UniProtKB - Q9W122 (Q9W122_DROME)
Protein
Submitted name:
Matrix metalloproteinase 1, isoform C
Gene
Mmp1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Cofactori
Zn2+ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 225 | UniRule annotation | 1 |
GO - Molecular functioni
- metalloendopeptidase activity Source: GO_Central
- zinc ion binding Source: InterPro
GO - Biological processi
- adult fat body development Source: FlyBase
- basement membrane disassembly Source: FlyBase
- basement membrane organization Source: FlyBase
- cell adhesion Source: FlyBase
- cell-cell junction organization Source: FlyBase
- collagen catabolic process Source: GO_Central
- dorsal trunk growth, open tracheal system Source: FlyBase
- embryonic heart tube formation Source: FlyBase
- extracellular matrix organization Source: FlyBase
- fasciculation of motor neuron axon Source: FlyBase
- imaginal disc eversion Source: FlyBase
- instar larval development Source: FlyBase
- molting cycle, chitin-based cuticle Source: FlyBase
- open tracheal system development Source: FlyBase
- regulation of tube length, open tracheal system Source: FlyBase
- response to wounding Source: FlyBase
- tissue regeneration Source: FlyBase
- ventral cord development Source: FlyBase
- wound healing Source: FlyBase
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | Metal-bindingARBA annotation, ZincARBA annotation |
Enzyme and pathway databases
Reactomei | R-DME-1442490, Collagen degradation R-DME-1474228, Degradation of the extracellular matrix R-DME-1592389, Activation of Matrix Metalloproteinases R-DME-2022090, Assembly of collagen fibrils and other multimeric structures R-DME-2168880, Scavenging of heme from plasma |
Protein family/group databases
MEROPSi | M10.031 |
Names & Taxonomyi
Protein namesi | Submitted name: Matrix metalloproteinase 1, isoform CImported (EC:3.4.24.-Imported)Submitted name: RE19818pImportedSubmitted name: RE62222pImported |
Gene namesi | Name:Mmp1Imported Synonyms:Dm1-MMPImported, dm1-MMPImported, Dmel\CG4859Imported, dMMP1Imported, dmmp1Imported, l(2)k04809Imported, MMPImported, Mmp 1Imported, MMP-1Imported, Mmp-1Imported, mmp-1Imported, MMP1Imported, MMp1Imported, mmp1Imported ORF Names:CG4859Imported, Dmel_CG4859Imported |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0035049, Mmp1 |
Subcellular locationi
Extracellular region or secreted
- collagen-containing extracellular matrix Source: FlyBase
- extracellular space Source: GO_Central
Other locations
- dendrite Source: FlyBase
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
ChainiPRO_5015020182 | 25 – 584 | Sequence analysisAdd BLAST | 560 |
Keywords - PTMi
ZymogenARBA annotationExpressioni
Gene expression databases
Bgeei | FBgn0035049, Expressed in seminal fluid secreting gland and 45 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 112 – 269 | ZnMcInterPro annotationAdd BLAST | 158 | |
Repeati | 302 – 347 | HemopexinPROSITE-ProRule annotationAdd BLAST | 46 | |
Repeati | 348 – 393 | HemopexinPROSITE-ProRule annotationAdd BLAST | 46 | |
Repeati | 394 – 443 | HemopexinPROSITE-ProRule annotationAdd BLAST | 50 | |
Repeati | 444 – 493 | HemopexinPROSITE-ProRule annotationAdd BLAST | 50 |
Sequence similaritiesi
Belongs to the peptidase M10A family.ARBA annotation
Keywords - Domaini
RepeatARBA annotation, SignalSequence analysisARBA annotationPhylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000166111 |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
Pfami | View protein in Pfam PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q9W122-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTNCQSSVFI VVGTLFSIMA AAQSAPVSTT TQAEIYLSQF GYLPASARNP
60 70 80 90 100
ASSGLHDQRT WVSAIEEFQS FAGLNITGEL DAETMKLMSL PRCGVRDRVG
110 120 130 140 150
TGDSRSKRYA LQGSRWRVKN LTYKISKYPK RLKRVDVDAE IGRAFAVWSE
160 170 180 190 200
DTDLTFTRKT SGPVHIEIKF VESEHGDGDA FDGQGGTLAH AFFPVFGGDA
210 220 230 240 250
HFDDAELWTI GSPRGTNLFQ VAAHEFGHSL GLSHSDQSSA LMAPFYRGFE
260 270 280 290 300
PVFKLDEDDK AAIQSLYGRK TNQLRPTNVY PATTQRPYSP PKVPLDDSIC
310 320 330 340 350
KDSKVDTLFN SAQGETYAFK GDKYYKLTTD SVEEGYPQLI SKGWPGLPGN
360 370 380 390 400
IDAAFTYKNG KTYFFKGTQY WRYQGRQMDG VYPKEISEGF TGIPDHLDAA
410 420 430 440 450
MVWGGNGKIY FFKGSKFWRF DPAKRPPVKA SYPKPISNWE GVPNNLDAAL
460 470 480 490 500
KYTNGYTYFF KGDKYYRFHD ARFAVDSATP PFPRPTAHWW FGCKNTPSST
510 520 530 540 550
GNIVEGSDNE FEQHSMIPHA DDGNGDDFDA AVGDHQSNDE PIVPEVAERT
560 570 580
GNGAMSQSKL TSSSAVSTVI TTILMCLVSK LIVS
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4JCU7 | A0A0B4JCU7_DROME | Matrix metalloproteinase 1, isoform... | Mmp1 Dm1-MMP, dm1-MMP, Dmel\CG4859, dMMP1, dmmp1 | 542 | Annotation score: | ||
A0A0B4JDA7 | A0A0B4JDA7_DROME | Matrix metalloproteinase 1, isoform... | Mmp1 Dm1-MMP, dm1-MMP, Dmel\CG4859, dMMP1, dmmp1 | 554 | Annotation score: | ||
A0A0B4K7H5 | A0A0B4K7H5_DROME | Matrix metalloproteinase 1, isoform... | Mmp1 Dm1-MMP, dm1-MMP, Dmel\CG4859, dMMP1, dmmp1 | 512 | Annotation score: | ||
Q8MLN6 | Q8MLN6_DROME | Matrix metalloproteinase 1, isoform... | Mmp1 Dm1-MMP, dm1-MMP, Dmel\CG4859, dMMP1, dmmp1 | 541 | Annotation score: | ||
A0A0B4JD53 | A0A0B4JD53_DROME | Matrix metalloproteinase 1, isoform... | Mmp1 Dm1-MMP, dm1-MMP, Dmel\CG4859, dMMP1, dmmp1 | 528 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF47255.3 AY118405 mRNA Translation: AAM48434.1 BT021303 mRNA Translation: AAX33451.1 |
RefSeqi | NP_726473.2, NM_166683.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0273263; FBpp0271771; FBgn0035049 |
GeneIDi | 37949 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AE013599 Genomic DNA Translation: AAF47255.3 AY118405 mRNA Translation: AAM48434.1 BT021303 mRNA Translation: AAX33451.1 |
RefSeqi | NP_726473.2, NM_166683.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7227.FBpp0271771 |
Protein family/group databases
MEROPSi | M10.031 |
Genome annotation databases
EnsemblMetazoai | FBtr0273263; FBpp0271771; FBgn0035049 |
GeneIDi | 37949 |
Organism-specific databases
CTDi | 4312 |
FlyBasei | FBgn0035049, Mmp1 |
Phylogenomic databases
eggNOGi | KOG1565, Eukaryota |
GeneTreei | ENSGT00940000166111 |
Enzyme and pathway databases
Reactomei | R-DME-1442490, Collagen degradation R-DME-1474228, Degradation of the extracellular matrix R-DME-1592389, Activation of Matrix Metalloproteinases R-DME-2022090, Assembly of collagen fibrils and other multimeric structures R-DME-2168880, Scavenging of heme from plasma |
Miscellaneous databases
BioGRID-ORCSi | 37949, 0 hits in 3 CRISPR screens |
ChiTaRSi | Mmp1, fly |
GenomeRNAii | 37949 |
Gene expression databases
Bgeei | FBgn0035049, Expressed in seminal fluid secreting gland and 45 other tissues |
Family and domain databases
CDDi | cd00094, HX, 1 hit cd04278, ZnMc_MMP, 1 hit |
Gene3Di | 2.110.10.10, 1 hit 3.40.390.10, 1 hit |
InterProi | View protein in InterPro IPR000585, Hemopexin-like_dom IPR036375, Hemopexin-like_dom_sf IPR018487, Hemopexin-like_repeat IPR018486, Hemopexin_CS IPR033739, M10A_MMP IPR024079, MetalloPept_cat_dom_sf IPR001818, Pept_M10_metallopeptidase IPR021190, Pept_M10A IPR006026, Peptidase_Metallo IPR002477, Peptidoglycan-bd-like IPR036365, PGBD-like_sf |
Pfami | View protein in Pfam PF00045, Hemopexin, 4 hits PF00413, Peptidase_M10, 1 hit PF01471, PG_binding_1, 1 hit |
PIRSFi | PIRSF001191, Peptidase_M10A_matrix, 1 hit |
PRINTSi | PR00138, MATRIXIN |
SMARTi | View protein in SMART SM00120, HX, 4 hits SM00235, ZnMc, 1 hit |
SUPFAMi | SSF47090, SSF47090, 1 hit SSF50923, SSF50923, 1 hit |
PROSITEi | View protein in PROSITE PS00024, HEMOPEXIN, 1 hit PS51642, HEMOPEXIN_2, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q9W122_DROME | |
Accessioni | Q9W122Primary (citable) accession number: Q9W122 Secondary accession number(s): Q8MT35 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | May 1, 2000 |
Last sequence update: | March 3, 2009 | |
Last modified: | December 2, 2020 | |
This is version 180 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |