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Entry version 141 (11 Dec 2019)
Sequence version 2 (01 Oct 2002)
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Protein
Submitted name:

Golgin-245

Gene

Golgin245

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6811440 Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Golgin-245Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Golgin245Imported
Synonyms:dGolgin-245Imported, dGolgin245Imported, Dmel\CG3493Imported
ORF Names:CG3493Imported, Dmel_CG3493Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0034854 Golgin245

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W1R3

PRoteomics IDEntifications database

More...
PRIDEi
Q9W1R3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0034854 Expressed in 27 organ(s), highest expression level in Malpighian tubule

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W1R3 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W1R3, 4 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0071945

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W1R3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1429 – 1477GRIPInterPro annotationAdd BLAST49

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 48DisorderedSequence analysisAdd BLAST21
Regioni76 – 100DisorderedSequence analysisAdd BLAST25
Regioni416 – 440DisorderedSequence analysisAdd BLAST25
Regioni493 – 519DisorderedSequence analysisAdd BLAST27
Regioni771 – 790DisorderedSequence analysisAdd BLAST20
Regioni832 – 870DisorderedSequence analysisAdd BLAST39

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili159 – 193Sequence analysisAdd BLAST35
Coiled coili198 – 218Sequence analysisAdd BLAST21
Coiled coili283 – 310Sequence analysisAdd BLAST28
Coiled coili329 – 374Sequence analysisAdd BLAST46
Coiled coili576 – 631Sequence analysisAdd BLAST56
Coiled coili895 – 929Sequence analysisAdd BLAST35
Coiled coili958 – 1063Sequence analysisAdd BLAST106
Coiled coili1071 – 1133Sequence analysisAdd BLAST63
Coiled coili1147 – 1181Sequence analysisAdd BLAST35
Coiled coili1189 – 1223Sequence analysisAdd BLAST35
Coiled coili1238 – 1272Sequence analysisAdd BLAST35
Coiled coili1286 – 1345Sequence analysisAdd BLAST60
Coiled coili1358 – 1392Sequence analysisAdd BLAST35
Coiled coili1396 – 1423Sequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi424 – 438PolarSequence analysisAdd BLAST15
Compositional biasi838 – 855PolyampholyteSequence analysisAdd BLAST18

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEA5 Eukaryota
ENOG410XQQG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00730000111139

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W1R3

KEGG Orthology (KO)

More...
KOi
K20283

Identification of Orthologs from Complete Genome Data

More...
OMAi
DKCDAYE

Database of Orthologous Groups

More...
OrthoDBi
155305at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W1R3

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000237 GRIP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01465 GRIP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00755 Grip, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50913 GRIP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W1R3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFANLKNKLI EEVKASPSKF QQFANAAQAA VSSSSSTTPN SETNTSNNEN
60 70 80 90 100
FFSITEEDTP QNSPYRIQKL PATSASALRG RSTQSLNGAT SRTRKLSNSS
110 120 130 140 150
MASDVSFRLP TYEAPAVYHL QSDLDETSSE FDDSASTARL DVITKDQLYD
160 170 180 190 200
AYKKSLDRYH KYRCRYTDLA KKYKELERDS SKARSVLVET QDKALRRISE
210 220 230 240 250
LREQCTLEQQ AKAHLEEALR VEMDDMSCKM QAYQTKLQLL GENPENITAA
260 270 280 290 300
LERSGQQLES EQLIDLEESI GKSPLSTNGS SGVSDLQRLL KERDEQLKSV
310 320 330 340 350
TEKYEAVRKQ EEENVLLLAQ TKQAIHTELE LKDTEVRKLQ EKLKQLESQR
360 370 380 390 400
ESHNNEVKEQ FKKLQATKQE VDAKLMATEH LLNTLKESYA IKEQQVVTLE
410 420 430 440 450
AQLEAIRVEN EQKVKDLQKQ NEDRNTQASD SSEQLKKLQA AVQDAESQLL
460 470 480 490 500
SKDQLLESLR SEQAAKEQQL KHLKEQLGKL KQENENYLDK LRENKKSSDS
510 520 530 540 550
QTNEAQDQQK KLQAAKDEAE SKLLATEELL HSLRNDYKAQ EEKVALLEDK
560 570 580 590 600
LKTLSKENDV NVEKLHHINE QREAQSTDSQ QKINELRAAK DEAEAKLLST
610 620 630 640 650
EHSLNALQAA LSAKEEQAAS LEQSLNALKT ESEHSLQDLR LHNDQLLEIV
660 670 680 690 700
QRHQQNDWEA QLARAREELA AIQSQRELHA LELEKSLEME RESVAALNSE
710 720 730 740 750
KASQEEQHRL KLEQLQREIQ ILQDQHANSE SETVAALKGQ LEALSQDLAT
760 770 780 790 800
SQASLLAKEK ELKASGNKLN KIKKQHEQHQ AKSSDQSARL EALQSELADR
810 820 830 840 850
LSHSRQVESE KEELQARVTG ILEEIGTMQA QMQQVQDSHS ELEREKRKLE
860 870 880 890 900
SRIESLQQEQ VDSSAQDERT SAKLEEIQSE NTKLAERNCL LEEQTNHLES
910 920 930 940 950
QLQAKQDEIG KIQAKLQQVL DEHSKLQNAQ ELMDHDHRTL QDKCDAYEKD
960 970 980 990 1000
KLLTKHTLDC LQSASEELHR VKANLDRELK EQDQQLSELR ERQREQEQQL
1010 1020 1030 1040 1050
KDQAERCAKL KAQNSESETQ LQATISNLRE QLDAYKQTEQ GIQEKLQATN
1060 1070 1080 1090 1100
SSYTTQIATL EARWSAANSD VERLHEANDA LQLEMEQLKI KHGQEREEVK
1110 1120 1130 1140 1150
ESIAQKNRQV VELQEAMATR DRQLQEKIEA SEKLAKFDEI LIENEYLNKH
1160 1170 1180 1190 1200
TKQLEAELAE SAELKEKLKS LQCELYVLQE KAEQHAVQMA EKETQSATAT
1210 1220 1230 1240 1250
AEVSELKKAI EEQAVELTRQ KEHASFVTEQ SDAVQKDLLQ AQQQLHDKQI
1260 1270 1280 1290 1300
ELAMSRDEQA LLQAEADGLR QEVICLKEHL SPSTDSDSLR SLNERLQREL
1310 1320 1330 1340 1350
EDLKHKSAGA ESNMQQEIEE LQANNQQMAE RINELETLRA GIQAQQLLAS
1360 1370 1380 1390 1400
MAPKNVQEAA AAGEKAELES KLKEIMNEVQ DVTNRNLFLE QKCENFLILE
1410 1420 1430 1440 1450
QSNERLKLQN AKLSRQLDET LVSMQHSEAV PANTEFEYLR NIMFQYLTGN
1460 1470 1480
TNNETLVKVI SAVLKFSPQQ AQVALEKEHQ RRSLLNKLI
Length:1,489
Mass (Da):170,129
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE405A369ADBF4AA3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46990.2

NCBI Reference Sequences

More...
RefSeqi
NP_611787.2, NM_137943.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072036; FBpp0071945; FBgn0034854

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37702

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG3493

UCSC genome browser

More...
UCSCi
CG3493-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF46990.2
RefSeqiNP_611787.2, NM_137943.3

3D structure databases

SMRiQ9W1R3
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9W1R3, 4 interactors
STRINGi7227.FBpp0071945

Proteomic databases

PaxDbiQ9W1R3
PRIDEiQ9W1R3

Genome annotation databases

EnsemblMetazoaiFBtr0072036; FBpp0071945; FBgn0034854
GeneIDi37702
KEGGidme:Dmel_CG3493
UCSCiCG3493-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37702
FlyBaseiFBgn0034854 Golgin245

Phylogenomic databases

eggNOGiENOG410IEA5 Eukaryota
ENOG410XQQG LUCA
GeneTreeiENSGT00730000111139
InParanoidiQ9W1R3
KOiK20283
OMAiDKCDAYE
OrthoDBi155305at2759
PhylomeDBiQ9W1R3

Enzyme and pathway databases

ReactomeiR-DME-6811440 Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37702

Gene expression databases

BgeeiFBgn0034854 Expressed in 27 organ(s), highest expression level in Malpighian tubule
GenevisibleiQ9W1R3 DM

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W1R3_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W1R3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: October 1, 2002
Last modified: December 11, 2019
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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