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Entry version 166 (11 Dec 2019)
Sequence version 1 (01 May 2000)
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Protein

Aladin

Gene

Aladin

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in mitotic spindle assembly.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-159227 Transport of the SLBP independent Mature mRNA
R-DME-159230 Transport of the SLBP Dependant Mature mRNA
R-DME-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4085377 SUMOylation of SUMOylation proteins
R-DME-4551638 SUMOylation of chromatin organization proteins
R-DME-4615885 SUMOylation of DNA replication proteins
R-DME-5578749 Transcriptional regulation by small RNAs

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9W351

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aladin1 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Aladin1 PublicationImported
ORF Names:CG16892Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0030122 Aladin

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004472611 – 466AladinAdd BLAST466

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W351

PRoteomics IDEntifications database

More...
PRIDEi
Q9W351

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0030122 Expressed in 25 organ(s), highest expression level in embryo

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W351, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071254

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati135 – 174WD 1Sequence analysisAdd BLAST40
Repeati179 – 218WD 2Sequence analysisAdd BLAST40
Repeati229 – 269WD 3Sequence analysisAdd BLAST41
Repeati271 – 310WD 4Sequence analysisAdd BLAST40
Repeati378 – 418WD 5Sequence analysisAdd BLAST41

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2139 Eukaryota
ENOG410XNTD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009446

KEGG Orthology (KO)

More...
KOi
K14320

Identification of Orthologs from Complete Genome Data

More...
OMAi
RVWNTGV

Database of Orthologous Groups

More...
OrthoDBi
628517at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q9W351

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR024977 Apc4_WD40_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W351-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALSNLKQC PPFSTLPDLA LRHNHIPELE RYPQINLNSE LLANPAGQRY
60 70 80 90 100
YGGQSFVSVN EGVLKRIARS FFNGGFWKTL EEARSPETRE QAPLIAQAGD
110 120 130 140 150
LIAQFLGLAT GLRILPHTQQ LSAERIAQFV ETRDWLNSDV RYLAWNQHFF
160 170 180 190 200
CLAVAGVDDV VRIYTKSSSA TTATVLKSPS QTQITCMAWR PLCASEIVIG
210 220 230 240 250
CRQGLCFWEV DSTLHLGRTN APSEIFKYPN NLPITSMQWN KDGTQLATAS
260 270 280 290 300
IGDRSIIIWQ PDTGMMQPLK RLGPPGSLLK WSPDNDWLFA ATVDRVFRVW
310 320 330 340 350
NCHQQWTTER WVCGPGGYVQ TACWSPCGRF LLFVSSAEPI LYRLQFVQQS
360 370 380 390 400
LLSSSADEKE ILPIADLNAC SIDANRTLVG GPAQQLAWDP HGNYLVVTFK
410 420 430 440 450
ATNCIAVFRT FIQKFDLQIS AAYYLSGETA AEHPSFICFQ PLYEDNDRSV
460
LTIAWSSGRI QYYAFD
Length:466
Mass (Da):52,279
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD5F77E06455735B0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46484.1
AE014298 Genomic DNA Translation: AHN59520.1
AY051958 mRNA Translation: AAK93382.1
BT125044 mRNA Translation: ADJ37240.1

NCBI Reference Sequences

More...
RefSeqi
NP_001285049.1, NM_001298120.1
NP_572557.1, NM_132329.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071319; FBpp0071254; FBgn0030122
FBtr0339949; FBpp0308972; FBgn0030122

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
31881

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG16892

UCSC genome browser

More...
UCSCi
CG16892-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46484.1
AE014298 Genomic DNA Translation: AHN59520.1
AY051958 mRNA Translation: AAK93382.1
BT125044 mRNA Translation: ADJ37240.1
RefSeqiNP_001285049.1, NM_001298120.1
NP_572557.1, NM_132329.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9W351, 7 interactors
STRINGi7227.FBpp0071254

Proteomic databases

PaxDbiQ9W351
PRIDEiQ9W351

Genome annotation databases

EnsemblMetazoaiFBtr0071319; FBpp0071254; FBgn0030122
FBtr0339949; FBpp0308972; FBgn0030122
GeneIDi31881
KEGGidme:Dmel_CG16892
UCSCiCG16892-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
31881
FlyBaseiFBgn0030122 Aladin

Phylogenomic databases

eggNOGiKOG2139 Eukaryota
ENOG410XNTD LUCA
GeneTreeiENSGT00390000009446
KOiK14320
OMAiRVWNTGV
OrthoDBi628517at2759
PhylomeDBiQ9W351

Enzyme and pathway databases

ReactomeiR-DME-159227 Transport of the SLBP independent Mature mRNA
R-DME-159230 Transport of the SLBP Dependant Mature mRNA
R-DME-159231 Transport of Mature mRNA Derived from an Intronless Transcript
R-DME-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-DME-3108214 SUMOylation of DNA damage response and repair proteins
R-DME-3301854 Nuclear Pore Complex (NPC) Disassembly
R-DME-3371453 Regulation of HSF1-mediated heat shock response
R-DME-4085377 SUMOylation of SUMOylation proteins
R-DME-4551638 SUMOylation of chromatin organization proteins
R-DME-4615885 SUMOylation of DNA replication proteins
R-DME-5578749 Transcriptional regulation by small RNAs
SignaLinkiQ9W351

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
31881

Protein Ontology

More...
PROi
PR:Q9W351

Gene expression databases

BgeeiFBgn0030122 Expressed in 25 organ(s), highest expression level in embryo

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR024977 Apc4_WD40_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
PfamiView protein in Pfam
PF12894 ANAPC4_WD40, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAAAS_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W351
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 8, 2019
Last sequence update: May 1, 2000
Last modified: December 11, 2019
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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