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Entry version 195 (10 Feb 2021)
Sequence version 1 (01 May 2000)
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Protein

Coatomer subunit alpha

Gene

alphaCOP

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processER-Golgi transportUniRule annotationARBA annotation, Protein transportUniRule annotation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-6807878, COPI-mediated anterograde transport
R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coatomer subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:alphaCOPImported
Synonyms:alpha-COPImported, alpha-CopImported, alphaCopImported, Dmel\CG7961Imported
ORF Names:CG7961Imported, Dmel_CG7961Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0025725, alphaCOP

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Capsid proteinImported, CytoplasmUniRule annotation, Golgi apparatusUniRule annotationARBA annotation, MembraneUniRule annotation, Virion

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0025725, Expressed in embryonic/larval hemocyte (Drosophila) and 58 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

UniRule annotation

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q9W0B8, 8 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072693

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 330WD_REPEATS_REGIONInterPro annotationAdd BLAST326
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati47 – 88WDPROSITE-ProRule annotationAdd BLAST42
Repeati89 – 130WDPROSITE-ProRule annotationAdd BLAST42
Repeati131 – 165WDPROSITE-ProRule annotationAdd BLAST35
Repeati204 – 238WDPROSITE-ProRule annotationAdd BLAST35
Repeati248 – 289WDPROSITE-ProRule annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni854 – 891DisorderedSequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi858 – 872AcidicSequence analysisAdd BLAST15

Keywords - Domaini

RepeatARBA annotation, WD repeatPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0292, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155451

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007565_1_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
GNQVFCL

Database of Orthologous Groups

More...
OrthoDBi
139008at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016391, Coatomer_asu
IPR010714, Coatomer_asu_C
IPR006692, Coatomer_WD-assoc_reg
IPR020472, G-protein_beta_WD-40_rep
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04053, Coatomer_WDAD, 1 hit
PF06957, COPI_C, 1 hit
PF00400, WD40, 5 hits

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF003354, Coatomer_alpha_subunit, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00320, GPROTEINBRPT

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978, SSF50978, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 5 hits
PS50294, WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W0B8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTNFESKSA RVKGLSFHPK RPWILVSLHS GVIQLWDYRM HTLLEKFDEH
60 70 80 90 100
DGPVRGVAFH QQMPLFVSGG DDYKIKVWNY KQRRCIFTLL AHLDYVRTVA
110 120 130 140 150
FHHEYPWILS ASDDQTIRIW NWQSRNCICV LTGHNHYVMC AQFHPTEDQI
160 170 180 190 200
VSASLDQTVR VWDISGLRKK NVAPGPGGLD DHLKGHPGAT DLFGQADAVV
210 220 230 240 250
KHVLEGHDRG VNWASFHPTL PLIVSGADDR LVKLWRMNEY KAWEVDTCRG
260 270 280 290 300
HYNNVSSVLF HPRQDLILSN GEDRSIRVWD MTKRQCLFTF RRDNERFWIL
310 320 330 340 350
TAHPTLNLFA AGHDGGMVVF KLERERPAYA VHGNILYYVK ERFLRKLDFT
360 370 380 390 400
TTKDTVVMQL RPGKSPVYSM SYNPALNAVL ICTRTNNLEN STYDLCQIPK
410 420 430 440 450
DTESQSESDS KRSSGITAIW VARNRFAVLD RNQQLVIKNF KNEVTKKLPT
460 470 480 490 500
FCEEIFYAGT GMLLIRDPEF VTLYEVQRLV SVGSIKLAKC RYVVWSPDMS
510 520 530 540 550
LVALLCKHSV TICDRRLQYL CTVQENCRVK SGAWDESGVF IYTTSNHIKY
560 570 580 590 600
AITNGDHGII RTLDLPIYLT RVKGNQVFCL DRECRTRVLH IDPTEYKFKL
610 620 630 640 650
ALIQRKYDEV LHMVRNARLV GQSIIAYLQQ KGYPEVALHF VKDEKTRFGL
660 670 680 690 700
ALECGNIEIA LEAAKALDDK DCWDRLGQSA LLQGNHQVVE MCYQRTKNFD
710 720 730 740 750
KLSFLYLITG NLEKLKKMNK IAEIRKDVSA QYQGALLLGD VKERVNILKN
760 770 780 790 800
CGQLSLAYLT AATHGFDELT ESLGESITSQ GNSLPEVNPN AQLLQPPVPI
810 820 830 840 850
QQLETNWPLL SVSKGFFEGA MVTRAGSSAT ARQALNINAD AALLDEHNGG
860 870 880 890 900
GDGWGADADL GLDEDGDDEM HDALSNDGDG GAGGEEGAGW DVGDDDLVVP
910 920 930 940 950
EELASKIKAS ALDSNYYAAP NKGLSPAQQW ANNSPLVLDH VKAGSFETAF
960 970 980 990 1000
RLLHDQLGVV NFQPFKTLFL QNYACSRTSY TANPNLQSLS GYPLRNYSET
1010 1020 1030 1040 1050
NIKLQRPAVG IKLNDLVARL QAGYQLTTSG KFSEAVEKFH SILISIPLLV
1060 1070 1080 1090 1100
VDTKLDAAEA QQLLRICAEY IVGLKMETVR KGMPKSTLEE QKRLCEMAAY
1110 1120 1130 1140 1150
FTHCKLQPVH QILTLRTALN MFFKLKNYKT AASFARRLLE LAPRPDVAQQ
1160 1170 1180 1190 1200
VRKILQACEV NPVDEHQLQY EEFNPFTICG ISWKPLYRGK PEVTCPFCSS
1210 1220 1230
SFDPQFKGNL CTVCEVSQIG KDSIGLRISN LQFR
Length:1,234
Mass (Da):139,329
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0815208E1EC82981
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47534.1
AE014296 Genomic DNA Translation: AAF47535.1
AY075425 mRNA Translation: AAL68241.1

NCBI Reference Sequences

More...
RefSeqi
NP_477395.1, NM_058047.5
NP_728648.1, NM_167908.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072811; FBpp0072693; FBgn0025725
FBtr0072812; FBpp0072694; FBgn0025725

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38199

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7961

UCSC genome browser

More...
UCSCi
CG7961-RA, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47534.1
AE014296 Genomic DNA Translation: AAF47535.1
AY075425 mRNA Translation: AAL68241.1
RefSeqiNP_477395.1, NM_058047.5
NP_728648.1, NM_167908.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ9W0B8, 8 interactors
STRINGi7227.FBpp0072693

Genome annotation databases

EnsemblMetazoaiFBtr0072811; FBpp0072693; FBgn0025725
FBtr0072812; FBpp0072694; FBgn0025725
GeneIDi38199
KEGGidme:Dmel_CG7961
UCSCiCG7961-RA, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38199
FlyBaseiFBgn0025725, alphaCOP

Phylogenomic databases

eggNOGiKOG0292, Eukaryota
GeneTreeiENSGT00940000155451
HOGENOMiCLU_007565_1_0_1
OMAiGNQVFCL
OrthoDBi139008at2759

Enzyme and pathway databases

ReactomeiR-DME-6807878, COPI-mediated anterograde transport
R-DME-6811434, COPI-dependent Golgi-to-ER retrograde traffic

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38199, 0 hits in 1 CRISPR screen

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
alphaCOP, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38199

Gene expression databases

BgeeiFBgn0025725, Expressed in embryonic/larval hemocyte (Drosophila) and 58 other tissues

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR016391, Coatomer_asu
IPR010714, Coatomer_asu_C
IPR006692, Coatomer_WD-assoc_reg
IPR020472, G-protein_beta_WD-40_rep
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF04053, Coatomer_WDAD, 1 hit
PF06957, COPI_C, 1 hit
PF00400, WD40, 5 hits
PIRSFiPIRSF003354, Coatomer_alpha_subunit, 1 hit
PRINTSiPR00320, GPROTEINBRPT
SMARTiView protein in SMART
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 2 hits
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 5 hits
PS50294, WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W0B8_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W0B8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: May 1, 2000
Last modified: February 10, 2021
This is version 195 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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