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UniProtKB - Q9W1T9 (Q9W1T9_DROME)

Entry version 154 (10 Feb 2021)
Sequence version 2 (01 Oct 2002)
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Protein

TPR_REGION domain-containing protein

Gene

dctr9

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TPR_REGION domain-containing proteinInterPro annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dctr9Imported
Synonyms:Dmel\CG9899Imported
ORF Names:CG9899Imported, Dmel_CG9899Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0034829, CG9899

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9W1T9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0034829, Expressed in testis and 11 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9W1T9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9W1T9, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7227.FBpp0071879

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9W1T9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 714TPR_REGIONInterPro annotationAdd BLAST589
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati126 – 159TPRPROSITE-ProRule annotationAdd BLAST34
Repeati161 – 194TPRPROSITE-ProRule annotationAdd BLAST34
Repeati269 – 302TPRPROSITE-ProRule annotationAdd BLAST34
Repeati304 – 337TPRPROSITE-ProRule annotationAdd BLAST34
Repeati377 – 410TPRPROSITE-ProRule annotationAdd BLAST34
Repeati493 – 526TPRPROSITE-ProRule annotationAdd BLAST34
Repeati577 – 610TPRPROSITE-ProRule annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni854 – 922DisorderedSequence analysisAdd BLAST69

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi864 – 883PolyampholyteSequence analysisAdd BLAST20
Compositional biasi893 – 922PolyampholyteSequence analysisAdd BLAST30

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatARBA annotation, TPR repeatPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2002, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000005097

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006386_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9W1T9

Identification of Orthologs from Complete Genome Data

More...OMAi		ARIHYAR

Database of Orthologous Groups

More...OrthoDBi		396755at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9W1T9

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.25.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR031101, Ctr9
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat

The PANTHER Classification System

More...PANTHERi		PTHR14027, PTHR14027, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13181, TPR_8, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00028, TPR, 10 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48452, SSF48452, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50005, TPR, 7 hits
PS50293, TPR_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W1T9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKMLSTYIE EAMEFYAIGK GADFKAIIEK GIASCMTTYS TYDRELYKAY 
        60         70         80         90        100
ALLATYLSNH AFKIIKSRPA FQAMAINCFD QLDSLRQQHD PHLQVTKGFL 
       110        120        130        140        150
WMLSSSRAQD ADALLISVLR NHPKNILALI GRACLAYNRQ DYIGALGYFK 
       160        170        180        190        200
SVLLIQPQGM ADVWVGIGHC FWKMGELEKA QLSFQIALEH NGQCLNAALA 
       210        220        230        240        250
LALVKFEHND EQSYQDGKML LTAAYKENNK NPDLLSILAG MYYADGNHKL 
       260        270        280        290        300
VWSFAGNAIK FTANKHIESR NYFQIAKSYH ATGQFESAKK YYLLSAKSAP 
       310        320        330        340        350
DGYILPLVGV AQMYLHEGEL NRSKAFLESF LTSEPDEPVV MDLLAKIYLE 
       360        370        380        390        400
YKCPEKIDKA IEMLVKVVES ASYHQNTNSW LNLAFAYEQK RLWAHGVNAY 
       410        420        430        440        450
QKAIDIYLSQ GHQIPIEWLN NLASSQLMAK MPEKALNTLD DALSKCRVMN 
       460        470        480        490        500
SDNKTTNLLS LQYNRGLVLE ELHMFTLAAE NYKSITKEYS SYHDCYLRLG 
       510        520        530        540        550
VMAIQKNNHT QAIEHLKDIL VEDNLNMTAR TYMGDCFKGL SLDKFATFNY 
       560        570        580        590        600
NMILARQSKF TNTYVSMAMG NFCLEKLQNW IAEGNFRAAR KQQEKALQCF 
       610        620        630        640        650
GKILDCNPKN LWAANGIGAV LSSCNNLSAG GAIFKQIIEC GNKCIPAIIN 
       660        670        680        690        700
SAHIALVSGQ YRLAIQTYER CLKDHLPKNR VDVMHCLAKA LYDNGDARKA 
       710        720        730        740        750
KMWLLKVRHL VPHDPFVIFN LGLAIKKETE QALALPRPQL DELMGLDGLL 
       760        770        780        790        800
KVAFKLFCHI NLNHPKISVR VSAKYAEDCQ NLMTELIAKK RQASESHAME 
       810        820        830        840        850
EDRVQLQKQR YRDHIEHQRQ QELQREEEER VRRENLKIQR KEVLERTRKI 
       860        870        880        890        900
ISAPLAPDVP KKSAGNGRAK KNQENGDGKA KKSGPPKKKT RKRAAGKEQE 
       910        920 
DIEPLKKPKS KEFIDTDDDN SE
Length:922
Mass (Da):104,769
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA4FF763FD118D253
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46964.2

NCBI Reference Sequences

More...RefSeqi		NP_611764.1, NM_137920.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0071969; FBpp0071879; FBgn0034829

Database of genes from NCBI RefSeq genomes

More...GeneIDi		37676

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG9899

UCSC genome browser

More...UCSCi		CG9899-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46964.2
RefSeqiNP_611764.1, NM_137920.3

3D structure databases

SMRiQ9W1T9
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7227.FBpp0071879

Proteomic databases

PaxDbiQ9W1T9

Genome annotation databases

EnsemblMetazoaiFBtr0071969; FBpp0071879; FBgn0034829
GeneIDi37676
KEGGidme:Dmel_CG9899
UCSCiCG9899-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0034829, CG9899

Phylogenomic databases

eggNOGiKOG2002, Eukaryota
GeneTreeiENSGT00390000005097
HOGENOMiCLU_006386_1_0_1
InParanoidiQ9W1T9
OMAiARIHYAR
OrthoDBi396755at2759
PhylomeDBiQ9W1T9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		37676, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		37676

Gene expression databases

BgeeiFBgn0034829, Expressed in testis and 11 other tissues
ExpressionAtlasiQ9W1T9, baseline and differential
GenevisibleiQ9W1T9, DM

Family and domain databases

Gene3Di1.25.40.10, 4 hits
InterProiView protein in InterPro
IPR031101, Ctr9
IPR013026, TPR-contain_dom
IPR011990, TPR-like_helical_dom_sf
IPR019734, TPR_repeat
PANTHERiPTHR14027, PTHR14027, 1 hit
PfamiView protein in Pfam
PF13181, TPR_8, 1 hit
SMARTiView protein in SMART
SM00028, TPR, 10 hits
SUPFAMiSSF48452, SSF48452, 4 hits
PROSITEiView protein in PROSITE
PS50005, TPR, 7 hits
PS50293, TPR_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W1T9_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W1T9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: February 10, 2021
This is version 154 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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