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Entry version 187 (07 Apr 2021)
Sequence version 1 (01 May 2000)
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Protein
Submitted name:

Defective proventriculus, isoform A

Gene

dve

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-bindingUniRule annotation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-111465, Apoptotic cleavage of cellular proteins
R-DME-4551638, SUMOylation of chromatin organization proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Defective proventriculus, isoform AImported
Submitted name:
IP14647pImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dveImported
Synonyms:depImported, Dmel\CG5799Imported, DVEImported, DveImported, Dve-sImported, l(2)01738Imported, SATB1Imported
ORF Names:CG5799Imported, Dmel_CG5799Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0020307, dve

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

NucleusUniRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0020307, Expressed in embryo and 62 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W268, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071689

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W268

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini555 – 625HomeoboxInterPro annotationAdd BLAST71
Domaini927 – 997HomeoboxInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni84 – 209DisorderedSequence analysisAdd BLAST126
Regioni535 – 559DisorderedSequence analysisAdd BLAST25
Regioni650 – 675DisorderedSequence analysisAdd BLAST26
Regioni691 – 780DisorderedSequence analysisAdd BLAST90
Regioni805 – 856DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi92 – 140PolarSequence analysisAdd BLAST49
Compositional biasi157 – 183PolarSequence analysisAdd BLAST27
Compositional biasi184 – 205PolyampholyteSequence analysisAdd BLAST22
Compositional biasi691 – 705PolyampholyteSequence analysisAdd BLAST15
Compositional biasi706 – 721PolarSequence analysisAdd BLAST16
Compositional biasi749 – 780PolyampholyteSequence analysisAdd BLAST32
Compositional biasi821 – 836AcidicSequence analysisAdd BLAST16

Keywords - Domaini

HomeoboxUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3755, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008096

Identification of Orthologs from Complete Genome Data

More...
OMAi
EPKNVQF

Database of Orthologous Groups

More...
OrthoDBi
855819at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00086, homeodomain, 2 hits
cd11585, SATB1_N, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.20.710, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR039673, SATB1/SATB2
IPR038224, SATB_ULD_sf
IPR032392, ULD

The PANTHER Classification System

More...
PANTHERi
PTHR15116, PTHR15116, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00046, Homeodomain, 2 hits
PF16534, ULD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00389, HOX, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50071, HOMEOBOX_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9W268-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFQSAMETF AEAWVAANAG QQSQALALTR AVNAAAVVAS ANAKSPNASS
60 70 80 90 100
SASASLADLA VKKEHSISPP HSVVSVGVGV AGEDQHRRSS LQGVQEKLTQ
110 120 130 140 150
LQMQQQHHQQ QQQQQQQQQQ QHQQQQQHHH HQQQAQQAGA GVGSGELAGR
160 170 180 190 200
RSSEGTPPTA HPPTNSEGQA LSSSTASSSQ NATPKSDRER ERERERDREE
210 220 230 240 250
RVERGSISCL PPAALGMAVG VQQAQHQEKL LSHPALDSRR EFDVSKVNPK
260 270 280 290 300
SLPLHCVVES VHSLHASLTI DTRQPWKRRP NIETDSYVII AAATPWSEIV
310 320 330 340 350
QTALQRLGYS QEVANTARGS LIIKHWKPIP LEQISDNPAV PVSDIVGELT
360 370 380 390 400
SVITLRIVIL RPKTSPFGEI KDKLLKLLVL QSHAVLRSTG CPLDEVTLSQ
410 420 430 440 450
ICRSSHQNTY ALPGGEISDE LRRKFDQWWS NQLSPQATAM TPKMLPFMTG
460 470 480 490 500
PSAVPVPVAV PGEMDFPVGT AMAAAAAAAA HAAAAGGAAG GNPLGSMGSR
510 520 530 540 550
ESLLLANEAA HHAGAGQAPG PGHHGSMLVH PMHASMHHHH HHGGGGGHGP
560 570 580 590 600
PYPNQKTRMR TSFDPEMELP KLQKWFADNP HPSRQQIQTY VVQLNALESR
610 620 630 640 650
RGRKPLDVNN VVYWFKNARA AQKRAEMRGG SLGSAISALG HAAMNGYLSQ
660 670 680 690 700
HAPLGQNSSS SAGSQPMSMG NLSMSHDYLK SPLSLKSEDI DTMSQHSDDM
710 720 730 740 750
DEEQSRPNTP QLPLSLTTHE RHRSSPLMDE DEDEAGEQQQ PQEAKSDGMN
760 770 780 790 800
GSVKDEERQE KSRDELQDNE KENSNGEDRH LDADAQMEAS SNLNNNHNNS
810 820 830 840 850
SLHIEQEVGS TPKRSTPKEE DDDLDMDEDE EDNENDASHL DEFRSPSPDL
860 870 880 890 900
AGGVVPHKDQ LPFPMVPNSM FSQSFMYMSH YIPAFGQAAA GHPHHHAAAA
910 920 930 940 950
AAAAGIQPNA LMGGGGLNLS SISNEERRKR NRTFIDPVTE VPKLEQWFAM
960 970 980 990 1000
NTHPSHNLIL KYTEDLNTMP YRQKFPRLES KNVQFWFKNR RAKCKRLKMS
1010 1020
LYDSNQCAQL GGLGSFVPKY EERD
Length:1,024
Mass (Da):111,982
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1F0A14801171C8A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8MLT6Q8MLT6_DROME
Defective proventriculus, isoform B
dve dep, Dmel\CG5799, DVE, Dve, Dve-s
780Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46827.1
BT025086 mRNA Translation: ABE73257.1

NCBI Reference Sequences

More...
RefSeqi
NP_477242.1, NM_057894.4

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0071775; FBpp0071689; FBgn0020307

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37546

UCSC genome browser

More...
UCSCi
CG5799-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46827.1
BT025086 mRNA Translation: ABE73257.1
RefSeqiNP_477242.1, NM_057894.4

3D structure databases

SMRiQ9W268
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9W268, 5 interactors
STRINGi7227.FBpp0071689

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
37546

Genome annotation databases

EnsemblMetazoaiFBtr0071775; FBpp0071689; FBgn0020307
GeneIDi37546
UCSCiCG5799-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37546
FlyBaseiFBgn0020307, dve

Phylogenomic databases

eggNOGiKOG3755, Eukaryota
GeneTreeiENSGT00390000008096
OMAiEPKNVQF
OrthoDBi855819at2759

Enzyme and pathway databases

ReactomeiR-DME-111465, Apoptotic cleavage of cellular proteins
R-DME-4551638, SUMOylation of chromatin organization proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
37546, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37546

Gene expression databases

BgeeiFBgn0020307, Expressed in embryo and 62 other tissues

Family and domain databases

CDDicd00086, homeodomain, 2 hits
cd11585, SATB1_N, 1 hit
Gene3Di3.10.20.710, 1 hit
InterProiView protein in InterPro
IPR009057, Homeobox-like_sf
IPR001356, Homeobox_dom
IPR039673, SATB1/SATB2
IPR038224, SATB_ULD_sf
IPR032392, ULD
PANTHERiPTHR15116, PTHR15116, 1 hit
PfamiView protein in Pfam
PF00046, Homeodomain, 2 hits
PF16534, ULD, 1 hit
SMARTiView protein in SMART
SM00389, HOX, 2 hits
SUPFAMiSSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS50071, HOMEOBOX_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W268_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W268
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: April 7, 2021
This is version 187 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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