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Entry version 195 (23 Feb 2022)
Sequence version 4 (24 Jan 2006)
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Protein

3-phosphoinositide-dependent protein kinase 1

Gene

Pdk1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine kinase required for embryonic development. Inhibits apoptosis. Acts in the insulin receptor transduction pathway which regulates cell growth and organ size, by phosphorylating and activating Akt1 and S6k. May be involved in axonal pathfinding and synaptogenesis, and in spermatogenesis.

7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei275ATPBy similarity1
Binding sitei331ATPBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei370Proton acceptorPROSITE-ProRule annotation1
Binding sitei374ATP; via carbonyl oxygenBy similarity1
Binding sitei388ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi256 – 258ATPBy similarity3
Nucleotide bindingi325 – 327ATPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Kinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis, Differentiation, Growth regulation, Spermatogenesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.7.11.1, 1994

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-110478, Insulin signaling pathway
R-DME-110523, TOR signaling pathway
R-DME-114604, GPVI-mediated activation cascade
R-DME-1257604, PIP3 activates AKT signaling
R-DME-165158, Activation of AKT2
R-DME-202424, Downstream TCR signaling
R-DME-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-354192, Integrin signaling
R-DME-389357, CD28 dependent PI3K/Akt signaling
R-DME-392451, G beta:gamma signalling through PI3Kgamma
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-5218921, VEGFR2 mediated cell proliferation
R-DME-5625740, RHO GTPases activate PKNs
R-DME-9634635, Estrogen-stimulated signaling through PRKCZ

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9W0V1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-phosphoinositide-dependent protein kinase 1 (EC:2.7.11.1)
Short name:
dPDK-1
Alternative name(s):
Serine/threonine-protein kinase 61C
dSTPK61
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pdk1
Synonyms:Pk61C
ORF Names:CG1210
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

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FlyBasei
FBgn0020386, Pdk1

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
VectorBase:FBgn0020386

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Death during the second instar stage.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000865041 – 8363-phosphoinositide-dependent protein kinase 1Add BLAST836

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei641Phosphothreonine1 Publication1
Modified residuei645Phosphoserine1 Publication1
Modified residuei804Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W0V1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9W0V1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Highly expressed in Malpighian tubule primordia from stage late 11 to 13. Expressed in hindgut at stage 13. After stage 14, ubiquitously expressed at low levels.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0020386, Expressed in embryo and 49 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9W0V1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W0V1, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
63582, 126 interactors

Database of interacting proteins

More...
DIPi
DIP-20399N

Protein interaction database and analysis system

More...
IntActi
Q9W0V1, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0305420

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W0V1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini246 – 571Protein kinasePROSITE-ProRule annotationAdd BLAST326

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni206 – 245DisorderedSequence analysisAdd BLAST40
Regioni277 – 322PIF-pocketBy similarityAdd BLAST46
Regioni401 – 464DisorderedSequence analysisAdd BLAST64
Regioni788 – 836DisorderedSequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi206 – 240Polar residuesSequence analysisAdd BLAST35
Compositional biasi401 – 418Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi419 – 449Acidic residuesSequence analysisAdd BLAST31

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PIF-pocket is a small lobe in the catalytic domain required by the enzyme for the binding to the hydrophobic motif of its substrates. It is an allosteric regulatory site that can accommodate small compounds acting as allosteric inhibitors.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0592, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155267

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W0V1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GHTENNN

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W0V1

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01262, PH_PDK1, 1 hit
cd05581, STKc_PDK1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR033931, PDK1-typ_PH
IPR039046, PDPK1
IPR011993, PH-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14593, PH_3, 1 hit
PF00069, Pkinase, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 4 (identifier: Q9W0V1-4) [UniParc]FASTAAdd to basket
Also known as: D

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKCKSWSNKI NNYVVRKIKS IKINGTQQQL QLPGSGASGI AAAAVITVAS
60 70 80 90 100
DCGENCSSNG TEHQQHFNIA TTTATSATEA TMPAMAKEKA SATVSLGESN
110 120 130 140 150
FRDINLKDLA VVVEAASRLH HQQNVCGCGA VSSTENNNNS RYGSSKYLTN
160 170 180 190 200
GHTSPLAAAV ASNSSSVATT PHCRMLHNCS LQQYQNDIRQ QTEILDMLRQ
210 220 230 240 250
QHQQGYQSQQ QQQQPQQQQE QQQQQEQSQQ QQQLQNPAPR RSPNDFIFGR
260 270 280 290 300
YIGEGSYSIV YLAVDIHSRR EYAIKVCEKR LILRERKQDY IKREREVMHQ
310 320 330 340 350
MTNVPGFVNL SCTFQDQRSL YFVMTYARKG DMLPYINRVG SFDVACTRHY
360 370 380 390 400
AAELLLACEH MHRRNVVHRD LKPENILLDE DMHTLIADFG SAKVMTAHER
410 420 430 440 450
ALATEHCSEQ RRSNSDEDDE DSDRLENEDE DFYDRDSEEL DDGDDEQQQE
460 470 480 490 500
EMDSPRHRQR RYNRHRKASF VGTAQYVSPE VLQNGPITPA ADLWALGCIV
510 520 530 540 550
YQMIAGLPPF RGSNDYVIFK EILDCAVDFP QGFDKDAEDL VRKLLRVDPR
560 570 580 590 600
DRLGAQDEFG YYESIRAHPF FAGIDWQTLR QQTPPPIYPY LPGVSQDEDF
610 620 630 640 650
RSSYTVPGDL EPGLDERQIS RLLSAELGVG SSVAMPVKRS TAKNSFDLND
660 670 680 690 700
AEKLQRLEQQ KTDKWHVFAD GEVILKKGFV NKRKGLFARK RMLLLTTGPR
710 720 730 740 750
LIYIDPVQMI KKGEIPWSPD LRAEYKNFKI FFVHTPNRTY YLDDPEGYAI
760 770 780 790 800
HWSEAIENMR KLAYGDPSST SAVSCSSGSS NSLAVISNSS AASSSNSPTV
810 820 830
KRSSPVNAPQ ASTASDNRTL GSTRTGTSPS KKTASK
Length:836
Mass (Da):94,079
Last modified:January 24, 2006 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCA274D2265D17AE2
GO
Isoform 1 (identifier: Q9W0V1-1) [UniParc]FASTAAdd to basket
Also known as: C

The sequence of this isoform differs from the canonical sequence as follows:
     1-22: MKCKSWSNKINNYVVRKIKSIK → MNIIQ

Show »
Length:819
Mass (Da):92,028
Checksum:iEA36359C8364A3A7
GO
Isoform 2 (identifier: Q9W0V1-2) [UniParc]FASTAAdd to basket
Also known as: A, F

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Show »
Length:755
Mass (Da):85,613
Checksum:i6375A99A25089FDD
GO
Isoform 3 (identifier: Q9W0V1-3) [UniParc]FASTAAdd to basket
Also known as: B, E

The sequence of this isoform differs from the canonical sequence as follows:
     1-297: Missing.

Show »
Length:539
Mass (Da):60,954
Checksum:iB9B864D2527D7260
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H5V8B9H5V8B9_DROME
3-phosphoinositide-dependent protei...
Pdk1 1210, CG1201, Dmel\CG1210, dPDK, dPDK-1
836Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V164A4V164_DROME
3-phosphoinositide-dependent protei...
Pdk1 1210, CG1201, Dmel\CG1210, dPDK, dPDK-1
755Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A4V166A4V166_DROME
3-phosphoinositide-dependent protei...
Pdk1 1210, CG1201, Dmel\CG1210, dPDK, dPDK-1
539Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN71019 differs from that shown. Reason: Frameshift.Curated
The sequence CAA69216 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti200 – 201QQ → HE in CAA69216 (PubMed:10336630).Curated2
Sequence conflicti443G → R in CAA69216 (PubMed:10336630).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0048971 – 297Missing in isoform 3. 1 PublicationAdd BLAST297
Alternative sequenceiVSP_0048961 – 81Missing in isoform 2. 2 PublicationsAdd BLAST81
Alternative sequenceiVSP_0170831 – 22MKCKS…IKSIK → MNIIQ in isoform 1. 1 PublicationAdd BLAST22

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y07908 mRNA Translation: CAA69216.1 Different initiation.
AE014296 Genomic DNA Translation: AAF47327.3
AE014296 Genomic DNA Translation: AAF47329.2
AE014296 Genomic DNA Translation: AAF47330.3
AE014296 Genomic DNA Translation: AAF47332.1
BT004489 mRNA Translation: AAO42653.1
BT001263 mRNA Translation: AAN71019.1 Frameshift.
BT011471 mRNA Translation: AAR99129.1

NCBI Reference Sequences

More...
RefSeqi
NP_001261183.1, NM_001274254.1 [Q9W0V1-4]
NP_525121.2, NM_080382.4 [Q9W0V1-2]
NP_728470.1, NM_167789.2 [Q9W0V1-1]
NP_728471.2, NM_167790.3 [Q9W0V1-4]
NP_728472.1, NM_167791.3 [Q9W0V1-2]
NP_728473.1, NM_167792.3 [Q9W0V1-2]
NP_728474.1, NM_167793.3 [Q9W0V1-3]
NP_728475.1, NM_167794.3 [Q9W0V1-3]
NP_728476.1, NM_167795.3 [Q9W0V1-3]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0072464; FBpp0072366; FBgn0020386 [Q9W0V1-4]
FBtr0072465; FBpp0072367; FBgn0020386 [Q9W0V1-2]
FBtr0072466; FBpp0072368; FBgn0020386 [Q9W0V1-2]
FBtr0072467; FBpp0072369; FBgn0020386 [Q9W0V1-2]
FBtr0072468; FBpp0072370; FBgn0020386 [Q9W0V1-1]
FBtr0072469; FBpp0072371; FBgn0020386 [Q9W0V1-3]
FBtr0072470; FBpp0072372; FBgn0020386 [Q9W0V1-3]
FBtr0072471; FBpp0072373; FBgn0020386 [Q9W0V1-3]
FBtr0333218; FBpp0305420; FBgn0020386 [Q9W0V1-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
38017

