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Protein

Breast cancer type 2 susceptibility protein homolog

Gene

Brca2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in and required for double-strand break repair by meiotic and mitotic homologous recombination. During meiosis, has a dual role in the repair of meiotic double-stranded breaks and the efficient activation of the meiotic recombination checkpoint.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Breast cancer type 2 susceptibility protein homolog1 Publication
Short name:
dmbrca21 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Brca2Imported
ORF Names:CG30169
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0050169 Brca2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Induced sensitivity to DNA damage induced by irradiation or treatment with hydroxyurea/ Repair by homologous recombination is dramatically decreased. Instead, large flanking deletions are formed, and repair by the non-conservative single-strand annealing pathway predominates.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003929161 – 971Breast cancer type 2 susceptibility protein homologAdd BLAST971

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W157

PRoteomics IDEntifications database

More...
PRIDEi
Q9W157

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0050169 Expressed in 27 organ(s), highest expression level in egg chamber

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W157 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Rad9 (PubMed:18266476). Interacts with spn-A/Rad51 (PubMed:17822964). Interacts with cyclin CycG (PubMed:22976300).3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
63488, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q9W157, 8 interactors

Molecular INTeraction database

More...
MINTi
Q9W157

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072209

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9W157

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W157

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati570 – 604BRCA2 1Sequence analysisAdd BLAST35
Repeati671 – 705BRCA2 2Sequence analysisAdd BLAST35
Repeati746 – 780BRCA2 3Sequence analysisAdd BLAST35

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J3H8 Eukaryota
ENOG410ZXUJ LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W157

Identification of Orthologs from Complete Genome Data

More...
OMAi
QWPGMDV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G01TF

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W157

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015525 BRCA2
IPR002093 BRCA2_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR11289 PTHR11289, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50138 BRCA2_REPEAT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W157-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDQNGASGSH PNRLSQGRGA HARERGATVS AAANRSNIID EMAKICEADR
60 70 80 90 100
QTFAIARRTR GHERLAVDNS DFVAVEDLIL SYAEPTPEDQ VEMIMSDFCS
110 120 130 140 150
SPTYAEDEDE PSHESEPWFR FRNKRIRTYS RKRDPKSHKA VQNEKRRGSS
160 170 180 190 200
GLSVQRDLNT SFTSMACDFD ASSQKIHEVL LNLSQYFSAT ATASGPTPVP
210 220 230 240 250
SQIDLPTEAR QDSGDECFNA ELENLRDDLL QSGFTFEASF YENEHEQEGP
260 270 280 290 300
GTMADTIYGD SMQSVPTTRL RLESGKRNVW SDADSTLKKA DVEIAENKKL
310 320 330 340 350
LMGQTQAKNV DIEENTNFIL EGIPLSEWLT PMELPEISKD VIKHIPDKKL
360 370 380 390 400
KLEPSSQKEQ KSSKDSNASK VRGASKQSCD INTKNEGTTI LDQPNAAEQE
410 420 430 440 450
NLLNDGELLE EFLFNDWQPM QCSNGPSTSK NAIQGPKENI NSINLDDKEQ
460 470 480 490 500
PEKQTPNKSQ TISSHQLNGI RKKSFKFIEV SEEMKIKGEE FVDKVVSGLY
510 520 530 540 550
HFSHKCNLRT EEYSDNHSQV MESTQCAEFK SAPSKPIEIL DGKETYNAIA
560 570 580 590 600
KVDVGEINGK FSPLNNDTIA EPEFCGFRTA SNKAIPISEK MKIKTAEFMA
610 620 630 640 650
EFQSKETIQQ NDYLVHQPND KPTSVGLDTA LKRSIESSEE MRSKASKLVV
660 670 680 690 700
VDTTMREPHQ PTLDPVCRDL NESQFFGFRT ASNKAIEITE AMEKRGAMFL
710 720 730 740 750
AQSKATDQLN GWQPSDFPDV LPTSPNNEIH SINVENNKAV NTKTVSETEF
760 770 780 790 800
FGFRTASNKG IVISENTKIK VAQFMSEFQA ADASTDSNQP TVISEESRNI
810 820 830 840 850
DAKFVDEAAA EDSANKPTFC NVQSLKNTSD IEHFKHDFFV EHSAKEEHPL
860 870 880 890 900
CSQPLVRTPR RSQEIHSSLS QLAGKSPLDQ ATKKSVIARR NLLSLKRKRK
910 920 930 940 950
IILSTETSTS CALPTMERFA PKPSSTSTPL ADRDLNRSKD CTKNRQDAED
960 970
MSPICMQPKK SRRLGLSRSR Y
Length:971
Mass (Da):108,649
Last modified:November 13, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9232DE2A667672CE
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAM51132 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti502F → S in AAM51132 (PubMed:12537569).Curated1
Sequence conflicti567D → E in AAM51132 (PubMed:12537569).Curated1
Sequence conflicti621K → Y in AAM51132 (PubMed:12537569).Curated1
Sequence conflicti650V → D in AAM51132 (PubMed:12537569).Curated1
Sequence conflicti791T → I in AAM51132 (PubMed:12537569).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti242E → K in strain: Zimbabwe30. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF47220.3
BT023811 mRNA Translation: AAZ66318.1
EU541213 Genomic DNA Translation: ACB30270.1
EU541214 Genomic DNA Translation: ACB30271.1
AY119272 mRNA Translation: AAM51132.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
NP_611925.2, NM_138081.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Dm.13825

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072302; FBpp0072209; FBgn0050169

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
37916

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG30169

UCSC genome browser

More...
UCSCi
CG30169-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE013599 Genomic DNA Translation: AAF47220.3
BT023811 mRNA Translation: AAZ66318.1
EU541213 Genomic DNA Translation: ACB30270.1
EU541214 Genomic DNA Translation: ACB30271.1
AY119272 mRNA Translation: AAM51132.1 Different initiation.
RefSeqiNP_611925.2, NM_138081.4
UniGeneiDm.13825

3D structure databases

ProteinModelPortaliQ9W157
SMRiQ9W157
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi63488, 24 interactors
IntActiQ9W157, 8 interactors
MINTiQ9W157
STRINGi7227.FBpp0072209

Proteomic databases

PaxDbiQ9W157
PRIDEiQ9W157

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0072302; FBpp0072209; FBgn0050169
GeneIDi37916
KEGGidme:Dmel_CG30169
UCSCiCG30169-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
675
FlyBaseiFBgn0050169 Brca2

Phylogenomic databases

eggNOGiENOG410J3H8 Eukaryota
ENOG410ZXUJ LUCA
InParanoidiQ9W157
OMAiQWPGMDV
OrthoDBiEOG091G01TF
PhylomeDBiQ9W157

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
37916

Protein Ontology

More...
PROi
PR:Q9W157

Gene expression databases

BgeeiFBgn0050169 Expressed in 27 organ(s), highest expression level in egg chamber
GenevisibleiQ9W157 DM

Family and domain databases

InterProiView protein in InterPro
IPR015525 BRCA2
IPR002093 BRCA2_repeat
PANTHERiPTHR11289 PTHR11289, 4 hits
PROSITEiView protein in PROSITE
PS50138 BRCA2_REPEAT, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBRCA2_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W157
Secondary accession number(s): B2CPK7
, B2CPK8, Q494G5, Q8MRU0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: November 13, 2007
Last modified: December 5, 2018
This is version 122 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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