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UniProtKB - Q9W1X5 (Q9W1X5_DROME)

Entry version 180 (19 Jan 2022)
Sequence version 2 (01 Oct 2002)
Previous versions | rss
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Protein
Submitted name:

GH04942p

Gene

nahoda

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GH04942pImported
Submitted name:
Nahoda, isoform AImported
Submitted name:
Nahoda, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nahodaImported
Synonyms:CT36793Imported, Dmel\CG12781Imported
ORF Names:CG12781Imported, Dmel_CG12781Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0034797, nahoda

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0034797

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1088 – 1111HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi229 ↔ 238PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0034797, Expressed in second segment of antenna (Drosophila) and 39 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...IntActi		Q9W1X5, 4 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0071853

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini198 – 239EGF-likeInterPro annotationAdd BLAST42
Domaini549 – 680DOMONInterPro annotationAdd BLAST132
Domaini767 – 887DOMONInterPro annotationAdd BLAST121
Domaini933 – 1046SEAInterPro annotationAdd BLAST114

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni319 – 590DisorderedSequence analysisAdd BLAST272
Regioni1147 – 1322DisorderedSequence analysisAdd BLAST176

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi324 – 426Basic and acidic residuesSequence analysisAdd BLAST103
Compositional biasi438 – 551Basic and acidic residuesSequence analysisAdd BLAST114
Compositional biasi1167 – 1223Polar residuesSequence analysisAdd BLAST57
Compositional biasi1237 – 1252Polar residuesSequence analysisAdd BLAST16
Compositional biasi1260 – 1302Basic and acidic residuesSequence analysisAdd BLAST43

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4293, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00610000087018

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_269388_0_0_1

Identification of Orthologs from Complete Genome Data

More...OMAi		LIQNSPW

Database of Orthologous Groups

More...OrthoDBi		1064366at2759

Family and domain databases

Conserved Domains Database

More...CDDi		cd09631, DOMON_DOH, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045266, DOH_DOMON
IPR005018, DOMON_domain
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR000082, SEA_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07974, EGF_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00664, DoH, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50836, DOMON, 2 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS50024, SEA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9W1X5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIQSTRHSP FAWTARALLL LATWCCYLGY LGSEAHVALT YPPARKFDLD 
        60         70         80         90        100
FLDNARTKAP CGMPKGSIRT SLLSGTQFNV TWHLAYAHKG GFRLQLLDAL 
       110        120        130        140        150
DRPVLDLTPH VNNSEFVSTD VTAQSYQVKI PNDFECYNCT LRLLRQADEW 
       160        170        180        190        200
TTSYRFWSCA DVDIKLRKDF KETCSGNGKY FPSRCKCDKN FYGPQCQYKD 
       210        220        230        240        250
ECSADSDCGV QGKCVELGGT SLPKKQCYCN FGWFGIGCNK RSPYKSTSLD 
       260        270        280        290        300
LSSYSKKELS PDYHVYWRLL EEQKEIEMVL KVNGTSWVGL GWRPRGMTPE 
       310        320        330        340        350
CKNFPLIRDI GDLTTTLEAS VPEPKSEPEP KSEPEPKSEP EPKSEPEPKS 
       360        370        380        390        400
EPEPKSEPEP KSEPEPKSEP EPKSEPEPKS EPEPKSEPEP KSEPEPKSEP 
       410        420        430        440        450
EPKSEPEPKS EPEPKSEPEP KSEPQPKQLA ELRAAPEPQS EPEPKSEPEP 
       460        470        480        490        500
KSEPEPKSEP EPKSEPEPKS EPEPKSEPEP KSEPEPKSEP EPTSEPEPKS 
       510        520        530        540        550
APEPKSEPEP TSEPEPTSKP EPTSEPEPKS EPEPKSEPEA QSSKSKRVAG 
       560        570        580        590        600
DFAKKGVSSV STSVSYRVST KSDRQRREAD SPKYRLNPYT PRHDFNGMDC 
       610        620        630        640        650
TDIVIGAARG MASRVGDYYS RDRSTPHTDE FFGGKSNLAL GTGFEENGVT 
       660        670        680        690        700
TIIFRKKLVA NEPTDHTLDD ALTHVIWAKG QEPEAYVHVP ASGLETQIAT 
       710        720        730        740        750
VKNFYQQDEL KYHGHQMQRG VTQINFFEKE KSATSTDRND LGTNVLDNDC 
       760        770        780        790        800
YGHWKYPSNC SPQEHTCEYY ASWETVGKGD EMRWHIETSN TQTWTGIGFS 
       810        820        830        840        850
DDQRMSQTDA IIGWVDGRSG RPFLMDTWVL GYAPPKLDDR QDIYNASGRI 
       860        870        880        890        900
EKGVTILEFN RKRVSNDEQD LSFTDDHCLY LFFPVLGGAF NVVNKKIRKH 
       910        920        930        940        950
EQVPPISSQR VCIKSCGKEL ESVFVGTSTP APSRLVYAVA VKLMNLGESY 
       960        970        980        990       1000
EAPKPGTVEF NNLAATISDS FNGILSPLTG YYKTEILGFE KEGSTMVAKV 
      1010       1020       1030       1040       1050
QAMFDKADVE KKHALETNEV DKTSEAAAQK NADVIRSALK DQVATGRVGS 
      1060       1070       1080       1090       1100
LTVDPQFLDF EALEYKSSSE PNAKETLLSF FDLSETRLYI VLGLIAALVL 
      1110       1120       1130       1140       1150
IALIQAFCTI WKTSRKSKNT KEKLIQNSPW KEFASNTNYA FDPYGETEEK 
      1160       1170       1180       1190       1200
NITNSSSGKE KARNRHQSTT SSQQTTLPMS HSPTSKSQMY YESPNGQGKS 
      1210       1220       1230       1240       1250
SNGNGSRGNG RATQESSVGG APYSRSSYAE RAYSLPRQAH QYQQSPASMQ 
      1260       1270       1280       1290       1300
PSGYYTHDRR AARQGSRDRE REREREEERR QRQDRDRDSG YDRSRDDPRQ 
      1310       1320       1330 
NGGSDTPDFY FMPSQRKYSG EVVRVYVDYN KDPKH
Length:1,335
Mass (Da):149,941
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDCC41B39FA3FC829
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4K7Z1A0A0B4K7Z1_DROME
Nahoda, isoform C
nahoda CT36793, Dmel\CG12781, CG12781, Dmel_CG12781
1,148Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46927.2
AY060632 mRNA Translation: AAL28180.1
AE013599 Genomic DNA Translation: AAN16114.1

NCBI Reference Sequences

More...RefSeqi		NP_523815.2, NM_079091.4
NP_726264.1, NM_166569.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0071942; FBpp0071853; FBgn0034797
FBtr0071943; FBpp0071854; FBgn0034797

Database of genes from NCBI RefSeq genomes

More...GeneIDi		37641

UCSC genome browser

More...UCSCi		CG12781-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46927.2
AY060632 mRNA Translation: AAL28180.1
AE013599 Genomic DNA Translation: AAN16114.1
RefSeqiNP_523815.2, NM_079091.4
NP_726264.1, NM_166569.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9W1X5, 4 interactors
STRINGi7227.FBpp0071853

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		37641

Genome annotation databases

EnsemblMetazoaiFBtr0071942; FBpp0071853; FBgn0034797
FBtr0071943; FBpp0071854; FBgn0034797
GeneIDi37641
UCSCiCG12781-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		37641
FlyBaseiFBgn0034797, nahoda
VEuPathDBiVectorBase:FBgn0034797

Phylogenomic databases

eggNOGiKOG4293, Eukaryota
GeneTreeiENSGT00610000087018
HOGENOMiCLU_269388_0_0_1
OMAiLIQNSPW
OrthoDBi1064366at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		37641, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		nahoda, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		37641

Gene expression databases

BgeeiFBgn0034797, Expressed in second segment of antenna (Drosophila) and 39 other tissues

Family and domain databases

CDDicd09631, DOMON_DOH, 2 hits
InterProiView protein in InterPro
IPR045266, DOH_DOMON
IPR005018, DOMON_domain
IPR000742, EGF-like_dom
IPR013111, EGF_extracell
IPR000082, SEA_dom
PfamiView protein in Pfam
PF07974, EGF_2, 1 hit
SMARTiView protein in SMART
SM00664, DoH, 2 hits
PROSITEiView protein in PROSITE
PS50836, DOMON, 2 hits
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 1 hit
PS50024, SEA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W1X5_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W1X5
Secondary accession number(s): Q95SR6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: January 19, 2022
This is version 180 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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