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Entry version 150 (17 Jun 2020)
Sequence version 2 (01 Oct 2002)
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Protein

Nucleosome-remodeling factor subunit NURF301

Gene

E(bx)

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone-binding component of NURF (nucleosome remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. Required for homeotic gene expression, proper larval blood cell development, normal male X chromosome morphology, ecdysteroid signaling and metamorphosis.4 Publications

Miscellaneous

Highly susceptible to proteolysis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei2497Histone H3K4me3By similarity1
Binding sitei2504Histone H3K4me3By similarity1
Binding sitei2510Histone H3K4me3By similarity1
Binding sitei2519Histone H3K4me3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi6 – 18A.T hookAdd BLAST13
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri339 – 386PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri2481 – 2546PHD-type 2PROSITE-ProRule annotationAdd BLAST66

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator, Developmental protein, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleosome-remodeling factor subunit NURF301
Alternative name(s):
Enhancer of bithorax
Nucleosome-remodeling factor 215 kDa subunit
Short name:
NURF-215
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:E(bx)
ORF Names:CG32346, CG7022, Nurf301
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0000541 E(bx)

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002493221 – 2669Nucleosome-remodeling factor subunit NURF301Add BLAST2669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei40Phosphoserine1 Publication1
Modified residuei52Phosphoserine1 Publication1
Modified residuei55Phosphoserine1 Publication1
Modified residuei59Phosphoserine1 Publication1
Modified residuei62Phosphoserine1 Publication1
Modified residuei1417Phosphoserine1 Publication1
Modified residuei1527Phosphothreonine1 Publication1
Modified residuei2395Phosphoserine1 Publication1
Modified residuei2398Phosphoserine1 Publication1
Modified residuei2403Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W0T1

PRoteomics IDEntifications database

More...
PRIDEi
Q9W0T1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9W0T1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0000541 Expressed in embryo and 30 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9W0T1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W0T1 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the NURF complex composed of Caf1, E(bx), Nurf-38 and Iswi.

Interacts with Trl.

Interacts with histone H3-K4Me3.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
69297, 24 interactors

Protein interaction database and analysis system

More...
IntActi
Q9W0T1, 10 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304412

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W0T1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 248DDTPROSITE-ProRule annotationAdd BLAST61
Domaini2573 – 2643BromoPROSITE-ProRule annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 121Required for function in nucleosome slidingAdd BLAST121

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili460 – 515Sequence analysisAdd BLAST56
Coiled coili688 – 720Sequence analysisAdd BLAST33
Coiled coili2338 – 2373Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi989 – 993Poly-Leu5
Compositional biasi1567 – 1571Poly-Ala5
Compositional biasi1626 – 1629Poly-Thr4
Compositional biasi1707 – 2113Gln-richAdd BLAST407

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The second PHD-type zinc finger mediates binding to histone H3K4Me3.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the BPTF family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri339 – 386PHD-type 1PROSITE-ProRule annotationAdd BLAST48
Zinc fingeri2481 – 2546PHD-type 2PROSITE-ProRule annotationAdd BLAST66

Keywords - Domaini

Bromodomain, Coiled coil, Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1473 Eukaryota
KOG1632 Eukaryota
COG5076 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154830

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W0T1

KEGG Orthology (KO)

More...
KOi
K11728

Identification of Orthologs from Complete Genome Data

More...
OMAi
RYWFIAR

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9W0T1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.920.10, 2 hits
3.30.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038028 BPTF
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR028942 WHIM1_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD

The PANTHER Classification System

More...
PANTHERi
PTHR45975 PTHR45975, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF00628 PHD, 3 hits
PF15612 WHIM1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00503 BROMODOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00249 PHD, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS01359 ZF_PHD_1, 3 hits
PS50016 ZF_PHD_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: Q9W0T1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGRGSRKRG RPPKTPNERA SGRFNYQLLK KPKYLSEGKS QPSTPSASRG
60 70 80 90 100
ISPQSDEGSR SSHNNHTNRS RGSAAKRGRG RKSAVQPNTS SYSGRKGYES
110 120 130 140 150
EYHYGSDFGD SEEDKSDNED DMLLTPSDDE SLEVANESES EFSVCSFNQN
160 170 180 190 200
GVGRPPRPPS PEPVWLQEGR QYAALDLPDS SEDLFIANTH VLRALSIYEV
210 220 230 240 250
LRRFRHMVRL SPFRFEDLCA ALACEEQSAL LTEVHIMLLK AILREEDAQG
260 270 280 290 300
THFGPLDQKD TVNISLYLID SITWPEVLRS YVESDKTFDR NVFHILSHTE
310 320 330 340 350
YPYTGIDNRL EVLQFLSDQF LTSNSIRDVM LQEGPIHYDD HCRVCHRLGD
360 370 380 390 400
LLCCETCPAV YHLECVDPPM NDVPTEDWQC GLCRSHKVSG VVDCVLPQEK
410 420 430 440 450
QGVLIRHDSL GVDRHGRKYW FIARRIFIED QENFTCWYYS TTSKLKLLLS
460 470 480 490 500
RLDAEELETR LHSQITERRD EIERQMKLTE TLTNEHKHTK RSVIEIEQEA
510 520 530 540 550
KNELLEKEVL DEDEKDGDAK SESQSIEGTK KQEECKMVTR QKSNQLTNGT
560 570 580 590 600
LHFKLGMEQG FKNYVNQYST NPIALNKPQR NEERDKRRHL SHKFSLTTAS
610 620 630 640 650
DFKWIGITMG TTDNMITTLR QTLINFESNI AASFLNINWV VNKKIWNAAV
660 670 680 690 700
MNARRPSEFA VVLLLFQASL KSVVFANVWH EQLGHTTLQR ITSAEREERK
710 720 730 740 750
KLEKREKRER DDEEERNRLA FNYIKYTLGL KHQVWKQKGE EYRVHGQWGW
760 770 780 790 800
LWLSSSRRCG VRARRAQPLT HNRVYVHYTM GEENDVNEII LVDPRTQRFM
810 820 830 840 850
QQCESSNVDG QVCHYLPDQY KNVKVIEDVT EKIKGHIDVS KALNAPGRTY
860 870 880 890 900
YSKVARKSRL DDLLDRRLKL AEVEEQMASK IPSDMKPLLV SSQNNTANSK
910 920 930 940 950
QTFLEKRLLR LTEVQAKGGP ANVNLELVNS LAKQIQTVRL QFSQLNRFAK
960 970 980 990 1000
VFRCYTKECN TNSNAVSQIT QNTCYSPLCL QKARAKKELL LLLRKAHTAG
1010 1020 1030 1040 1050
NGSKETVAAI LGAVKKPSIL EQKLTEGKRE STQVAVDDSE EGKPAESEAP
1060 1070 1080 1090 1100
LDLLQDWEHA RAHAVPFSDS LLTECILVDQ ECVTNTKIKQ EVNASSGCNT
1110 1120 1130 1140 1150
TPDSNTQDSD KIDYIESMDV CSNVEIESTE DSIVTGLNSG NAEDVDMTPG
1160 1170 1180 1190 1200
WRRKRNQKSK KSYIGTKDVL DQTLDKDIPL NKQNRRFPIT ARPVKRECVK
1210 1220 1230 1240 1250
KYERETFENG NERVYSTSSP RGRVYLLNDA AKLYEQAVKT EDKSTITKKP
1260 1270 1280 1290 1300
SYSRYPLISN FLTHKKKRSL LVLPRFELLK LARLGGKSST NGFHHAAKNN
1310 1320 1330 1340 1350
TIWQYQCSRP LFRTCWSYRT SNATSLSSLA LQLRILWSCL RWDDMIAKPP
1360 1370 1380 1390 1400
STDGKHQVTT DTEIVTLELL KLRHSGRYGE KTSYLRRKVV IPLEMPKTVR
1410 1420 1430 1440 1450
EVTSIRSGLR KRKRAESPQP TEPQITEEWV DEDKLELWEI KFMGEKQEKA
1460 1470 1480 1490 1500
RLSAVTRSVA SRQLEASGSN GSNTSTNGAL GVAGRVQLAP KLSEDVKEKM
1510 1520 1530 1540 1550
EQQLKLQRAV HQQRKLVATG EITRSVTPVK GQVIGSRRVI VKNPDGTTRI
1560 1570 1580 1590 1600
IQQAVTQVSR TGGANTAAAA ASPTVGGSTS TQSNPSTSTP HKVQIIRGPD
1610 1620 1630 1640 1650
GKVSVRGLNP GQQLVQMPDG KLHVLTTTTS SNSAGQGNKM KVPIKPASTS
1660 1670 1680 1690 1700
SSPAISSAQT TTNPVTPVIK QIAVKHVTKN SATQSIASSS RVALPLAQIK
1710 1720 1730 1740 1750
NKLLLAQQQQ QSTSSSPATS SSPVQKIVSK VVNTSTSGQT LQQVFVQSGS
1760 1770 1780 1790 1800
KLVVGQNAQG QKVIISTSAA QQQGTSPVQQ QQLVQSQPIQ QSPQQISMTQ
1810 1820 1830 1840 1850
VGNQPTQKVI QQIVNTSNVQ QQIVVGGQRI ILSPGQTIVT QRNVPQSQAL
1860 1870 1880 1890 1900
QMVQQQIQTQ QQQQQHHVVQ PQQQFVVQSN QIVQSSPSAQ TKLVKQLVVQ
1910 1920 1930 1940 1950
QQSQQTIEEK TQITTTDSNE TGTQQVLVPN STLAQQLAQG KLQVATVNGQ
1960 1970 1980 1990 2000
QVIVKPLGNN QAQIVAHIKH QGDGNAHIVT SNSATAVPQA NPQTSPVKQQ
2010 2020 2030 2040 2050
ALPPQSPQQV VVQQQQIHQQ SPTNFESGVT PITQQPVLTQ AVQAPAQQQA
2060 2070 2080 2090 2100
LSVEESLLQN QPPGTVIKCV TAQVLQTEHG PRIVLQGLVG NDFTAQQLQL
2110 2120 2130 2140 2150
VQTQVKQQLM KAQESNGKLG VLGPTKIYLA VQPENAVQSQ PPPLTPVHQS
2160 2170 2180 2190 2200
AAHQQTNNIE IDADTLATTY EANSTIKDIA INNGDDQENS KCAETENSNI
2210 2220 2230 2240 2250
TTNESFAGTS SLLEGSEHDE PTNLAGLDIS ETDLENKQNE SFVVTRGYIQ
2260 2270 2280 2290 2300
KSISNALKQG NLSPELEEKL VCMQKQQENA NSTNEWETCS RGSVNEEALT
2310 2320 2330 2340 2350
PSRQTDDTEW KIRTSLRRPN AMTTSSQFNR ILKKNRSKND EVAELGEQKQ
2360 2370 2380 2390 2400
SQLERHKELL KKNILRKRSL LERNLQSEIH EDVKTKVQRH VRPLSNASPD
2410 2420 2430 2440 2450
EQSENERSGE PNLDFKRTEV QNPRHGAGRP KKLTRKKEKL YCICRTPYDD
2460 2470 2480 2490 2500
TKFYVGCDLC SNWFHGDCVS ITEEASKKLS EFICIDCKRA RETQQLYCSC
2510 2520 2530 2540 2550
RQPYDESQFY ICCDKCQDWF HGRCVGILQS EAEFIDEYVC PECQRKNDAN
2560 2570 2580 2590 2600
AANMKKLTSN DVEELKNLIK QMQLHKSAWP FMEPVDPKEA PDYYKVIKEP
2610 2620 2630 2640 2650
MDLKRMEIKL ESNTYTKLSE FIGDMTKIFD NCRYYNPKES SFYKCAEALE
2660
SYFVQKIKNF RENVFDQRT
Length:2,669
Mass (Da):300,686
Last modified:October 1, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i261FF7B7CEEF781B
GO
Isoform B (identifier: Q9W0T1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1800-1819: Missing.

Show »
Length:2,649
Mass (Da):298,508
Checksum:iC0D7F7E015EA5403
GO
Isoform C (identifier: Q9W0T1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2156-2159: TNNI → VSSF
     2160-2669: Missing.

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Length:2,159
Mass (Da):241,634
Checksum:i3188DE0E966A5CF8
GO
Isoform D (identifier: Q9W0T1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1800-1819: Missing.
     2156-2159: TNNI → VSSF
     2160-2669: Missing.

Show »
Length:2,139
Mass (Da):239,456
Checksum:i144D5FD2A2EEFE0A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E1JHV6E1JHV6_DROME
Enhancer of bithorax, isoform E
E(bx) CG10894, CG17135, CG32478, CG7022, Dmel\CG32346
2,669Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PDH1M9PDH1_DROME
Enhancer of bithorax, isoform H
E(bx) CG10894, CG17135, CG32478, CG7022, Dmel\CG32346
2,761Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E1JHV7E1JHV7_DROME
Enhancer of bithorax, isoform F
E(bx) CG10894, CG17135, CG32478, CG7022, Dmel\CG32346
2,139Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PE12M9PE12_DROME
Enhancer of bithorax, isoform I
E(bx) CG10894, CG17135, CG32478, CG7022, Dmel\CG32346
2,668Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBG5M9PBG5_DROME
Enhancer of bithorax, isoform G
E(bx) CG10894, CG17135, CG32478, CG7022, Dmel\CG32346
2,163Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK93200 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAY51526 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAY55558 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti307D → Y in AAL16644 (PubMed:11583616).Curated1
Sequence conflicti2156T → A in AAL16644 (PubMed:11583616).Curated1
Sequence conflicti2252S → A in AAL16644 (PubMed:11583616).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0204221800 – 1819Missing in isoform B and isoform D. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_0204232156 – 2159TNNI → VSSF in isoform C and isoform D. 1 Publication4
Alternative sequenceiVSP_0204242160 – 2669Missing in isoform C and isoform D. 1 PublicationAdd BLAST510

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF417921 mRNA Translation: AAL16644.1
AE014296 Genomic DNA Translation: AAN11431.1
AE014296 Genomic DNA Translation: AAF47361.2
AE014296 Genomic DNA Translation: AAS64922.1
AY051776 mRNA Translation: AAK93200.1 Different initiation.
BT023142 mRNA Translation: AAY55558.1 Sequence problems.
BT022131 mRNA Translation: AAY51526.1 Sequence problems.

NCBI Reference Sequences

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RefSeqi
NP_001163304.1, NM_001169833.2 [Q9W0T1-1]
NP_001261190.1, NM_001274261.1 [Q9W0T1-1]
NP_728505.1, NM_167817.3 [Q9W0T1-2]
NP_728507.1, NM_167819.3 [Q9W0T1-1]
NP_995946.1, NM_206224.3 [Q9W0T1-3]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0072521; FBpp0072421; FBgn0000541 [Q9W0T1-1]
FBtr0072522; FBpp0072422; FBgn0000541 [Q9W0T1-2]
FBtr0072523; FBpp0089425; FBgn0000541 [Q9W0T1-3]
FBtr0301348; FBpp0290562; FBgn0000541 [Q9W0T1-1]
FBtr0301349; FBpp0290563; FBgn0000541 [Q9W0T1-4]
FBtr0332104; FBpp0304414; FBgn0000541 [Q9W0T1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
44811

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG32346

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF417921 mRNA Translation: AAL16644.1
AE014296 Genomic DNA Translation: AAN11431.1
AE014296 Genomic DNA Translation: AAF47361.2
AE014296 Genomic DNA Translation: AAS64922.1
AY051776 mRNA Translation: AAK93200.1 Different initiation.
BT023142 mRNA Translation: AAY55558.1 Sequence problems.
BT022131 mRNA Translation: AAY51526.1 Sequence problems.
RefSeqiNP_001163304.1, NM_001169833.2 [Q9W0T1-1]
NP_001261190.1, NM_001274261.1 [Q9W0T1-1]
NP_728505.1, NM_167817.3 [Q9W0T1-2]
NP_728507.1, NM_167819.3 [Q9W0T1-1]
NP_995946.1, NM_206224.3 [Q9W0T1-3]

3D structure databases

SMRiQ9W0T1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi69297, 24 interactors
IntActiQ9W0T1, 10 interactors
STRINGi7227.FBpp0304412

PTM databases

iPTMnetiQ9W0T1

Proteomic databases

PaxDbiQ9W0T1
PRIDEiQ9W0T1

Genome annotation databases

EnsemblMetazoaiFBtr0072521; FBpp0072421; FBgn0000541 [Q9W0T1-1]
FBtr0072522; FBpp0072422; FBgn0000541 [Q9W0T1-2]
FBtr0072523; FBpp0089425; FBgn0000541 [Q9W0T1-3]
FBtr0301348; FBpp0290562; FBgn0000541 [Q9W0T1-1]
FBtr0301349; FBpp0290563; FBgn0000541 [Q9W0T1-4]
FBtr0332104; FBpp0304414; FBgn0000541 [Q9W0T1-1]
GeneIDi44811
KEGGidme:Dmel_CG32346

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
44811
FlyBaseiFBgn0000541 E(bx)

Phylogenomic databases

eggNOGiKOG1473 Eukaryota
KOG1632 Eukaryota
COG5076 LUCA
GeneTreeiENSGT00940000154830
InParanoidiQ9W0T1
KOiK11728
OMAiRYWFIAR
PhylomeDBiQ9W0T1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
44811 1 hit in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
E(bx) fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
44811

Protein Ontology

More...
PROi
PR:Q9W0T1

Gene expression databases

BgeeiFBgn0000541 Expressed in embryo and 30 other tissues
ExpressionAtlasiQ9W0T1 baseline and differential
GenevisibleiQ9W0T1 DM

Family and domain databases

Gene3Di1.20.920.10, 2 hits
3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR038028 BPTF
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR018359 Bromodomain_CS
IPR018501 DDT_dom
IPR028942 WHIM1_dom
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR45975 PTHR45975, 2 hits
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF02791 DDT, 1 hit
PF00628 PHD, 3 hits
PF15612 WHIM1, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SM00571 DDT, 1 hit
SM00249 PHD, 3 hits
SUPFAMiSSF47370 SSF47370, 1 hit
SSF57903 SSF57903, 3 hits
PROSITEiView protein in PROSITE
PS00633 BROMODOMAIN_1, 1 hit
PS50014 BROMODOMAIN_2, 1 hit
PS50827 DDT, 1 hit
PS01359 ZF_PHD_1, 3 hits
PS50016 ZF_PHD_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNU301_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W0T1
Secondary accession number(s): Q4V464
, Q7KVD8, Q95VB8, Q960Y3, Q9W0T2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2002
Last modified: June 17, 2020
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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