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UniProtKB - Q9W266 (WDP_DROME)
Protein
Protein windpipe
Gene
wdp
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Plays a role in negative regulation of the JAK/STAT pathway by binding to the receptor dome and promoting its internalization for subsequent lysosomal degradation, thereby reducing JAK/STAT signaling.
1 PublicationGO - Biological processi
- negative regulation of receptor signaling pathway via JAK-STAT Source: UniProtKB
- negative regulation of stem cell proliferation Source: UniProtKB
- positive regulation of endocytosis Source: UniProtKB
- synaptic target recognition Source: FlyBase
- tissue homeostasis Source: UniProtKB
- trachea development Source: FlyBase
Enzyme and pathway databases
Reactomei | R-DME-193634, Axonal growth inhibition (RHOA activation) R-DME-388844, Receptor-type tyrosine-protein phosphatases |
SignaLinki | Q9W266 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein windpipe1 Publication |
Gene namesi | Name:wdpImported ORF Names:CG3413Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034718, wdp |
VEuPathDBi | VectorBase:FBgn0034718 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Single-pass type I membrane protein Curated
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 21 – 451 | ExtracellularCuratedAdd BLAST | 431 | |
Transmembranei | 452 – 472 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 473 – 677 | CytoplasmicCuratedAdd BLAST | 205 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Homozygotes are semi-lethal with a few escapers displaying no visual phenotype but showing disruption of midgut homeostasis under normal conditions and enhanced tissue damage-induced midgut regeneration.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_0000434607 | 21 – 677 | Protein windpipeSequence analysisAdd BLAST | 657 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 53 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 80 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 145 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Glycosylationi | 170 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q9W266 |
PRIDEi | Q9W266 |
PTM databases
GlyGeni | Q9W266, 4 sites |
SwissPalmi | Q9W266 |
Expressioni
Tissue specificityi
In adult intestine, expressed in both small progenitor cells and large nuclei enterocytes (at protein level) (PubMed:25923769). During embryogenesis, restricted to the developing trachea (PubMed:11804792).2 Publications
Developmental stagei
Detected in embryo, third instar larva and adult.1 Publication
Gene expression databases
Bgeei | FBgn0034718, Expressed in adult midgut (Drosophila) and 43 other tissues |
Genevisiblei | Q9W266, DM |
Interactioni
Subunit structurei
Interacts with dome; the interaction promotes internalization of dome and its subsequent lysosomal degradation.
1 PublicationProtein-protein interaction databases
IntActi | Q9W266, 1 interactor |
STRINGi | 7227.FBpp0071760 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 91 – 116 | LRR 1Sequence analysisAdd BLAST | 26 | |
Repeati | 118 – 133 | LRR 2Sequence analysisAdd BLAST | 16 | |
Repeati | 134 – 156 | LRR 3Sequence analysisAdd BLAST | 23 | |
Repeati | 158 – 183 | LRR 4Sequence analysisAdd BLAST | 26 | |
Domaini | 184 – 216 | LRRCTSequence analysisAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 264 – 285 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 298 – 317 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 325 – 385 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 502 – 523 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 539 – 677 | DisorderedSequence analysisAdd BLAST | 139 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 349 – 374 | Basic and acidic residuesSequence analysisAdd BLAST | 26 | |
Compositional biasi | 586 – 612 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 645 – 659 | Polar residuesSequence analysisAdd BLAST | 15 |
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0619, Eukaryota |
HOGENOMi | CLU_024471_0_0_1 |
InParanoidi | Q9W266 |
OMAi | PLELTHM |
OrthoDBi | 284329at2759 |
PhylomeDBi | Q9W266 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf |
PROSITEi | View protein in PROSITE PS51450, LRR, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q9W266-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERVHLTAWL ALFLIVVANA TPTPARTPTG CPADCTCSLS QHTHKPLYHL
60 70 80 90 100
KCNSTRGLRL TEKTFQSTVP VHSIDLSHLN LTRLSHLLDK LPELTSADLS
110 120 130 140 150
HNQLKDLGHL GKGLKRLNLK HNQLTSDKLR KLPQHLQVLN LQHNNITHLP
160 170 180 190 200
LELTHMHQLH QLELSHNAIN CSCQTLEVRN WLVERIVYME HPVVCSYPLE
210 220 230 240 250
FRGRSWLQLK QDEICKKEKY QWFDTEENEL MMGDQPAAVS AEREDEEELG
260 270 280 290 300
KDFLPIVGNP AATAKKVRSP QIPLPSDQVE GSGDLSETNM ELKLPEETVA
310 320 330 340 350
EPEAAESQLV DAAASPSVLE EHIVKDEDED DEGSGSGGGL LIIPDPSKVK
360 370 380 390 400
ITSEDDIDSD GKPEESDVRP LENPENSENP DTVFSNKIGI YEGDQEEKKP
410 420 430 440 450
VEEDNIVPVV MTNLDTGLES DVVTDGPLDS SKESEDILTA KIGKPKDDSS
460 470 480 490 500
AIYYLLAVIG LIVVGLVLFV AIKRCKYDSN AAARDAEAQR QTELLDMDKK
510 520 530 540 550
QLGKPLHKNG HGNGQEHSPL IGEKTKLDEA QIVKKPYENG EAKDGAGQQP
560 570 580 590 600
LLNGNGSANG GTKEAPETGE PAAHEYYPIT PRYPTPQSPR ASKYAQQQQL
610 620 630 640 650
AEQNNNEPDG AYLPSSPKSG RYSPVYSPET GRVKIKLTET PKPKTPMLVT
660 670
RSKSNAGDII TTPVRPIEPT HQVINGH
Sequence cautioni
The sequence AAL13499 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 490 | R → Q in AAN71448 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 518 | S → T in AAN71448 (PubMed:12537569).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF395331 mRNA Translation: AAK77868.1 AE013599 Genomic DNA Translation: AAF46829.1 AE013599 Genomic DNA Translation: AAF46830.1 AE013599 Genomic DNA Translation: AAM68219.1 AE013599 Genomic DNA Translation: AAM68220.1 AE013599 Genomic DNA Translation: AHN56507.1 AY058270 mRNA Translation: AAL13499.1 Different initiation. BT001693 mRNA Translation: AAN71448.1 BT125698 mRNA Translation: ADO16264.1 BT150349 mRNA Translation: AGW52158.1 |
RefSeqi | NP_001286712.1, NM_001299783.1 NP_611661.1, NM_137817.3 NP_726187.1, NM_166524.2 NP_726188.1, NM_166525.2 NP_726189.1, NM_166526.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0071849; FBpp0071760; FBgn0034718 FBtr0071850; FBpp0071761; FBgn0034718 FBtr0071851; FBpp0071762; FBgn0034718 FBtr0071852; FBpp0071763; FBgn0034718 FBtr0342984; FBpp0309748; FBgn0034718 |
GeneIDi | 37548 |
KEGGi | dme:Dmel_CG3413 |
UCSCi | CG3413-RA, d. melanogaster CG3413-RB, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF395331 mRNA Translation: AAK77868.1 AE013599 Genomic DNA Translation: AAF46829.1 AE013599 Genomic DNA Translation: AAF46830.1 AE013599 Genomic DNA Translation: AAM68219.1 AE013599 Genomic DNA Translation: AAM68220.1 AE013599 Genomic DNA Translation: AHN56507.1 AY058270 mRNA Translation: AAL13499.1 Different initiation. BT001693 mRNA Translation: AAN71448.1 BT125698 mRNA Translation: ADO16264.1 BT150349 mRNA Translation: AGW52158.1 |
RefSeqi | NP_001286712.1, NM_001299783.1 NP_611661.1, NM_137817.3 NP_726187.1, NM_166524.2 NP_726188.1, NM_166525.2 NP_726189.1, NM_166526.2 |
3D structure databases
AlphaFoldDBi | Q9W266 |
SMRi | Q9W266 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q9W266, 1 interactor |
STRINGi | 7227.FBpp0071760 |
PTM databases
GlyGeni | Q9W266, 4 sites |
SwissPalmi | Q9W266 |
Proteomic databases
PaxDbi | Q9W266 |
PRIDEi | Q9W266 |
Genome annotation databases
EnsemblMetazoai | FBtr0071849; FBpp0071760; FBgn0034718 FBtr0071850; FBpp0071761; FBgn0034718 FBtr0071851; FBpp0071762; FBgn0034718 FBtr0071852; FBpp0071763; FBgn0034718 FBtr0342984; FBpp0309748; FBgn0034718 |
GeneIDi | 37548 |
KEGGi | dme:Dmel_CG3413 |
UCSCi | CG3413-RA, d. melanogaster CG3413-RB, d. melanogaster |
Organism-specific databases
CTDi | 37548 |
FlyBasei | FBgn0034718, wdp |
VEuPathDBi | VectorBase:FBgn0034718 |
Phylogenomic databases
eggNOGi | KOG0619, Eukaryota |
HOGENOMi | CLU_024471_0_0_1 |
InParanoidi | Q9W266 |
OMAi | PLELTHM |
OrthoDBi | 284329at2759 |
PhylomeDBi | Q9W266 |
Enzyme and pathway databases
Reactomei | R-DME-193634, Axonal growth inhibition (RHOA activation) R-DME-388844, Receptor-type tyrosine-protein phosphatases |
SignaLinki | Q9W266 |
Miscellaneous databases
BioGRID-ORCSi | 37548, 0 hits in 1 CRISPR screen |
GenomeRNAii | 37548 |
PROi | PR:Q9W266 |
Gene expression databases
Bgeei | FBgn0034718, Expressed in adult midgut (Drosophila) and 43 other tissues |
Genevisiblei | Q9W266, DM |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR001611, Leu-rich_rpt IPR032675, LRR_dom_sf |
PROSITEi | View protein in PROSITE PS51450, LRR, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | WDP_DROME | |
Accessioni | Q9W266Primary (citable) accession number: Q9W266 Secondary accession number(s): E1NZE9, Q8IGN2, Q95U72 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 11, 2015 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 164 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase