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UniProtKB - Q9W0Y6 (PAIN_DROME)
Protein
Transient receptor potential cation channel protein painless
Gene
pain
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Receptor-activated non-selective cation channel involved in detection of pain sensation due to high temperature. Involved in heat nociception by being activated by noxious temperature of 38 degrees Celsius.
1 PublicationGO - Molecular functioni
- calcium activated cation channel activity Source: FlyBase
- calcium channel activity Source: FlyBase
- ion channel activity Source: FlyBase
GO - Biological processi
- behavioral response to pain Source: FlyBase
- calcium ion transmembrane transport Source: FlyBase
- calcium ion transport Source: FlyBase
- copulation Source: FlyBase
- detection of mechanical stimulus involved in sensory perception Source: FlyBase
- detection of mechanical stimulus involved in sensory perception of pain Source: UniProtKB
- detection of temperature stimulus involved in sensory perception of pain Source: UniProtKB
- detection of temperature stimulus involved in thermoception Source: FlyBase
- feeding behavior Source: FlyBase
- larval turning behavior Source: FlyBase
- male courtship behavior Source: FlyBase
- mechanosensory behavior Source: FlyBase
- negative gravitaxis Source: FlyBase
- olfactory behavior Source: FlyBase
- regulation of female receptivity Source: FlyBase
- regulation of heart contraction Source: FlyBase
- response to heat Source: FlyBase
- response to mechanical stimulus Source: FlyBase
- sensory perception of pain Source: FlyBase
Keywordsi
Molecular function | Ion channel |
Biological process | Ion transport, Sensory transduction, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Transient receptor potential cation channel protein painless |
Gene namesi | Name:pain ORF Names:CG15860 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0060296, pain |
VEuPathDBi | VectorBase:FBgn0060296 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Plasma Membrane
- plasma membrane Source: FlyBase
Other locations
- calcium channel complex Source: FlyBase
- integral component of membrane Source: FlyBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 490 | CytoplasmicSequence analysisAdd BLAST | 490 | |
Transmembranei | 491 – 511 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 512 – 523 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 524 – 544 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 545 – 555 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 556 – 576 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 577 – 586 | ExtracellularSequence analysis | 10 | |
Transmembranei | 587 – 607 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 608 – 628 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 629 – 649 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 650 – 708 | ExtracellularSequence analysisAdd BLAST | 59 | |
Transmembranei | 709 – 729 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 730 – 913 | CytoplasmicSequence analysisAdd BLAST | 184 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215374 | 1 – 913 | Transient receptor potential cation channel protein painlessAdd BLAST | 913 |
Proteomic databases
PaxDbi | Q9W0Y6 |
PRIDEi | Q9W0Y6 |
PTM databases
SwissPalmi | Q9W0Y6 |
Expressioni
Tissue specificityi
Present in multidendritic neurons, chordotonal neurons, a subset of cells in the central nervous system and a subset of sensory neurons in the antennal-maxillary complex. Not detected in gonads and dorsal vessels (at protein level). Expressed in peripheral neurons that extend multiple branched dendrites beneath the larval epidermis, similar to vertebrate pain receptors.1 Publication
Developmental stagei
Expressed from stage 13 of embryonic development in a small number of cells in the central nervous system and in a subset of neurons of the peripheral nervous system. Such cells may include sensory precursors of multidendritic (md) neurons. At embryonic stage 16, prior to when dendritic process are elaborated, it appears to be expressed in multidendritic neurons in a polarized manner. At stage 17 of development, when the md neurons first initiate dendritogenesis, it is localized to branched projections initiating from clusters of multidendritic neurons.
Gene expression databases
Bgeei | FBgn0060296, Expressed in oviduct (Drosophila) and 39 other tissues |
ExpressionAtlasi | Q9W0Y6, baseline and differential |
Genevisiblei | Q9W0Y6, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 63553, 2 interactors |
IntActi | Q9W0Y6, 1 interactor |
STRINGi | 7227.FBpp0072323 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 154 – 189 | ANK 1Add BLAST | 36 | |
Repeati | 260 – 289 | ANK 2Add BLAST | 30 | |
Repeati | 368 – 397 | ANK 3Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 656 – 675 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Keywords - Domaini
ANK repeat, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0510, Eukaryota |
GeneTreei | ENSGT00940000170332 |
InParanoidi | Q9W0Y6 |
OMAi | HTSIYEK |
OrthoDBi | 246352at2759 |
PhylomeDBi | Q9W0Y6 |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q9W0Y6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDFNNCGFID PQAQLAGALA KQDIRQFVAA LDSGALADLQ DDRHTSIYEK
60 70 80 90 100
ALSTPGCRDF IEACIDHGSQ VNYINKKLDK AAISYAADSR DPGNLAALLK
110 120 130 140 150
YRPGNKVQVD RKYGQLTPLN SLAKNLTDEN APDVYSCMQL LLDYGASPNI
160 170 180 190 200
VDQGEFTPLH HVLRKSKVKA GKKELIQLFL DHPELDIDSY RNGEVRRLLQ
210 220 230 240 250
AQFPELKLPE ERHTGPEIDI QTLQRTLRDG DETLFEQQFA EYLQNLKGGA
260 270 280 290 300
DNQLNAHQEE YFGLLQESIK RGRQRAFDVI LSTGMDINSR PGRANEANLV
310 320 330 340 350
ETAVIYGNWQ ALERLLKEPN LRLTPDSKLL NAVIGRLDEP PYDGSSHQRC
360 370 380 390 400
FELLINSDRV DINEADSGRL VPLFFAVKYR NTSAMQKLLK NGAYIGSKSA
410 420 430 440 450
FGTLPIKDMP PEVLEEHFDS CITTNGERPG DQNFEIIIDY KNLMRQERDS
460 470 480 490 500
GLNQLQDEMA PIAFIAESKE MRHLLQHPLI SSFLFLKWHR LSVIFYLNFL
510 520 530 540 550
IYSLFTASII TYTLLKFHES DQRALTAFFG LLSWLGISYL ILRECIQWIM
560 570 580 590 600
SPVRYFWSIT NIMEVALITL SIFTCMESSF DKETQRVLAV FTILLVSMEF
610 620 630 640 650
CLLVGSLPVL SISTHMLMLR EVSNSFLKSF TLYSIFVLTF SLCFYILFGK
660 670 680 690 700
SVEEDQSKSA TPCPPLGKKE GKDEEQGFNT FTKPIEAVIK TIVMLTGEFD
710 720 730 740 750
AGSIQFTSIY TYLIFLLFVI FMTIVLFNLL NGLAVSDTQV IKAQAELNGA
760 770 780 790 800
ICRTNVLSRY EQVLTGHGRA GFLLGNHLFR SICQRLMNIY PNYLSLRQIS
810 820 830 840 850
VLPNDGNKVL IPMSDPFEMR TLKKASFQQL PLSAAVPQKK LLDPPLRLLP
860 870 880 890 900
CCCSLLTGKC SQMSGRVVKR ALEVIDQKNA AEQRRKQEQI NDSRLKLIEY
910
KLEQLIQLVQ DRK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0B4KEZ8 | A0A0B4KEZ8_DROME | Painless, isoform B | pain CT31987, Dmel\CG15860, EP2251, Pain, CG15860 | 629 | Annotation score: | ||
A0A0B4KFI2 | A0A0B4KFI2_DROME | Painless, isoform C | pain CT31987, Dmel\CG15860, EP2251, Pain, CG15860 | 529 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY268106 mRNA Translation: AAP03646.1 AE013599 Genomic DNA Translation: AAF47293.1 BT011483 mRNA Translation: AAR99141.1 |
RefSeqi | NP_611979.1, NM_138135.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0072417; FBpp0072323; FBgn0060296 |
GeneIDi | 37985 |
KEGGi | dme:Dmel_CG15860 |
UCSCi | CG15860-RA, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY268106 mRNA Translation: AAP03646.1 AE013599 Genomic DNA Translation: AAF47293.1 BT011483 mRNA Translation: AAR99141.1 |
RefSeqi | NP_611979.1, NM_138135.2 |
3D structure databases
AlphaFoldDBi | Q9W0Y6 |
SMRi | Q9W0Y6 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 63553, 2 interactors |
IntActi | Q9W0Y6, 1 interactor |
STRINGi | 7227.FBpp0072323 |
PTM databases
SwissPalmi | Q9W0Y6 |
Proteomic databases
PaxDbi | Q9W0Y6 |
PRIDEi | Q9W0Y6 |
Protocols and materials databases
DNASUi | 37985 |
Genome annotation databases
EnsemblMetazoai | FBtr0072417; FBpp0072323; FBgn0060296 |
GeneIDi | 37985 |
KEGGi | dme:Dmel_CG15860 |
UCSCi | CG15860-RA, d. melanogaster |
Organism-specific databases
CTDi | 37985 |
FlyBasei | FBgn0060296, pain |
VEuPathDBi | VectorBase:FBgn0060296 |
Phylogenomic databases
eggNOGi | KOG0510, Eukaryota |
GeneTreei | ENSGT00940000170332 |
InParanoidi | Q9W0Y6 |
OMAi | HTSIYEK |
OrthoDBi | 246352at2759 |
PhylomeDBi | Q9W0Y6 |
Miscellaneous databases
BioGRID-ORCSi | 37985, 0 hits in 1 CRISPR screen |
GenomeRNAii | 37985 |
PROi | PR:Q9W0Y6 |
Gene expression databases
Bgeei | FBgn0060296, Expressed in oviduct (Drosophila) and 39 other tissues |
ExpressionAtlasi | Q9W0Y6, baseline and differential |
Genevisiblei | Q9W0Y6, DM |
Family and domain databases
Gene3Di | 1.25.40.20, 2 hits |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR005821, Ion_trans_dom |
Pfami | View protein in Pfam PF00520, Ion_trans, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 2 hits |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PAIN_DROME | |
Accessioni | Q9W0Y6Primary (citable) accession number: Q9W0Y6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 21, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | May 25, 2022 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families