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Entry version 165 (16 Oct 2019)
Sequence version 2 (16 Feb 2004)
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Protein
Submitted name:

FI03690p

Gene

Gk2

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glycerol kinase activity Source: FlyBase

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-75109 Triglyceride biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
FI03690pImported
Submitted name:
Glycerol kinase 2, isoform AImported
Submitted name:
Glycerol kinase 2, isoform BImported
Submitted name:
Glycerol kinase 2, isoform CImported
Submitted name:
Glycerol kinase 2, isoform DImported
Submitted name:
Glycerol kinase 2, isoform EImported
Submitted name:
Glycerol kinase 2, isoform FImported (EC:2.7.1.30Imported)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Gk2Imported
Synonyms:CG7995-RAImported, dGKImported, Dmel\CG7995Imported, GkImported
ORF Names:CG7995Imported, Dmel_CG7995Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0035266 Gk2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q9W095

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0035266 Expressed in 28 organ(s), highest expression level in crop (Drosophila)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q9W095, 2 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072650

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9W095

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 284FGGY_NInterPro annotationAdd BLAST252
Domaini294 – 483FGGY_CInterPro annotationAdd BLAST190

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2517 Eukaryota
COG0554 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182753

KEGG Orthology (KO)

More...
KOi
K00864

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRQNARG

Database of Orthologous Groups

More...
OrthoDBi
519426at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07792 FGGY_GK1-3_metazoa, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR042018 GK1-3_metazoa
IPR005999 Glycerol_kin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000538 GlpK, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01311 glycerol_kin, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W095-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEGKNLPHS SADVPFRSKE LRKQSLIQHT GLVGVIDEGT KTIGFSIYTT
60 70 80 90 100
PDFKEIAAHR VELSVITPQD GWYEQDPLEM MASINKCAEE AIKQLPEQGF
110 120 130 140 150
SASDIVTVGI TNQRETTIVW DAVTGKPLYN ALLWKDIRTS TTVEQIVAKV
160 170 180 190 200
QDPNHFRSST GLPISTYFSA LKIRWLRDNV PEVRQAIRER RCKAGTVDSW
210 220 230 240 250
IVWNLTNGAL HITDVTNASR TLLMNLETQA WDPVLLKTFG IREEMLPTIH
260 270 280 290 300
SCSEIFGKIT SERSPLRGMT LSGIMGNQQA SLLGQMCVKP GQTKNTYRSG
310 320 330 340 350
CFLLCNTGDK PVFSRHGLLT TVAYKLGPQA PTIYAIEGAV SVAGHALSWL
360 370 380 390 400
QNKVRILPDS RDAEKYAEMV PTSGDVYFVP AFTGLYAPYW RQNARGIIIG
410 420 430 440 450
LTQFTRKNHI VRAALESICF QTRDILECMH QECGYEINKL HADGKLTTNN
460 470 480 490 500
LLMQLQADTI GMPVFRSQLM DSTAFGAAMC AAQADGVNLC QFEPEKRYYE
510 520 530 540 550
NVHYDTFLAT TTDVERKERY GKWKRAVERS LGWVIKQKKT REYTEENYRM
560 570
LSSLPASIFL ISSFAMLVHS LAASGQ
Length:576
Mass (Da):64,588
Last modified:February 16, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i58FA50A3C1ECBDA7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47558.2
AE014296 Genomic DNA Translation: AAF47559.1
AE014296 Genomic DNA Translation: AAF47560.1
AE014296 Genomic DNA Translation: AAN11496.1
AE014296 Genomic DNA Translation: AAN11497.1
BT044165 mRNA Translation: ACH92230.1
AE014296 Genomic DNA Translation: AHN57929.1

NCBI Reference Sequences

More...
RefSeqi
NP_001286904.1, NM_001299975.1
NP_647655.1, NM_139398.3
NP_728664.1, NM_167912.2
NP_728665.1, NM_167913.3
NP_728666.1, NM_167914.2
NP_728667.1, NM_167915.3

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0072767; FBpp0072650; FBgn0035266
FBtr0072768; FBpp0072651; FBgn0035266
FBtr0072769; FBpp0072652; FBgn0035266
FBtr0072770; FBpp0072653; FBgn0035266
FBtr0072771; FBpp0072654; FBgn0035266
FBtr0345817; FBpp0311803; FBgn0035266

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38221

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7995

UCSC genome browser

More...
UCSCi
CG7995-RA d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47558.2
AE014296 Genomic DNA Translation: AAF47559.1
AE014296 Genomic DNA Translation: AAF47560.1
AE014296 Genomic DNA Translation: AAN11496.1
AE014296 Genomic DNA Translation: AAN11497.1
BT044165 mRNA Translation: ACH92230.1
AE014296 Genomic DNA Translation: AHN57929.1
RefSeqiNP_001286904.1, NM_001299975.1
NP_647655.1, NM_139398.3
NP_728664.1, NM_167912.2
NP_728665.1, NM_167913.3
NP_728666.1, NM_167914.2
NP_728667.1, NM_167915.3

3D structure databases

SMRiQ9W095
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ9W095, 2 interactors
STRINGi7227.FBpp0072650

Proteomic databases

PRIDEiQ9W095

Genome annotation databases

EnsemblMetazoaiFBtr0072767; FBpp0072650; FBgn0035266
FBtr0072768; FBpp0072651; FBgn0035266
FBtr0072769; FBpp0072652; FBgn0035266
FBtr0072770; FBpp0072653; FBgn0035266
FBtr0072771; FBpp0072654; FBgn0035266
FBtr0345817; FBpp0311803; FBgn0035266
GeneIDi38221
KEGGidme:Dmel_CG7995
UCSCiCG7995-RA d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2712
FlyBaseiFBgn0035266 Gk2

Phylogenomic databases

eggNOGiKOG2517 Eukaryota
COG0554 LUCA
GeneTreeiENSGT00950000182753
KOiK00864
OMAiWRQNARG
OrthoDBi519426at2759

Enzyme and pathway databases

ReactomeiR-DME-75109 Triglyceride biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
rdgA fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38221

Gene expression databases

BgeeiFBgn0035266 Expressed in 28 organ(s), highest expression level in crop (Drosophila)

Family and domain databases

CDDicd07792 FGGY_GK1-3_metazoa, 1 hit
InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
IPR042018 GK1-3_metazoa
IPR005999 Glycerol_kin
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
TIGRFAMsiTIGR01311 glycerol_kin, 1 hit
PROSITEiView protein in PROSITE
PS00933 FGGY_KINASES_1, 1 hit
PS00445 FGGY_KINASES_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ9W095_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W095
Secondary accession number(s): Q9W094
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: February 16, 2004
Last modified: October 16, 2019
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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