Matrix metalloproteinase 1, isoform C

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• metalloendopeptidase activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• adult fat body development Source: FlyBase <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Mmp1 and Mmp2 cooperatively induce Drosophila fat body cell dissociation with distinct roles."
    Jia Q., Liu Y., Liu H., Li S.
    Sci. Rep. 4:7535-7535(2014) [PubMed] [Europe PMC] [Abstract]
• basement membrane disassembly Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion."
    Srivastava A., Pastor-Pareja J.C., Igaki T., Pagliarini R., Xu T.
    Proc. Natl. Acad. Sci. U.S.A. 104:2721-2726(2007) [PubMed] [Europe PMC] [Abstract]
• basement membrane organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A secreted MMP is required for reepithelialization during wound healing."
    Stevens L.J., Page-McCaw A.
    Mol. Biol. Cell 23:1068-1079(2012) [PubMed] [Europe PMC] [Abstract]
• cell adhesion Source: FlyBase <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion."
    Zhang S., Dailey G.M., Kwan E., Glasheen B.M., Sroga G.E., Page-McCaw A.
    Genes Dev 20:1899-1910(2006) [PubMed] [Europe PMC] [Abstract]
• cell-cell junction organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Mmp1 and Mmp2 cooperatively induce Drosophila fat body cell dissociation with distinct roles."
    Jia Q., Liu Y., Liu H., Li S.
    Sci. Rep. 4:7535-7535(2014) [PubMed] [Europe PMC] [Abstract]
• collagen catabolic process Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• dorsal trunk growth, open tracheal system Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development."
    Page-McCaw A., Serano J., Sante J.M., Rubin G.M.
    Dev. Cell 4:95-106(2003) [PubMed] [Europe PMC] [Abstract]
• embryonic heart tube formation Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Matrix Metalloproteinases are required for membrane motility and lumenogenesis during Drosophila heart development."
    Raza Q.S., Vanderploeg J.L., Jacobs J.R.
    PLoS One 12:e0171905-e0171905(2017) [PubMed] [Europe PMC] [Abstract]
• extracellular matrix organization Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A matrix metalloproteinase mediates airway remodeling in Drosophila."
    Glasheen B.M., Robbins R.M., Piette C., Beitel G.J., Page-McCaw A.
    Dev Biol 344:772-783(2010) [PubMed] [Europe PMC] [Abstract]
• fasciculation of motor neuron axon Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Matrix metalloproteinases promote motor axon fasciculation in the Drosophila embryo."
    Miller C.M., Page-McCaw A., Broihier H.T.
    Development 135:95-109(2008) [PubMed] [Europe PMC] [Abstract]
• imaginal disc eversion Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion."
    Srivastava A., Pastor-Pareja J.C., Igaki T., Pagliarini R., Xu T.
    Proc. Natl. Acad. Sci. U.S.A. 104:2721-2726(2007) [PubMed] [Europe PMC] [Abstract]
  • "Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase."
    Glasheen B.M., Kabra A.T., Page-McCaw A.
    Proc Natl Acad Sci U S A 106:2659-2664(2009) [PubMed] [Europe PMC] [Abstract]
• instar larval development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Drosophila matrix metalloproteinases are required for tissue remodeling, but not embryonic development."
    Page-McCaw A., Serano J., Sante J.M., Rubin G.M.
    Dev. Cell 4:95-106(2003) [PubMed] [Europe PMC] [Abstract]
• molting cycle, chitin-based cuticle Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A matrix metalloproteinase mediates airway remodeling in Drosophila."
    Glasheen B.M., Robbins R.M., Piette C., Beitel G.J., Page-McCaw A.
    Dev Biol 344:772-783(2010) [PubMed] [Europe PMC] [Abstract]
• open tracheal system development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila."
    Uhlirova M., Bohmann D.
    EMBO J 25:5294-5304(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of tube length, open tracheal system Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Distinct functions for the catalytic and hemopexin domains of a Drosophila matrix metalloproteinase."
    Glasheen B.M., Kabra A.T., Page-McCaw A.
    Proc Natl Acad Sci U S A 106:2659-2664(2009) [PubMed] [Europe PMC] [Abstract]
• response to wounding Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration in Drosophila."
    Harris R.E., Stinchfield M.J., Nystrom S.L., McKay D.J., Hariharan I.K.
    Elife 9:0-0(2020) [PubMed] [Europe PMC] [Abstract]
• tissue regeneration Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Three genes control the timing, the site and the size of blastema formation in Drosophila."
    McClure K.D., Sustar A., Schubiger G.
    Dev Biol 319:68-77(2008) [PubMed] [Europe PMC] [Abstract]
  • "Damage-responsive, maturity-silenced enhancers regulate multiple genes that direct regeneration in Drosophila."
    Harris R.E., Stinchfield M.J., Nystrom S.L., McKay D.J., Hariharan I.K.
    Elife 9:0-0(2020) [PubMed] [Europe PMC] [Abstract]
• ventral cord development Source: FlyBaseInferred from mutant phenotypeⁱ
  • "Glia ECM interactions are required to shape the Drosophila nervous system."
    Meyer S., Schmidt I., Klambt C.
    Mech Dev 133:105-116(2014) [PubMed] [Europe PMC] [Abstract]
• wound healing Source: FlyBaseInferred from mutant phenotypeⁱ
  • "A secreted MMP is required for reepithelialization during wound healing."
    Stevens L.J., Page-McCaw A.
    Mol. Biol. Cell 23:1068-1079(2012) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MTNCQSSVFI VVGTLFSIMA AAQSAPVSTT TQAEIYLSQF GYLPASARNP 
        60         70         80         90        100
ASSGLHDQRT WVSAIEEFQS FAGLNITGEL DAETMKLMSL PRCGVRDRVG 
       110        120        130        140        150
TGDSRSKRYA LQGSRWRVKN LTYKISKYPK RLKRVDVDAE IGRAFAVWSE 
       160        170        180        190        200
DTDLTFTRKT SGPVHIEIKF VESEHGDGDA FDGQGGTLAH AFFPVFGGDA 
       210        220        230        240        250
HFDDAELWTI GSPRGTNLFQ VAAHEFGHSL GLSHSDQSSA LMAPFYRGFE 
       260        270        280        290        300
PVFKLDEDDK AAIQSLYGRK TNQLRPTNVY PATTQRPYSP PKVPLDDSIC 
       310        320        330        340        350
KDSKVDTLFN SAQGETYAFK GDKYYKLTTD SVEEGYPQLI SKGWPGLPGN 
       360        370        380        390        400
IDAAFTYKNG KTYFFKGTQY WRYQGRQMDG VYPKEISEGF TGIPDHLDAA 
       410        420        430        440        450
MVWGGNGKIY FFKGSKFWRF DPAKRPPVKA SYPKPISNWE GVPNNLDAAL 
       460        470        480        490        500
KYTNGYTYFF KGDKYYRFHD ARFAVDSATP PFPRPTAHWW FGCKNTPSST 
       510        520        530        540        550
GNIVEGSDNE FEQHSMIPHA DDGNGDDFDA AVGDHQSNDE PIVPEVAERT 
       560        570        580 
GNGAMSQSKL TSSSAVSTVI TTILMCLVSK LIVS                  

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