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UniProtKB - Q9W0L6 (Q9W0L6_DROME)

Entry version 154 (19 Jan 2022)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein
Submitted name:

GH22266p

Gene

Dmel\CG13907

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-210991, Basigin interactions
R-DME-433692, Proton-coupled monocarboxylate transport
R-DME-70268, Pyruvate metabolism

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
GH22266pImported
Submitted name:
Uncharacterized protein, isoform AImported
Submitted name:
Uncharacterized protein, isoform BImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dmel\CG13907Imported
ORF Names:CG13907Imported, Dmel_CG13907Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0035173, CG13907

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		VectorBase:FBgn0035173

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Transmembranei116 – 138HelicalSequence analysisAdd BLAST23
Transmembranei145 – 164HelicalSequence analysisAdd BLAST20
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei235 – 253HelicalSequence analysisAdd BLAST19
Transmembranei571 – 592HelicalSequence analysisAdd BLAST22
Transmembranei607 – 625HelicalSequence analysisAdd BLAST19
Transmembranei637 – 654HelicalSequence analysisAdd BLAST18
Transmembranei660 – 686HelicalSequence analysisAdd BLAST27
Transmembranei698 – 719HelicalSequence analysisAdd BLAST22
Transmembranei731 – 750HelicalSequence analysisAdd BLAST20

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0035173, Expressed in adult organism and 37 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		7227.FBpp0072490

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni35 – 71DisorderedSequence analysisAdd BLAST37
Regioni350 – 395DisorderedSequence analysisAdd BLAST46
Regioni452 – 481DisorderedSequence analysisAdd BLAST30
Regioni761 – 783DisorderedSequence analysisAdd BLAST23
Regioni796 – 816DisorderedSequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi47 – 66Acidic residuesSequence analysisAdd BLAST20
Compositional biasi350 – 368Polar residuesSequence analysisAdd BLAST19
Compositional biasi459 – 479Polar residuesSequence analysisAdd BLAST21
Compositional biasi799 – 816Polar residuesSequence analysisAdd BLAST18

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2504, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000173943

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001265_59_2_1

Identification of Orthologs from Complete Genome Data

More...OMAi		TKYEKSM

Database of Orthologous Groups

More...OrthoDBi		916876at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1250.20, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07690, MFS_1, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF103473, SSF103473, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W0L6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVDTNSSNPG IVGGNSASSA RLRRFERTDS ELACEEAARL TAEQSPEDED 
        60         70         80         90        100
NQDNDEDDDD EESVYGELPP PPDGGYGWVI CFASFMCNMI VDGIAYTFGI 
       110        120        130        140        150
FLEEFVAYFH EGKGTVAWVG SLLSGVYLSA GPIVSALANK YGCRAVCIAG 
       160        170        180        190        200
SIIACIAFVL STFSTNVSML MATYGFMGGF GFGMIYLPAV VAVGYYFETK 
       210        220        230        240        250
RSLATGIAVC GSGFGTFAFA PLATYLLEEY GWKNALLIFA GLILNCAIFG 
       260        270        280        290        300
AMMRPLTYPK KKKQKPLMQR MYEEKQLQLE RGSFAGSHFM VQLPDGTIER 
       310        320        330        340        350
KLKMPLNADP GVHSSLNLEL LAQQAGGGGL HPVSTLPTIT ESKVVDVHRQ 
       360        370        380        390        400
NGAQSPPNGD SNGQLSARSA AGAVGRRPHR NSESENSPYH SQDAMTRNAS 
       410        420        430        440        450
QPAFLAGDHQ SLPKNGSVPA FNTRVRKTSA SERFQPSLAA IRATSRGDLE 
       460        470        480        490        500
AGAGGDFASS KLSLSQRQGG SQTGSSGRMV RPMSRKDIFY SGSVTNLPQY 
       510        520        530        540        550
QSQKSLANYR NSVLSLTKYE KSMQSVAKLD PLAEAEKHRE EYDLCPCLGI 
       560        570        580        590        600
PDSVKSVVNT MLDVSLLKDP VFMLIGVSNI FGMAGLYVPF VYLVDAAKEH 
       610        620        630        640        650
DIPKNDAAML LSIIGITNTV GRVFCGWVAD LPQVNSLLLN NCCLLVSTIA 
       660        670        680        690        700
VTLTPLCYSY AAYITMSIFF GLAISGYISL TSIILVDLLG LDKLTNAFGL 
       710        720        730        740        750
LILFRGFAAL IGTPLAGAIY DMTHTYDLPF YMAGALFGIS TITSFLAPCL 
       760        770        780        790        800
KRCSPSEETP VHVETLTPID EEQGEDAEDD EDQPITIVPK IIKTLASPQQ 
       810 
EEGHPQFPQK TSESKL
Length:816
Mass (Da):88,036
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i50BE65184E3DD900
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47427.1
AY089513 mRNA Translation: AAL90251.1
AE014296 Genomic DNA Translation: AHN57919.1

NCBI Reference Sequences

More...RefSeqi		NP_001286894.1, NM_001299965.1
NP_612069.1, NM_138225.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0072593; FBpp0072490; FBgn0035173
FBtr0345005; FBpp0311256; FBgn0035173

Database of genes from NCBI RefSeq genomes

More...GeneIDi		38104

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG13907

UCSC genome browser

More...UCSCi		CG13907-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47427.1
AY089513 mRNA Translation: AAL90251.1
AE014296 Genomic DNA Translation: AHN57919.1
RefSeqiNP_001286894.1, NM_001299965.1
NP_612069.1, NM_138225.3

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi7227.FBpp0072490

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		38104

Genome annotation databases

EnsemblMetazoaiFBtr0072593; FBpp0072490; FBgn0035173
FBtr0345005; FBpp0311256; FBgn0035173
GeneIDi38104
KEGGidme:Dmel_CG13907
UCSCiCG13907-RA, d. melanogaster

Organism-specific databases

FlyBaseiFBgn0035173, CG13907
VEuPathDBiVectorBase:FBgn0035173

Phylogenomic databases

eggNOGiKOG2504, Eukaryota
GeneTreeiENSGT00940000173943
HOGENOMiCLU_001265_59_2_1
OMAiTKYEKSM
OrthoDBi916876at2759

Enzyme and pathway databases

ReactomeiR-DME-210991, Basigin interactions
R-DME-433692, Proton-coupled monocarboxylate transport
R-DME-70268, Pyruvate metabolism

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		38104, 0 hits in 3 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		38104

Gene expression databases

BgeeiFBgn0035173, Expressed in adult organism and 37 other tissues

Family and domain databases

Gene3Di1.20.1250.20, 2 hits
InterProiView protein in InterPro
IPR011701, MFS
IPR036259, MFS_trans_sf
PfamiView protein in Pfam
PF07690, MFS_1, 2 hits
SUPFAMiSSF103473, SSF103473, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W0L6_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W0L6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: January 19, 2022
This is version 154 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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