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG1210

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07908 mRNA Translation: CAA69216.1 Different initiation.
AE014296 Genomic DNA Translation: AAF47327.3
AE014296 Genomic DNA Translation: AAF47329.2
AE014296 Genomic DNA Translation: AAF47330.3
AE014296 Genomic DNA Translation: AAF47332.1
BT004489 mRNA Translation: AAO42653.1
BT001263 mRNA Translation: AAN71019.1 Frameshift.
BT011471 mRNA Translation: AAR99129.1
RefSeqiNP_001261183.1, NM_001274254.1 [Q9W0V1-4]
NP_525121.2, NM_080382.4 [Q9W0V1-2]
NP_728470.1, NM_167789.2 [Q9W0V1-1]
NP_728471.2, NM_167790.3 [Q9W0V1-4]
NP_728472.1, NM_167791.3 [Q9W0V1-2]
NP_728473.1, NM_167792.3 [Q9W0V1-2]
NP_728474.1, NM_167793.3 [Q9W0V1-3]
NP_728475.1, NM_167794.3 [Q9W0V1-3]
NP_728476.1, NM_167795.3 [Q9W0V1-3]

3D structure databases

SMRiQ9W0V1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63582, 126 interactors
DIPiDIP-20399N
IntActiQ9W0V1, 3 interactors
STRINGi7227.FBpp0305420

PTM databases

iPTMnetiQ9W0V1

Proteomic databases

PaxDbiQ9W0V1

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
38017

Genome annotation databases

EnsemblMetazoaiFBtr0072464; FBpp0072366; FBgn0020386 [Q9W0V1-4]
FBtr0072465; FBpp0072367; FBgn0020386 [Q9W0V1-2]
FBtr0072466; FBpp0072368; FBgn0020386 [Q9W0V1-2]
FBtr0072467; FBpp0072369; FBgn0020386 [Q9W0V1-2]
FBtr0072468; FBpp0072370; FBgn0020386 [Q9W0V1-1]
FBtr0072469; FBpp0072371; FBgn0020386 [Q9W0V1-3]
FBtr0072470; FBpp0072372; FBgn0020386 [Q9W0V1-3]
FBtr0072471; FBpp0072373; FBgn0020386 [Q9W0V1-3]
FBtr0333218; FBpp0305420; FBgn0020386 [Q9W0V1-4]
GeneIDi38017
KEGGidme:Dmel_CG1210

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5163
FlyBaseiFBgn0020386, Pdk1
VEuPathDBiVectorBase:FBgn0020386

Phylogenomic databases

eggNOGiKOG0592, Eukaryota
GeneTreeiENSGT00940000155267
InParanoidiQ9W0V1
OMAiGHTENNN
PhylomeDBiQ9W0V1

Enzyme and pathway databases

BRENDAi2.7.11.1, 1994
ReactomeiR-DME-110478, Insulin signaling pathway
R-DME-110523, TOR signaling pathway
R-DME-114604, GPVI-mediated activation cascade
R-DME-1257604, PIP3 activates AKT signaling
R-DME-165158, Activation of AKT2
R-DME-202424, Downstream TCR signaling
R-DME-2730905, Role of LAT2/NTAL/LAB on calcium mobilization
R-DME-354192, Integrin signaling
R-DME-389357, CD28 dependent PI3K/Akt signaling
R-DME-392451, G beta:gamma signalling through PI3Kgamma
R-DME-5218920, VEGFR2 mediated vascular permeability
R-DME-5218921, VEGFR2 mediated cell proliferation
R-DME-5625740, RHO GTPases activate PKNs
R-DME-9634635, Estrogen-stimulated signaling through PRKCZ
SignaLinkiQ9W0V1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
38017, 3 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pdk1, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38017

Protein Ontology

More...
PROi
PR:Q9W0V1

Gene expression databases

BgeeiFBgn0020386, Expressed in embryo and 49 other tissues
ExpressionAtlasiQ9W0V1, baseline and differential
GenevisibleiQ9W0V1, DM

Family and domain databases

CDDicd01262, PH_PDK1, 1 hit
cd05581, STKc_PDK1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR011009, Kinase-like_dom_sf
IPR033931, PDK1-typ_PH
IPR039046, PDPK1
IPR011993, PH-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF14593, PH_3, 1 hit
PF00069, Pkinase, 2 hits
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPDPK1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W0V1
Secondary accession number(s): O62534
, Q0E8K9, Q53XF5, Q7KVE1, Q8IHG6, Q9W0V2, Q9W0V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: January 24, 2006
Last modified: February 23, 2022
This is version 195 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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