UniProtKB - Q9W0K7 (BAB1_DROME)
Protein
Protein bric-a-brac 1
Gene
bab1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.1 Publication1 Publication
Miscellaneous
'Bric-a-brac' means 'jumble' in French (referring to the mutant ovary phenotype).
Caution
A paper showing that the protein forms homodimers via the BTB domain has been retracted by the authors, due to concerns regarding the validity of their data. However, they still consider that their main conclusions may be correct and require further testing.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 569 – 614 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 46 | |
DNA bindingi | 621 – 632 | A.T hookAdd BLAST | 12 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: FlyBase
- minor groove of adenine-thymine-rich DNA binding Source: FlyBase
GO - Biological processi
- eye-antennal disc morphogenesis Source: UniProtKB
- female sex differentiation Source: FlyBase
- leg disc morphogenesis Source: UniProtKB
- negative regulation of developmental pigmentation Source: FlyBase
- negative regulation of male pigmentation Source: FlyBase
- regulation of developmental pigmentation Source: FlyBase
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- sex differentiation Source: FlyBase
- sex-specific pigmentation Source: FlyBase
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
SignaLinki | Q9W0K7 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein bric-a-brac 1 |
Gene namesi | Name:bab1 Synonyms:bab ORF Names:CG9097 |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0004870, bab1 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064790 | 1 – 977 | Protein bric-a-brac 1Add BLAST | 977 |
Proteomic databases
PaxDbi | Q9W0K7 |
Expressioni
Tissue specificityi
Leg imaginal disk at the central region of the tarsus and in eye antenna disk at the basal cylinder.1 Publication
Gene expression databases
Bgeei | FBgn0004870, Expressed in antenna and 24 other tissues |
ExpressionAtlasi | Q9W0K7, baseline and differential |
Genevisiblei | Q9W0K7, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 63665, 13 interactors |
DIPi | DIP-18590N |
IntActi | Q9W0K7, 9 interactors |
STRINGi | 7227.FBpp0072538 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 127 – 192 | BTBPROSITE-ProRule annotationCuratedAdd BLAST | 66 | |
Domaini | 559 – 611 | HTH psq-typePROSITE-ProRule annotationAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | ENOG502RYZ4, Eukaryota |
GeneTreei | ENSGT00940000173981 |
InParanoidi | Q9W0K7 |
OrthoDBi | 686400at2759 |
PhylomeDBi | Q9W0K7 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR009057, Homeobox-like_sf IPR007889, HTH_Psq IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF05225, HTH_psq, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS50960, HTH_PSQ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9W0K7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASAQAETNV GLASEQGPVA QRQRKGTGSG ADSPKSNRSS PTQQEEKRIK
60 70 80 90 100
SEDRTSPTGG AKDEDKESQG HAVAGGGGSS PVSSPQGRSS SVASPSSSSQ
110 120 130 140 150
QFCLRWNNYQ TNLTTIFDQL LQNECFVDVT LACDGRSMKA HKMVLSACSP
160 170 180 190 200
YFQTLLAETP CQHPIVIMRD VNWSDLKAIV EFMYRGEINV SQDQIGPLLR
210 220 230 240 250
IAEMLKVRGL ADVTHMEAAT AAAAAASSER MPSSPKESTS TSRTEHDRER
260 270 280 290 300
EAEELLAFMQ PEKKLRTSDW DPAELRLSPL ERQQGRNVRK RRWPSADTIF
310 320 330 340 350
NPPAPPSPLS SLIAAERMEL EQKERERQRD CSLMTPPPKP PMSSGSTVGA
360 370 380 390 400
TRRLETAIHA LDMPSPAATP GPLSRSSRPH SQSPQQQQAQ QQGQLPLPLP
410 420 430 440 450
LHPHHHASPA PHPSQTAGSA HHPASPAGDS RFPLGPAAAM AAARELSGLG
460 470 480 490 500
PGPSAEPRLP PPPPHHHGGG GVGGGGVGGG GAGGVGSGGG SSLADDLEIK
510 520 530 540 550
PGIAEMIREE ERAKMMENSH AWMGATGSTL AADSYQYQLQ SMWQKCWNTN
560 570 580 590 600
QNLMHHMRFR ERGPLKSWRP ETMAEAIFSV LKEGLSLSQA ARKYDIPYPT
610 620 630 640 650
FVLYANRVHN MLGPSIDGGP DLRPKGRGRP QRILLGIWPD EHIKGVIKTV
660 670 680 690 700
VFRDTKDIKD ESLAAHMPPY GRHSPAFPLQ DLPLSYPGAS GALAGAPSSM
710 720 730 740 750
ACPNGSGPQT GVGVAGEQHM SQETAAAVAA VAHNIRQQMQ MAAVPPGLFN
760 770 780 790 800
LPPHPGVGGG VGNVPGAAGG RASISPALSS GSGPRHAPSP CGPAGLLPNL
810 820 830 840 850
PPSMAVALHH QQQQQAAHHH MQQLHLQQQQ AHLHHHQQQQ QQQQQQHHQG
860 870 880 890 900
GHQVAHKSGF GASSSSSASS SSMGQHHAPK AKSSPLRSET PRLHSPLGDL
910 920 930 940 950
GLDMASYKRE FSPSRLFAED LAELVGASVS SSSSSAAAAT APPERSAGAA
960 970
SAATGADAPS SSSSGGIKVE PITTTSE
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM9PDT5 | M9PDT5_DROME | Bric a brac 1, isoform D | bab1 anon-WO0118547.639, BAB, bab, BAB-1, bab-I | 971 | Annotation score: | ||
M9PGP8 | M9PGP8_DROME | Bric a brac 1, isoform E | bab1 anon-WO0118547.639, BAB, bab, BAB-1, bab-I | 976 | Annotation score: | ||
M9PE50 | M9PE50_DROME | Bric a brac 1, isoform C | bab1 anon-WO0118547.639, BAB, bab, BAB-1, bab-I | 970 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 66 | K → R in CAB64385 (PubMed:11973274).Curated | 1 | |
Sequence conflicti | 188 – 189 | IN → VS in CAB64385 (PubMed:11973274).Curated | 2 | |
Sequence conflicti | 221 | A → R in CAB64385 (PubMed:11973274).Curated | 1 | |
Sequence conflicti | 221 | A → R in AAM52587 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 257 | A → G in CAB64385 (PubMed:11973274).Curated | 1 | |
Sequence conflicti | 264 – 265 | KL → NV in CAB64385 (PubMed:11973274).Curated | 2 | |
Sequence conflicti | 283 – 284 | QQ → HE in CAB64385 (PubMed:11973274).Curated | 2 | |
Sequence conflicti | 362 | D → E in CAB64385 (PubMed:11973274).Curated | 1 | |
Sequence conflicti | 444 | R → M in CAB64385 (PubMed:11973274).Curated | 1 | |
Sequence conflicti | 444 | R → M in AAM52587 (PubMed:12537569).Curated | 1 | |
Sequence conflicti | 763 | N → S in CAB64385 (PubMed:11973274).Curated | 1 | |
Sequence conflicti | 846 | Q → QQQ in CAB64385 (PubMed:11973274).Curated | 1 | |
Sequence conflicti | 862 | A → V in CAB64385 (PubMed:11973274).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ252082 mRNA Translation: CAB64385.1 AE014296 Genomic DNA Translation: AAF47439.2 AY122075 mRNA Translation: AAM52587.1 Sequence problems. U01333 Genomic DNA Translation: AAA87052.1 |
RefSeqi | NP_728565.1, NM_167852.2 |
Genome annotation databases
EnsemblMetazoai | FBtr0072642; FBpp0072538; FBgn0004870 |
GeneIDi | 38116 |
KEGGi | dme:Dmel_CG9097 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ252082 mRNA Translation: CAB64385.1 AE014296 Genomic DNA Translation: AAF47439.2 AY122075 mRNA Translation: AAM52587.1 Sequence problems. U01333 Genomic DNA Translation: AAA87052.1 |
RefSeqi | NP_728565.1, NM_167852.2 |
3D structure databases
SMRi | Q9W0K7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 63665, 13 interactors |
DIPi | DIP-18590N |
IntActi | Q9W0K7, 9 interactors |
STRINGi | 7227.FBpp0072538 |
Proteomic databases
PaxDbi | Q9W0K7 |
Genome annotation databases
EnsemblMetazoai | FBtr0072642; FBpp0072538; FBgn0004870 |
GeneIDi | 38116 |
KEGGi | dme:Dmel_CG9097 |
Organism-specific databases
CTDi | 38116 |
FlyBasei | FBgn0004870, bab1 |
Phylogenomic databases
eggNOGi | ENOG502RYZ4, Eukaryota |
GeneTreei | ENSGT00940000173981 |
InParanoidi | Q9W0K7 |
OrthoDBi | 686400at2759 |
PhylomeDBi | Q9W0K7 |
Enzyme and pathway databases
SignaLinki | Q9W0K7 |
Miscellaneous databases
BioGRID-ORCSi | 38116, 0 hits in 1 CRISPR screen |
GenomeRNAii | 38116 |
PROi | PR:Q9W0K7 |
Gene expression databases
Bgeei | FBgn0004870, Expressed in antenna and 24 other tissues |
ExpressionAtlasi | Q9W0K7, baseline and differential |
Genevisiblei | Q9W0K7, DM |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR009057, Homeobox-like_sf IPR007889, HTH_Psq IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF05225, HTH_psq, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS50960, HTH_PSQ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BAB1_DROME | |
Accessioni | Q9W0K7Primary (citable) accession number: Q9W0K7 Secondary accession number(s): Q23968, Q8MR78, Q9U1H7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 28, 2003 |
Last sequence update: | October 1, 2002 | |
Last modified: | April 7, 2021 | |
This is version 166 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase