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UniProtKB - Q9W0P8 (MED14_DROME)

Entry version 122 (02 Dec 2020)
Sequence version 4 (01 Jun 2003)
Previous versions | rss
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Protein

Mediator of RNA polymerase II transcription subunit 14

Gene

MED14

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. Required for activated transcription of the MtnA, MtnB and MtnD genes.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transcription coregulator activity Source: UniProtKB
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 14
Alternative name(s):
Mediator complex subunit 14
dRGR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MED14
Synonyms:Trap170
ORF Names:CG12031
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0035145, MED14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003045881 – 1553Mediator of RNA polymerase II transcription subunit 14Add BLAST1553

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei615Phosphoserine1 Publication1
Modified residuei1015Phosphoserine1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9W0P8

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9W0P8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0035145, Expressed in female gonad and 18 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9W0P8, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9W0P8, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which may include CDK8, MED4, MED6, MED11, MED14, MED17, MED18, MED20, MED21, MED22, MED27, MED28, MED30 and MED31.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		63628, 49 interactors

Database of interacting proteins

More...DIPi		DIP-60711N

Protein interaction database and analysis system

More...IntActi		Q9W0P8, 2 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0072453

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi55 – 59LXXLL motif 15
Motifi472 – 476LXXLL motif 25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1048 – 1172Pro-richAdd BLAST125
Compositional biasi1496 – 1552Pro-richAdd BLAST57

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 14 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1875, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001021

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001928_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9W0P8

Identification of Orthologs from Complete Genome Data

More...OMAi		HLDCPIT

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9W0P8

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013947, Mediator_Med14

The PANTHER Classification System

More...PANTHERi		PTHR12809, PTHR12809, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF08638, Med14, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9W0P8-1) [UniParc]FASTAAdd to basket
Also known as: AImported

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPTPLPLEQ MPGVGGGGGG YLPAAQEGGP RINTMSMSVL IDFIIQRTYH 
        60         70         80         90        100
ELTVLAELLP RKTDMERKVE IYNYAARTRH LFTRLNALVK WGNSVSKVDK 
       110        120        130        140        150
SSQIMSFLDK QNMLFVETAD MLARMSRETL VRARLPNFHI PAAVEVLTTG 
       160        170        180        190        200
TYNRLPTCIR ERIVPADAIT PAEKRQTLLR LNQVIQHRLV TGKLLPQMRE 
       210        220        230        240        250
FRIRNGRVTF EVKHEFSVSL TVMGDNPTVP WRLLDIDVLV EDKETGDGKS 
       260        270        280        290        300
LVHPLQVNYI HQLIQARLVE NPNALSEVYN CLHYFCQSLQ LEVLYTQTLR 
       310        320        330        340        350
LNYERLDDNN ITVEEYVPGV KLTVSYWRDL KSELGYRLTV QSDPSEIGRP 
       360        370        380        390        400
LAVVHVPSLG AKESAEVADR AVRSEHLSME RLIVHTVYIR SVSRLSDLKL 
       410        420        430        440        450
EFQAFLKDVD FNLQGTPAIL TVPVLSPCLR AEQIHITIDT HTGMFRCHVP 
       460        470        480        490        500
KHLDCPIMEE MQDCLNGDRS KLPALLSELR FWITHRRCDK TLQHLPATAT 
       510        520        530        540        550
ETLPFLVQPD QEILQPGRHK IYVKLHRHPN IVLVVQLKEK TTMPNEMEYT 
       560        570        580        590        600
FHLGFVAYQK DELDVIDDSA MQLVSIVAQP HSDIPKCYTK LMRLIEFDTF 
       610        620        630        640        650
VATHGPGTEV DAEVSPHKRK SNGDLLAPPA KQQKTIFPAY FIPELAHVVA 
       660        670        680        690        700
MCDEKIPFMN LAQTLSKHNI PHSGLQVEAN ATSLVLKILA LPQPGKTTFA 
       710        720        730        740        750
TQQQQQQGAP AVAGENKPSG TSGLPKIDSH VWDDLMRRVL SISIRSQTNK 
       760        770        780        790        800
NSQVRIWVVE FVFYSTPLQS SHPKEQGSRR TVYLTYEQAN YDFSKTVEDL 
       810        820        830        840        850
LNDWSKIVYL YTLVYDFAEQ LLNKRLSLCD MLVVKSYSYM NLLLGYGPKK 
       860        870        880        890        900
EVSCNIYWSV QSHGFRLTFV GGMSAVNGHS MMRDQLAQHL NQQHSITQIA 
       910        920        930        940        950
QILHETYNPL SSIAKLPVLP FLGIPRPQVP VLSFCVLAQS PCLIRLTYQA 
       960        970        980        990       1000
VYCLELRFRA NRLVSIRDGA SSRFERNVVE EFTPIQGLKA FLSKYVDESA 
      1010       1020       1030       1040       1050
VYRGRASHED DNPLSPMGME DNFGGPSSVA GVSAGGSSPF LGTGMRGPQS 
      1060       1070       1080       1090       1100
PRDSGLRFPA PHTPPSSSNP HTPASPHPSA GAGGGSGPQG HGNFNLTSPP 
      1110       1120       1130       1140       1150
APHMPHPSPS GLMPSSPLNP QPSPHMVHSP GPNTLYMQSH QDSPFTAMSP 
      1160       1170       1180       1190       1200
ANNNWPGSPS MPRPSPRPGQ SPDHKSTGGG AGVAGGTDRG GSRGTLNRPW 
      1210       1220       1230       1240       1250
AGAVPTLLTH EALETLCRPS PYPNKDINVP DMSPLERFLG CVYMRRQLHR 
      1260       1270       1280       1290       1300
NIQSEETLTA LNSTEPGVVL FKVDGLQCQV VLNQMHMQTL HLKVSQLPPM 
      1310       1320       1330       1340       1350
PDKHPPPFQL SQDDLLVIEQ YFDTRVAAPP YRPNSLHSIC RLLNLPAQVL 
      1360       1370       1380       1390       1400
KDFVQIMRLD LKPELGGDQL KWTVQICLRM PPSAVPIVPS GNACVVMGRM 
      1410       1420       1430       1440       1450
KILFFLQITR IPYGAVIGVG KDWKDSPSLV LPIVYDIQTN VTQLAERTGQ 
      1460       1470       1480       1490       1500
VISPTMTAAS TLLRRFAEFN AQQNQCTLFP AITDLLTNLQ LAAEMPQPPP 
      1510       1520       1530       1540       1550
NQSIGPPVGV GVGVGSSPNP MMPMQQLPQQ VGPQGPVGPG GYPQMGPNPG 

GPQ
Length:1,553
Mass (Da):172,341
Last modified:June 1, 2003 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71CF4DA8A23A5023
GO
Isoform 2Curated (identifier: Q9W0P8-3) [UniParc]FASTAAdd to basket
Also known as: CImported

The sequence of this isoform differs from the canonical sequence as follows:
     410-410: D → DCE

Show »
Length:1,555
Mass (Da):172,573
Checksum:i593980FAF78DAD37
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAG02462 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAK84939 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti698T → N in AAK84939 (PubMed:12537569).Curated1
Sequence conflicti698T → N in AAV36836 (Ref. 3) Curated1
Sequence conflicti822L → Q in AAK84939 (PubMed:12537569).Curated1
Sequence conflicti822L → Q in AAV36836 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_058119410D → DCE in isoform 2. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47395.4
AE014296 Genomic DNA Translation: AAN11445.2
BT015951 mRNA Translation: AAV36836.1
AF289997 mRNA Translation: AAG02462.1 Different initiation.
AY050240 mRNA Translation: AAK84939.1 Different initiation.

NCBI Reference Sequences

More...RefSeqi		NP_612041.2, NM_138197.3 [Q9W0P8-1]
NP_728534.2, NM_167835.2 [Q9W0P8-3]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0072554; FBpp0072453; FBgn0035145 [Q9W0P8-1]
FBtr0344912; FBpp0311212; FBgn0035145 [Q9W0P8-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		38073

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG12031

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47395.4
AE014296 Genomic DNA Translation: AAN11445.2
BT015951 mRNA Translation: AAV36836.1
AF289997 mRNA Translation: AAG02462.1 Different initiation.
AY050240 mRNA Translation: AAK84939.1 Different initiation.
RefSeqiNP_612041.2, NM_138197.3 [Q9W0P8-1]
NP_728534.2, NM_167835.2 [Q9W0P8-3]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi63628, 49 interactors
DIPiDIP-60711N
IntActiQ9W0P8, 2 interactors
STRINGi7227.FBpp0072453

PTM databases

iPTMnetiQ9W0P8

Proteomic databases

PaxDbiQ9W0P8

Genome annotation databases

EnsemblMetazoaiFBtr0072554; FBpp0072453; FBgn0035145 [Q9W0P8-1]
FBtr0344912; FBpp0311212; FBgn0035145 [Q9W0P8-3]
GeneIDi38073
KEGGidme:Dmel_CG12031

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		9282
FlyBaseiFBgn0035145, MED14

Phylogenomic databases

eggNOGiKOG1875, Eukaryota
GeneTreeiENSGT00390000001021
HOGENOMiCLU_001928_0_0_1
InParanoidiQ9W0P8
OMAiHLDCPIT
PhylomeDBiQ9W0P8

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		38073, 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		38073

Protein Ontology

More...PROi		PR:Q9W0P8

Gene expression databases

BgeeiFBgn0035145, Expressed in female gonad and 18 other tissues
ExpressionAtlasiQ9W0P8, baseline and differential
GenevisibleiQ9W0P8, DM

Family and domain databases

InterProiView protein in InterPro
IPR013947, Mediator_Med14
PANTHERiPTHR12809, PTHR12809, 1 hit
PfamiView protein in Pfam
PF08638, Med14, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED14_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W0P8
Secondary accession number(s): Q5U1E1
, Q8IRI9, Q961S0, Q9GYW6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: June 1, 2003
Last modified: December 2, 2020
This is version 122 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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