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Entry version 170 (19 Jan 2022)
Sequence version 2 (01 Mar 2001)
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Protein
Submitted name:

LP03320p

Gene

sktl

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinasePROSITE-ProRule annotation, Transferase
LigandATP-bindingPROSITE-ProRule annotation, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-1660499, Synthesis of PIPs at the plasma membrane
R-DME-201688, WNT mediated activation of DVL
R-DME-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-8856828, Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LP03320pImported
Submitted name:
Skittles, isoform AImported (EC:2.7.1.68Imported)
Submitted name:
Skittles, isoform BImported
Submitted name:
Skittles, isoform CImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:sktlImported
Synonyms:17Imported, 25Imported, Dmel\CG9985Imported, famImported, l(2)05475Imported, l(2)k12405Imported, PIP5-kinaseImported, PIP5KImported, PIP5K 57B6Imported, skiImported, SKTLImported, SktlImported
ORF Names:CG9985Imported, Dmel_CG9985Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0016984, sktl

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
VectorBase:FBgn0016984

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0016984, Expressed in saliva-secreting gland and 75 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W2R3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071491

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini155 – 573PIPKInterPro annotationAdd BLAST419

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 74DisorderedSequence analysisAdd BLAST74
Regioni105 – 139DisorderedSequence analysisAdd BLAST35
Regioni423 – 446DisorderedSequence analysisAdd BLAST24
Regioni577 – 612DisorderedSequence analysisAdd BLAST36
Regioni640 – 714DisorderedSequence analysisAdd BLAST75

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 41Basic and acidic residuesSequence analysisAdd BLAST41
Compositional biasi105 – 129Polar residuesSequence analysisAdd BLAST25
Compositional biasi584 – 612Polar residuesSequence analysisAdd BLAST29
Compositional biasi640 – 665Polar residuesSequence analysisAdd BLAST26
Compositional biasi673 – 714Polar residuesSequence analysisAdd BLAST42

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0229, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154703

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004312_3_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
SMCASPM

Database of Orthologous Groups

More...
OrthoDBi
1562683at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023610, PInositol-4-P-5-kinase
IPR002498, PInositol-4-P-5-kinase_core
IPR027484, PInositol-4-P-5-kinase_N

The PANTHER Classification System

More...
PANTHERi
PTHR23086, PTHR23086, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01504, PIP5K, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00330, PIPKc, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51455, PIPK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W2R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDTRVELELE PVGKQDRLKD QPDDENEPLE NQLELEQEHK SLLTPVKIPP
60 70 80 90 100
AQTASPDQEA TPSTPPPMSL QPGTSRQLFR DAAMAHGGQE TTSLLQQELN
110 120 130 140 150
NIAATQTPAS KLRSASSTLD ASISRNPSTT GGKHEKKLGH RRVAEGGEVT
160 170 180 190 200
YKKIQSKQIM GSIQLGIQHT VGSLASKPKR DLLMNDFWEM ETISFPPDGS
210 220 230 240 250
SITPAHHYND FRFKVYAPIA FRYFRDLFGI APDDFLMSMC ASPLRELSNP
260 270 280 290 300
GASGSIFYLT TDDEFIIKTV QKKECEFLQK LLPGYYMNLS QNPRTLLPKF
310 320 330 340 350
FGLYCFHYNS KNVRLVAMNN LLPSDIKMHC KYDLKGSSFR RKASKAERQK
360 370 380 390 400
ASPTFKDLDF AEHHPNGIFL ETDKYNALMS TIKRDCMVLE SFQIMDYSLL
410 420 430 440 450
VGIHNLDLAA KEKREERILN ARAKLQRKES AAQGPPSLNP DDDAPEADQN
460 470 480 490 500
QLQAVASYAS IPGTSAGAAL NRTRSMNRQR LVAHSTALES ITADMDVPLE
510 520 530 540 550
EDEDVPAGGI PARSENDERL ILYIGIIDIL QSYRLEKKLE HTFKSILYNG
560 570 580 590 600
DTVSVCRPSF YAKRFQDAMG KQVFKKTPTF PLKHSPSKRK TSTTQLRSPA
610 620 630 640 650
SRLPPLSTPT NAVRQPIMTM SGMSTPPPAF DDISEEDITA ASTSSLQQQR
660 670 680 690 700
SSNQSNNNRG ETEVALREGN NTRGGSGEPS STYHTQYSYD SSGRTGSALT
710 720 730 740 750
SDYSDDESTG TDLSSRLPKL RTHRLTKTSV QVTTVGYVEG VDTPPKGGQD
760 770 780 790
VVHADVNGKT TMTTTTMLTT TKTAHIQAPS YTSTLVLNDL PR
Length:792
Mass (Da):87,758
Last modified:March 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i45F7584FA2B008A4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46627.2
AY058737 mRNA Translation: AAL13966.1
AE013599 Genomic DNA Translation: AHN56441.1
AE013599 Genomic DNA Translation: AHN56442.1

NCBI Reference Sequences

More...
RefSeqi
NP_001286646.1, NM_001299717.1
NP_001286647.1, NM_001299718.1
NP_477206.1, NM_057858.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071563; FBpp0071491; FBgn0016984
FBtr0342801; FBpp0309638; FBgn0016984
FBtr0344196; FBpp0310605; FBgn0016984

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG9985

UCSC genome browser

More...
UCSCi
CG9985-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46627.2
AY058737 mRNA Translation: AAL13966.1
AE013599 Genomic DNA Translation: AHN56441.1
AE013599 Genomic DNA Translation: AHN56442.1
RefSeqiNP_001286646.1, NM_001299717.1
NP_001286647.1, NM_001299718.1
NP_477206.1, NM_057858.4

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9W2R3, 2 interactors
STRINGi7227.FBpp0071491

Genome annotation databases

EnsemblMetazoaiFBtr0071563; FBpp0071491; FBgn0016984
FBtr0342801; FBpp0309638; FBgn0016984
FBtr0344196; FBpp0310605; FBgn0016984
GeneIDi37356
KEGGidme:Dmel_CG9985
UCSCiCG9985-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37356
FlyBaseiFBgn0016984, sktl
VEuPathDBiVectorBase:FBgn0016984

Phylogenomic databases

eggNOGiKOG0229, Eukaryota
GeneTreeiENSGT00940000154703
HOGENOMiCLU_004312_3_1_1
OMAiSMCASPM
OrthoDBi1562683at2759

Enzyme and pathway databases

ReactomeiR-DME-1660499, Synthesis of PIPs at the plasma membrane
R-DME-201688, WNT mediated activation of DVL
R-DME-399955, SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-DME-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-DME-8856828, Clathrin-mediated endocytosis

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
37356, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37356

Gene expression databases

BgeeiFBgn0016984, Expressed in saliva-secreting gland and 75 other tissues

Family and domain databases

Gene3Di3.30.800.10, 1 hit
InterProiView protein in InterPro
IPR023610, PInositol-4-P-5-kinase
IPR002498, PInositol-4-P-5-kinase_core
IPR027484, PInositol-4-P-5-kinase_N
PANTHERiPTHR23086, PTHR23086, 1 hit
PfamiView protein in Pfam
PF01504, PIP5K, 1 hit
SMARTiView protein in SMART
SM00330, PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455, PIPK, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W2R3_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W2R3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: January 19, 2022
This is version 170 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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