UniProtKB - Q9W0K4 (BAB2_DROME)
Protein
Protein bric-a-brac 2
Gene
bab2
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Probably acts as a transcriptional regulator. Required for the specification of the tarsal segment. Also involved in antenna development.1 Publication1 Publication
Miscellaneous
'Bric-a-brac' means 'jumble' in French (referring to the mutant ovary phenotype).
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 645 – 690 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 46 | |
DNA bindingi | 697 – 708 | A.T hookAdd BLAST | 12 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: FlyBase
- minor groove of adenine-thymine-rich DNA binding Source: FlyBase
GO - Biological processi
- eye-antennal disc morphogenesis Source: UniProtKB
- female gonad morphogenesis Source: FlyBase
- leg disc morphogenesis Source: UniProtKB
- regulation of stem cell differentiation Source: FlyBase
- regulation of transcription, DNA-templated Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Protein bric-a-brac 2 |
Gene namesi | Name:bab2 Synonyms:BtbII ORF Names:CG9102 |
Organismi | Drosophila melanogaster (Fruit fly)Imported |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0025525, bab2 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation1 Publication
Nucleus
- nucleus Source: FlyBase
Other locations
- polytene chromosome Source: FlyBase
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064792 | 1 – 1067 | Protein bric-a-brac 2Add BLAST | 1067 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 55 | Phosphotyrosine1 Publication | 1 | |
Modified residuei | 56 | Phosphoserine1 Publication | 1 | |
Modified residuei | 87 | Phosphoserine1 Publication | 1 | |
Modified residuei | 147 | Phosphoserine1 Publication | 1 | |
Modified residuei | 377 | Phosphoserine1 Publication | 1 | |
Modified residuei | 384 | Phosphothreonine1 Publication | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q9W0K4 |
PTM databases
iPTMneti | Q9W0K4 |
Expressioni
Tissue specificityi
Leg imaginal disk at the central region of the tarsus and in eye antenna disk at the basal cylinder.1 Publication
Gene expression databases
Bgeei | FBgn0025525, Expressed in crop (Drosophila) and 51 other tissues |
ExpressionAtlasi | Q9W0K4, baseline and differential |
Genevisiblei | Q9W0K4, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 68922, 7 interactors |
DIPi | DIP-20101N |
IntActi | Q9W0K4, 2 interactors |
STRINGi | 7227.FBpp0072535 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 223 – 288 | BTBPROSITE-ProRule annotationCuratedAdd BLAST | 66 | |
Domaini | 635 – 687 | HTH psq-typePROSITE-ProRule annotationAdd BLAST | 53 |
Phylogenomic databases
eggNOGi | ENOG502RYZ4, Eukaryota |
GeneTreei | ENSGT00940000173981 |
HOGENOMi | CLU_009130_0_0_1 |
InParanoidi | Q9W0K4 |
OrthoDBi | 686400at2759 |
PhylomeDBi | Q9W0K4 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR009057, Homeobox-like_sf IPR007889, HTH_Psq IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF05225, HTH_psq, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS50960, HTH_PSQ, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q9W0K4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDMTKQIVDF EIKSELIGEI DQFEASDYTM APPEEPKMVE ESPQLGHLED
60 70 80 90 100
QNRKYSPERE VEPTLQDPSE VVDQMQKDTE SVGEVKSPEK DVETELVKSK
110 120 130 140 150
ASPMNDQALT PPPRPLTSSE VVGLRDPEHT ELRMCLEAKK SRSLPVSPQP
160 170 180 190 200
QPNLKLAGSA LFEFGQRSSP VETKIKTNPE TKPPRRKIVP PSGEGQQFCL
210 220 230 240 250
RWNNYQSNLT NVFDELLQSE SFVDVTLSCE GHSIKAHKMV LSACSPYFQA
260 270 280 290 300
LFYDNPCQHP IIIMRDVSWS DLKALVEFMY KGEINVCQDQ INPLLKVAET
310 320 330 340 350
LKIRGLAEVS AGRGEGGASA LPMSAFDDED EEEELASATA ILQQDGDADP
360 370 380 390 400
DEEMKAKRPR LLPEGVLDLN QRQRKRSRDG SYATPSPSLQ GGESEISERG
410 420 430 440 450
SSGTPGQSQS QPLAMTTSTI VRNPFASPNP QTLEGRNSAM NAVANQRKSP
460 470 480 490 500
APTATGHSNG NSGAAMHSPP GGVAVQSALP PHMAAIVPPP PSAMHHHAQQ
510 520 530 540 550
LAAQHQLAHS HAMASALAAA AAGAGAAGAG GAGSGSGSGA SAPTGGTGVA
560 570 580 590 600
GSGAGAAVGS HHDDMEIKPE IAEMIREEER AKMIESGGHG GWMGAAAAAT
610 620 630 640 650
GAASVAADSY QYQLQSMWQK CWNTNQQNLV QQLRFRERGP LKSWRPEAMA
660 670 680 690 700
EAIFSVLKEG LSLSQAARKF DIPYPTFVLY ANRVHNMLGP SLDGGADPRP
710 720 730 740 750
KARGRPQRIL LGMWPEELIR SVIKAVVFRD YREIKEDMSA HQYANGQGHG
760 770 780 790 800
TYIGGGTTTN GYHSAAAAKL AAQNAALAPP DAGSPLSSMT ETLRRQILSQ
810 820 830 840 850
QQQHQQHHQQ QAHHQQQPSH HQQQSPHAQS MNMYKSPAYL QRSEIEDQVS
860 870 880 890 900
AAAAVAAAAA KHQQQQGERR GSENLPDLSA LGLMGLPGLN VMPSRGSGGG
910 920 930 940 950
SGGAAPNSAA SYARELSRER ERDRERERER ELSRQYGSQS RGSSSGSGSA
960 970 980 990 1000
KSLTASQRPG AASPYSAAHY AKHQASAYNK RFLESLPAGI DLEAFANGLL
1010 1020 1030 1040 1050
QKSVNKSPRF EDFFPGPGQD MSELFANPDA SAAAAAAAYA PPGAIRESPL
1060
MKIKLEQQHA TELPHED
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9PBH6 | M9PBH6_DROME | Bric a brac 2, isoform B | bab2 BAB, bab, bab-II, BAB2, Bab2 | 1,066 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | E → G in AAQ22432 (Ref. 4) Curated | 1 | |
Sequence conflicti | 91 | D → G in AAQ22432 (Ref. 4) Curated | 1 | |
Sequence conflicti | 378 | R → G in AAQ22432 (Ref. 4) Curated | 1 | |
Sequence conflicti | 858 | A → R in CAB64388 (PubMed:11973274).Curated | 1 | |
Sequence conflicti | 911 | S → F in AAQ22432 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ252173 mRNA Translation: CAB64388.1 AE014296 Genomic DNA Translation: AAF47442.2 BT009963 mRNA Translation: AAQ22432.1 U14399 Genomic DNA Translation: AAA50834.1 |
RefSeqi | NP_523879.2, NM_079155.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0072639; FBpp0072535; FBgn0025525 |
GeneIDi | 44254 |
KEGGi | dme:Dmel_CG9102 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ252173 mRNA Translation: CAB64388.1 AE014296 Genomic DNA Translation: AAF47442.2 BT009963 mRNA Translation: AAQ22432.1 U14399 Genomic DNA Translation: AAA50834.1 |
RefSeqi | NP_523879.2, NM_079155.3 |
3D structure databases
SMRi | Q9W0K4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 68922, 7 interactors |
DIPi | DIP-20101N |
IntActi | Q9W0K4, 2 interactors |
STRINGi | 7227.FBpp0072535 |
PTM databases
iPTMneti | Q9W0K4 |
Proteomic databases
PaxDbi | Q9W0K4 |
Genome annotation databases
EnsemblMetazoai | FBtr0072639; FBpp0072535; FBgn0025525 |
GeneIDi | 44254 |
KEGGi | dme:Dmel_CG9102 |
Organism-specific databases
CTDi | 44254 |
FlyBasei | FBgn0025525, bab2 |
Phylogenomic databases
eggNOGi | ENOG502RYZ4, Eukaryota |
GeneTreei | ENSGT00940000173981 |
HOGENOMi | CLU_009130_0_0_1 |
InParanoidi | Q9W0K4 |
OrthoDBi | 686400at2759 |
PhylomeDBi | Q9W0K4 |
Miscellaneous databases
BioGRID-ORCSi | 44254, 0 hits in 1 CRISPR screen |
ChiTaRSi | bab2, fly |
GenomeRNAii | 44254 |
PROi | PR:Q9W0K4 |
Gene expression databases
Bgeei | FBgn0025525, Expressed in crop (Drosophila) and 51 other tissues |
ExpressionAtlasi | Q9W0K4, baseline and differential |
Genevisiblei | Q9W0K4, DM |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR009057, Homeobox-like_sf IPR007889, HTH_Psq IPR011333, SKP1/BTB/POZ_sf |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF05225, HTH_psq, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF54695, SSF54695, 1 hit |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS50960, HTH_PSQ, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BAB2_DROME | |
Accessioni | Q9W0K4Primary (citable) accession number: Q9W0K4 Secondary accession number(s): Q24001, Q7YU69, Q9U1H3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 28, 2003 |
Last sequence update: | March 28, 2003 | |
Last modified: | December 2, 2020 | |
This is version 164 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase