UniProtKB - Q9W1T9 (Q9W1T9_DROME)
Protein
TPR_REGION domain-containing protein
Gene
dctr9
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
GO - Molecular functioni
- RNA polymerase II complex binding Source: GO_Central
- SH2 domain binding Source: FlyBase
GO - Biological processi
- histone modification Source: InterPro
- positive regulation of transcription by RNA polymerase II Source: FlyBase
- regulation of histone H3-K4 methylation Source: GO_Central
- regulation of transcription, DNA-templated Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: TPR_REGION domain-containing proteinInterPro annotation |
Gene namesi | Name:dctr9Imported Synonyms:Dmel\CG9899Imported ORF Names:CG9899Imported, Dmel_CG9899Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0034829, CG9899 |
Subcellular locationi
Nucleus
- Cdc73/Paf1 complex Source: GO_Central
Other locations
- transcriptionally active chromatin Source: FlyBase
Expressioni
Gene expression databases
Bgeei | FBgn0034829, Expressed in testis and 11 other tissues |
ExpressionAtlasi | Q9W1T9, baseline and differential |
Genevisiblei | Q9W1T9, DM |
Interactioni
GO - Molecular functioni
- RNA polymerase II complex binding Source: GO_Central
- SH2 domain binding Source: FlyBase
Protein-protein interaction databases
STRINGi | 7227.FBpp0071879 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 126 – 714 | TPR_REGIONInterPro annotationAdd BLAST | 589 | |
Repeati | 126 – 159 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 161 – 194 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 269 – 302 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 304 – 337 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 377 – 410 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 493 – 526 | TPRPROSITE-ProRule annotationAdd BLAST | 34 | |
Repeati | 577 – 610 | TPRPROSITE-ProRule annotationAdd BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 854 – 922 | DisorderedSequence analysisAdd BLAST | 69 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 864 – 883 | PolyampholyteSequence analysisAdd BLAST | 20 | |
Compositional biasi | 893 – 922 | PolyampholyteSequence analysisAdd BLAST | 30 |
Keywords - Domaini
RepeatARBA annotation, TPR repeatPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG2002, Eukaryota |
GeneTreei | ENSGT00390000005097 |
HOGENOMi | CLU_006386_1_0_1 |
InParanoidi | Q9W1T9 |
OMAi | ARIHYAR |
OrthoDBi | 396755at2759 |
PhylomeDBi | Q9W1T9 |
Family and domain databases
Gene3Di | 1.25.40.10, 4 hits |
InterProi | View protein in InterPro IPR031101, Ctr9 IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR14027, PTHR14027, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 10 hits |
SUPFAMi | SSF48452, SSF48452, 4 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 7 hits PS50293, TPR_REGION, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9W1T9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEKMLSTYIE EAMEFYAIGK GADFKAIIEK GIASCMTTYS TYDRELYKAY
60 70 80 90 100
ALLATYLSNH AFKIIKSRPA FQAMAINCFD QLDSLRQQHD PHLQVTKGFL
110 120 130 140 150
WMLSSSRAQD ADALLISVLR NHPKNILALI GRACLAYNRQ DYIGALGYFK
160 170 180 190 200
SVLLIQPQGM ADVWVGIGHC FWKMGELEKA QLSFQIALEH NGQCLNAALA
210 220 230 240 250
LALVKFEHND EQSYQDGKML LTAAYKENNK NPDLLSILAG MYYADGNHKL
260 270 280 290 300
VWSFAGNAIK FTANKHIESR NYFQIAKSYH ATGQFESAKK YYLLSAKSAP
310 320 330 340 350
DGYILPLVGV AQMYLHEGEL NRSKAFLESF LTSEPDEPVV MDLLAKIYLE
360 370 380 390 400
YKCPEKIDKA IEMLVKVVES ASYHQNTNSW LNLAFAYEQK RLWAHGVNAY
410 420 430 440 450
QKAIDIYLSQ GHQIPIEWLN NLASSQLMAK MPEKALNTLD DALSKCRVMN
460 470 480 490 500
SDNKTTNLLS LQYNRGLVLE ELHMFTLAAE NYKSITKEYS SYHDCYLRLG
510 520 530 540 550
VMAIQKNNHT QAIEHLKDIL VEDNLNMTAR TYMGDCFKGL SLDKFATFNY
560 570 580 590 600
NMILARQSKF TNTYVSMAMG NFCLEKLQNW IAEGNFRAAR KQQEKALQCF
610 620 630 640 650
GKILDCNPKN LWAANGIGAV LSSCNNLSAG GAIFKQIIEC GNKCIPAIIN
660 670 680 690 700
SAHIALVSGQ YRLAIQTYER CLKDHLPKNR VDVMHCLAKA LYDNGDARKA
710 720 730 740 750
KMWLLKVRHL VPHDPFVIFN LGLAIKKETE QALALPRPQL DELMGLDGLL
760 770 780 790 800
KVAFKLFCHI NLNHPKISVR VSAKYAEDCQ NLMTELIAKK RQASESHAME
810 820 830 840 850
EDRVQLQKQR YRDHIEHQRQ QELQREEEER VRRENLKIQR KEVLERTRKI
860 870 880 890 900
ISAPLAPDVP KKSAGNGRAK KNQENGDGKA KKSGPPKKKT RKRAAGKEQE
910 920
DIEPLKKPKS KEFIDTDDDN SE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF46964.2 |
RefSeqi | NP_611764.1, NM_137920.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0071969; FBpp0071879; FBgn0034829 |
GeneIDi | 37676 |
KEGGi | dme:Dmel_CG9899 |
UCSCi | CG9899-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF46964.2 |
RefSeqi | NP_611764.1, NM_137920.3 |
3D structure databases
SMRi | Q9W1T9 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0071879 |
Proteomic databases
PaxDbi | Q9W1T9 |
Genome annotation databases
EnsemblMetazoai | FBtr0071969; FBpp0071879; FBgn0034829 |
GeneIDi | 37676 |
KEGGi | dme:Dmel_CG9899 |
UCSCi | CG9899-RA, d. melanogaster |
Organism-specific databases
FlyBasei | FBgn0034829, CG9899 |
Phylogenomic databases
eggNOGi | KOG2002, Eukaryota |
GeneTreei | ENSGT00390000005097 |
HOGENOMi | CLU_006386_1_0_1 |
InParanoidi | Q9W1T9 |
OMAi | ARIHYAR |
OrthoDBi | 396755at2759 |
PhylomeDBi | Q9W1T9 |
Miscellaneous databases
BioGRID-ORCSi | 37676, 0 hits in 1 CRISPR screen |
GenomeRNAii | 37676 |
Gene expression databases
Bgeei | FBgn0034829, Expressed in testis and 11 other tissues |
ExpressionAtlasi | Q9W1T9, baseline and differential |
Genevisiblei | Q9W1T9, DM |
Family and domain databases
Gene3Di | 1.25.40.10, 4 hits |
InterProi | View protein in InterPro IPR031101, Ctr9 IPR013026, TPR-contain_dom IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
PANTHERi | PTHR14027, PTHR14027, 1 hit |
Pfami | View protein in Pfam PF13181, TPR_8, 1 hit |
SMARTi | View protein in SMART SM00028, TPR, 10 hits |
SUPFAMi | SSF48452, SSF48452, 4 hits |
PROSITEi | View protein in PROSITE PS50005, TPR, 7 hits PS50293, TPR_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9W1T9_DROME | |
Accessioni | Q9W1T9Primary (citable) accession number: Q9W1T9 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | October 1, 2002 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |