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Protein
Submitted name:

Activated Cdc42 kinase

Gene

Ack

Organism
Drosophila melanogaster (Fruit fly)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • ATP binding Source: InterPro
  • non-membrane spanning protein tyrosine kinase activity Source: GO_Central
  • protein tyrosine kinase activity Source: FlyBase
  • SH2 domain binding Source: FlyBase
  • signaling receptor binding Source: GO_Central

GO - Biological processi

  • cell migration Source: GO_Central
  • cellular protein localization Source: FlyBase
  • dorsal closure Source: FlyBase
  • innate immune response Source: GO_Central
  • negative regulation of apoptotic process Source: FlyBase
  • negative regulation of hippo signaling Source: FlyBase
  • peptidyl-tyrosine autophosphorylation Source: GO_Central
  • peptidyl-tyrosine phosphorylation Source: FlyBase
  • protein phosphorylation Source: FlyBase
  • regulation of cell proliferation Source: GO_Central
  • spermatid development Source: FlyBase
  • transmembrane receptor protein tyrosine kinase signaling pathway Source: GO_Central

Keywordsi

Molecular functionKinaseImported, Transferase

Names & Taxonomyi

Protein namesi
Submitted name:
Activated Cdc42 kinaseImported (EC:2.7.10.-Imported)
Submitted name:
BcDNA.GH10777Imported
Gene namesi
Name:AckImported
Synonyms:ACKImported, ACK2Imported, BcDNA.GH10777Imported, BcDNA:GH10777Imported, DACKImported, DAckImported, Dmel\CG14992Imported, p145Imported
ORF Names:CG14992Imported, Dmel_CG14992Imported
OrganismiDrosophila melanogaster (Fruit fly)Imported
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0028484 Ack

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Proteomic databases

PRIDEiQ9VZI2

Expressioni

Gene expression databases

BgeeiFBgn0028484

Interactioni

GO - Molecular functioni

  • SH2 domain binding Source: FlyBase
  • signaling receptor binding Source: GO_Central

Protein-protein interaction databases

IntActiQ9VZI2, 3 interactors
STRINGi7227.FBpp0073067

Structurei

3D structure databases

SMRiQ9VZI2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini123 – 383Protein kinaseInterPro annotationAdd BLAST261
Domaini1029 – 1072UBAInterPro annotationAdd BLAST44

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family.SAAS annotation

Phylogenomic databases

eggNOGiKOG0199 Eukaryota
ENOG410XPRC LUCA
GeneTreeiENSGT00760000118799
KOiK08252
OMAiPTYSNTM
OrthoDBiEOG091G03HT

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
IPR020635 Tyr_kinase_cat_dom
IPR015940 UBA
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SMARTiView protein in SMART
SM00219 TyrKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit
PS50030 UBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9VZI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTSAVDGG LGSETAWLED LLREVQLEQF LDRIRDDLQV TRLAHFDYVL
60 70 80 90 100
PDDLERCGLG KPAIRRLMEA VRKKKAHQWR KNILSKLIGG GKQPSSKKQS
110 120 130 140 150
SAARESSQGN GTQLTCLIHE KDITMGLKLG DGSFGVVRRG EWSASPAGKV
160 170 180 190 200
IPVAVKVLKS DNLTQPGIID DFFREVQAMH ALDHANLVRL YGVVLSQPMM
210 220 230 240 250
MITELAERGS LLDTLRKQCR HTSLTIIWNW SVQIVTGMAY LEQKRFLHRD
260 270 280 290 300
LACRNVLLAA GNKIKIGDFG LMRALPQEDD CYVMSEHKKV PFPWCAPESL
310 320 330 340 350
RFRQFSHASD TWMFGVTLWE MFSFGEDPWV GLNGSQILRK IDREGERLHQ
360 370 380 390 400
PDACPPDVYA MMLQCWDKTP AERPTFAALK EYLASMSPPV MRASRSHHES
410 420 430 440 450
KGLQIEPGDT IAIIDGRHEL KLIKGQNQRT FDIGIFPRNL LEQRKVGAAG
460 470 480 490 500
DVVMRSSVGN GSSSSPFGFC WGGAAAMANG DDRQRKCASM TNQPHAKERK
510 520 530 540 550
STSSKQFAYN KLVNDSATGL QRRNAVKHKG VVVGPQRPPP PQFQQEGILI
560 570 580 590 600
DISPDMRPIA EAGTGGAKGA GDSSSLQADS SFCILDAPID VPTYAGSSGS
610 620 630 640 650
GDLNVSPTYY NEQPQFDFDP AKMTASPGRL QPPPYQMPPT YSNTMEFVQK
660 670 680 690 700
RDLHQQQLAT PVRERDPFDT TNVETTVALY SNFNQSLEAA SPPAPIYNSP
710 720 730 740 750
SVRKSLFGGS KSNKENIPAL ESAAMQLNLS NLTLERHDAT CIQPVEPVPA
760 770 780 790 800
PPGDGVLLDK SFIAELEKDM YSNGQNRAQE EYQRNSTQMY ASKDMVYKQN
810 820 830 840 850
LTPLKNGAAP GSVHSNHSSP SSTASPKQNN VEAAAAAAAT TQSVVNRIWY
860 870 880 890 900
EQVASTQSEY YAQPPTEQAE EQIYQNHRHQ QQQQQELNHS FVAISNRVVA
910 920 930 940 950
PKNNAYSSTA SLYDAVAAST AGSTYYGQVP NGSGAVLYDE VTQDDYLRPT
960 970 980 990 1000
RPAPLAPPPL SAQQIQRRME KMRLQQQQQL DGAHQLYAPV PSDYGREQEK
1010 1020 1030 1040 1050
LQQLMQELGS SAVEQDVRNA LRAASGDVGL ATRHYKIDQL ARLGVAGRPQ
1060 1070
CEQALQQTNW SLEVAAELLL NAG
Length:1,073
Mass (Da):118,418
Last modified:March 1, 2001 - v2
Checksum:iD9BF4BD87235D691
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF181642 mRNA Translation: AAD55428.1
AE014296 Genomic DNA Translation: AAF47839.2
RefSeqiNP_647859.1, NM_139602.3
UniGeneiDm.3018

Genome annotation databases

EnsemblMetazoaiFBtr0073211; FBpp0073067; FBgn0028484
GeneIDi38489
KEGGidme:Dmel_CG14992
UCSCiCG14992-RA d. melanogaster

Similar proteinsi

Entry informationi

Entry nameiQ9VZI2_DROME
AccessioniPrimary (citable) accession number: Q9VZI2
Secondary accession number(s): Q9U4G3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 1, 2000
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 170 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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