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UniProtKB - Q9VZZ4 (PXDN_DROME)

Entry version 166 (02 Dec 2020)
Sequence version 1 (01 May 2000)
Previous versions | rss
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Protein

Peroxidasin

Gene

Pxn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in extracellular matrix consolidation, phagocytosis and defense.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei862Heme (covalent; via 2 links)By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei863Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi864CalciumPROSITE-ProRule annotation1
Metal bindingi941CalciumPROSITE-ProRule annotation1
Metal bindingi943Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi945CalciumPROSITE-ProRule annotation1
Metal bindingi947CalciumPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1012Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei1015Heme (covalent; via 2 links)By similarity1
Metal bindingi1109Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-209968, Thyroxine biosynthesis
R-DME-6798695, Neutrophil degranulation
R-DME-8941413, Events associated with phagocytolytic activity of PMN cells

Protein family/group databases

PeroxiBase, a peroxidase database

More...PeroxiBasei		3369, DmPxd-A
3370, DmPxd
7646, CflPxd01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxidasin (EC:1.11.1.7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pxn
ORF Names:CG12002
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0011828, Pxn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031962424 – 1527PeroxidasinAdd BLAST1504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi257 ↔ 307By similarity
Disulfide bondi388 ↔ 437By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi479 ↔ 529By similarity
Disulfide bondi574 ↔ 627By similarity
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi682N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi767N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi768 ↔ 784By similarity
Disulfide bondi882 ↔ 892By similarity
Disulfide bondi886 ↔ 909By similarity
Glycosylationi962N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi994 ↔ 1005By similarity
Glycosylationi1120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1212 ↔ 1269By similarity
Glycosylationi1213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1310 ↔ 1336By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9VZZ4

PRoteomics IDEntifications database

More...PRIDEi		Q9VZZ4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9VZZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in hemocytes. Also expressed in the fat body and gastric caeca.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryonic and larval development. Expressed in hemocytes as they migrate in the early embryo and later in embryogenesis, become localized to basement membranes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0011828, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9VZZ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9VZZ4, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; disulfide-linked.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		63831, 6 interactors

Protein interaction database and analysis system

More...IntActi		Q9VZZ4, 3 interactors

STRING: functional protein association networks

More...STRINGi		7227.FBpp0072828

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9VZZ4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 52LRRNTAdd BLAST29
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati53 – 74LRR 1Add BLAST22
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 122LRR 3Add BLAST22
Repeati125 – 146LRR 4Add BLAST22
Repeati149 – 170LRR 5Add BLAST22
Domaini182 – 235LRRCTAdd BLAST54
Domaini236 – 322Ig-like C2-type 1Add BLAST87
Domaini365 – 453Ig-like C2-type 2Add BLAST89
Domaini458 – 545Ig-like C2-type 3Add BLAST88
Domaini553 – 643Ig-like C2-type 4Add BLAST91
Domaini1463 – 1524VWFCPROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1403 – 1441Sequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0619, Eukaryota
KOG2408, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000168557

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006087_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9VZZ4

Identification of Orthologs from Complete Genome Data

More...OMAi		NCVPRIT

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9VZZ4

Family and domain databases

Conserved Domains Database

More...CDDi		cd09826, peroxidasin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR034824, Peroxidasin_peroxidase
IPR001007, VWF_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07679, I-set, 3 hits
PF13855, LRR_8, 2 hits
PF00093, VWC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SM00369, LRR_TYP, 5 hits
SM00013, LRRNT, 1 hit
SM00214, VWC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48113, SSF48113, 1 hit
SSF48726, SSF48726, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 4 hits
PS50292, PEROXIDASE_3, 1 hit
PS01208, VWFC_1, 1 hit
PS50184, VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q9VZZ4-1) [UniParc]FASTAAdd to basket
Also known as: C, D, E

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRFMLLMLQL LGLLLLLAGG VQSVYCPAGC TCLERTVRCI RAKLSAVPKL 
        60         70         80         90        100
PQDTQTLDLR FNHIEELPAN AFSGLAQLTT LFLNDNELAY LQDGALNGLT 
       110        120        130        140        150
ALRFVYLNNN RLSRLPATIF QRMPRLEAIF LENNDIWQLP AGLFDNLPRL 
       160        170        180        190        200
NRLIMYNNKL TQLPVDGFNR LNNLKRLRLD GNAIDCNCGV YSLWRRWHLD 
       210        220        230        240        250
VQRQLVSISL TCAAPQMLQN QGFSSLGEHH FKCAKPQFLV APQDAQVAAG 
       260        270        280        290        300
EQVELSCEVT GLPRPQITWM HNTQELGLEE QAQAEILPSG SLLIRSADTS 
       310        320        330        340        350
DMGIYQCIAR NEMGALRSQP VRLVVNGGNH PLDSPIDARS NQVWADAGTP 
       360        370        380        390        400
MHGATPLPSP LPSPPHFTHQ PHDQIVALHG SGHVLLDCAA SGWPQPDIQW 
       410        420        430        440        450
FVNGRQLLQS TPSLQLQANG SLILLQPNQL SAGTYRCEAR NSLGSVQATA 
       460        470        480        490        500
RIELKELPEI LTAPQSQTIK LGKAFVLECD ADGNPLPTID WQLNGVPLPG 
       510        520        530        540        550
NTPDLQLENE NTELVVGAAR QEHAGVYRCT AHNENGETSV EATIKVERSQ 
       560        570        580        590        600
SPPQLAIEPS NLVAITGTTI ELPCQADQPE DGLQISWRHD GRLIDPNVQL 
       610        620        630        640        650
AEKYQISGAG SLFVKNVTIP DGGRYECQLK NQFGRASASA LVTIRNNVDL 
       660        670        680        690        700
APGDRYVRIA FAEAAKEIDL AINNTLDMLF SNRSDKAPPN YGELLRVFRF 
       710        720        730        740        750
PTGEARQLAR AAEIYERTLV NIRKHVQEGD NLTMKSEEYE FRDLLSREHL 
       760        770        780        790        800
HLVAELSGCM EHREMPNCTD MCFHSRYRSI DGTCNNLQHP TWGASLTAFR 
       810        820        830        840        850
RLAPPIYENG FSMPVGWTKG MLYSGHAKPS ARLVSTSLVA TKEITPDARI 
       860        870        880        890        900
THMVMQWGQF LDHDLDHAIP SVSSESWDGI DCKKSCEMAP PCYPIEVPPN 
       910        920        930        940        950
DPRVRNRRCI DVVRSSAICG SGMTSLFFDS VQHREQINQL TSYIDASQVY 
       960        970        980        990       1000
GYSTAFAQEL RNLTSQEGLL RVGVHFPRQK DMLPFAAPQD GMDCRRNLDE 
      1010       1020       1030       1040       1050
NTMSCFVSGD IRVNEQVGLL AMHTIWMREH NRIASKLKQI NSHWDGDTLY 
      1060       1070       1080       1090       1100
QEARKIVGAQ MQHITFKQWL PLIIGESGME MMGEYQGYNP QLNPSIANEF 
      1110       1120       1130       1140       1150
ATAALRFGHT IINPILHRLN ETFQPIPQGH LLLHKAFFAP WRLAYEGGVD 
      1160       1170       1180       1190       1200
PLMRGFLAVP AKLKTPDQNL NTELTEKLFQ TAHAVALDLA AINIQRGRDH 
      1210       1220       1230       1240       1250
GMPGYNVYRK LCNLTVAQDF EDLAGEISSA EIRQKMKELY GHPDNVDVWL 
      1260       1270       1280       1290       1300
GGILEDQVEG GKVGPLFQCL LVEQFRRLRD GDRLYYENPG VFSPEQLTQI 
      1310       1320       1330       1340       1350
KQANFGRVLC DVGDNFDQVT ENVFILAKHQ GGYKKCEDII GINLYLWQEC 
      1360       1370       1380       1390       1400
GRCNSPPAIF DSYIPQTYTK RSNRQKRDLG KENDEVATAE SYDSPLESLY 
      1410       1420       1430       1440       1450
DVNEERVSGL EELIGSFQKE LKKLHKKLRK LEDSCNSADS EPVAQVVQLA 
      1460       1470       1480       1490       1500
AAPPQLVSKP KRSHCVDDKG TTRLNNEVWS PDVCTKCNCF HGQVNCLRER 
      1510       1520 
CGEVSCPPGV DPLTPPEACC PHCPMVK
Length:1,527
Mass (Da):170,514
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71174FEBEA7C9152
GO
Isoform B (identifier: Q9VZZ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     456-457: EL → GE
     458-1527: Missing.

Show »
Length:457
Mass (Da):50,558
Checksum:i243FB8041A16D483
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA61568 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128A → G in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti183A → AID in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti263P → H in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti282A → T in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti294I → H in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti351M → T in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti361 – 362LP → SPSH in AAA61568 (PubMed:8062820).Curated2
Sequence conflicti380G → S in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti692G → D in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti959 – 960EL → LA in AAA61568 (PubMed:8062820).Curated2
Sequence conflicti1083G → S in AAA61568 (PubMed:8062820).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032693456 – 457EL → GE in isoform B. 1 Publication2
Alternative sequenceiVSP_032694458 – 1527Missing in isoform B. 1 PublicationAdd BLAST1070

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U11052 mRNA Translation: AAA61568.1 Frameshift.
AE014296 Genomic DNA Translation: AAF47668.1
AE014296 Genomic DNA Translation: AAN11518.1
AE014296 Genomic DNA Translation: AAS64946.1
AE014296 Genomic DNA Translation: AAS64947.1
AE014296 Genomic DNA Translation: AAS64948.1
AY051536 mRNA Translation: AAK92960.1
AY052120 mRNA Translation: AAK93544.1

NCBI Reference Sequences

More...RefSeqi		NP_523891.2, NM_079167.5 [Q9VZZ4-1]
NP_728759.1, NM_167957.3 [Q9VZZ4-2]
NP_995975.1, NM_206253.3 [Q9VZZ4-1]
NP_995976.1, NM_206254.3 [Q9VZZ4-1]
NP_995977.1, NM_206255.3 [Q9VZZ4-1]

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0072950; FBpp0072827; FBgn0011828 [Q9VZZ4-2]
FBtr0072951; FBpp0072828; FBgn0011828 [Q9VZZ4-1]
FBtr0072952; FBpp0089205; FBgn0011828 [Q9VZZ4-1]
FBtr0072953; FBpp0089215; FBgn0011828 [Q9VZZ4-1]
FBtr0072954; FBpp0089216; FBgn0011828 [Q9VZZ4-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		38326

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG12002

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11052 mRNA Translation: AAA61568.1 Frameshift.
AE014296 Genomic DNA Translation: AAF47668.1
AE014296 Genomic DNA Translation: AAN11518.1
AE014296 Genomic DNA Translation: AAS64946.1
AE014296 Genomic DNA Translation: AAS64947.1
AE014296 Genomic DNA Translation: AAS64948.1
AY051536 mRNA Translation: AAK92960.1
AY052120 mRNA Translation: AAK93544.1
RefSeqiNP_523891.2, NM_079167.5 [Q9VZZ4-1]
NP_728759.1, NM_167957.3 [Q9VZZ4-2]
NP_995975.1, NM_206253.3 [Q9VZZ4-1]
NP_995976.1, NM_206254.3 [Q9VZZ4-1]
NP_995977.1, NM_206255.3 [Q9VZZ4-1]

3D structure databases

SMRiQ9VZZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63831, 6 interactors
IntActiQ9VZZ4, 3 interactors
STRINGi7227.FBpp0072828

Protein family/group databases

PeroxiBasei3369, DmPxd-A
3370, DmPxd
7646, CflPxd01

PTM databases

iPTMnetiQ9VZZ4

Proteomic databases

PaxDbiQ9VZZ4
PRIDEiQ9VZZ4

Genome annotation databases

EnsemblMetazoaiFBtr0072950; FBpp0072827; FBgn0011828 [Q9VZZ4-2]
FBtr0072951; FBpp0072828; FBgn0011828 [Q9VZZ4-1]
FBtr0072952; FBpp0089205; FBgn0011828 [Q9VZZ4-1]
FBtr0072953; FBpp0089215; FBgn0011828 [Q9VZZ4-1]
FBtr0072954; FBpp0089216; FBgn0011828 [Q9VZZ4-1]
GeneIDi38326
KEGGidme:Dmel_CG12002

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5829
FlyBaseiFBgn0011828, Pxn

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
KOG2408, Eukaryota
GeneTreeiENSGT00940000168557
HOGENOMiCLU_006087_0_1_1
InParanoidiQ9VZZ4
OMAiNCVPRIT
PhylomeDBiQ9VZZ4

Enzyme and pathway databases

ReactomeiR-DME-209968, Thyroxine biosynthesis
R-DME-6798695, Neutrophil degranulation
R-DME-8941413, Events associated with phagocytolytic activity of PMN cells

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		38326, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pxn, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		38326

Protein Ontology

More...PROi		PR:Q9VZZ4

Gene expression databases

BgeeiFBgn0011828, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues
ExpressionAtlasiQ9VZZ4, baseline and differential
GenevisibleiQ9VZZ4, DM

Family and domain databases

CDDicd09826, peroxidasin_like, 1 hit
Gene3Di1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR034824, Peroxidasin_peroxidase
IPR001007, VWF_dom
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07679, I-set, 3 hits
PF13855, LRR_8, 2 hits
PF00093, VWC, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SM00369, LRR_TYP, 5 hits
SM00013, LRRNT, 1 hit
SM00214, VWC, 1 hit
SUPFAMiSSF48113, SSF48113, 1 hit
SSF48726, SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 4 hits
PS50292, PEROXIDASE_3, 1 hit
PS01208, VWFC_1, 1 hit
PS50184, VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXDN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VZZ4
Secondary accession number(s): Q23991, Q960D1, Q961K8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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