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Entry version 166 (02 Dec 2020)
Sequence version 1 (01 May 2000)
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Protein

Peroxidasin

Gene

Pxn

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in extracellular matrix consolidation, phagocytosis and defense.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei862Heme (covalent; via 2 links)By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei863Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi864CalciumPROSITE-ProRule annotation1
Metal bindingi941CalciumPROSITE-ProRule annotation1
Metal bindingi943Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi945CalciumPROSITE-ProRule annotation1
Metal bindingi947CalciumPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1012Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei1015Heme (covalent; via 2 links)By similarity1
Metal bindingi1109Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-209968, Thyroxine biosynthesis
R-DME-6798695, Neutrophil degranulation
R-DME-8941413, Events associated with phagocytolytic activity of PMN cells

Protein family/group databases

PeroxiBase, a peroxidase database

More...
PeroxiBasei
3369, DmPxd-A
3370, DmPxd
7646, CflPxd01

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxidasin (EC:1.11.1.7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pxn
ORF Names:CG12002
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0011828, Pxn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031962424 – 1527PeroxidasinAdd BLAST1504

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi257 ↔ 307By similarity
Disulfide bondi388 ↔ 437By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi479 ↔ 529By similarity
Disulfide bondi574 ↔ 627By similarity
Glycosylationi616N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi673N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi682N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi731N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi767N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi768 ↔ 784By similarity
Disulfide bondi882 ↔ 892By similarity
Disulfide bondi886 ↔ 909By similarity
Glycosylationi962N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi994 ↔ 1005By similarity
Glycosylationi1120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1212 ↔ 1269By similarity
Glycosylationi1213N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1310 ↔ 1336By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9VZZ4

PRoteomics IDEntifications database

More...
PRIDEi
Q9VZZ4

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9VZZ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in hemocytes. Also expressed in the fat body and gastric caeca.1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryonic and larval development. Expressed in hemocytes as they migrate in the early embryo and later in embryogenesis, become localized to basement membranes.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0011828, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9VZZ4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9VZZ4, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer; disulfide-linked.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
63831, 6 interactors

Protein interaction database and analysis system

More...
IntActi
Q9VZZ4, 3 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0072828

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9VZZ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 52LRRNTAdd BLAST29
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati53 – 74LRR 1Add BLAST22
Repeati77 – 98LRR 2Add BLAST22
Repeati101 – 122LRR 3Add BLAST22
Repeati125 – 146LRR 4Add BLAST22
Repeati149 – 170LRR 5Add BLAST22
Domaini182 – 235LRRCTAdd BLAST54
Domaini236 – 322Ig-like C2-type 1Add BLAST87
Domaini365 – 453Ig-like C2-type 2Add BLAST89
Domaini458 – 545Ig-like C2-type 3Add BLAST88
Domaini553 – 643Ig-like C2-type 4Add BLAST91
Domaini1463 – 1524VWFCPROSITE-ProRule annotationAdd BLAST62

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1403 – 1441Sequence analysisAdd BLAST39

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0619, Eukaryota
KOG2408, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168557

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006087_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9VZZ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
NCVPRIT

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9VZZ4

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09826, peroxidasin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR034824, Peroxidasin_peroxidase
IPR001007, VWF_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07679, I-set, 3 hits
PF13855, LRR_8, 2 hits
PF00093, VWC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00457, ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SM00369, LRR_TYP, 5 hits
SM00013, LRRNT, 1 hit
SM00214, VWC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48113, SSF48113, 1 hit
SSF48726, SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835, IG_LIKE, 4 hits
PS50292, PEROXIDASE_3, 1 hit
PS01208, VWFC_1, 1 hit
PS50184, VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform A (identifier: Q9VZZ4-1) [UniParc]FASTAAdd to basket
Also known as: C, D, E

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRFMLLMLQL LGLLLLLAGG VQSVYCPAGC TCLERTVRCI RAKLSAVPKL
60 70 80 90 100
PQDTQTLDLR FNHIEELPAN AFSGLAQLTT LFLNDNELAY LQDGALNGLT
110 120 130 140 150
ALRFVYLNNN RLSRLPATIF QRMPRLEAIF LENNDIWQLP AGLFDNLPRL
160 170 180 190 200
NRLIMYNNKL TQLPVDGFNR LNNLKRLRLD GNAIDCNCGV YSLWRRWHLD
210 220 230 240 250
VQRQLVSISL TCAAPQMLQN QGFSSLGEHH FKCAKPQFLV APQDAQVAAG
260 270 280 290 300
EQVELSCEVT GLPRPQITWM HNTQELGLEE QAQAEILPSG SLLIRSADTS
310 320 330 340 350
DMGIYQCIAR NEMGALRSQP VRLVVNGGNH PLDSPIDARS NQVWADAGTP
360 370 380 390 400
MHGATPLPSP LPSPPHFTHQ PHDQIVALHG SGHVLLDCAA SGWPQPDIQW
410 420 430 440 450
FVNGRQLLQS TPSLQLQANG SLILLQPNQL SAGTYRCEAR NSLGSVQATA
460 470 480 490 500
RIELKELPEI LTAPQSQTIK LGKAFVLECD ADGNPLPTID WQLNGVPLPG
510 520 530 540 550
NTPDLQLENE NTELVVGAAR QEHAGVYRCT AHNENGETSV EATIKVERSQ
560 570 580 590 600
SPPQLAIEPS NLVAITGTTI ELPCQADQPE DGLQISWRHD GRLIDPNVQL
610 620 630 640 650
AEKYQISGAG SLFVKNVTIP DGGRYECQLK NQFGRASASA LVTIRNNVDL
660 670 680 690 700
APGDRYVRIA FAEAAKEIDL AINNTLDMLF SNRSDKAPPN YGELLRVFRF
710 720 730 740 750
PTGEARQLAR AAEIYERTLV NIRKHVQEGD NLTMKSEEYE FRDLLSREHL
760 770 780 790 800
HLVAELSGCM EHREMPNCTD MCFHSRYRSI DGTCNNLQHP TWGASLTAFR
810 820 830 840 850
RLAPPIYENG FSMPVGWTKG MLYSGHAKPS ARLVSTSLVA TKEITPDARI
860 870 880 890 900
THMVMQWGQF LDHDLDHAIP SVSSESWDGI DCKKSCEMAP PCYPIEVPPN
910 920 930 940 950
DPRVRNRRCI DVVRSSAICG SGMTSLFFDS VQHREQINQL TSYIDASQVY
960 970 980 990 1000
GYSTAFAQEL RNLTSQEGLL RVGVHFPRQK DMLPFAAPQD GMDCRRNLDE
1010 1020 1030 1040 1050
NTMSCFVSGD IRVNEQVGLL AMHTIWMREH NRIASKLKQI NSHWDGDTLY
1060 1070 1080 1090 1100
QEARKIVGAQ MQHITFKQWL PLIIGESGME MMGEYQGYNP QLNPSIANEF
1110 1120 1130 1140 1150
ATAALRFGHT IINPILHRLN ETFQPIPQGH LLLHKAFFAP WRLAYEGGVD
1160 1170 1180 1190 1200
PLMRGFLAVP AKLKTPDQNL NTELTEKLFQ TAHAVALDLA AINIQRGRDH
1210 1220 1230 1240 1250
GMPGYNVYRK LCNLTVAQDF EDLAGEISSA EIRQKMKELY GHPDNVDVWL
1260 1270 1280 1290 1300
GGILEDQVEG GKVGPLFQCL LVEQFRRLRD GDRLYYENPG VFSPEQLTQI
1310 1320 1330 1340 1350
KQANFGRVLC DVGDNFDQVT ENVFILAKHQ GGYKKCEDII GINLYLWQEC
1360 1370 1380 1390 1400
GRCNSPPAIF DSYIPQTYTK RSNRQKRDLG KENDEVATAE SYDSPLESLY
1410 1420 1430 1440 1450
DVNEERVSGL EELIGSFQKE LKKLHKKLRK LEDSCNSADS EPVAQVVQLA
1460 1470 1480 1490 1500
AAPPQLVSKP KRSHCVDDKG TTRLNNEVWS PDVCTKCNCF HGQVNCLRER
1510 1520
CGEVSCPPGV DPLTPPEACC PHCPMVK
Length:1,527
Mass (Da):170,514
Last modified:May 1, 2000 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71174FEBEA7C9152
GO
Isoform B (identifier: Q9VZZ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     456-457: EL → GE
     458-1527: Missing.

Show »
Length:457
Mass (Da):50,558
Checksum:i243FB8041A16D483
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA61568 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti128A → G in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti183A → AID in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti263P → H in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti282A → T in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti294I → H in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti351M → T in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti361 – 362LP → SPSH in AAA61568 (PubMed:8062820).Curated2
Sequence conflicti380G → S in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti692G → D in AAA61568 (PubMed:8062820).Curated1
Sequence conflicti959 – 960EL → LA in AAA61568 (PubMed:8062820).Curated2
Sequence conflicti1083G → S in AAA61568 (PubMed:8062820).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_032693456 – 457EL → GE in isoform B. 1 Publication2
Alternative sequenceiVSP_032694458 – 1527Missing in isoform B. 1 PublicationAdd BLAST1070

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U11052 mRNA Translation: AAA61568.1 Frameshift.
AE014296 Genomic DNA Translation: AAF47668.1
AE014296 Genomic DNA Translation: AAN11518.1
AE014296 Genomic DNA Translation: AAS64946.1
AE014296 Genomic DNA Translation: AAS64947.1
AE014296 Genomic DNA Translation: AAS64948.1
AY051536 mRNA Translation: AAK92960.1
AY052120 mRNA Translation: AAK93544.1

NCBI Reference Sequences

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RefSeqi
NP_523891.2, NM_079167.5 [Q9VZZ4-1]
NP_728759.1, NM_167957.3 [Q9VZZ4-2]
NP_995975.1, NM_206253.3 [Q9VZZ4-1]
NP_995976.1, NM_206254.3 [Q9VZZ4-1]
NP_995977.1, NM_206255.3 [Q9VZZ4-1]

Genome annotation databases

Ensembl metazoan genome annotation project

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EnsemblMetazoai
FBtr0072950; FBpp0072827; FBgn0011828 [Q9VZZ4-2]
FBtr0072951; FBpp0072828; FBgn0011828 [Q9VZZ4-1]
FBtr0072952; FBpp0089205; FBgn0011828 [Q9VZZ4-1]
FBtr0072953; FBpp0089215; FBgn0011828 [Q9VZZ4-1]
FBtr0072954; FBpp0089216; FBgn0011828 [Q9VZZ4-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
38326

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dme:Dmel_CG12002

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U11052 mRNA Translation: AAA61568.1 Frameshift.
AE014296 Genomic DNA Translation: AAF47668.1
AE014296 Genomic DNA Translation: AAN11518.1
AE014296 Genomic DNA Translation: AAS64946.1
AE014296 Genomic DNA Translation: AAS64947.1
AE014296 Genomic DNA Translation: AAS64948.1
AY051536 mRNA Translation: AAK92960.1
AY052120 mRNA Translation: AAK93544.1
RefSeqiNP_523891.2, NM_079167.5 [Q9VZZ4-1]
NP_728759.1, NM_167957.3 [Q9VZZ4-2]
NP_995975.1, NM_206253.3 [Q9VZZ4-1]
NP_995976.1, NM_206254.3 [Q9VZZ4-1]
NP_995977.1, NM_206255.3 [Q9VZZ4-1]

3D structure databases

SMRiQ9VZZ4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi63831, 6 interactors
IntActiQ9VZZ4, 3 interactors
STRINGi7227.FBpp0072828

Protein family/group databases

PeroxiBasei3369, DmPxd-A
3370, DmPxd
7646, CflPxd01

PTM databases

iPTMnetiQ9VZZ4

Proteomic databases

PaxDbiQ9VZZ4
PRIDEiQ9VZZ4

Genome annotation databases

EnsemblMetazoaiFBtr0072950; FBpp0072827; FBgn0011828 [Q9VZZ4-2]
FBtr0072951; FBpp0072828; FBgn0011828 [Q9VZZ4-1]
FBtr0072952; FBpp0089205; FBgn0011828 [Q9VZZ4-1]
FBtr0072953; FBpp0089215; FBgn0011828 [Q9VZZ4-1]
FBtr0072954; FBpp0089216; FBgn0011828 [Q9VZZ4-1]
GeneIDi38326
KEGGidme:Dmel_CG12002

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5829
FlyBaseiFBgn0011828, Pxn

Phylogenomic databases

eggNOGiKOG0619, Eukaryota
KOG2408, Eukaryota
GeneTreeiENSGT00940000168557
HOGENOMiCLU_006087_0_1_1
InParanoidiQ9VZZ4
OMAiNCVPRIT
PhylomeDBiQ9VZZ4

Enzyme and pathway databases

ReactomeiR-DME-209968, Thyroxine biosynthesis
R-DME-6798695, Neutrophil degranulation
R-DME-8941413, Events associated with phagocytolytic activity of PMN cells

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
38326, 0 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Pxn, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
38326

Protein Ontology

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PROi
PR:Q9VZZ4

Gene expression databases

BgeeiFBgn0011828, Expressed in embryonic/larval hemocyte (Drosophila) and 42 other tissues
ExpressionAtlasiQ9VZZ4, baseline and differential
GenevisibleiQ9VZZ4, DM

Family and domain databases

CDDicd09826, peroxidasin_like, 1 hit
Gene3Di1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR019791, Haem_peroxidase_animal
IPR010255, Haem_peroxidase_sf
IPR037120, Haem_peroxidase_sf_animal
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR000372, LRRNT
IPR034824, Peroxidasin_peroxidase
IPR001007, VWF_dom
PfamiView protein in Pfam
PF03098, An_peroxidase, 1 hit
PF07679, I-set, 3 hits
PF13855, LRR_8, 2 hits
PF00093, VWC, 1 hit
PRINTSiPR00457, ANPEROXIDASE
SMARTiView protein in SMART
SM00409, IG, 4 hits
SM00408, IGc2, 4 hits
SM00369, LRR_TYP, 5 hits
SM00013, LRRNT, 1 hit
SM00214, VWC, 1 hit
SUPFAMiSSF48113, SSF48113, 1 hit
SSF48726, SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 4 hits
PS50292, PEROXIDASE_3, 1 hit
PS01208, VWFC_1, 1 hit
PS50184, VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXDN_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9VZZ4
Secondary accession number(s): Q23991, Q960D1, Q961K8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 1, 2000
Last modified: December 2, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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