 1470 1480 1490 1500
LRKELENILT QEGDIALIKP EFVDEHPIIY WNLLWLMERI ESKTHLPELC
1510 1520 1530 1540 1550
LPVPSDKEHI DPLSKVKTVH IQCLWDNLSL HTEASGPPMY LLYRETQPTS
1560 1570 1580 1590 1600
PLIKALLTDQ AQLNKNVIQQ IISAIRCNDF ATPLKRLANE RHKLKSNGVE
1610 1620 1630 1640 1650
RSHSFYRDIL FLALTAIGRS NVDLATFHRE YAAVFDKLTE RECNMYYRNQ
1660 1670
DLPPSASTIF CRAYFRPLLL P
Length:1,671
Mass (Da):187,010
Last modified:July 5, 2004 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C06079C01DCB55B
GO
Isoform B1 PublicationImported (identifier: Q9W3D3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1180-1206: Missing.
     1431-1435: IANGN → TANGT

Show »
Length:1,644
Mass (Da):183,975
Checksum:i2C7FF884EE9F265A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAA76938 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1347 – 1349LTS → VTG in CAA76938 (PubMed:9813038).Curated3

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0598141180 – 1206Missing in isoform B. CuratedAdd BLAST27
Alternative sequenceiVSP_0598151431 – 1435IANGN → TANGT in isoform B. 5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y17918 mRNA Translation: CAA76938.1 Frameshift.
AE014298 Genomic DNA Translation: AAF46397.3
AE014298 Genomic DNA Translation: AAF46398.3
AE014298 Genomic DNA Translation: ACZ95245.2
BT031006 mRNA Translation: ABV82388.1
AY094962 mRNA Translation: AAM11315.1

Protein sequence database of the Protein Information Resource

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PIRi
T13717

NCBI Reference Sequences

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RefSeqi
NP_001162710.2, NM_001169239.2 [Q9W3D3-1]
NP_525080.3, NM_080341.4 [Q9W3D3-1]
NP_727281.2, NM_167164.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071219; FBpp0071165; FBgn0025864 [Q9W3D3-1]
FBtr0071220; FBpp0089320; FBgn0025864
FBtr0343356; FBpp0310013; FBgn0025864 [Q9W3D3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
31800

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG12737

UCSC genome browser

More...
UCSCi
CG12737-RA, d. melanogaster [Q9W3D3-1]
CG12737-RB, d. melanogaster

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y17918 mRNA Translation: CAA76938.1 Frameshift.
AE014298 Genomic DNA Translation: AAF46397.3
AE014298 Genomic DNA Translation: AAF46398.3
AE014298 Genomic DNA Translation: ACZ95245.2
BT031006 mRNA Translation: ABV82388.1
AY094962 mRNA Translation: AAM11315.1
PIRiT13717
RefSeqiNP_001162710.2, NM_001169239.2 [Q9W3D3-1]
NP_525080.3, NM_080341.4 [Q9W3D3-1]
NP_727281.2, NM_167164.4

3D structure databases

SMRiQ9W3D3
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-59994N
IntActiQ9W3D3, 2 interactors
STRINGi7227.FBpp0071165

Proteomic databases

PaxDbiQ9W3D3
PRIDEiQ9W3D3

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
31800

Genome annotation databases

EnsemblMetazoaiFBtr0071219; FBpp0071165; FBgn0025864 [Q9W3D3-1]
FBtr0071220; FBpp0089320; FBgn0025864
FBtr0343356; FBpp0310013; FBgn0025864 [Q9W3D3-1]
GeneIDi31800
KEGGidme:Dmel_CG12737
UCSCiCG12737-RA, d. melanogaster [Q9W3D3-1]
CG12737-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31800
FlyBaseiFBgn0025864, Crag
VEuPathDBiVectorBase:FBgn0025864

Phylogenomic databases

eggNOGiKOG2127, Eukaryota
GeneTreeiENSGT00940000168597
HOGENOMiCLU_003074_0_0_1
InParanoidiQ9W3D3
OrthoDBi75304at2759
PhylomeDBiQ9W3D3

Enzyme and pathway databases

ReactomeiR-DME-8876198, RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
31800, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Crag, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
31800

Protein Ontology

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PROi
PR:Q9W3D3

Gene expression databases

BgeeiFBgn0025864, Expressed in cleaving embryo and 40 other tissues
ExpressionAtlasiQ9W3D3, baseline and differential

Family and domain databases

Gene3Di3.40.50.11500, 1 hit
InterProiView protein in InterPro
IPR001194, cDENN_dom
IPR005112, dDENN_dom
IPR043153, DENN_C
IPR023341, MABP
IPR037516, Tripartite_DENN
IPR005113, uDENN_dom
PfamiView protein in Pfam
PF03455, dDENN, 1 hit
PF02141, DENN, 1 hit
PF03456, uDENN, 1 hit
SMARTiView protein in SMART
SM00801, dDENN, 1 hit
SM00799, DENN, 1 hit
SM00800, uDENN, 1 hit
PROSITEiView protein in PROSITE
PS50211, DENN, 1 hit
PS51498, MABP, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRAG_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W3D3
Secondary accession number(s): O96957, Q8T3K8, Q9W3D2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 12, 2018
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 142 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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