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Entry version 136 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein

Protein tamozhennic

Gene

tamo

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has an essential role during oogenesis and embryogenesis, perhaps in modulating the levels of nuclear import of additional proteins. Modulates the nuclear import of dorsal (dl), Dif and male specific lethal 1 (msl-1). Negatively regulates nuclear import of dl and controls the accumulation of dl in the nucleus after immune challenge.1 Publication

Miscellaneous

'Tamozhennic' means 'customs officer' in Russian.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri735 – 766RanBP2-typeSequence analysisAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • Ran GTPase binding Source: UniProtKB

GO - Biological processi

  • multicellular organism development Source: UniProtKB
  • protein transport Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein tamozhennic
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:tamo
ORF Names:CG4057
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0041582, tamo

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000724251 – 797Protein tamozhennicAdd BLAST797

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W1A4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed both maternally and zygotically, zygotic expression is seen throughout development.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0041582, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9W1A4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W1A4, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homomultimer. Binds to dl and msl-1 via their nuclear localization signal (NLS). Also binds to Ran, Ran-like and mbo.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
63443, 30 interactors

Protein interaction database and analysis system

More...
IntActi
Q9W1A4, 13 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072188

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W1A4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini79 – 146PUBSequence analysisAdd BLAST68

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri735 – 766RanBP2-typeSequence analysisAdd BLAST32

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RR2T, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063956

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_310844_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W1A4

Identification of Orthologs from Complete Genome Data

More...
OMAi
PLMPKVQ

Database of Orthologous Groups

More...
OrthoDBi
312617at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W1A4

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036339, PUB-like_dom_sf
IPR018997, PUB_domain
IPR029746, Tamozhennic
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

The PANTHER Classification System

More...
PANTHERi
PTHR15326:SF2, PTHR15326:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09409, PUB, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00547, ZnF_RBZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143503, SSF143503, 1 hit
SSF90209, SSF90209, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01358, ZF_RANBP2_1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q9W1A4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDFVPHDLI PDLWDEILRR HWMFLETEES IEKLEERKQL EGCLKEFLCV
60 70 80 90 100
VQHDRKFFLP ETGHVLRRSV LELPDFSAQN AIVAFETISQ YANNLFTKPW
110 120 130 140 150
RKEYRTLKTY SGCFQHDIQS RLLDAEQLFL AMGYRRAAED TFVLEGPICP
160 170 180 190 200
DQVTNVSRDA MAAYVECQIM KHIYAGVTAA GYVCTWKDIL QFRERYVGGT
210 220 230 240 250
STTIKEMVRQ LSEKRVRMEQ PPMQENTYSN VVSAAPTACG MRSNNVAHHP
260 270 280 290 300
SSSGTCALHP NGLNEAGKYL PPYPAPPPQQ PHLPGPLMTH SRSLDHYQEP
310 320 330 340 350
QAHLPHRHSF DQQLQQQCQL PHVYEAPYDC LDGLSMGSSA SYAAVTGAYN
360 370 380 390 400
APGNRYPLPY NISSQLNAPY ASPADFYGNG QHTNMYATLG KTGPAHSCDL
410 420 430 440 450
HRRQPNTSAA AAAALAAMQH RQSTYPPDHH LIDFDERAHL TQHDFGTHDY
460 470 480 490 500
DPQYAELRGQ VQPSMRGNPV AMYATYGGYD LPTTLPQAPP PTGQDMYIYA
510 520 530 540 550
RPVPKSSRMR ALAEAGGINS TDKHPRSAEK QSTMDNNRKM HKELKERNSR
560 570 580 590 600
TAPAKRSGTE RDIPTTISDL NSYDSASLDG FVALDSSSSP PLMPKVQEGV
610 620 630 640 650
GSFESWNYVF KNLERSGYTK DLGDREDLLV QSLDLGSLSI TNGGAAPPAE
660 670 680 690 700
KRREATNPTN GEKARTLDKK SGTGRREAKV VQAPAPSPLP NSSSAGVKKV
710 720 730 740 750
KSALKTAVVD NRGTGSRQRT GAVPKQPPNV SPQLIVTSPN EWSCSFCTFL
760 770 780 790
NPDTKRICEM CCRSKDFNLE AASAASSSAA AAAASAASVS HASSTCV
Length:797
Mass (Da):87,914
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3362970101C170DE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7YZS3B7YZS3_DROME
Tamo, isoform B
tamo 60B, Dmel\CG4057, CG4057, Dmel_CG4057
797Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAL48016 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF47169.1
AY070545 mRNA Translation: AAL48016.1 Sequence problems.
BT001486 mRNA Translation: AAN71241.1

NCBI Reference Sequences

More...
RefSeqi
NP_001286827.1, NM_001299898.1
NP_611889.1, NM_138045.2
NP_726426.1, NM_166664.1

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072281; FBpp0072188; FBgn0041582
FBtr0072282; FBpp0072189; FBgn0041582
FBtr0343438; FBpp0310082; FBgn0041582

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37864

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG4057

UCSC genome browser

More...
UCSCi
CG4057-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF47169.1
AY070545 mRNA Translation: AAL48016.1 Sequence problems.
BT001486 mRNA Translation: AAN71241.1
RefSeqiNP_001286827.1, NM_001299898.1
NP_611889.1, NM_138045.2
NP_726426.1, NM_166664.1

3D structure databases

SMRiQ9W1A4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63443, 30 interactors
IntActiQ9W1A4, 13 interactors
STRINGi7227.FBpp0072188

Proteomic databases

PaxDbiQ9W1A4

Genome annotation databases

EnsemblMetazoaiFBtr0072281; FBpp0072188; FBgn0041582
FBtr0072282; FBpp0072189; FBgn0041582
FBtr0343438; FBpp0310082; FBgn0041582
GeneIDi37864
KEGGidme:Dmel_CG4057
UCSCiCG4057-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
37864
FlyBaseiFBgn0041582, tamo

Phylogenomic databases

eggNOGiENOG502RR2T, Eukaryota
GeneTreeiENSGT00530000063956
HOGENOMiCLU_310844_0_0_1
InParanoidiQ9W1A4
OMAiPLMPKVQ
OrthoDBi312617at2759
PhylomeDBiQ9W1A4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
37864, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37864

Protein Ontology

More...
PROi
PR:Q9W1A4

Gene expression databases

BgeeiFBgn0041582, Expressed in embryonic/larval hemocyte (Drosophila) and 39 other tissues
ExpressionAtlasiQ9W1A4, baseline and differential
GenevisibleiQ9W1A4, DM

Family and domain databases

InterProiView protein in InterPro
IPR036339, PUB-like_dom_sf
IPR018997, PUB_domain
IPR029746, Tamozhennic
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PANTHERiPTHR15326:SF2, PTHR15326:SF2, 1 hit
PfamiView protein in Pfam
PF09409, PUB, 1 hit
SMARTiView protein in SMART
SM00547, ZnF_RBZ, 1 hit
SUPFAMiSSF143503, SSF143503, 1 hit
SSF90209, SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS01358, ZF_RANBP2_1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTAMO_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W1A4
Secondary accession number(s): Q0E8W9, Q8SZS5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 136 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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