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Entry version 152 (16 Oct 2019)
Sequence version 3 (14 May 2014)
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Protein

Intraflagellar transport protein 172 homolog

Gene

Oseg2

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for the maintenance and formation of cilia.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-5610787 Hedgehog 'off' state
R-DME-5620924 Intraflagellar transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intraflagellar transport protein 172 homologBy similarity
Alternative name(s):
Osmotic avoidance abnormal protein 1 homolog
Outer segment 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Oseg2Imported
Synonyms:osm-1
ORF Names:CG13809Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0035317 Oseg2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003289461 – 1754Intraflagellar transport protein 172 homologAdd BLAST1754

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9W040

PRoteomics IDEntifications database

More...
PRIDEi
Q9W040

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0035317 Expressed in 5 organ(s), highest expression level in antenna

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9W040 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
63798, 2 interactors

Protein interaction database and analysis system

More...
IntActi
Q9W040, 7 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304907

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati14 – 53WD 1Add BLAST40
Repeati64 – 103WD 2Add BLAST40
Repeati110 – 149WD 3Add BLAST40
Repeati151 – 190WD 4Add BLAST40
Repeati194 – 232WD 5Add BLAST39
Repeati283 – 322WD 6Add BLAST40
Repeati519 – 557WD 7Add BLAST39
Repeati623 – 656TPR 1Add BLAST34
Repeati690 – 723TPR 2Add BLAST34
Repeati748 – 781TPR 3Add BLAST34
Repeati807 – 840TPR 4Add BLAST34
Repeati852 – 885TPR 5Add BLAST34
Repeati1041 – 1074TPR 6Add BLAST34
Repeati1140 – 1166TPR 7Add BLAST27
Repeati1167 – 1199TPR 8Add BLAST33
Repeati1211 – 1250TPR 9Add BLAST40
Repeati1282 – 1315TPR 10Add BLAST34
Repeati1698 – 1733TPR 11Add BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IFT172 family.Curated

Keywords - Domaini

Repeat, TPR repeat, WD repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3616 Eukaryota
ENOG410XR2C LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153417

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9W040

KEGG Orthology (KO)

More...
KOi
K19676

Identification of Orthologs from Complete Genome Data

More...
OMAi
VSMDQQV

Database of Orthologous Groups

More...
OrthoDBi
30851at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q9W040-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLKYLRTLL EGQEQIQRIA GLAWSPNQQR LAIATADRHI LLYDDAGERR
60 70 80 90 100
DKFSTKPANP ANGKNSYVIR GLAFSPDSTK LAVGQSDSIV YVYKLGESWN
110 120 130 140 150
DKKVICNKFP QASAVTALIW LTSGSIIAGL EDGKVRALHS KSNKSQSLYG
160 170 180 190 200
GDSICISLAA NTKGTGFLSG HNDGTIIRYF MTDEATEPLG RVVQHPVPPF
210 220 230 240 250
ALAWPQGGFC AGGCDQRIVF YDSMGRQLRT FDHSRTEGER EFTVAACSPN
260 270 280 290 300
GQAVAFGSFD RIRIFAWSPR QGAWSESATK EVACLYTLSS LLWRRDGARL
310 320 330 340 350
ALGSVSGAVL LFESVLRRTV WQDKFELIFV APSQLLVRSL TEPSQALTIE
360 370 380 390 400
SQLGLEIDDV RIMGRDNYLV ARTEESLILC DLTRNLSSEV PWTASGHHER
410 420 430 440 450
FYFENPTVCL IFNVGELSLV EYGENSILGS VRTEFVNPHV ISVRLNERGN
460 470 480 490 500
AKENKKLAFL LDAKTICVVD LISRMTSGQI SHETKIDWLE LSETAHKLLF
510 520 530 540 550
RDKKLRLILV DNYTGKKQTL LSNISFVQWV PQSDVVVAQS NSNLAIWYNI
560 570 580 590 600
DLPEHVTMQS VRGEAIEVLR ENGRTVVRSQ DGPSEHNYQL DEGLVEFGTA
610 620 630 640 650
VNDSDFGRAV HFLESLGDKP AAKAMWHNLA LIALEDGNLR VAQRCYAALG
660 670 680 690 700
NVSKAYYLAG MIQQADEFEE SSGSPGILCP EVRAKLALLG SDLRTAERIY
710 720 730 740 750
LEQGDIESAL KMYQQLGMWD EAVALAERRG YNRIAELKQQ HMDYLLSSEQ
760 770 780 790 800
QEKAGQVLEE QGDLQQAMSL YMKANKPARA ARLALKTPHI LQDEQVMLQV
810 820 830 840 850
TEGLVRSELY ELAGDIAHRL SRPEAALALY RKGGAYARAL EIGRVVAPQE
860 870 880 890 900
VTALEEEWGD WLVSRKQLDA SINHYIEAGA TQKALEAAVG AKQWRKAVQI
910 920 930 940 950
AKVLDEPELI QRYAVDLAKH LAFAGDLDGA EDMLVRANLH KDAIELLNRH
960 970 980 990 1000
GKWERAYLIG EKHLKAEQVR ELFVQLAGTL EEQGKFRDAE KVLIAVNEPD
1010 1020 1030 1040 1050
LAIAMYKRRE LYDSMIRLVE RYHKDLLDST HLHLARQLES RGKLKNAEMH
1060 1070 1080 1090 1100
FVASGDWKSA VHMYCSSGRW EDGYRVAKLK GTEGASQQVA YMWAKSMPTE
1110 1120 1130 1140 1150
GAVRLLSKLG LLDTAVGFAC DSGQFEFAME LCKFAGKPTD EVHLKIAMSL
1160 1170 1180 1190 1200
EDEGKFEAAE AEFLKANKPR EAILMYQHAG DWQAALNVAE NHLPDAVGEV
1210 1220 1230 1240 1250
LIGQASAALE TSNYKDYEAL LLRAHRPDLI IEHYKQESLY EDALRIAEEH
1260 1270 1280 1290 1300
YPSALNDLRR LQAQLQRGQA QAQAGEDAAS ISRSYLQKAA EFAKKEQFRK
1310 1320 1330 1340 1350
AAECLMQIDS SNAEDASTLE RALLRAAEIC NQFLEGQDAQ ELAQSLGPRL
1360 1370 1380 1390 1400
LAIKQIGPAA QLYLAADMPK QAVDVFIKTE QWSKARRLAK EIDPDLQLLA
1410 1420 1430 1440 1450
YVEQQQKASL KHEGNIEQLA DIDIVSALDL LAEHGEWQRC LEKAKGLNPA
1460 1470 1480 1490 1500
LLQKYVAVYA AQLIREGNCT TALGLYLSYG APPIEAHFNI YTRIALDCLA
1510 1520 1530 1540 1550
LREEQTERGT TWRQLRDFLF RLLQSLKATP AQSQTKFAAS MEQFLLIAHY
1560 1570 1580 1590 1600
YATRAACKEV QALQPVALRL SLALLRHTDL LPVDKGFYEA GMDLRQAGRE
1610 1620 1630 1640 1650
AEAFVMLNHY LDVCEAIEEG SGQLVDHSDL ASTDFPSSVP LPEDIHLKND
1660 1670 1680 1690 1700
PSLHEEVREW VLAVSMDQQV DQQLPTDDRG LYESSLGPND LPCMLSGFPV
1710 1720 1730 1740 1750
RGRQPVTFQG SSNQVNRDVW SKFSVALKMS PGSGIADIIS FTEKWQGAAN

YVMH
Length:1,754
Mass (Da):195,708
Last modified:May 14, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i673CE3C889A0C50B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47619.3

NCBI Reference Sequences

More...
RefSeqi
NP_647700.2, NM_139443.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0332661; FBpp0304907; FBgn0035317

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38282

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG13809

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014296 Genomic DNA Translation: AAF47619.3
RefSeqiNP_647700.2, NM_139443.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi63798, 2 interactors
IntActiQ9W040, 7 interactors
STRINGi7227.FBpp0304907

Proteomic databases

PaxDbiQ9W040
PRIDEiQ9W040

Genome annotation databases

EnsemblMetazoaiFBtr0332661; FBpp0304907; FBgn0035317
GeneIDi38282
KEGGidme:Dmel_CG13809

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38282
FlyBaseiFBgn0035317 Oseg2

Phylogenomic databases

eggNOGiKOG3616 Eukaryota
ENOG410XR2C LUCA
GeneTreeiENSGT00940000153417
InParanoidiQ9W040
KOiK19676
OMAiVSMDQQV
OrthoDBi30851at2759

Enzyme and pathway databases

ReactomeiR-DME-5610787 Hedgehog 'off' state
R-DME-5620924 Intraflagellar transport

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38282

Protein Ontology

More...
PROi
PR:Q9W040

Gene expression databases

BgeeiFBgn0035317 Expressed in 5 organ(s), highest expression level in antenna
GenevisibleiQ9W040 DM

Family and domain databases

Gene3Di2.130.10.10, 2 hits
InterProiView protein in InterPro
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR036322 WD40_repeat_dom_sf
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSM1_DROME
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9W040
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 14, 2014
Last modified: October 16, 2019
This is version 152 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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