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Entry version 154 (12 Aug 2020)
Sequence version 3 (03 Mar 2009)
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Protein

Cubilin homolog

Gene

Cubn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required in the nephrocyte for normal uptake of proteins and elimination of toxins, and for maintenance of endocytic trafficking structures. May function together with Amnionless.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi1026Calcium 1By similarity1
Metal bindingi1034Calcium 1By similarity1
Metal bindingi1080Calcium 1By similarity1
Metal bindingi1148Calcium 2By similarity1
Metal bindingi1156Calcium 2By similarity1
Metal bindingi1197Calcium 2By similarity1
Metal bindingi1264Calcium 3By similarity1
Metal bindingi1272Calcium 3By similarity1
Metal bindingi1316Calcium 3By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cubilin homologImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CubnImported
ORF Names:CG32702Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0052702, Cubn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500433646229 – 3750Cubilin homologAdd BLAST3722

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi51N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi123N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi158 ↔ 169PROSITE-ProRule annotation
Disulfide bondi163 ↔ 178PROSITE-ProRule annotation
Disulfide bondi180 ↔ 189PROSITE-ProRule annotation
Disulfide bondi196 ↔ 212PROSITE-ProRule annotation
Disulfide bondi206 ↔ 221PROSITE-ProRule annotation
Disulfide bondi223 ↔ 232PROSITE-ProRule annotation
Glycosylationi424N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi430 ↔ 441PROSITE-ProRule annotation
Disulfide bondi435 ↔ 451PROSITE-ProRule annotation
Glycosylationi448N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi453 ↔ 462PROSITE-ProRule annotation
Disulfide bondi469 ↔ 480PROSITE-ProRule annotation
Disulfide bondi474 ↔ 491PROSITE-ProRule annotation
Disulfide bondi493 ↔ 502PROSITE-ProRule annotation
Disulfide bondi509 ↔ 535PROSITE-ProRule annotation
Glycosylationi542N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi548N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi562 ↔ 584PROSITE-ProRule annotation
Glycosylationi609N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi627 ↔ 654PROSITE-ProRule annotation
Disulfide bondi681 ↔ 701PROSITE-ProRule annotation
Disulfide bondi744 ↔ 770PROSITE-ProRule annotation
Disulfide bondi853 ↔ 879PROSITE-ProRule annotation
Glycosylationi871N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi913 ↔ 933PROSITE-ProRule annotation
Disulfide bondi978 ↔ 1004PROSITE-ProRule annotation
Disulfide bondi1031 ↔ 1058PROSITE-ProRule annotation
Disulfide bondi1100 ↔ 1126PROSITE-ProRule annotation
Glycosylationi1119N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1152N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1153 ↔ 1175PROSITE-ProRule annotation
Disulfide bondi1216 ↔ 1242PROSITE-ProRule annotation
Disulfide bondi1269 ↔ 1292PROSITE-ProRule annotation
Disulfide bondi1332 ↔ 1360PROSITE-ProRule annotation
Glycosylationi1335N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1359N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1413N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1424N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1439 ↔ 1465PROSITE-ProRule annotation
Glycosylationi1491N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1492 ↔ 1513PROSITE-ProRule annotation
Disulfide bondi1554 ↔ 1580PROSITE-ProRule annotation
Disulfide bondi1607 ↔ 1631PROSITE-ProRule annotation
Disulfide bondi1671 ↔ 1697PROSITE-ProRule annotation
Glycosylationi1694N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi1733 ↔ 1755PROSITE-ProRule annotation
Disulfide bondi1792 ↔ 1818PROSITE-ProRule annotation
Disulfide bondi1845 ↔ 1866PROSITE-ProRule annotation
Glycosylationi1908N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2009N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2019 ↔ 2048PROSITE-ProRule annotation
Disulfide bondi2077 ↔ 2100PROSITE-ProRule annotation
Glycosylationi2092N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2128N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2140 ↔ 2167PROSITE-ProRule annotation
Glycosylationi2152N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2231N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2324 ↔ 2346PROSITE-ProRule annotation
Glycosylationi2377N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2385 ↔ 2416PROSITE-ProRule annotation
Glycosylationi2442N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2445 ↔ 2474PROSITE-ProRule annotation
Disulfide bondi2516 ↔ 2542PROSITE-ProRule annotation
Glycosylationi2655N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2671N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2682N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2761 ↔ 2790PROSITE-ProRule annotation
Glycosylationi2772N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2837 ↔ 2859PROSITE-ProRule annotation
Glycosylationi2885N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2889N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi2898 ↔ 2921PROSITE-ProRule annotation
Disulfide bondi2949 ↔ 2973PROSITE-ProRule annotation
Glycosylationi2960N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2965N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi2982N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3011 ↔ 3039PROSITE-ProRule annotation
Glycosylationi3040N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3070 ↔ 3092PROSITE-ProRule annotation
Glycosylationi3074N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3130 ↔ 3157PROSITE-ProRule annotation
Glycosylationi3160N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3184 ↔ 3207PROSITE-ProRule annotation
Disulfide bondi3249 ↔ 3278PROSITE-ProRule annotation
Glycosylationi3256N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3305 ↔ 3327PROSITE-ProRule annotation
Disulfide bondi3368 ↔ 3402PROSITE-ProRule annotation
Glycosylationi3427N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3430 ↔ 3475PROSITE-ProRule annotation
Glycosylationi3543N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3560 ↔ 3579PROSITE-ProRule annotation
Glycosylationi3572N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3623 ↔ 3649PROSITE-ProRule annotation
Glycosylationi3645N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi3676 ↔ 3699PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W332

PRoteomics IDEntifications database

More...
PRIDEi
Q9W332

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed in nephrocytes.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Detected only in garland nephrocytes at the embryonic stage. Highly expressed in both garland and pericardial nephrocytes at the larval stage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0052702, Expressed in midgut and 36 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9W332, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W332, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W332, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0271945

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W332

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini154 – 190EGF-like 1PROSITE-ProRule annotationAdd BLAST37
Domaini192 – 233EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini282 – 308EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST27
Domaini324 – 352EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST29
Domaini426 – 463EGF-like 5PROSITE-ProRule annotationAdd BLAST38
Domaini465 – 503EGF-like 6PROSITE-ProRule annotationAdd BLAST39
Domaini509 – 623CUB 1PROSITE-ProRule annotationAdd BLAST115
Domaini627 – 738CUB 2PROSITE-ProRule annotationAdd BLAST112
Domaini744 – 852CUB 3PROSITE-ProRule annotationAdd BLAST109
Domaini853 – 971CUB 4PROSITE-ProRule annotationAdd BLAST119
Domaini978 – 1095CUB 5PROSITE-ProRule annotationAdd BLAST118
Domaini1100 – 1212CUB 6PROSITE-ProRule annotationAdd BLAST113
Domaini1216 – 1331CUB 7PROSITE-ProRule annotationAdd BLAST116
Domaini1332 – 1434CUB 8PROSITE-ProRule annotationAdd BLAST103
Domaini1439 – 1550CUB 9PROSITE-ProRule annotationAdd BLAST112
Domaini1554 – 1670CUB 10PROSITE-ProRule annotationAdd BLAST117
Domaini1671 – 1788CUB 11PROSITE-ProRule annotationAdd BLAST118
Domaini1792 – 1902CUB 12PROSITE-ProRule annotationAdd BLAST111
Domaini1903 – 2001CUB 13PROSITE-ProRule annotationAdd BLAST99
Domaini2019 – 2139CUB 14PROSITE-ProRule annotationAdd BLAST121
Domaini2140 – 2256CUB 15PROSITE-ProRule annotationAdd BLAST117
Domaini2262 – 2383CUB 16PROSITE-ProRule annotationAdd BLAST122
Domaini2385 – 2512CUB 17PROSITE-ProRule annotationAdd BLAST128
Domaini2516 – 2646CUB 18PROSITE-ProRule annotationAdd BLAST131
Domaini2761 – 2895CUB 19PROSITE-ProRule annotationAdd BLAST135
Domaini2898 – 3010CUB 20PROSITE-ProRule annotationAdd BLAST113
Domaini3011 – 3128CUB 21PROSITE-ProRule annotationAdd BLAST118
Domaini3130 – 3246CUB 22PROSITE-ProRule annotationAdd BLAST117
Domaini3249 – 3364CUB 23PROSITE-ProRule annotationAdd BLAST116
Domaini3368 – 3512CUB 24PROSITE-ProRule annotationAdd BLAST145
Domaini3522 – 3615CUB 25PROSITE-ProRule annotationAdd BLAST94
Domaini3623 – 3736CUB 26PROSITE-ProRule annotationAdd BLAST114

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4292, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000167878

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000172_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W332

KEGG Orthology (KO)

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KOi
K14616

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHLEYHP

Database of Orthologous Groups

More...
OrthoDBi
4105at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W332

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041, CUB, 21 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.290, 26 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR035914, Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431, CUB, 19 hits
PF00008, EGF, 2 hits
PF07645, EGF_CA, 3 hits
PF12661, hEGF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00042, CUB, 23 hits
SM00181, EGF, 8 hits
SM00179, EGF_CA, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49854, SSF49854, 26 hits
SSF57184, SSF57184, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 23 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 4 hits
PS01187, EGF_CA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9W332-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGAARSRLL LCWTLLAIIT DTWPIAEGFV NSPKIISKDG NLIFESGANR
60 70 80 90 100
NISFRLSGNS RLTINEELDV MELLLATSGS KKRSGGKDDD FVDARELADQ
110 120 130 140 150
LADFNRRAFG ANGLSAMLRV QQNRTRGSMA LLRRFQTRLR ALENRVDRMK
160 170 180 190 200
TDLEANSCAS GPCENGGTCY NTYTGFRCQC RSAFEGTKCE MDVNECALYE
210 220 230 240 250
GTDLGCQNGG QCQNHFGTYS CLCQPGWHGM HCTQRKADCS QSSAWELCGH
260 270 280 290 300
GSCVPSADDA GYRCICEPGW KTNGLTPICG EDVDECSDSA AHKPCSTSCI
310 320 330 340 350
NLPGSFTCAP CPAGLTGNGV SCRDLDECQT NNGGCSLSPK VDCINTYGSY
360 370 380 390 400
HCGECPVGWT GDGRKCERSP QDIDIPAGQT PRTCPAGNNP CYPTASCFLI
410 420 430 440 450
SGTTSCRCPM GMVGTGYGPN GCVNGTTTNC KENPCLNGGI CLFAGPSNYT
460 470 480 490 500
CLCPIGFRPP ICEPQPSPCD QHPCKNGGRC RPTTSGDLFV CQCLPGYRGR
510 520 530 540 550
LCETRFSSCN GMLSAQSGRL RYPPEGTGYE HNAQCAWVIR TNESLVVNVT
560 570 580 590 600
FNSFDVEDST ECRFDWLQIN DGRSAAAQII GRYCGNHLPH GGNIVSSGNQ
610 620 630 640 650
LYLWFRSDNS TAKEGFDLTW NSMEPQCGGR LNFETHGTLA SPGSPGNYPK
660 670 680 690 700
NRDCRWQLVA PTTKRIKLTF FSLQLEQHAN CNFDYVLIKD SISGRELAKY
710 720 730 740 750
CTTGAPAPLL LPTHLAEIHF HSDAEGSDTG FQLHYSVEER VPGCGGVYTA
760 770 780 790 800
KEGTISESST ANTEPGGVSC EYEIHLAVGE QVVIQFARLE LDPLDCLEVL
810 820 830 840 850
DITDEGGSIL QEKICGSDAS RLNPPTFTSE FNRLKIKFYA RAGSFQLNYR
860 870 880 890 900
MACDYKLNNE QGTITSPGYP NLTRSDRICT YTISTATNTV ISLKRIDFQL
910 920 930 940 950
TNGESDDDDN DECLTTNLRI NDGLNRKILG PYCGKNQPEE NFVSETNYLQ
960 970 980 990 1000
LHLSTDVDSM GRGFKFEYRA LATGNDKCGG VHTRSGDHIR LPVHDDSYAG
1010 1020 1030 1040 1050
EATCYWVIMA PANKAIRLHW NSFSLENAVD CIYDYLEIYD SLGAQVNDER
1060 1070 1080 1090 1100
SKPLAKYCGN SVPEDLLSHS RQLVLKFVSD YSESDGGFDL TYTFEDRAKC
1110 1120 1130 1140 1150
GGHIHASSGE LTSPEYPANY SAGLDCDWHL TGTIDHLLEI QVENFELEQS
1160 1170 1180 1190 1200
PNCSADYLEV RNGGGTDSPL IGRFCGRDIP ARIPGFSHEM RLILHTDSAI
1210 1220 1230 1240 1250
NGRGFRLRWR IFAFGCGGSL RSNMGAISSP RYPNSYPNMA HCEWRISLHP
1260 1270 1280 1290 1300
GSGISLLIED LELEGLSNCY YDSVKIYTGI KLPNQSPCKV LCKDDDLHNP
1310 1320 1330 1340 1350
LIQLENNKGT IVFDSDASNT FRGFRISYKA NCIRNLTATT GTIESLNYME
1360 1370 1380 1390 1400
PFWETIPINC SWTIRAPKGN RVLVEVSHLA RHEQHVPTAT MPGGLYIVDG
1410 1420 1430 1440 1450
RNVQEIVTPQ AMNISGEVLT VVHNASNVNF QLDYRIDGCM EELRGTFGFF
1460 1470 1480 1490 1500
QSPNYPKMYP NNLECYWLIT VEQDSAIELT INNIDLEDSP NCTKDALTVS
1510 1520 1530 1540 1550
NHKNSVEVHE RHCGSTTKLV ITSSGHRLHV RFISDNSHNG LGFEATYRTV
1560 1570 1580 1590 1600
KATCGGKLTA RNGVIESPNY PLNYPAHSRC EWQVEVSQHH QIVFEMADLN
1610 1620 1630 1640 1650
LESGYDCNWD YLEAYDLTED DTEGERLFKV CGDETEDDKL LSSSSNMAVV
1660 1670 1680 1690 1700
RFISDDSVSK KGFRLHFHES CGQTIIVDET MFDYIQMSRQ AARNESCLWV
1710 1720 1730 1740 1750
FQAVEPNKRI IFTPTHVKLR EDANQQYPTE GDCLNVGVKI YEGTEPQGTP
1760 1770 1780 1790 1800
RLKFCRSHPP ALISNGQALT VSVPLQLVEE FQGHYMTMDT SCGSIYNALS
1810 1820 1830 1840 1850
GKFTSPYYPA SYPPNIECLW LLEASMGNSL SLTLESMDLE KSESCNRDYL
1860 1870 1880 1890 1900
EVREESESGQ LIGVYCGNEV PGVIHSRGAI WMKFKSDDDN VGEGFMASYN
1910 1920 1930 1940 1950
YEHHNELNGT EGTIESPHFP SKFQDPVPYS WRITVDKEYV VAISLLYLRD
1960 1970 1980 1990 2000
LDQPHLNFYD GYSDIGARIE VTDPDETIIS STNVVYFTSN RGPFKLNWNR
2010 2020 2030 2040 2050
LSKEALRSNR TAEERTRQCG NQLITIDRSV IGFHSPGYPN GYEQDLNCFW
2060 2070 2080 2090 2100
TLVPSNPAMH AVLTLSQIDL EIFSEDCIAD YVKIFSGSDL QNWSELRTLC
2110 2120 2130 2140 2150
SLPTESSDRV FHGRPYLRVE FVTDPSVNKT GFNGIVRTAC GSEITASKGL
2160 2170 2180 2190 2200
VNITEILKVL PRPNHDCVWT IKVRQGRRIK IDFPDFQLQN NMASGSSDCR
2210 2220 2230 2240 2250
NYLLLRNGND EDSPFLGRGK YCEDVVHEVL NTSSNKAYIK FHFASPPRFL
2260 2270 2280 2290 2300
VSFRFEELRY TDSGRIRLSA SGDEQFISSP YYPHLPHPHS ECIWIVEAPP
2310 2320 2330 2340 2350
EHRIMLHFQG AFDMLDATGE PEECQREFVL INDGSTELRP EIGRYCGNRK
2360 2370 2380 2390 2400
PDTIYSTGNQ MRIRYFTDVS EPHMGFNASL SVARCGGSFH SPEGVIASPS
2410 2420 2430 2440 2450
RDLLLIHEEG KQLQECVYTI ELEKGSTIDL TSEYLQIPTL RNGSCSQRNH
2460 2470 2480 2490 2500
LMLEEMDAFG LDGEEKIVDT LMLCGMEAKH LISETNKIVF RYRFLDGIPA
2510 2520 2530 2540 2550
ENQGFRLKYT SLGSRCGETI YASVGVLQTP GYPLGVPHPM HCKWQVQVPK
2560 2570 2580 2590 2600
GRRVRLEILD FNTGTNMDLR GRLGFRGRLT VANDFKMQSI LGRYNVDPPA
2610 2620 2630 2640 2650
EVLSSDNTMG IDAFLLPIVQ NHGIKLRFSA YGSSSCPGFT VMMNEVADIQ
2660 2670 2680 2690 2700
FQRFNISRPL HCSYKVVPPS NSTLLIRVKE YNTTSVMMWN THMCALLSPL
2710 2720 2730 2740 2750
KFNRLEQEEE LMERILCDYQ SPAPGKPLPS IRLPFPIQLV VSASARNAMT
2760 2770 2780 2790 2800
NLVLSYSTQS CGGVIILEPG DNMTVHQPSG MVSAAGAIDC AWAIGPYTDA
2810 2820 2830 2840 2850
SGEDEVLVPQ DIQLEVSVYN VNLPAPSPSA QSPEAPCLHH YLKVYNGPDQ
2860 2870 2880 2890 2900
NSPSLGLFCN QATAVNMVVE RGLFLEYHSD SFSANATFNV SIKYGSGCGG
2910 2920 2930 2940 2950
KLVYPYRAID FAEQYKNNVE CIWEVEATMG YHIGLTFQGR FYIEDSPGCT
2960 2970 2980 2990 3000
KDYLLVQQRN ETTGNWTDLQ RICGRVAPEM INTTSPYLRL IFRSDGDVVA
3010 3020 3030 3040 3050
DGFLAKFERN CGGLLYADST EQELASPGFP NGYEKYLQCN WTIVPRSPSM
3060 3070 3080 3090 3100
GGVLVSFVNF DLEQGPISVC LYDNLTVTTK DKGKDPQQTT LCGVKHNHEY
3110 3120 3130 3140 3150
RGKEYVNLLL RTDGSYSGRG FTLLYTSRLC GGIISRTSMV ESPVQHTDNT
3160 3170 3180 3190 3200
LPPGSDCYWN LTAPAGYKFN IKFLFIDFEA NSNCAYDGVE VFSGPIPDER
3210 3220 3230 3240 3250
YRWGRFCGRI NEDLPLISIP QERGIIHSFS DDRDPSRGFR ALVRVMPNCD
3260 3270 3280 3290 3300
EKISLNGSSR YVYSKFNNAG GYQNDLDCQI VFRVNPDQQI SVEFSNFHVQ
3310 3320 3330 3340 3350
DTDGCRSDYV ELRDGGGTFA DIIGRFCGQN QPPTLRTTRH TLYMRFVTDN
3360 3370 3380 3390 3400
KVTDTGFQVT INAIPRLCGS SEITLSADGT KEVTINSPAR TPGGNYPNGV
3410 3420 3430 3440 3450
SCFWKIKGDS LLRVQFVNFD LHGPNQNGSC VDDYLKIYNS EDAPLLEQGL
3460 3470 3480 3490 3500
GTDLVFNGQT SSKNGFGFAT EHVYCGNVKP DIYYGRSSEV YLKFRSKGLE
3510 3520 3530 3540 3550
QHGGFQLQVA LNSNRERHYD GLQGRVHLSQ SADCNIIIRA PPNYTLSLYY
3560 3570 3580 3590 3600
TELIFGTYDC EMENLEVFDR TNRSLQRVCS FVDMGKSLFS NANELRLQMK
3610 3620 3630 3640 3650
TGSYLTSLDL TYLASPVEKG PGCGGQFYNT EGIFSNPFYP NNVRNNSECQ
3660 3670 3680 3690 3700
WIVRVPSNNV VFLTFEVFNL GSKTTCHTDY LQILEQDATG EEREMRRFCG
3710 3720 3730 3740 3750
EDNPKYYKSR RSQVLVRFHK TVNYDGIGWV IRFAGVYSDH QIPRHLLGGS
Length:3,750
Mass (Da):418,179
Last modified:March 3, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5AB91F68084C5B6C
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL89938 differs from that shown. Reason: Frameshift.Curated
The sequence AAL89938 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46505.3
AY084200 mRNA Translation: AAL89938.1 Sequence problems.

NCBI Reference Sequences

More...
RefSeqi
NP_727348.2, NM_167193.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0273437; FBpp0271945; FBgn0052702

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
326235

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG32702

UCSC genome browser

More...
UCSCi
CG32702-RB, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014298 Genomic DNA Translation: AAF46505.3
AY084200 mRNA Translation: AAL89938.1 Sequence problems.
RefSeqiNP_727348.2, NM_167193.2

3D structure databases

SMRiQ9W332
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9W332, 4 interactors
STRINGi7227.FBpp0271945

Proteomic databases

PaxDbiQ9W332
PRIDEiQ9W332

Genome annotation databases

EnsemblMetazoaiFBtr0273437; FBpp0271945; FBgn0052702
GeneIDi326235
KEGGidme:Dmel_CG32702
UCSCiCG32702-RB, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8029
FlyBaseiFBgn0052702, Cubn

Phylogenomic databases

eggNOGiKOG4292, Eukaryota
GeneTreeiENSGT00940000167878
HOGENOMiCLU_000172_1_0_1
InParanoidiQ9W332
KOiK14616
OMAiFHLEYHP
OrthoDBi4105at2759
PhylomeDBiQ9W332

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
326235, 0 hits in 5 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
326235

Protein Ontology

More...
PROi
PR:Q9W332

Gene expression databases

BgeeiFBgn0052702, Expressed in midgut and 36 other tissues
ExpressionAtlasiQ9W332, baseline and differential
GenevisibleiQ9W332, DM

Family and domain databases

CDDicd00041, CUB, 21 hits
Gene3Di2.60.120.290, 26 hits
InterProiView protein in InterPro
IPR000859, CUB_dom
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR035914, Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431, CUB, 19 hits
PF00008, EGF, 2 hits
PF07645, EGF_CA, 3 hits
PF12661, hEGF, 1 hit
SMARTiView protein in SMART
SM00042, CUB, 23 hits
SM00181, EGF, 8 hits
SM00179, EGF_CA, 7 hits
SUPFAMiSSF49854, SSF49854, 26 hits
SSF57184, SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 2 hits
PS01180, CUB, 23 hits
PS00022, EGF_1, 3 hits
PS01186, EGF_2, 4 hits
PS50026, EGF_3, 4 hits
PS01187, EGF_CA, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCUBN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W332
Secondary accession number(s): Q8T4G4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 11, 2016
Last sequence update: March 3, 2009
Last modified: August 12, 2020
This is version 154 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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