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Protein

Probable transaldolase

Gene

Taldo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.By similarity

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Probable transaldolase (Taldo), Transaldolase (CG2827-RA)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142Schiff-base intermediate with substrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-DME-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-DME-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00414

Names & Taxonomyi

Protein namesi
Recommended name:
Probable transaldolase (EC:2.2.1.2)
Gene namesi
Name:TaldoImported
Synonyms:TalImported
ORF Names:CG2827Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0023477 Taldo

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735691 – 331Probable transaldolaseAdd BLAST331

Proteomic databases

PaxDbiQ9W1G0
PRIDEiQ9W1G0

Expressioni

Gene expression databases

BgeeiFBgn0023477
ExpressionAtlasiQ9W1G0 baseline and differential
GenevisibleiQ9W1G0 DM

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi63394, 4 interactors
IntActiQ9W1G0, 9 interactors
STRINGi7227.FBpp0072050

Structurei

3D structure databases

ProteinModelPortaliQ9W1G0
SMRiQ9W1G0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2772 Eukaryota
COG0176 LUCA
GeneTreeiENSGT00390000017361
InParanoidiQ9W1G0
KOiK00616
OMAiMAFDKLH
OrthoDBiEOG091G0FTU
PhylomeDBiQ9W1G0

Family and domain databases

CDDicd00957 Transaldolase_TalAB, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00492 Transaldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR004730 Transaldolase_1
IPR018225 Transaldolase_AS
PANTHERiPTHR10683 PTHR10683, 1 hit
PTHR10683:SF20 PTHR10683:SF20, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00874 talAB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9W1G0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSDRTLKKQ KMSVLQELKK ITTIVADTGD FEAINIYKPT DATTNPSLIL
60 70 80 90 100
SASSMERYQP LVQKAVEYAK GKKGSVSEQV AEAMDYLCVL FGTEILKVVP
110 120 130 140 150
GRVSTEIDAR LSFDTKKSVE KALKLIALYK SLGVDKERIL IKLASTWEGI
160 170 180 190 200
KAAEILENEH GVHCNLTLLF SFAQAVACAE AGVTLISPFV GRILDWYVAN
210 220 230 240 250
TDTKKFEALK DPGVISVTNI YNYYKKFGYK TLVMGASFRN VGEIKALAGC
260 270 280 290 300
DLLTISPALL KELENETESV VTYLSVSNAK LQDIEKITVD ESRFRWLLNE
310 320 330
DAMATDKLSE GIRKFAVDTV KLENLIKTYL K
Length:331
Mass (Da):36,734
Last modified:November 9, 2004 - v2
Checksum:i7EB1CDDFC4441C6A
GO

Sequence cautioni

The sequence AAM50780 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF47106.2
AY118920 mRNA Translation: AAM50780.1 Different initiation.
RefSeqiNP_523835.2, NM_079111.3
UniGeneiDm.6550

Genome annotation databases

EnsemblMetazoaiFBtr0072141; FBpp0072050; FBgn0023477
GeneIDi37804
KEGGidme:Dmel_CG2827
UCSCiCG2827-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiTALDO_DROME
AccessioniPrimary (citable) accession number: Q9W1G0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: November 9, 2004
Last modified: May 23, 2018
This is version 136 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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